Table of contents:
- Ketoprofen Organic
- Release form and composition
- Pharmacological properties
- Indications for use
- Ketoprofen Organic, instructions for use: method and dosage
- Side effects
- special instructions
- Application during pregnancy and lactation
- Pediatric use
- With impaired renal function
- For violations of liver function
- Use in the elderly
- Drug interactions
- Terms of dispensing from pharmacies
- Reviews about Ketoprofen Organic
- Price for Ketoprofen Organic in pharmacies
- Ketoprofen Organic: prices in online pharmacies
Video: Ketoprofen Organic - Instructions For Use, Tablets, Price, Reviews
Ketoprofen Organic: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Ketoprofen Organica
ATX code: M01AE03
Active ingredient: ketoprofen (Ketoprofen)
Manufacturer: JSC "ORGANIKA" (Russia)
Description and photo update: 2019-12-07
Prices in pharmacies: from 66 rubles.
Ketoprofen Organic is a non-steroidal anti-inflammatory drug (NSAID).
Release form and composition
Dosage form of Ketoprofen Organic:
- capsules: orange, size No. 2, inside filled with white granules with a creamy or yellowish tint (in a cardboard box 2, 3 or 5 blisters containing 10 capsules each; in a cardboard box 1 can of light-protective glass containing 20, 30 or 50 capsules);
- film-coated tablets: white or almost white, biconvex, round (in a cardboard box 2, 3 or 5 blister packs containing 10 tablets each; in a cardboard box 1 polymer can or light-protective glass containing 20, 30 or 50 tablets);
- solution for intravenous (intravenous) and intramuscular (intramuscular) administration: colorless, transparent, slightly colored (in a cardboard box 1 or 2 blister packs containing 5 ampoules of light-shielding glass containing 2 ml of solution each).
Each pack also contains instructions for the use of Ketoprofen Organic.
Composition of 1 capsule:
- active substance: ketoprofen - 50 mg;
- auxiliary components: magnesium stearate - 0.9 mg; colloidal silicon dioxide (aerosil) - 0.5 mg; microcrystalline cellulose - 24.2 mg; croscarmellose sodium (primellose) - 2.7 mg; mannitol (mannitol) - 10.5 g; hyprolose (hydroxypropyl cellulose, Klucel LF) - 1.2 mg;
- shell: gelatin - up to 100%; titanium dioxide - 2%; sunset yellow (E110) or yellow sunset - 2%.
Composition of 1 film-coated tablet:
- active substance: ketoprofen - 100 mg;
- auxiliary components: magnesium stearate monohydrate - 1.8 mg; colloidal silicon dioxide (aerosil) - 1 mg; microcrystalline cellulose - 48.4 mg; sodium croscarmellose (primellose) - 5.4 mg; mannitol (D-mannitol) - 21 mg; hyprolosis (Klucel LF) - 2.4 mg;
- shell: Opadray II white [talc - 1.48 mg; macrogol (polyethylene glycol) - 2.02 mg; titanium dioxide - 2.5 mg; polyvinyl alcohol - 4 mg] - 10 mg.
Composition of 1 ml solution for i / v and i / m administration:
- active substance: ketoprofen - 50 mg;
- auxiliary components: sodium hydroxide solution 1M - up to pH 6.0–7.5; benzyl alcohol - 20 mg; ethanol (ethyl alcohol) 96% - 100 mg; propylene glycol - 400 mg; water for injection - up to 1 ml.
Ketoprofen Organic belongs to NSAIDs, derivatives of propionic acid. The drug has antipyretic, analgesic and anti-inflammatory properties, which is associated with the suppression of the activity of cyclooxygenase-1 and cyclooxygenase-2, which regulate the synthesis of prostaglandins.
By acting on the lipoxygenase and cyclooxygenase link of the metabolism of arachidonic acid, ketoprofen inhibits the synthesis of thromboxanes, leukotrienes and prostaglandins. The drug leads to a significant inhibition of neutrophil activity in rheumatoid arthritis, stabilizes lysosomal membranes, has a powerful anti-bradykinin activity, central and peripheral analgesic action.
Ketoprofen has no catabolic effect on articular cartilage. The onset of its anti-inflammatory action is noted by the end of 1 week of therapy.
Pharmacokinetic characteristics of ketoprofen with oral administration of the drug (capsules, tablets):
- absorption: Ketoprofen is rapidly absorbed, its bioavailability exceeds 90%. The substance is absorbed from the gastrointestinal tract (GIT) sufficiently completely and quickly;
- distribution: up to 99% of adsorbed ketoprofen binds to plasma proteins, to a greater extent to albumin. Its maximum plasma concentration of 0.1–0.2 liters per kg is reached quickly due to the low volume of distribution. After 24 hours from the beginning of regular intake of the drug, its equilibrium concentration is reached. The substance passes well into connective tissues and synovial fluid. It does not penetrate the blood-brain barrier in a significant volume. Despite the fact that the concentration of ketoprofen in synovial fluid is slightly lower than in plasma, they are characterized by greater stability (persist up to 30 hours). Thanks to this, joint stiffness and pain syndrome are reduced for a long period;
- metabolism: ketoprofen is mostly metabolized by the liver, where it undergoes glucuronization to form esters with glucuronic acid, which are excreted by the kidneys by 60–80% in 24 hours;
- excretion: less than 1% of the drug is excreted with feces. The half-life (T 1/2) varies from 1.6 to 1.9 hours. Ketoprofen, due to its rapid and fairly complete elimination, does not possess cumulative properties.
Pharmacokinetic characteristics of ketoprofen with parenteral (i / v or i / m) administration of Ketoprofen Organic (solution):
- absorption: with intravenous administration, the maximum concentration in the blood plasma is noted after 5 minutes, with intramuscular injection - 15–30 minutes. For parenteral administration, the area under the concentration-time curve (AUC) is proportional to the dose administered;
- distribution: the connection of ketoprofen with blood plasma proteins is 99%. Its equilibrium concentration in the cerebrospinal fluid and blood plasma is maintained for 2-18 hours. The drug penetrates well into the connective tissues and synovial fluid. 15 minutes after a single intramuscular injection of 0.1 g of ketoprofen, significant levels of its concentrations in the synovial fluid are achieved. As with oral administration, the concentration of the substance in the synovial fluid is lower than in the blood plasma, but more stable (persist up to 30 hours). Due to this, the therapeutic effect of the drug is preserved for a longer period;
- metabolism: through conjugation with hyaluronic acid, ketoprofen is metabolized in the liver;
- excretion: mainly excretion is carried out by the kidneys in the form of metabolites, to a lesser extent through the intestines. Plasma half-life is 1.65 hours.
In renal failure, the excretion of ketoprofen slows down, and T 1/2 increases by 1 hour. In cases of liver failure, T 1/2 increases, which can lead to the accumulation of the drug in the tissues. In elderly patients, this indicator is increased by 48%.
Indications for use
Ketoprofen Organic is used for symptomatic treatment, reducing pain and inflammation at the time of application. The drug has no effect on the progression of the disease.
Oral administration (capsules and film-coated tablets):
- pathologies of the musculoskeletal system (degenerative and inflammatory): osteoarthritis, ankylosing spondylitis (ankylosing spondylitis), psoriatic / rheumatoid / gouty arthritis (for an acute attack of gout, the use of fast-acting dosage forms of the drug is recommended);
- pain syndrome: postoperative and post-traumatic pain syndrome, accompanied by inflammation, toothache and headache, pain on the background of oncological pathologies, otitis media, adnexitis, radiculitis, bursitis, arthralgia, tendinitis, neuralgia, ossalgia, myalgia;
- algodismenorrhea (as an analgesic and tocolytic drug).
Parenteral administration (solution for intravenous and intramuscular administration):
- degenerative and inflammatory pathologies of the musculoskeletal system (for symptomatic treatment): ankylosing spondylitis, osteoarthritis, gout, pseudogout, rheumatoid, psoriatic and reactive arthritis (Reiter's syndrome);
- pain syndrome: pain in cancer, post-traumatic and postoperative pain (with inflammation and an increase in body temperature inclusive), sciatica, neuralgia, myalgia, bursitis, tendonitis, migraine, headache;
Absolute contraindications for use for all forms of release of Ketoprofen Organic:
- progressive kidney disease, severe renal failure (creatinine clearance up to 30 ml per minute);
- severe (severe) liver dysfunction;
- decompensated heart failure, the period after coronary artery bypass grafting;
- inflammatory bowel disease in the acute stage (Crohn's disease, ulcerative colitis);
- erosive and ulcerative lesions of the gastrointestinal tract and duodenum, active gastrointestinal bleeding (cerebrovascular or other bleeding);
- complete / incomplete combination of intolerance to acetylsalicylic acid or other NSAIDs, recurrent polyposis of the paranasal sinuses and nose, as well as bronchial asthma, including a history;
- hemophilia and other blood clotting disorders;
- III trimester of pregnancy, lactation period;
- Children and adolescents under 15 years of age;
- individual intolerance to the components of the drug, salicylates and other NSAIDs.
Additional absolute contraindications for Ketoprofen Organic capsules: pain relief before and during surgical interventions (due to the high risk of bleeding), chronic pain therapy, confirmed hyperkalemia.
Additional absolute contraindications for Ketoprofen Organic film-coated tablets: chronic dyspepsia, active peptic ulcer, ulceration or perforation of the stomach, tendency to hemorrhage, diverticulitis.
Additional absolute contraindications for solution for intravenous and intramuscular administration: chronic dyspepsia, confirmed hyperkalemia.
Relative contraindications for use for all forms of drug release (Ketoprofen Organic is prescribed under medical supervision):
- history of ulcerative lesions of the gastrointestinal tract;
- presence of Helicobacter pylori infection;
- cerebrovascular diseases;
- peripheral arterial pathology;
- chronic renal failure (creatinine clearance from 30 to 60 ml per minute);
- chronic heart failure (NYHA classification II – IV functional class);
- arterial hypertension;
- blood diseases (including leukopenia);
- smoking, alcoholism;
- long-term use of NSAIDs;
- combination therapy with selective serotonin reuptake inhibitors (including sertraline, fluoxetine, paroxetine, citalopram), antiplatelet agents (including clopidogrel), anticoagulants (including warfarin), oral glucocorticosteroids (including prednisolone);
- I and II trimester of pregnancy;
- elderly age.
Additional relative contraindications for the use of oral dosage forms of Ketoprofen Organic (capsules and film-coated tablets): liver failure, alcoholic liver cirrhosis, bronchial asthma, anemia, sepsis, edema, stomatitis, ischemic heart disease, hyperlipidemia, severe somatic diseases.
Additional relative contraindications for parenteral administration of Ketoprofen Organic (solution for intravenous and intramuscular administration): systemic lupus erythematosus and other autoimmune pathologies of connective tissue, history of bronchial asthma, progressive liver disease, clinically expressed cardiovascular pathologies.
Ketoprofen Organic, instructions for use: method and dosage
Oral administration (capsules and film-coated tablets)
Ketoprofen Organic capsules and tablets are taken orally, simultaneously with food or immediately after a meal, without chewing, drinking plenty of water.
Recommended dosing regimen for adolescents over 15 years of age and adult patients:
- capsules: 4 pcs. in a day. The daily dose can be divided into 3 doses (depending on the severity of the pain syndrome). No more than 2 capsules can be taken at a time;
- film-coated tablets: 1 pc. 1-2 times a day with an interval of 8 hours.
The maximum daily dose of ketoprofen in dosage forms for oral administration is 0.2 g.
To prevent the negative effect of ketoprofen on the mucous membranes of the gastrointestinal tract, antacids can be taken simultaneously with the tablets.
Parenteral administration (solution for intravenous and intramuscular administration)
Ketoprofen Organic solution is administered intravenously and intramuscularly. In order to reduce the frequency of side effects, the drug is recommended to be used in the minimum effective doses.
The recommended dose for intramuscular administration is 0.1 g of ketoprofen (contents of 1 ampoule), 1-2 times a day.
IV infusions are carried out only in a hospital setting. Their duration varies from 30 to 60 minutes. This method of administration can be used for 48 hours (no more).
Recommended dose for intravenous infusion:
- short-term administration: 0.1–0.2 g of the drug (contents of 1–2 ampoules) diluted in 0.1 l of 0.9% sodium chloride solution. The dose is administered for ½ – 1 hour;
- long-term administration: 0.1–0.2 g of the drug (contents of 1–2 ampoules), diluted in 0.5 g of lactate-containing Ringer's solution, 5% dextrose solution or 0.9% sodium chloride solution. The dose is administered over 8 hours; repeated infusion is allowed after 8 hours.
The maximum daily dose of ketoprofen administered parenterally is 0.2 g. The duration of therapy is set by the doctor individually for each patient.
Ketoprofen Organic can be used in combination with central analgesics. The solution can be mixed in the same bottle with opioids (for example, morphine).
If necessary, therapy can be supplemented with the use of external or oral (capsules, tablets) forms of ketoprofen, as well as rectal suppositories.
Elderly patients are advised to start treatment with a low dose of the solution, and to carry out maintenance therapy in its minimum effective dose.
In renal failure (creatinine clearance up to 20 ml per minute) or chronic liver pathology (serum albumin level is reduced), the dose of the drug is reduced.
It should be borne in mind that ketoprofen is incompatible with tramadol solution (due to precipitation as a result of mixing them).
Because the drug is sensitive to light, solution vials should be wrapped in aluminum foil or black paper.
Possible adverse reactions when using Ketoprofen Organic were evaluated on the following scale: [> 10% - very often; (> 1% and 0.1% and 0.01% and <0.1%) - rarely; <0.01%, including isolated messages - very rare].
Oral administration (capsules and film-coated tablets Ketoprofen Organic):
- digestive system: often - dyspepsia (nausea, diarrhea, vomiting, loss of appetite, flatulence, heartburn), abdominal pain, NSAID-gastropathy; infrequently - impaired liver function, stomatitis; rarely - erosive and ulcerative lesions; very rarely - change in taste, bleeding / perforation of the gastrointestinal tract;
- nervous system: often - asthenia, depression, drowsiness, nervousness, agitation, insomnia, dizziness, headache; rarely - peripheral neuropathy, migraine, memory impairment, forgetfulness, confusion / loss of consciousness;
- sense organs: rarely - vertigo, dizziness, hearing loss, conjunctival hyperemia, eye pain, dryness of the mucous membrane of the eye, conjunctivitis, blurred vision, noise / ringing in the ears;
- cardiovascular system: infrequently - increased blood pressure, edema; rarely - tachycardia;
- respiratory system: infrequently - laryngeal edema (signs of anaphylactic reaction), bronchospasm, rhinitis, pharyngitis, shortness of breath, hemoptysis; rarely - asthma attacks;
- hematopoietic organs: rarely - leukopenia, anemia, thrombocytopenia, hemolytic anemia, agranulocytosis. Taking ketoprofen in high doses can inhibit platelet aggregation, thereby prolonging bleeding time, causing bruising and epistaxis;
- urinary system: infrequently - edematous syndrome; rarely - nephrotic syndrome, interstitial nephritis, renal dysfunction, urethritis, cystitis; very rarely - hematuria;
- immune system: infrequently - the reactivity of the respiratory system, including shortness of breath, bronchospasm, bronchial asthma and its exacerbation (especially against the background of individual intolerance to acetylsalicylic acid and other NSAIDs); very rarely - anaphylaxis, angioedema;
- allergic reactions: often - itchy skin / rash (including erythematous urticaria); infrequently - rhinitis; rarely - exfoliative dermatitis;
- others: infrequently - increased sweating; rarely - photosensitization, thirst, shortness of breath, muscle twitching, myalgia, epistaxis; with prolonged use in high doses - vaginal bleeding;
- laboratory indicators: very often - abnormal liver function indicators (tablets).
Parenteral administration (solution for intravenous and intramuscular administration of Ketoprofen Organic):
- hematopoietic system, lymphatic system: rarely - leukopenia, hemolytic / hemorrhagic anemia; frequency unknown - impaired bone marrow function, thrombocytopenia, agranulocytosis;
- immune system: frequency unknown - anaphylactic reactions (including anaphylactic shock);
- nervous system: often - asthenia, insomnia, depression; infrequently - drowsiness, dizziness, headache; rarely - peripheral neuropathy, confusion / loss of consciousness, paresthesia; the frequency is unknown - emotional lability, impaired taste, convulsions;
- sense organs: rarely - hearing loss, eye pain, dryness of the mucous membrane of the eye, conjunctivitis, tinnitus, blurred vision; frequency unknown - optic neuritis;
- cardiovascular system: infrequently - tachycardia; frequency unknown - vasodilation, arterial hypertension, heart failure;
- respiratory system: infrequently - laryngeal edema, nosebleeds, exacerbation of bronchial asthma; the frequency is unknown - rhinitis, bronchospasm (especially with individual intolerance to NSAIDs);
- Gastrointestinal tract: often - NSAID gastropathy, abdominal pain, dyspepsia, nausea, vomiting; infrequently - gastritis, bloating, diarrhea, constipation; rarely - stomatitis, peptic ulcer; very rarely - perforation of the gastrointestinal tract, melena, hemorrhoidal / gastrointestinal / gingival bleeding, Crohn's disease, exacerbation of ulcerative colitis; frequency unknown - stomach pain, gastrointestinal discomfort;
- liver and biliary tract: rarely - increased activity of bilirubin and liver enzymes, hepatitis;
- skin: infrequently - skin rash / itching; frequency unknown - urticaria, purpura, toxic epidermal necrolysis, bullous rash, including Stevens-Johnson syndrome, erythema, Quincke's edema, exacerbation of chronic urticaria, alopecia, photosensitivity;
- urinary system: rarely - hematuria, urethritis, cystitis; very rarely - abnormal values of indicators of renal function, nephrotic syndrome, interstitial nephritis, acute renal failure; the frequency is unknown - hyperkalemia, fluid retention in the body and, as a result, an increase in body weight;
- other: infrequently - fatigue, peripheral edema; rarely - muscle twitching, thirst, shortness of breath, menometrorrhagia, hemoptysis.
Oral overdose cases of Ketoprofen Organic (capsules, film-coated tablets) are not described. As with intoxication with other NSAIDs, with an overdose of ketoprofen, the main symptoms can be: abdominal pain, nausea, vomiting (including blood), headache, convulsions, respiratory depression, impaired consciousness, melena, renal failure, impaired renal function;
For therapy, gastric lavage, the appointment of activated carbon, symptomatic and supportive treatment are recommended. The effect of ketoprofen on the gastrointestinal tract can be weakened by drugs that lower the secretion of gastric glands (for example, proton pump inhibitors) and prostaglandins. Monitoring of cardiovascular and respiratory activity is recommended. No specific antidote was found, hemodialysis is ineffective.
Oral administration (capsules and film-coated tablets)
During the period of taking Ketoprofen Organic, it is recommended to monitor the functional state of the kidneys / liver and the picture of peripheral blood.
It should be borne in mind that 48 hours before the study for the determination of 17-ketosteroids, the drug should be discontinued.
The use of ketoprofen can mask the symptoms of infectious pathologies.
In case of impaired liver / kidney function, Ketoprofen Organic is prescribed in reduced doses. In such cases, during the period of therapy, patients are closely monitored.
Parenteral administration (solution for intravenous and intramuscular administration)
Long-term NSAID therapy requires periodic assessment of a clinical blood test, fecal occult blood test, and monitoring of renal / liver function, especially in elderly patients (over the age of 65).
In connection with the existing reports of the appearance or increased retention of fluid in the body during the period of use of ketoprofen, patients with congestive heart failure and / or arterial hypertension should be carefully monitored.
During the period of drug use, it is recommended to monitor blood pressure, especially against the background of cardiovascular pathologies.
With caution, treatment with Ketoprofen Organica is carried out for cerebrovascular diseases, pathologies of peripheral arteries, coronary heart disease, acute and severe chronic heart failure and / or uncontrolled arterial hypertension. Taking some NSAIDs may be associated with the risk of arterial thrombosis (stroke, myocardial infarction). The available data to exclude this risk in cases of ketoprofen therapy is insufficient.
The risk of developing allergic reactions while taking the drug is increased in patients with nasal polyposis, asthma, chronic sinusitis / rhinitis.
Ketoprofen, like other NSAIDs, can mask the manifestations of infectious and inflammatory pathologies. If you find symptoms of infection or a deterioration in the patient's well-being when using the solution, you should immediately consult a doctor.
The presence of contraindications from the gastrointestinal tract (peptic ulcer disease, perforation, bleeding) in the anamnesis requires careful monitoring of the patient when prescribing long-term treatment or prescribing high doses of ketoprofen.
Caution when using the solution must also be observed in cases of taking anticoagulants (heparin derivatives, primarily low molecular weight, coumarin), hepatic / renal failure, severe thrombocytopenia, von Willebrand-Jurgens disease, hemophilia and hemostasis disorders.
In chronic renal failure (especially in elderly patients), taking diuretics, nephrosis, cirrhosis and heart failure at the beginning of therapy, renal function should be carefully monitored. In such cases, the use of ketoprofen can lead to a decrease in renal blood flow due to inhibition of prostaglandin, as well as renal decompensation.
Before carrying out radical surgical interventions, Ketoprofen Organic should be canceled.
Due to the fact that the drug can negatively affect female fertility, its use is not recommended for patients planning a pregnancy.
Influence on the ability to drive vehicles and complex mechanisms
During the period of therapy, care should be taken when driving vehicles and conducting potentially hazardous activities, since the use of Ketoprofen Organic can cause dizziness and other side effects that affect the patient's cognitive functions.
Application during pregnancy and lactation
Ketoprofen Organic in the third trimester of pregnancy (especially after 36 weeks) is not prescribed due to the potential effect on the tone of the uterus, the possible occurrence of renal failure, oligohydramnios, increased bleeding time, premature closure of the ductus arteriosus and / or the development of weakness in the uterine labor.
Under medical supervision, Ketoprofen Organic can be used in the I and II trimester in cases where the potential therapeutic effect for the mother outweighs the expected risks to the fetus.
When planning a pregnancy, the use of the drug is not recommended, since it can reduce the likelihood of egg implantation.
Like other substances that are extracted into breast milk, Ketoprofen Organic is not recommended for use during lactation.
All forms of release of Ketoprofen Organic are prohibited for use in pediatric practice for the treatment of children and adolescents under 15 years of age.
With impaired renal function
- use is contraindicated: progressive kidney disease, severe renal failure;
- the appointment requires medical supervision: chronic renal failure.
For violations of liver function
Dosage forms of Ketoprofen Organic are contraindicated in the following cases:
- capsules: active liver disease or severe hepatic impairment;
- solution: severe liver dysfunction;
- tablets: severe liver dysfunction.
Use in the elderly
Therapy with Ketoprofen Organic in elderly patients requires medical supervision.
Possible interactions of ketoprofen with other substances / drugs:
- antihypertensive / uricosuric drugs, diuretics: decrease in their effectiveness;
- ethanol, fibrinolytics, antiplatelet agents, anticoagulants: enhancing their action;
- estrogens, mineralocorticosteroids, glucocorticosteroids: increased side effects;
- corticotropin, salicylates, other NSAIDs: possible ulceration, gastrointestinal bleeding, increased likelihood of renal dysfunction;
- cefotetan, cefamandol, cefoperazone, antiplatelet agents, thrombolytics, heparin, oral anticoagulants: increased risk of bleeding;
- trimethoprim, tacrolimus, low molecular weight heparins, angiotensin-converting enzyme inhibitors, potassium-sparing diuretics, potassium salts: increased risk of renal dysfunction and hyperkalemia;
- digoxin, methotrexate, cyclosporine, lithium preparations, nifedipine, verapamil, slow calcium channel blockers, cardiac glycosides: increasing their concentration in blood plasma;
- probenecid: a significant decrease in the clearance of ketoprofen in blood plasma;
- Mifepristone: Potentially reduced effectiveness. Ketoprofen should be started no earlier than 8–12 days after discontinuation of mifepristone;
- oral hypoglycemic drugs, insulin: increasing their hypoglycemic action (dose recalculation is required);
- tricyclic antidepressants, phenylbutazone, rifampicin, barbiturates, phenytoin (inducers of microsomal oxidation in the liver): increase the production of hydroxylated active metabolites of the drug;
- pentoxifylline: strengthening its anticoagulant effect and increasing the risk of hemorrhagic complications;
- sodium valproate: impaired platelet aggregation;
- cholestyramine, antacids: decreased drug absorption;
- myelotoxic drugs: increased manifestations of ketoprofen hematotoxicity;
- angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers: against the background of impaired renal function (dehydration, in elderly patients), renal function may deteriorate, up to the development of acute renal failure;
- selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding;
- cyclosporine, tacrolimus: possible development of an additive nephrotoxic effect (especially in elderly patients);
- antiplatelet agents, platelet aggregation inhibitors (iloprost, abciximab, eptifibatide, tirofiban): increased likelihood of bleeding.
During the first weeks of combination therapy of ketoprofen with methotrexate in a dose not exceeding 15 mg in 7 days, it is recommended to carry out weekly monitoring of the blood test. When symptoms of renal dysfunction appear and in elderly patients, the study should be carried out more often.
Ketoprofen Organic solution is pharmaceutically incompatible with tramadol solution.
Analogs of Ketoprofen Organic are Ketonal, Ketoprofen, Bystrumkaps, Ketoprofen-SOLOpharm, Artrum, Ketoprofen-ESKOM, Ketonal UNO, Artrozilen, Ketoprofen MV, Ketonal DUO, Arketal Rompharm, Ketoprofen DS, etc.
Store in a place protected from light and moisture: capsules and solution for i / v and i / m administration - at temperatures up to 25 ° C; film-coated tablets - up to 30 ° C.
Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Ketoprofen Organic
According to reviews, Ketoprofen Organic is a safe, effective and affordable pain reliever.
Among the shortcomings, patients most often note the development of side effects from the gastrointestinal tract.
Price for Ketoprofen Organic in pharmacies
The approximate price for Ketoprofen Organic is:
- film-coated tablets (20 pcs in a package) - from 68 to 97 rubles;
- capsules (pack of 20) - 63 rubles.
Ketoprofen Organic: prices in online pharmacies
Ketoprofen Organic 50 mg capsules 20 pcs.
Ketoprofen Organic capsules 50mg 20 pcs.
Ketoprofen Organic 50 mg / ml solution for intravenous and intramuscular administration 2 ml 10 pcs.
Ketoprofen Organic 100 mg film-coated tablets 20 pcs.
Ketoprofen Organic solution for intravenous and intramuscular injection. 50mg / ml ampoule 2ml 10pcs
Ketoprofen Organic tablets p.o. 100mg 20 pcs.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!