Mucosol - Instructions For Use, Price, Syrup, Capsules, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Mucosol

Mukosol: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. Drug interactions
13. 13. Analogs
14. 14. Terms and conditions of storage
15. 15. Terms of dispensing from pharmacies
16. 16. Reviews
17. 17. Price in pharmacies

Latin name: Mucosol

ATX code: R05CB03

Active ingredient: carbocisteine (carbocisteine)

Manufacturer: STS Chemical Industries Ltd. (Israel), Medical Union Pharmaceuticals (Egypt)

Description and photo updated: 22.11.2018

Mucosol is a mucolytic drug that dilutes bronchial secretions and enhances the excretion of sputum from the bronchi and lungs.

Release form and composition

Dosage forms of Mucosol:

• capsules: size No. 0, hard gelatinous, the body is bright red, the cap is green; filler - white powder (10 pcs. in blisters, 2 blisters in a cardboard box);
• syrup: transparent thick yellowish-brown liquid, sweet with a characteristic odor (in bottles of 80 or 110 ml, in a cardboard box 1 bottle).

Composition of 1 capsule:

• active substance: carbocisteine - 0.375 g;
• auxiliary components: corn starch, talc, K30 povidone, magnesia stearate;
• capsule cap: gelatin, titanium dioxide (E171), brilliant blue dye (E133), quinoline yellow dye (E104), carmoisin (E122);
• capsule body: gelatin, titanium dioxide (E171), carmoisin (E122), sunset yellow dye (E110), brilliant blue dye (E133);

Composition of 5 g syrup:

• active substance: carbocisteine - 0.25 g;
• auxiliary components: purified water, disodium edetate, cream additive, 70% sorbitol solution, sodium carbonate decahydrate, methyl parahydroxybenzoate, sodium saccharinate.

Pharmacological properties

Pharmacodynamics

Mucosol is an expectorant and mucolytic drug, the action of which is due to the activation of sialic transferase.

Taking the drug helps to normalize the quantitative ratio of neutral and acidic sialomucins of bronchial secretions: increases the amount of hydroxysialoglycopeptides, reduces the amount of neutral glycopeptides. The drug reduces cough, facilitates the discharge of sputum and mucus, reduces the viscosity of bronchial secretions and sinus secretions.

By reducing the number of goblet cells, especially in the terminal bronchi, regenerating and normalizing the structure of the mucous membrane, Mucosol reduces mucus production, as well as improves mucociliary clearance and restores the secretion of immunologically active immunoglobulin A.

Pharmacokinetics

The main pharmacokinetic characteristics of carbocisteine:

• absorption: quickly and almost completely absorbed; the time to reach the maximum concentration in blood plasma (TC _max) and in the mucous membrane varies from 1.5 to 2 hours; for 8 hours, its therapeutic concentration is maintained in the blood;
• distribution: lingers longest in the middle ear, liver and blood; in high concentrations (17.5% of the dose taken) accumulates in bronchial secretions;
• metabolism: metabolized in the liver through presystemic elimination (first pass effect through the liver);
• excretion: from 60 to 90% of the substance is excreted by the kidneys unchanged, the rest is in the form of metabolites; half-life (T _1/2) is 2-3.15 hours; it is completely eliminated after 3 days after administration.

Indications for use

• bronchiectasis, bronchitis, bronchial asthma, tracheobronchitis, tracheitis (infectious and inflammatory diseases of the respiratory system, accompanied by the formation of high-viscosity sputum);
• sinusitis, otitis media, adenoiditis, rhinitis (inflammatory pathologies of the middle ear, nose and its paranasal sinuses).

Mucosol syrup is taken in preparation for bronchography and / or bronchoscopy.

Contraindications

Absolute:

• acute glomerulonephritis;
• impaired renal function;
• cystitis;
• ulcerative pathologies of the digestive tract in the acute stage;
• children and adolescents up to 18 years old - for capsules;
• children's age up to 1 month or up to 2 years (depending on the manufacturer) - for syrup;
• I trimester of pregnancy;
• period of breastfeeding (syrup);
• individual intolerance to the components contained in the preparation.

Relative (diseases / conditions in the presence of which the appointment of Mucosol requires caution):

• history of erosive and ulcerative diseases of the digestive system;
• II and III trimester of pregnancy;
• lactation period (capsules).

Instructions for the use of Mucosol: method and dosage

Capsules

Mukosol capsules are taken orally after meals with water.

The recommended dose at the beginning of therapy is 2 pcs. 3 times a day; when the condition improves, the dose is reduced to 1 pc. 4 times a day.

The duration of treatment varies from 8 to 10 days.

Syrup

Mucosol syrup is taken orally.

Recommended dosage regimen:

• children aged 1 month to 2 years: 1.25 ml 2 times a day;
• children aged 2 to 5 years: 2.5 ml 2-3 times a day;
• children aged 5 to 12 years: 5 ml of syrup 2-3 times a day;
• adults: 15 ml 2-3 times a day, with a possible dose reduction to 10 ml a day if the symptoms of the disease improve.

The duration of therapy varies from 8 to 10 days.

Side effects

During the period of taking Mucosol, the development of nausea, vomiting, gum disease is possible; rarely, there is the development of headache, dizziness, malaise, weakness, runny nose, diarrhea, gastrointestinal bleeding. Allergic reactions to the components of the drug may also develop in the form of anaphylactic shock, edema of the extremities, urticaria, skin rash and itching.

Overdose

The main symptoms are: headache, upset stool, nausea, stomach pain.

Therapy: measures to cleanse the stomach (lavage), symptomatic treatment. Carbocisteine has no specific antidote.

special instructions

With the development of pain in the epigastric region, it is recommended to reduce the dose of the drug.

It is important to consider that in 1 tbsp. a spoonful of syrup contains 6 g of sucrose.

Influence on the ability to drive vehicles and complex mechanisms

Since when taking Mucosol capsules, side reactions such as weakness and dizziness are possible, it is necessary to drive vehicles or perform potentially dangerous types of work during drug treatment with caution.

Application during pregnancy and lactation

The use of the drug is contraindicated in the first trimester of pregnancy. With caution, Mucosol is prescribed in the II and III trimester of pregnancy.

During lactation, the use of syrup is contraindicated, capsules are prescribed with caution.

Pediatric use

Taking capsules is contraindicated in children and adolescents under 18 years of age. The syrup is contraindicated in children under the age of 1 month or under 2 years old, depending on the manufacturer.

With impaired renal function

According to the instructions, Mucosol is not prescribed to patients with acute glomerulonephritis and impaired renal function.

Drug interactions

With the combined use of carbocisteine with certain drugs / substances, the following effects may develop:

• theophylline: carbocisteine potentiates its bronchodilator effect;
• antitussives (libexin, eucabal, pharingomed, butamirate, codeine), M-anticholinergics (platifillin, scopolamine, atropine): reduce the therapeutic activity of carbocysteine;
• glucocorticosteroids / antibacterial agents: the use with Mucosol for inflammatory pathologies of the respiratory tract potentiates the mutual increase in the effectiveness of the drugs.

Analogs

Mukosol analogs are Mukopront, Libeksin Muko, Fluifort, Mukodin, Bronchobos, Carbocistein, Fluditek.

Terms and conditions of storage

Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children. Do not freeze the syrup.

Shelf life: syrup - 3 years; capsules - 3 or 5 years (depending on the manufacturer).

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Mucosol

According to reviews, Mucosol syrup is a convenient and effective preparation. Among the disadvantages are the lack of a measuring cup in the kit.

The price of Mucosol in pharmacies

Since the drug is currently not available in pharmacies, the price of Mucosol is unknown. In the presence of group analogs: Libexin Muko syrup (125 ml in a bottle) - 500 rubles; Libeksin Muko syrup for children (125 ml in a bottle) - 461 rubles; Fluifort syrup (120 ml in a bottle) - 340 rubles; Fluifort granules for the preparation of a suspension for oral administration (10 sachets of 5 g of granules per package) - 424 rubles. Replacement of a medicinal product must be agreed with a specialist.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!