Genferon
Genferon: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Genferone
ATX code: L03AB05
Active ingredient: recombinant human interferon alpha-2b (interferon alfa-2b) + taurine (taurine) + benzocaine (benzocaine)
Manufacturer: CJSC "Biocad" (Russia)
Description and photo update: 2019-14-08
Prices in pharmacies: from 195 rubles.
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Genferon is a local and systemic immunomodulatory drug with antioxidant, immunomodulatory, local anesthetic and antiviral effects.
Release form and composition
Genferon is produced in the form of suppositories: a cylindrical shape with a pointed end, a homogeneous structure, from white to white with a yellow tint, the presence of a funnel-shaped depression or a hollow rod on the cut is possible (5 pcs. In a blister strip, in a cardboard box 1 or 2 packages).
Content of active ingredients in 1 suppository:
- Recombinant human interferon alpha-2 - 250 thousand, 500 thousand or 1 million IU;
- Taurine - 10 mg;
- Benzocaine - 55 mg
Excipients: dextran 60,000, tween-80, sodium citrate, polyethylene oxide 1500, citric acid, T2 emulsifier, solid fat, purified water.
Pharmacological properties
Pharmacodynamics
The active component of Genferon is recombinant human interferon alpha-2b, synthesized by a strain of the bacterium Escherichia coli, modified using genetic engineering methods, allowing to introduce the human interferon alpha-2b gene into it.
Interferon alfa-2b is characterized by antiviral, antibacterial, antiproliferative and immunomodulatory effects. The antiviral effect is associated with the activation of some intracellular enzymes that inhibit viral replication. The immunomodulatory effect is expressed primarily in the stimulation of cell-mediated reactions of the immune system, which enhances the effectiveness of the immune response against cells undergoing tumor transformation, intracellular parasites and viruses. This is possible due to the activation of phagocytosis and the monocyte-macrophage system, increased differentiation of B-lymphocytes and their synthesis of antibodies, stimulation of the activity of NK-cells (natural killers) and CD8 + T-killers, as well as an increase in the expression of molecules that make up the main histocompatibility complex of type I,which increases the chances of recognition of infected cells by cells of the immune system. Since interferon enhances the functions of leukocytes localized in all layers of the mucous membrane, this allows them to actively participate in the elimination of pathological foci. Also, under the influence of interferon, the production of secretory immunoglobulin A is normalized. The antibacterial effect is due to the reactions of the immune system, which are enhanced by interferon.which is enhanced by interferon.which is enhanced by interferon.
Taurine normalizes metabolic processes and ensures tissue regeneration, and is also characterized by an immunomodulatory and membrane-stabilizing effect. The substance belongs to strong antioxidants, therefore, enters into direct reactions with reactive oxygen species, the excessive accumulation of which increases the risk of pathological processes. Taurine ensures the preservation of the biological activity of interferon and enhances the therapeutic effect of Genferon.
Benzocaine (anesthesin) is a local anesthetic. It reduces the permeability of cell membranes for sodium ions, replaces calcium ions in receptors located on the inner surface of the membrane, and blocks the transport of nerve impulses. This active component of Genferon prevents the occurrence of pain impulses in the endings of the nerves with sensitivity and their transmission along the nerve fibers. Benzocaine has an exclusively local effect and does not enter the systemic circulation.
Pharmacokinetics
With rectal administration of Genferon, there is a high bioavailability of interferon, exceeding 80%, which explains both local and pronounced systemic immunomodulatory effects. With intravaginal use, due to the high concentration of this component in the focus of infection and its fixation on the cells of the mucous membrane, a pronounced local antibacterial, antiproliferative and antiviral effect is observed. Since the vaginal mucosa has a low absorption capacity, the systemic effect of interferon is insignificant.
The maximum level of interferon in the blood serum is recorded 5 hours after the administration of Genferon. The elimination of this substance from the body is mainly carried out by renal catabolism. The half-life is 12 hours, which is due to the frequency of application of the drug 2 times a day.
Indications for use
According to the instructions, Genferon is indicated for use as part of the complex treatment of such diseases / conditions:
- Acute bronchitis;
- Infectious and inflammatory diseases of the urogenital tract: chlamydia, genital herpes, ureaplasmosis, recurrent vaginal candidiasis, mycoplasmosis, gardnerellosis, human papillomavirus infection, trichomoniasis, bacterial vaginosis, erosion of the cervix, vulvovaginitis, ballexolethycinitis, ureteritis, ureteritis, balvovaginitis, ballexolrethynostanitis,
- Chronic recurrent cystitis of bacterial etiology.
Contraindications
Hypersensitivity to the components of the drug is the only contraindication to its use.
Genferon is prescribed with caution to patients with allergic or autoimmune diseases in the acute stage.
Instructions for the use of Genferon: method and dosage
Genferon is used intravaginally and / or rectally:
- Infectious and inflammatory diseases of the urogenital tract of men: rectally, 1 suppository (depending on the severity of the condition, 500,000 or 1,000,000 IU), 2 times a day for 10 days;
- Infectious and inflammatory diseases of the urogenital tract of women: rectally or intravaginally (depending on the nature of the disease), 1 suppository 250,000, 500,000 or 1,000,000 IU (depending on the severity of the condition) 2 times a day, for 10 days daily. In the case of protracted illnesses, 1 suppository 3 times a week (every other day), duration - 1-3 months. For the treatment of a pronounced infectious-inflammatory process in the vagina - 1 suppository 500,000 IU intravaginally in the morning and 1 suppository 1,000,000 IU rectally at night, at the same time a suppository with antibacterial / fungicidal agents should be inserted into the vagina;
- Normalization of local immunity indices in women at 13-40 weeks of gestation during the treatment of infectious and inflammatory diseases of the urogenital tract: 1 suppository 250,000 IU intravaginally 2 times a day, for 10 days daily;
- Chronic recurrent cystitis (as part of complex therapy) in adults: in case of exacerbation - in combination with a standard course of antibiotic therapy, 1 suppository 1,000,000 IU rectally 2 times a day for 10 days, then every other day, for 40 days, in that the same dose for the prevention of relapse;
- Acute bronchitis (as part of complex therapy) in adults: 1 suppository 1,000,000 IU rectally 2 times a day for 5 days.
Side effects
The use of the drug can cause the development of allergic reactions in the form of itching, skin rash, burning sensation in the vagina. Side effects are reversible and disappear within 72 hours after discontinuation or dose reduction.
The temperature may rise after drug administration.
With a daily dose of 10 million IU, the following side effects are highly likely:
- From the hematopoietic system: thrombocytopenia, leukopenia;
- From the central nervous system: headache;
- Others: increased sweating, fever, loss of appetite, weakness, myalgia, arthralgia.
Overdose
Cases of Genferon overdose in clinical practice are almost unknown. In case of accidental single administration of suppositories in a larger amount than was prescribed by the doctor, it is necessary to suspend further administration of the drug for at least 24 hours, after which you can return to the original treatment regimen.
special instructions
It is allowed to use the drug in the II and III trimester of pregnancy if the expected benefit to the mother outweighs the potential risk to the fetus.
To exclude urogenital reinfection, simultaneous treatment of the sexual partner is recommended.
It is possible to use the drug during menstruation.
Influence on the ability to drive vehicles and complex mechanisms
The use of Genferon does not affect the patient's ability to drive vehicles and perform potentially hazardous types of work that require a high concentration of attention and a significant speed of psychomotor reactions.
Application during pregnancy and lactation
It is allowed to use Genferon to normalize local immunity indicators during pregnancy from 13 to 40 weeks as part of complex therapy for papillomavirus infection, genital herpes, cytomegalovirus infection, chlamydia, mycoplasmosis, ureaplasmosis, bacterial vaginosis, often accompanied by itching, discomfort and pain in the lower region the urogenital tract.
Clinical studies have confirmed the safety of intravaginal administration of Genferon at a dose of 250,000 IU for periods of 13-40 weeks. The safety of drug treatment in the first trimester of pregnancy is currently not well understood.
Pediatric use
There are no age restrictions in the official instructions for the drug. Nevertheless, doctors do not recommend the use of Genferon for children under 7 years old (for this age category, including infants, Genferon Light has been developed at a dosage of 125 thousand). Genferon is allowed for children over 7 years old at a dosage of 250 thousand.
Drug interactions
The effectiveness of Genferon increases with simultaneous use with antimicrobial agents for the treatment of urogenital infections and antibiotics.
The action of interferon is enhanced by vitamins E and C.
The effect of benzocaine is increased by the combination with anticholinesterase and non-steroidal anti-inflammatory drugs.
Benzocaine inhibits the antibacterial activity of sulfonamides.
Analogs
Genferon's analogs are: Viferon, Vitaferon, Viferon-Feron, Kipferon, Laferon, Laferobion, Pharmbotek, Alfarekin, Alfarona, Bioferon, Gerpferon, Grippferon, Virogel, Intron A, Lipoferon, Interoferobion, interferon interferon Interfa-2b-2b Pharmiotek, Okoferon, Realdiron.
Terms and conditions of storage
Keep out of the reach of children. Store between 2 and 8 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Genferon
Basically, reviews about Genferon that patients leave on the forums vary from neutral to positive. Opinions about the use of suppositories in the combination therapy of viral diseases of the genitourinary system (herpes, cytomegalovirus, human papillomavirus) in women are ambiguous. Most often, the treatment of these diseases, in particular HPV, is effective with the introduction of suppositories of 1,000,000 IU.
Do not use dosages of Genferon intended for adults, in children, since there are reports of a deterioration in well-being and periodic rises in temperature in patients of this age category. The introduction of the drug during pregnancy is unacceptable without consulting a doctor. Genferon is considered more effective than Kipferon, and the treatment regimens and properties of Viferon and this drug are identical.
The price of Genferon in pharmacies
The approximate price for Genferon with a dosage of 500,000 IU is 490–647 rubles, and with a dosage of 1,000,000 IU - 685–969 rubles (the package includes 10 suppositories).
Genferon: prices in online pharmacies
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Drug name Price Pharmacy |
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Genferon Light 125000 IU + 5 mg vaginal and rectal suppositories 10 pcs. 195 RUB Buy |
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Reviews Genferon Light 195 RUB Buy |
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Genferon Light 250,000 IU + 5 mg vaginal and rectal suppositories 10 pcs. 236 r Buy |
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Reviews Genferon Light 236 r Buy |
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Genferon Light 10000 IU + 0.8 mg / ml nasal drops 10 ml 1 pc. 303 RUB Buy |
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Reviews Genferon Light 303 RUB Buy |
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Genferon Light gave drops. 10,000 IU / ml + 0.8mg / ml vial + nozzle-drip. 10ml 347 r Buy |
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Genferon 500000 IU + 10 mg + 55 mg, vaginal and rectal suppositories 10 pcs. RUB 400 Buy |
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Genferon Light spray 50,000 IU + 1 mg / dose 100 doses nasal spray dosed 1 pc. 446 r Buy |
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Reviews Genferon Light 446 r Buy |
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Genferon Light vaginal suppositories. and rectal. 250000ME + 5mg 10 pcs. 475 RUB Buy |
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Genferon 1,000,000 IU + 10 mg + 55 mg, vaginal and rectal suppositories 10 pcs. 568 r Buy |
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Genferon vaginal suppositories. and rectal. 500000ME 10 pcs. 683 r Buy |
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Genferon vaginal suppositories. and rectal. 1000000ME 10 pcs. RUB 875 Buy |
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Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
