Ursodeoxycholic acid
Instructions for use:
- 1. Pharmacological properties
- 2. Release form
- 3. Indications for use
- 4. Contraindications to use
- 5. Instructions for use
- 6. Side effects
Prices in online pharmacies:
from 619 rub.
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Ursodeoxycholic acid is a hepatoprotective and choleretic agent.
Pharmacological properties of ursodeoxycholic acid
Ursodeoxycholic acid is bile acid in origin. In addition to choleretic and liver-protecting properties, it has an immunomodulatory effect, reduces the formation of stones in the gallbladder and lowers cholesterol.
The mechanism of action of ursodeoxycholic acid is to stabilize the liver cells. Its molecules are able to integrate into the membranes of hepatocytes (liver cells) and make them more resistant to damage by aggressive media. Due to the formation of safe complexes with toxic bile acids, Ursodeoxycholic acid neutralizes them, preventing a damaging effect on cell membranes.
Ursodeoxycholic acid preparations affect the hepatic recirculation of bile acids (their reabsorption from the intestine into bile), they reduce the absorption of cholesterol in the intestine and thus have a hypocholesterolemic effect.
Combining with cholesterol in the contents of the gallbladder, this drug increases the solubility of cholesterol crystals, promotes the destruction of gallstones and prevents the formation of new cholesterol stones. In addition, preparations of ursodeoxycholic acid reduce the formation of cholesterol directly in the liver, that is, they reduce the content of this substance throughout the body.
The immunomodulatory effect of ursodeoxycholic acid on the body is to normalize the activity of lymphocytes and impair the expression of antigens on the cells of the liver and hepatic ducts. Specialists in the field of hepatology give positive reviews about Ursodeoxycholic acid as a means that reliably reduces liver fibrosis in primary biliary cirrhosis, cystic fibrosis, and alcoholic fatty degeneration of the liver.
The drug is absorbed in the small intestine (in the jejunum and ileum), 3 hours after ingestion, its maximum concentration is reached in the blood. Regular intake of drugs ursodeoxycholic acid leads to the fact that it becomes the main bile acid in the blood. In the body, it undergoes a number of transformations, after which it is excreted in the form of metabolites in the feces, in small quantities in the urine.
Release form Ursodeoxycholic acid
According to the instructions, the medicine is available in capsules of 250 mg. It is the main active ingredient of various pharmaceutical preparations of choleretic action. On the basis of ursodeoxycholic acid, such drugs have been created:
- Ursosan;
- Ursofalk;
- Urso;
- Ursoliv;
- Ursodex.
Indications for use
According to the instructions, ursodeoxycholic acid is used in the complex treatment of gallstone disease if they are of cholesterol origin, and their removal by surgery or endoscopic is impossible. Cholesterol stones should be no more than 2 cm in size after lithotripsy (stone crushing).
Ursodeoxycholic acid is prescribed in cases of chronic active hepatitis with bile congestion, with primary biliary cirrhosis up to the stage of active fibrosis, with cystic fibrosis of the liver, biliary reflux esophagitis, acute hepatitis.
According to reviews, Ursodeoxycholic acid helps with biliary dyskinesia and cholecystopathies. Another area of its use is the prevention of bile stagnation when taking hormonal contraceptives, improving liver function during treatment with cytostatics, as an aid in liver and other organ transplants.
Contraindications to the use of ursodeoxycholic acid
According to the instructions, the drug is contraindicated in acute inflammation in the biliary tract and bladder (cholecystitis, cholangitis), with cirrhosis of the liver in the stage of pronounced activity and decompensation, with ulcerative colitis, Crohn's disease, severe renal dysfunction. Individual intolerance is also a contraindication to ursodeoxycholic acid.
Instructions for use
There are no age restrictions for the use of this drug; if necessary, Ursodeoxycholic acid can be prescribed from the neonatal period. The dose is selected individually, depending on body weight and the severity of the disease. The average dose per day is up to 10 mg / kg, it is taken once in the evening. The duration of admission and the number of courses of ursodeoxycholic acid is determined by the doctor, they are different for different diseases. During treatment, once every 3 months, a determination of the level of liver enzymes is required, and when gallstones are dissolved, an ultrasound and X-ray examination of the liver and biliary tract is required every 6 months.
Side effects of ursodeoxycholic acid
According to the instructions, preparations based on ursodeoxycholic acid can sometimes cause a temporary increase in the level of liver enzymes, itching of the skin, allergic skin manifestations, calcification of gallstones, diarrhea.
Ursodeoxycholic acid: prices in online pharmacies
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Drug name Price Pharmacy |
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Ursodeoxycholic acid 250 mg capsule 50 pcs. RUB 619 Buy |
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Ursodeoxycholic acid 250 mg capsule 50 pcs. 626 r Buy |
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Ursodeoxycholic acid Vertex capsules 250mg 50pcs 748 RUB Buy |
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Ursodeoxycholic acid 250 mg capsule 100 pcs. 1108 RUB Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
