Urofuragin - Instructions For Use, Reviews, Price, Tablet Analogs

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Urofuragin - Instructions For Use, Reviews, Price, Tablet Analogs
Urofuragin - Instructions For Use, Reviews, Price, Tablet Analogs

Video: Urofuragin - Instructions For Use, Reviews, Price, Tablet Analogs

Video: Urofuragin - Instructions For Use, Reviews, Price, Tablet Analogs
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Urofuragin

Urofuragin: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  11. 11. In case of impaired renal function
  12. 12. For violations of liver function
  13. 13. Use in the elderly
  14. 14. Drug interactions
  15. 15. Analogs
  16. 16. Terms and conditions of storage
  17. 17. Terms of dispensing from pharmacies
  18. 18. Reviews
  19. 19. Price in pharmacies

Latin name: Urofuragin

ATX code: J01XE03

Active ingredient: furazidin (furazidin)

Producer: Polfa JSC, Pabianitsky pharmaceutical plant (Pharmaceutical Works Polfa in Pabianice) (Poland)

Description and photo updated: 2018-23-11

Prices in pharmacies: from 283 rubles.

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Urofuragin tablets
Urofuragin tablets

Urofuragin is a synthetic antimicrobial drug; uroantiseptic used for urogenital infections.

Release form and composition

Dosage form Urofuragin - tablets: flat-cylindrical, round, with a double-sided bevel and a dividing line on one side, the color of the tablets - from yellow to orange (30 pcs. In blisters, in a cardboard box 1 blister).

Composition for 1 tablet:

  • active substance: furazidine - 50 mg;
  • auxiliary ingredients: corn starch - 27.5 mg; anhydrous colloidal silicon dioxide - 1.25 mg; sucrose - 13.75 mg; stearic acid - 7.5 mg.

Pharmacological properties

Pharmacodynamics

The active component of Urofuragin is furazidine, a broad-spectrum antimicrobial substance from the group of nitrofurans. The mechanism of its effect is based on inhibition of nucleic acid synthesis. Nitrofurans inhibit the activity of the respiratory chain and the Krebs cycle (tricarboxylic acid cycle), as well as inhibit other biochemical processes of microorganisms, as a result of which their membrane or cytoplasmic membrane is destroyed.

Furazidine exhibits pharmacological activity against the following microorganisms:

  • gram-positive cocci: Streptococcus spp., Staphylococcus spp.;
  • gram-negative bacilli: Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp.

Resistance to furazidine is shown by: Acinetobacter spp., Pseudomonas aeruginosa, Serratia spp., Enterococcus spp. and most strains of bacteria Proteus spp.

Depending on the dose used, Urofuragin can have a bactericidal or bacteriostatic effect. For most of the bacterial microflora, the concentration providing the bacteriostatic efficacy of furazidine is 10–20 μg / ml. For bactericidal action, doses should be used 2 or more times higher.

Pharmacokinetics

  • absorption: from the small intestine absorption of the substance occurs by passive diffusion; in the distal segment of the small intestine, nitrofurans are absorbed more intensively than from the proximal and medial segments by 2 and 4 times, respectively; in the colon, furazidine is poorly absorbed. The maximum concentration (C max) of the substance in the blood serum is observed for 3 to 7-8 hours;
  • distribution: occurs evenly, high concentrations are noted in the lymph, in bile the content is several times higher than serum, and in the cerebrospinal fluid - several times lower; concentration in saliva is up to 30% of serum; the content of furazidine in the blood and tissues is low, this is due to the rapid elimination of the substance, its concentration in the urine is significantly higher than the level in the blood;
  • metabolism: furazidine is metabolized in the liver (less than 10%), in patients with reduced renal excretory function, the metabolic rate increases; 3-4 hours after ingestion, the substance is found in the urine, but, unlike nitrofurantoin, it does not affect its pH;
  • excretion: furazidine is excreted mainly by the kidneys (up to 85%) with urine by glomerular filtration and tubular secretion, partly undergoing reverse reabsorption in the tubules. Low concentrations of the substance in the urine ensure the predominance of the filtration and secretion process; at high concentrations of furazidine, tubular secretion decreases and reabsorption increases. Possessing the properties of a weak acid, it does not dissociate; in patients with increased acidity of urine, furazidine is intensively reabsorbed, which can cause an increase in systemic side effects.

Indications for use

According to the instructions, Urofuragin is recommended for the treatment of such infectious and inflammatory diseases of the urinary tract as urethritis, cystitis, pyelonephritis, caused by microorganisms sensitive to furazidine.

The drug is also used for the prevention of infectious complications in the postoperative period during surgical interventions on the organs of the genitourinary system.

Contraindications

Absolute:

  • renal / hepatic impairment;
  • infectious lesions of the renal parenchyma, urosepsis;
  • pregnancy and lactation period;
  • children and adolescents under 18 years of age;
  • lactase deficiency, congenital malabsorption of sucrose, isomaltose, glucose, galactose, lactose intolerance, fructose;
  • hypersensitivity to nitrofuran derivatives, including furazidine, as well as other components of Urofuragin.

Relative contraindications, in which furazidine is prescribed with caution, for the drug are: anemia, lung disease (especially in elderly patients over 65 years of age), diseases of the nervous system, diabetes mellitus, porphyria, deficiency of B vitamins, folic acid and glucose-6- phosphate dehydrogenase.

Instructions for the use of Urofuragin: method and dosage

Urofuragin tablets are intended for oral administration, preferably after meals.

Recommended dosage:

  • therapy of urogenital infections: 2-4 tablets (100-200 mg) 2-3 times a day for 7-10 days. If necessary, a second course is allowed after a break of 10-15 days;
  • prevention of infectious complications in the postoperative period during surgical interventions on the organs of the genitourinary system: half an hour before the start of the operation, 1 tablet (50 mg) once.

The maximum allowable daily dose is 12 tablets (600 mg).

Side effects

  • hematopoietic system: agranulocytosis, aplastic anemia, thrombocytopenia, eosinophilia;
  • nervous system: headache, dizziness, weakness, drowsiness, development of polyneuritis, peripheral neuropathy;
  • cardiovascular system: intracranial hypertension;
  • organ of vision: visual impairment;
  • respiratory system: chest pain, shortness of breath, cough with and without phlegm, interstitial pneumonitis, pulmonary fibrosis;
  • digestive system: decreased appetite, nausea / vomiting, diarrhea, anorexia, liver dysfunction, pancreatitis, cholestatic jaundice, hepatitis;
  • musculoskeletal system: arthralgia, myalgia;
  • skin and subcutaneous tissue: itching, skin rash (including papular), enanthema, reversible alopecia, exfoliative dermatitis;
  • hypersensitivity reactions: urticaria, angioedema, erythema multiforme;
  • other: fever.

Overdose

Symptoms of an overdose of Urofuragin are: polyneuritis, neurotoxic reactions, hepatic dysfunction, acute toxic hepatitis.

It is recommended to stop taking the drug, drink large amounts of liquid, carry out symptomatic treatment, use antihistamines and B vitamins. The specific antidote of furazidine is unknown.

special instructions

In order to prevent the appearance of undesirable side reactions, an abundant drink is prescribed.

To prevent the development of neuritis, the simultaneous use of B vitamins is required.

As a result of drug therapy, urine may turn brown.

Long-term treatment requires monitoring of the function of the lungs, kidneys, liver and peripheral blood picture.

When testing for the presence of glucose in urine using enzymatic methods, false positive results are likely.

The use of Urofuragin can contribute to the development of diarrhea caused by Clostridium difficile (pseudomembranous colitis). In case of a mild illness, it is enough to cancel the drug; in severe cases, appropriate treatment is required. It is impossible to use drugs that inhibit intestinal peristalsis.

Influence on the ability to drive vehicles and complex mechanisms

Patients taking Urofuragin should refrain from driving vehicles and mechanisms, as well as performing other potentially hazardous work that requires concentration of attention and speed of psychomotor reactions.

Application during pregnancy and lactation

Urofuragin is contraindicated for use during pregnancy and during breastfeeding.

Pediatric use

Urofuragin is not used in pediatrics.

With impaired renal function

The use of the drug is contraindicated in patients with impaired renal function, with infection of the renal parenchyma and urosepsis.

For violations of liver function

The use of Urofuragin is contraindicated in patients with impaired hepatic function.

Use in the elderly

Elderly patients over 65 years of age with pulmonary diseases Urofuragin is prescribed with caution.

Drug interactions

  • ristomycin (ristocein), chloramphenicol, sulfonamides: increase the likelihood of hematotoxic action;
  • other nitrofuran derivatives, drugs that acidify urine (including ascorbic acid and calcium chloride): simultaneous use with furazidine should be avoided;
  • alkalizing drugs for urine: accelerate the excretion of furazidine by the kidneys;
  • ethanol: can potentiate the severity of negative side effects;
  • probenecid and sulfinpyrazone: inhibit the excretion of furazidine by the kidneys, as a result of which its cumulation and increased toxicity are possible;
  • magnesium-containing antacids: reduce the absorption of furazidine.

Analogs

Analogs of Urofuragin are: Furagin, Furagin-LekT, Furagin-Aktifur, Furagin-SZ, Furassol, Furamag, etc.

Terms and conditions of storage

Store at 25 ° C. Keep out of the reach of children.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Urofuragin

To date, there are no reviews about Urofuragin, since patients mainly use an analogue drug made in Russia - Furagin.

Price for Urofuragin in pharmacies

Estimated price of Urofuragin (50 mg tablets) for 30 pcs. in the package is 324 rubles.

Urofuragin: prices in online pharmacies

Drug name

Price

Pharmacy

Urofuragin 50 mg tablets 30 pcs.

283 r

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Urofuragin tablets 50mg 30 pcs.

302 RUB

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Maria Kulkes
Maria Kulkes

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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