Anzales
Anzales: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Anasales
ATX code: L02BG03
Active ingredient: anastrozole (Anastrozole)
Manufacturer: Natco Pharma, Ltd. (Natco Pharma, Ltd.) (India); Synthon Spain, S. L. (Synthon Hispania, SL) (Spain)
Description and photo update: 2020-14-05
Prices in pharmacies: from 1050 rubles.
Buy
Anzales is an antineoplastic drug.
Release form and composition
The drug is produced in the form of film-coated tablets: white, round, biconvex, engraved on one side "ANA 1", a white or almost white core (in blisters of 10 pcs., In a cardboard box of 3 or 9 blisters; in blisters of 14 pcs., in a cardboard box 2 blisters. Each box also contains instructions for the use of Anzales).
1 tablet contains:
- active substance: anastrozole - 1 mg;
- auxiliary components: lactose monohydrate, sodium carboxymethyl starch, povidone, magnesium stearate;
- film shell: White opadrai (hypromellose, macrogol 400, titanium dioxide).
Pharmacological properties
Pharmacodynamics
Anzales is an antineoplastic drug. Its active ingredient - anastrozole, being a selective non-steroidal aromatase inhibitor, helps to reduce the concentration of circulating estradiol and has a therapeutic effect in women with breast cancer. The mechanism of action of the drug is due to the fact that postmenopausal estradiol is predominantly formed from estrone produced in peripheral tissues by conversion with the participation of the aromatase enzyme from androstenedione. Taking anastrozole in postmenopausal women at a dose of 1 mg per day reduces estradiol levels by 80%.
The drug does not possess estrogenic, progestogenic and androgenic activity. Therapeutic doses of anastrozole do not affect the secretion of cortisol and aldosterone.
Pharmacokinetics
After oral administration, anastrozole is rapidly absorbed from the gastrointestinal tract. When used on an empty stomach, the maximum plasma concentration (C max) is reached within 2 hours. The presence of food in the stomach slightly reduces the rate, but does not affect the degree of absorption.
Plasma protein binding - 40%.
Metabolized by N-dealkylation, hydroxylation and glucuronidation. The main metabolite of anastrozole is triazole, it does not inhibit aromatase.
It is excreted mainly through the kidneys within 72 hours after taking a single dose, including in unchanged form - less than 10%. The half-life (T 1/2) from plasma is 40-50 hours. There is no information on cumulation.
With stabilized liver cirrhosis or impaired renal function, the clearance of anastrozole does not change.
In the postmenopausal period, the pharmacokinetic characteristics of anastrozole do not change.
Indications for use
The use of the drug Anzales is indicated for the treatment of postmenopausal breast cancer.
Contraindications
Absolute:
- premenopause;
- severe liver failure;
- concomitant use of tamoxifen or drugs containing estrogens;
- period of pregnancy and lactation;
- childhood;
- hypersensitivity to the components of the drug.
Anzales should be taken with caution, preferably under medical supervision, with osteoporosis, hypercholesterolemia, ischemic heart disease, mild to moderate liver dysfunction, severe renal failure (creatinine clearance less than 20 ml / min), lactase deficiency, lactose intolerance, glucose-galactose malabsorption (this dosage form contains lactose).
Anazales, instructions for use: method and dosage
Anzales tablets are taken orally, swallowing whole and drinking plenty of water, regardless of the meal, but always at the same time of day, convenient for the patient.
Recommended dosage for adults, including elderly patients: 1 pc. (1 mg) once a day, the drug is taken for a long time.
If signs of progression of the disease appear, taking the tablets should be discontinued. The optimal duration of adjuvant therapy is 5 years.
Side effects
- from the central nervous system: drowsiness, headache, asthenia;
- from the digestive system: nausea, vomiting, diarrhea, anorexia; with advanced breast cancer (mainly with liver metastases) - an increase in the level of alkaline phosphatase (alkaline phosphatase) and more often - GGT (gamma-glutamyltransferase);
- from the endocrine system: flushing of the face, hair thinning, vaginal dryness;
- from the side of metabolism: a slight increase in the level of total cholesterol;
- allergic reactions: skin rash.
Overdose
Overdose symptoms have not been established.
special instructions
If the patient's hormonal status is in doubt, additional biochemical studies should be carried out to confirm the state of menopause.
Influence on the ability to drive vehicles and complex mechanisms
During the period of treatment with Anzales, it is recommended to avoid performing work that requires concentration of attention and a high speed of psychomotor reactions, including driving vehicles and complex mechanisms.
Application during pregnancy and lactation
The use of Anzales is contraindicated during pregnancy and lactation.
Pediatric use
The use of Anazalez in childhood is contraindicated.
With impaired renal function
With severe renal failure (CC less than 20 ml / min), Anzales tablets should be used with caution.
No dose adjustment is required in patients with impaired renal function.
For violations of liver function
The use of the drug Anzales is contraindicated with a pronounced degree of liver failure.
No dose adjustment is required in patients with mild to moderate renal impairment.
Drug interactions
With the simultaneous use of Anzales, the effectiveness of estrogens decreases, therefore, the appointment of such combinations is not recommended.
The results of clinical studies indicate a low probability of drug interactions when anastrozole is combined with antipyrine or cimetidine.
Analogs
Analogues of Anazales are Axastrol, Anabrez, Anaster, Anastrozole, Anastrozole-TL, Anastreks, ARIMIDEX, Vero-Anastrozole, Selana.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 30 ° C.
Shelf life is 4 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Anazales
Reviews of specialists and patients about Anzales are currently absent.
Price for Anzales in pharmacies
The price of Anzales, film-coated tablets, 1 mg, for a package containing 28 pieces, can range from 904 rubles, for a package containing 90 pieces. - from 2907 rubles.
Anazales: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Anzales 1 mg film-coated tablets 28 pcs. 1050 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
