Venter

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Venter: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Drug interactions
10. Analogs
11. Terms and conditions of storage
12. Terms of dispensing from pharmacies
13. Reviews
14. Price in pharmacies

Latin name: Venter

ATX code: A02BX02

Active ingredient: Sukralfat (Sucralfate)

Manufacturer: KRKA, Slovenia

Description and photo update: 2019-17-09

Venter is an antiulcer drug that has a protective effect on the mucous membrane of the duodenum and stomach.

Release form and composition

Venter dosage form:

Tablets, 10 pcs. in blisters, 5 or 10 packs in a cardboard box;
Granules for oral administration, in sachets, 50 sachets in a cardboard box.

The preparation contains the active substance - sucralfate, in the amount of:

1 tablet - 0.5 g or 1 g;
1 sachet - 1 g.

Pharmacological properties

Pharmacodynamics

The active component of Venter is sucralfate disaccharide, which contains sucrose sulfate and aluminum hydroxide. This compound promotes rapid healing of peptic ulcers, prevents the development of gastric ulcer and duodenal ulcer, protects the mucous membranes of the gastrointestinal tract from the effects of hydrochloric acid and pepsin.

Sucralfate reduces the activity of pepsin by about 30%, while minimally affecting the acidity of gastric juice. The substance binds to protein compounds of the affected tissues of the mucous membranes, which leads to the formation of a protective film on the surface of the ulcer. Venter accelerates the regeneration of damaged areas of the mucous membrane, improves scarring of ulcers and is used to prevent recurrence of peptic ulcer disease, including as a result of stress. It also reduces the absorption of phosphates in the digestive tract.

Pharmacokinetics

When taken orally, Venter is slightly absorbed and enters the systemic circulation. In plasma, clinically significant concentrations of the drug are not detected, the systemic effect is also not detected. Sucralfate is not involved in metabolic processes. Venter is partially excreted through the kidneys, and the remainder is excreted unchanged through the intestines.

Indications for use

Reflux esophagitis;
Hyperacid gastritis;
Gastroduodenitis;
Peptic ulcer of the stomach and duodenum in the acute phase;
Symptomatic ulcers;
Reflux gastritis;
Stress ulcers and erosive and ulcerative lesions of the gastrointestinal tract associated with the use of non-steroidal anti-inflammatory drugs;
Medicinal ulcer;
Hyperphosphatemia in patients with uremia on hemodialysis;
Heartburn.

Contraindications

Severe renal dysfunction;
Bleeding from the gastrointestinal tract;
Obstruction or dysphagia of the gastrointestinal tract;
Hypersensitivity to drug components.

Venter should be used with caution in nursing and pregnant women.

Instructions for use of Venter: method and dosage

Venter for adults is usually prescribed by mouth at 0.5-1 g, the frequency of administration is 4 times a day. Also, the drug can be taken 1 g 2 times a day (morning and evening) or 2 g 2 times a day 1 hour before meals and before bedtime.

The maximum daily dose is 12 g. The average duration of peptic ulcer therapy is 4-6 weeks, if necessary, up to 12 weeks.

In patients with hyperphosphatemia, with a decrease in plasma phosphate concentration, the dosage can be reduced.

For children, the drug is prescribed 0.5 g 4 times a day.

The tablets can be swallowed whole with a liquid, or, like granules, dissolved in 1/2 glass of water before taking.

Side effects

According to the instructions, Venter can cause the following side effects:

Central nervous system: dizziness, drowsiness, headache;
Digestive system: diarrhea, constipation, dry mouth, nausea, gastralgia;
Dermatological reactions: urticaria, rash, pruritus;
Others: pain in the lumbar region.

Overdose

Usually, patients tolerate Venter treatment well, therefore, cases of overdose are extremely rare. However, when taking the drug in significant doses, allergic reactions may occur, which are the result of individual sensitivity to sucralfate. Such conditions are characterized by the appearance of a skin rash, irritation of the skin, pain in the abdomen, nausea and vomiting. In this case, symptomatic therapy is prescribed.

With prolonged Venter therapy, patients with renal insufficiency may develop intoxication with aluminum, among the significant consequences of which is osteomalacia or encephalopathy. In this case, the drug is immediately canceled, hemodialysis, peritoneal dialysis and hemofiltration are performed as treatment, and deferoxamine is also administered.

special instructions

If necessary, the simultaneous use of Venter with antacids, they should be taken half an hour before or half an hour after taking the drug.

The appearance of seizures and drowsiness may indicate toxic effects of aluminum.

In renal failure, serum phosphate and aluminum concentrations must be monitored.

Short therapy can lead to complete scarring of the ulcer, but Venter's administration does not change the severity and frequency of recurrence of peptic ulcer disease that occurs after scarring.

Drug interactions

With the simultaneous use of Venter:

A decrease in the anticoagulant activity of indirect anticoagulants (including warfarin) is possible;
The absorption of antimicrobial agents of fluoroquinolone derivatives, digoxin, tetracycline, sulpiride, phenytoin, and amitriptyline is reduced, which can lead to a decrease in the clinical effectiveness of the latter;
The effectiveness of levothyroxine is markedly reduced;
Some decrease in bioavailability of ranitidine, cimetidine, roxatidine is possible;
The concentration of quinidine in the blood plasma decreases;
Minor changes in theophylline pharmacokinetics are observed. It is also possible to significantly decrease the absorption of theophylline from sustained-release dosage forms;
A slight decrease in the absorption of fluconazole and ketoconazole is possible.

It is believed that when used together, the formation of chelate complexes with tobramycin sucralfate, colistin sulfate, amphotericin B is possible, which can lead to a decrease in their antimicrobial activity.

Analogs

Venter's analogues are: Ankrusal, Alsukral, Sukrat, Sukralfat, Ulgastran.

Terms and conditions of storage

Store in a dark, dry place out of reach of children at temperatures up to 25 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Venter

Reviews about Venter are mixed. Many patients suffering from gastritis and peptic ulcer disease, use it on the recommendation of friends, pharmacists or guided by opinions on the Internet. They also combine the drug with other antiulcer drugs. An incorrect dosing regimen or the appointment of Venter off-label can lead to the fact that it will be ineffective. Therefore, experts recommend not to self-medicate, but to immediately contact a gastroenterologist, without waiting for an aggravation and intensification of stomach pain. He will select the correct drug treatment tactics.

Price for Venter in pharmacies

The price of Venter tablets with a dosage of 1 g ranges from 282 to 350 rubles (50 pcs per pack). Oral granules are currently not commercially available.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!