Panum
Panum: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. For violations of liver function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Panum
ATX code: A02BC02
Active ingredient: Pantoprazole (Pantoprazole)
Manufacturer: Unique Pharmaceutical Laboratories (a division of JBChemicals & Pharmaceuticals Ltd.) (India)
Description and photo update: 2018-23-10
Prices in pharmacies: from 132 rubles.
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Panum is a drug with antiulcer action.
Release form and composition
Dosage forms of release of Panum:
- enteric-coated tablets: from yellow to light yellow, biconvex, round (10 pcs. in blisters, in a cardboard box 1 or 2 blisters);
- lyophilisate for the preparation of a solution for intravenous administration: white or almost white (in 10 ml vials, 1 vial in a cardboard box).
Composition of 1 tablet:
- active substance: pantoprazole - 40 mg (pantoprazole sodium sesquihydrate - 45.1 mg);
- auxiliary components: mannitol, crospovidone, 30% simethicone emulsion, calcium stearate, anhydrous sodium carbonate, povidone, sodium hydroxide, Opadry dye acrilez yellow 93O92052 (methacrylic acid copolymer type C, talc, titanium dioxide, triethyl citrate, colloidal sodium hydroxide, silicon dioxide yellow iron oxide, sodium lauryl sulfate), Opadry YS-1R-7006 transparent dye (macrogol 400, hypromellose 5cP, macrogol 6000).
Composition of 1 bottle of lyophilisate:
- active substance: pantoprazole - 40 mg (pantoprazole sodium sesquihydrate - 45.1 mg);
- auxiliary component: mannitol - 45 mg.
Pharmacological properties
Pharmacodynamics
Panum belongs to the number of proton pump inhibitors (H + / K + -ATPase). By lowering the basal and stimulated secretion, it blocks the final stage of hydrochloric acid secretion, regardless of the nature of the stimulus.
In case of duodenal ulcer associated with Helicobacter pylori, a decrease in gastric secretion leads to an increase in the sensitivity of microorganisms to drugs with antibacterial action. It has no effect on the motility of the gastrointestinal tract. The normalization of secretory activity occurs 3-4 days after the end of the application.
Compared to other proton pump inhibitors, pantoprazole has a lower potential for interaction with the liver oxidase system, which depends on cytochrome P 450. In this regard, Panum does not interact with many other drugs.
Pharmacokinetics
The volume of distribution of pantoprazole is 0.15 l / kg, the clearance is 0.1 l / h / kg.
The half-life of the drug is 1 hour. The pharmacokinetics of pantoprazole after single / repeated use does not change. When administered orally / intravenously at a daily dose of 10–80 mg, the kinetic curve of the plasma concentration of pantoprazole in the blood is linear.
The substance in a high degree (98%) binds to blood plasma proteins. Metabolism takes place in the liver. 80% of pantoprazole is excreted as metabolites through the kidneys, a small amount in the feces.
Desmethylpantoprazole is the main metabolite in urine and blood plasma, conjugated with sulfate, its half-life is approximately 1.5 hours.
In case of impaired hepatic function, the half-life of desmethylpantoprazole increases to 2-3 hours, the excretion of pantoprazole occurs quickly enough, no cumulation is observed.
The half-life in liver failure increases to 7-9 hours, the time to reach the maximum plasma concentration in comparison with healthy patients increases by 1.5 times.
Indications for use
- peptic ulcer of the stomach and duodenum (with exacerbation), erosive gastritis, including associated with the use of non-steroidal anti-inflammatory drugs;
- gastroesophageal reflux disease: erosive reflux esophagitis (therapy), symptomatic therapy of gastroesophageal reflux disease (i.e., non-erosive reflux disease);
- Zollinger-Ellison syndrome;
- eradication of Helicobacter pylori (in combination with antibacterial drugs);
- stress ulcers, including their complications (perforation, bleeding, penetration) (therapy and prevention).
Contraindications
Absolute:
- dyspepsia of neurotic etiology;
- severe liver failure;
- malignant diseases of the gastrointestinal tract;
- lactation period;
- individual intolerance to the components of the drug.
Relative (Panum is prescribed under medical supervision):
- liver dysfunction;
- pregnancy;
- age up to 6 years (tablets), up to 18 years (injection solution).
Instructions for the use of Panum: method and dosage
Pills
Panum is taken orally with a small amount of liquid. The tablets are not chewed.
Recommended dosage regimen:
- peptic ulcer and duodenal ulcer, gastroesophageal reflux disease: daily dose - 40 mg in 1 dose, possibly a 2-fold increase in dose. The duration of the course of therapy for duodenal ulcer is 2 weeks, gastric ulcer and gastroesophageal reflux disease - 4 weeks (in some cases, treatment can be continued for the same period);
- eradication anti-Helicobacter pylori therapy for gastric / duodenal ulcer (simultaneously with azithromycin, amoxicillin, metronidazole, clarithromycin): 2 times a day (before breakfast and dinner or during meals) 40 mg for a course of 7 to 14 (maximum) days.
In case of impaired renal function, as well as elderly patients, it is not recommended to prescribe Panum in a daily dose of more than 40 mg.
In severe hepatic insufficiency, the drug should be used under the control of the level of hepatic enzymes 1 time in 2 days, 40 mg each (in case of deterioration of the indicators, the drug is canceled).
Injection solution
Panum is administered intravenously. This dosage form of the drug is used in cases where oral administration is not possible.
The recommended daily dose is 40 mg.
With prolonged therapy of Zollinger-Ellison syndrome and other pathological hypersecretory conditions, at the beginning of treatment, the drug is prescribed in a daily dose of 80 mg (administered 2 times a day). Possible short-term dose increases up to 160 mg per day.
For stress ulcers (treatment and prevention), as well as in cases of complications of peptic ulcer disease (in the form of bleeding, perforation, penetration), Panum is used at 80 mg per day (administered 2 times a day). Possible short-term dose increases up to 160 mg per day.
In case of impaired renal function, as well as elderly patients, it is not recommended to prescribe Panum in a daily dose of more than 40 mg.
For patients with severe hepatic impairment, the daily dose is reduced to 20 mg. Therapy should be carried out under constant control of liver enzymes; if the indicators deteriorate, the drug is canceled.
To prepare an injection solution, 10 ml of physiological sodium chloride solution should be added to a vial with a lyophilisate. It is also possible to administer after further mixing with saline sodium chloride solution or 5% glucose solution.
The solution is injected immediately after preparation for 2-15 minutes. It must not be mixed with other medicines.
Side effects
Possible adverse reactions (> 10% - very common;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01%, including isolated messages - very rare):
- digestive system: diarrhea; rarely - increased appetite, increased activity of transaminases, dry mouth, nausea, constipation, belching, flatulence, vomiting, abdominal pain;
- central nervous system and sensory organs: headache; rarely - asthenia, drowsiness, dizziness, insomnia; very rarely - tinnitus, visual disturbances, nervousness, depression, paresthesia, tremor, photophobia;
- genitourinary system: very rarely - hematuria, impotence, edema;
- skin: very rarely - alopecia, exfoliative dermatitis, acne;
- allergic reactions: rarely - angioedema, rash, itching, urticaria;
- others: rarely - myalgia, hyperglycemia; very rarely - eosinophilia, fever, hypercholesterolemia, hyperlipoproteinemia.
The frequency and severity of adverse reactions may vary depending on the dosage form of Panum.
Overdose
When using Panum in the recommended doses, there were no cases of overdose.
There is no specific antidote. Hemodialysis is ineffective. In case of clinical manifestations of an overdose (in the form of increased adverse reactions), supportive / symptomatic treatment is indicated.
special instructions
Before starting the course, it is necessary to exclude malignant diseases of the esophagus and stomach, since symptomatic improvement can lead to a delay in making the correct diagnosis.
Gastroesophageal reflux disease must be confirmed endoscopically.
Panum should not be used for the treatment of mild gastrointestinal disorders (in particular, dyspepsia of neurogenic genesis).
Application during pregnancy and lactation
- lactation period: therapy is contraindicated;
- pregnancy: Panum is prescribed with caution.
Pediatric use
For patients under 6 years old, Panum in the form of tablets is prescribed with caution (due to the lack of the necessary experience of use).
For violations of liver function
- severe hepatic impairment: therapy is contraindicated;
- hepatic dysfunction: Panum is prescribed with caution.
Drug interactions
According to the instructions, Panum reduces the effectiveness of drugs that are absorbed at acidic pH values (including ketoconazole).
Analogs
Panum's analogs are: Pantoprazole Canon, Peptazol, Pantaz, Krosatsid, Controloc, Zipantola, Sanpraz, Puloref, Pizhenum-sanovel.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25/30 ° C (lyophilisate / tablets). Keep out of the reach of children.
Shelf life:
- lyophilisate - 2 years;
- tablets - 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Panuma
According to reviews, Panum is an affordable and effective drug. Of the advantages, they also indicate the minimal likelihood of overdose. Side effects are rarely reported.
Price for Panum in pharmacies
The approximate price for Panum tablets (20 pcs per pack) is 230-266 rubles.
Panum: prices in online pharmacies
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Drug name Price Pharmacy |
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Panum 20 mg enteric film coated tablets 14 pcs. 132 RUB Buy |
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Panum 40 mg enteric coated tablets 20 pcs. 170 RUB Buy |
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Panum 20 mg enteric film coated tablets 28 pcs. 207 r Buy |
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Panum tablets for enteric p.p. for 20mg 28pcs 209 RUB Buy |
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Panum tablets p.p. 40mg 20 pcs. 258 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
