Pantotropil - Instructions For Use, Reviews, Price, Tablet Analogs

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Pantotropil

Pantotropil: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. Drug interactions
13. 13. Analogs
14. 14. Terms and conditions of storage
15. 15. Terms of dispensing from pharmacies
16. 16. Reviews
17. 17. Price in pharmacies

Latin name: Pantotropil

ATX code: N06BX

Active ingredient: hopantenic acid (Hopantenic acid)

Producer: JSC "Obninsk Chemical-Pharmaceutical Company" (Russia)

Description and photo update: 2019-13-11

Pantotropil is a nootropic agent.

Release form and composition

The drug is produced in the form of tablets: flat-cylindrical, round, white, with a risk and a chamfer (10 pieces in a blister strip, in a cardboard box 1, 2, 3, 4, 5 or 6 packages and instructions for use of Pantotropil).

1 tablet contains:

• active substance: hopantenic acid - 250 or 500 mg;
• additional components: calcium stearate, talc, magnesium carbonate.

Pharmacological properties

Pharmacodynamics

Pantotropil is a nootropic agent with neurometabolic, neuroprotective and neurotrophic effects. The spectrum of activity of the active substance of the drug (hopantenic acid) is due to the presence of gamma-aminobutyric acid (GABA) in its structure. The mechanism of action of the agent is associated with a direct effect on the GABA _B receptor-channel complex. The drug demonstrates an anticonvulsant effect, enhances the resistance of brain tissue to hypoxia and the action of toxic substances, activates the processes of anabolism in neurons, exhibits a moderate sedative effect and a mild stimulating effect. Reduces motor excitability, enhances physical and mental performance.

The drug Pantotropil promotes the metabolism of GABA in chronic alcohol intoxication and after ethanol withdrawal. The agent inhibits acetylation reactions involved in the mechanisms of inactivation of novocaine (procaine) and sulfonamides, resulting in a prolonged effect of the latter. Provides a decrease in the pathologically increased visceral reflex and detrusor tone.

Pharmacokinetics

After oral administration, hopantenic acid is rapidly absorbed in the gastrointestinal tract (GIT). The period of reaching the maximum concentration (T _max) is 1 hour. The highest concentrations of the active substance are determined in the stomach wall, liver, kidneys and skin.

Hopantenic acid passes through the blood-brain barrier (BBB), does not undergo metabolic transformation. Eliminated within 48 hours unchanged: with urine - 67.5% of the dose taken, with feces - 28.5%.

Indications for use

• cognitive impairment against the background of organic brain lesions, including with craniocerebral trauma, the consequences of neuroinfections, neurotic disorders;
• extrapyramidal hyperkinesis in hereditary diseases of the nervous system - in combination with ongoing therapy;
• epilepsy with a slowdown in mental processes - in combination with anticonvulsants;
• neuroleptic extrapyramidal syndrome (hyperkinetic and akinetic); as a corrector for side effects of neuroleptic drugs; cerebral organic insufficiency in the presence of schizophrenia - as part of complex treatment;
• psycho-emotional overload, decrease in mental and physical performance - in order to improve memorization and concentration;
• neurogenic disorders of urination (pollakiuria, enuresis, urgency, urge incontinence);
• developmental delay (mental, motor, speech or their combination) in children, including in the case of previous perinatal encephalopathy and with various forms of cerebral palsy;
• neurosis-like conditions (tics; stuttering, mainly in the clonic form) in children;
• hyperkinetic disorders (attention deficit hyperactivity disorder) in children.

Contraindications

• acute severe kidney damage;
• pregnancy, breastfeeding;
• age up to 3 years;
• hypersensitivity to any component of Pantotropil.

Pantotropil, instructions for use: method and dosage

Pantotropil tablets are taken orally, 15-30 minutes after meals.

A single dose for adults can be 250–1000 mg, the daily dose is 1500–3000 mg, for children - 250–500 mg and 750–3000 mg, respectively. The course of therapy is 1–4 months, in some cases it can reach 6 months. A second course of treatment can be prescribed after 3–6 months.

Recommended dosage regimen of Pantotropil:

• cognitive disorders accompanying organic lesions of the brain, including in traumatic brain injury, the consequences of neuroinfections, neurotic disorders: 3-4 times a day, 250 mg;
• neuroleptic extrapyramidal syndrome (hyperkinetic and akinetic); as a corrector for the side effects of neuroleptic drugs; cerebral organic insufficiency in schizophrenia (as part of complex treatment): adults - 3 times a day, 500-1000 mg, children - 3-4 times a day, 250-500 mg; course - 1-3 months;
• extrapyramidal hyperkinesis against the background of hereditary diseases of the nervous system (in combination with ongoing treatment): daily dose - 500-3000 mg, course - up to 4 months or more;
• epilepsy with a slowdown in mental processes (in combination with anticonvulsants): adults - 3 times a day, 500-1000 mg, children - 3-4 times a day, 250-500 mg; course - up to 6 months;
• psycho-emotional overload, decreased physical and mental performance (to enhance concentration and memorization): 3 times a day, 250 mg;
• neurogenic disorders of urination: adults - 2–3 times a day, 500–1000 mg, children - 3 times a day, 250–500 mg (daily dose - 25–50 mg / kg); course - 1-3 months.

For various pathologies of the nervous system in children, Pantotropil is recommended to be used, taking into account age, in a daily dose of 1000–3000 mg. Dose escalation is usually carried out over 7-12 days. The maximum dose is taken for 15–40 days and then gradually reduced until the drug is discontinued for 7–8 days. The intervals between the course receptions of the nootropic agent can vary from 1 to 3 months.

For children, depending on the indications, the following dosage regimen of Pantotropil is recommended:

• developmental delay: 3-4 times a day, 500 mg, course - 2-3 months;
• attention deficit hyperactivity disorder: given body weight, at an average therapeutic daily dose of 30 mg / kg, morning and afternoon; for each patient, the optimal dose is set individually by gradually increasing the initial dose during the first 5–7 days; course - 3-4 months;
• neurosis-like states (tics; stuttering, mainly in the clonic form): 3-6 times a day, 250-500 mg, course - 1-4 months; since Pantotropil has a nootropic effect, it is advisable to take it in the morning and afternoon (up to 17 hours).

Side effects

• allergic reactions: skin rashes, rhinitis, conjunctivitis; with the development of such effects, Pantotropil should be canceled;
• central nervous system: drowsiness / sleep disturbance, lethargy, hyperexcitation, lethargy, noise in the head, dizziness, headache; in this case, it is recommended to reduce the dose.

Overdose

Symptoms of a Pantotropil overdose may include noise in the head, sleep disturbances, or drowsiness. With a similar condition, the intake of activated charcoal, gastric lavage, symptomatic treatment are prescribed.

special instructions

With a long course of therapy with Pantotropil, concomitant treatment with other stimulating and nootropic agents is not recommended.

Influence on the ability to drive vehicles and complex mechanisms

In the first days of the course, you need to be careful when driving vehicles and operating other complex mechanisms due to the possible appearance of drowsiness.

Application during pregnancy and lactation

Pantotropil is contraindicated in pregnant and lactating women due to the lack of information confirming the efficacy and safety of its use in this category of patients.

Pediatric use

Treatment with the drug is recommended for children over 3 years old according to the dosage regimen.

With impaired renal function

Pantotropil tablets are contraindicated in patients with acute severe kidney disease.

Drug interactions

• barbiturates: the effect of these drugs is lengthened;
• etidronic acid, glycine: the effectiveness of hopantenic acid increases;
• anticonvulsants: their effect is enhanced;
• antipsychotics (neuroleptics), carbamazepine, phenobarbital: hopantenic acid prevents the development of side reactions of these drugs;
• local anesthetics (procaine): the effect of these drugs is potentiated.

Analogs

The analogues of Pantotropil are Hopantenic acid, Gopantam, Pantogam, Calcium hopantenate, Pantogam Active, Pantocalcin, etc.

Terms and conditions of storage

Store in a place protected from light, out of reach of children, at a temperature not exceeding 30 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Pantotropil

The few reviews about Pantotropil, found on medical websites, indicate the effectiveness of the drug in the treatment of extrapyramidal hyperkinesis, cognitive impairment associated with organic brain lesions, with psycho-emotional overload. A nootropic agent helps to reduce motor excitability, enhances physical and mental performance, helps with neurosis-like conditions in children. Also, patients note that Pantotropil has shown good results in the treatment of neurogenic urinary disorders.

There are no complaints about negative phenomena.

Price for Pantotropil in pharmacies

The price of Pantotropil, 250 mg tablets, can be 270–420 rubles. per package containing 50 pcs.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!