Givalex

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Givalex: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. Drug interactions
12. Analogs
13. Terms and conditions of storage
14. Terms of dispensing from pharmacies
15. Reviews
16. Price in pharmacies

Latin name: Givalex

ATX code: R02AA20

Active ingredient: geksetidine (Hexetidine) + choline salicylate (Choline Salicylate) + chlorobutanol hemihydrate (Chlorobutanol Hemihydrate)

Producer: Norgine Pharma (France)

Description and photo update: 2019-26-08

Givalex is a local drug with antifungal, antibacterial, analgesic and anti-inflammatory effects, used in dental and ENT practice.

Release form and composition

Spray (in bottles of 50 ml, complete with a spray, 1 bottle in a cardboard box);
Solution for local use (in vials of 125 ml, 1 bottle in a cardboard box).

The composition of 100 ml of the drug contains active substances:

Hexetidine - 100 mg;
Choline salicylate - 500 mg;
Chlorobutanol hemihydrate - 250 mg.

Pharmacological properties

Pharmacodynamics

Givalex is a combined drug with a pronounced antibacterial, anti-inflammatory, antifungal and anesthetic effect. Contains hexetidine, choline salicylate and chlorobutanol as active ingredients.

The pharmacological properties of these substances determine the mechanism of action of the drug:

Hexetidine: antibacterial agent active against gram-negative and gram-positive aerobic and anaerobic microorganisms. It has a predominantly bacteriostatic effect on aerobic bacteria and a bactericidal effect on anaerobic bacteria. Its mechanism of action is due to the ability of the hexetidine molecule to competitively replace thiamine, which leads to impaired bacterial growth;
Chlorobutanol: an antibacterial and antifungal agent used in combination drugs for the treatment of dental and ENT diseases. Has some local anesthetic effect;
choline salicylate: a non-steroidal anti-inflammatory agent with antipyretic and analgesic action, which is highly effective when applied topically. By inhibiting cyclooxygenase, choline salicylate reduces the synthesis of pro-inflammatory cytokines.

After spraying a spray or rinsing the mouth with a solution, the active components of Givalex are deposited on the mucous membrane and gradually released, due to which they have a long-term therapeutic effect.

Pharmacokinetics

There are no data on the pharmacokinetic parameters of the drug.

Indications for use

According to the instructions, Givalex is prescribed as a means of local therapy in patients with infections of the pharynx and oral cavity caused by microorganisms sensitive to the action of the drug, including tonsillitis, tonsillitis, laryngitis (acute and chronic), pharyngitis, gingivitis, aphthae, stomatitis.

Also, Givalex can be used as a prophylactic agent in patients who have undergone dental surgery.

Contraindications

The use of Givalex is contraindicated in case of hypersensitivity to its components.

Spray Givalex is prohibited for children under 12 years old, solution up to 6 years old.

For lactating and pregnant women, the drug is prescribed only after the doctor evaluates the benefit / risk ratio for the health of the mother and the child.

Instructions for the use of Givalex: method and dosage

Givalex is used topically. The duration of the course of treatment, the dose and frequency of application of the drug, the doctor determines individually.

The spray is used to irrigate the pharynx and oral cavity. It is not recommended to take food for at least 10 minutes after the procedure.

As a rule, adults and children from 15 years old are prescribed 1 spray of the drug 4-6 times a day, children 12-15 years old - 2-3 times a day.

Before using Givalex in the form of a solution, it should be diluted. To do this, pour 10 ml of the drug into a measuring cup and add 40 ml of water (temperature - 30-35 ° C). In the absence of a measuring cup, 2 teaspoons of the solution must be diluted in a quarter of a glass of water.

Adults and children from 6 years of age are usually prescribed 2-4 rinses per day at regular intervals. Do not swallow the drug.

Unless otherwise prescribed by a doctor, the duration of therapy is usually 5 days.

Avoid getting Givalex in the eyes. With the development of symptoms of a common bacterial infection, the drug can be used simultaneously with oral or parenteral antimicrobial drugs. If during treatment there is an increase in body temperature or symptoms of the disease persist for 5 days, a second diagnosis should be carried out and the therapy regimen should be revised.

Side effects

As a rule, Givalex is well tolerated by patients. Sometimes during therapy, there may be irritation of the oral mucosa, impaired sense of smell and a change in taste. It is also possible to develop allergic skin reactions. With prolonged use of Givalex, superinfection may develop. If any irregularities appear, you should consult a doctor.

Overdose

When using the drug in accordance with the recommendations specified in the instructions for use, overdose is unlikely. No cases of intoxication have been reported.

If the drug was accidentally taken orally, you should immediately consult a doctor.

special instructions

Before starting the use of Givalex, as well as with the development of uncharacteristic symptoms, you should consult your doctor.

Application during pregnancy and lactation

To date, there are no reliable data confirming the complete safety of Givalex when used during pregnancy and lactation. Pregnant women can use the drug only as directed by a doctor, after assessing the ratio of expected benefits and possible risks.

If treatment is required during lactation, it is recommended that you consult with your doctor about possible interruption of breastfeeding.

Pediatric use

Spray Givalex is approved for use from the age of 12 years, solution for rinsing the mouth - from 6 years.

Drug interactions

Do not use other antiseptic agents at the same time.

Analogs

Analogues of Givalex are the drugs Angilex, Ingalipt, Falimint, Faringosept, Cameton, Lugol, Eucalyptus, Anginovag, Ajisept, Anginal, Hexasprey, Yoks, Lizak, Lisobakt, Septolete, Hepilor, etc.

Terms and conditions of storage

Store in a dark, dry place out of the reach of children, at a temperature of 15-25 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Givalex

Reviews about Givalex are mostly positive. Patients confirm the high efficiency of both the spray and the rinse solution, however, they note that for successful treatment, the drug should be used as early as possible, when the first symptoms of the disease appear.

The disadvantages of Givalex certain patients include: age restrictions for use for children, weak effect in the case of use in the later stages of the disease, burning sensation in the mouth due to the presence of ethanol in the composition, as well as the relatively high cost of the drug.

Price for Givalex in pharmacies

The price of Givalex is currently unknown, since the drug is not available commercially.

The cost of some popular analogues:

Ingalipt (aerosol for topical use) - 60–150 rubles. for a bottle of 30 ml;
Lugol (spray for topical application 1.25%) - 57-110 rubles. for a bottle of 50 ml;
Hexasprey (aerosol for topical application 2.5%) - 245-430 rubles. per bottle 30 g.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!