Benzydamine

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Benzydamine: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. Drug interactions
12. Analogs
13. Terms and conditions of storage
14. Terms of dispensing from pharmacies
15. Reviews
16. Price in pharmacies

Latin name: Benzydamine

ATX code: A01AD02

Active ingredient: benzydamine (Benzydamine)

Manufacturer: Vertex, JSC (Russia)

Description and photo update: 2019-11-07

Benzydamine is a local drug with anti-inflammatory, analgesic, antiseptic effects.

Release form and composition

Dosage form - solution for topical use: colorless, transparent, has a characteristic odor (1 bottle containing 50 or 100 ml of solution is placed in a cardboard box, complete with a measuring cup and instructions for the use of Benzydamine).

Composition of 1 ml solution:

active substance: benzydamine hydrochloride - 1.5 mg;
auxiliary components: ethanol (95% ethyl alcohol) - 8 mg; sodium bicarbonate - in the amount necessary to establish the pH; methylparaben (E218) - 1 mg; glycerin (E422) - 50 mg; natural food flavoring Mint - 0.3 mg; polysorbate 20 (E433) - 0.05 mg; sodium saccharinate (E954) - 0.24 mg; purified water - up to 1 ml.

Pharmacological properties

Pharmacodynamics

Benzydamine hydrochloride - the active substance of the drug, is an NSAID (non-steroidal anti-inflammatory agent), a derivative of indazole without a carboxyl group. Due to the absence of a carboxyl group, the substance is a weak base (most NSAIDs are among weak acids), has a high lipophilicity, and penetrates well into the inflammatory focus along a pH gradient (where the pH is lower), in which it accumulates in therapeutic concentrations.

Benzydamine hydrochloride has anti-inflammatory and local analgesic effects, has antifungal and antiseptic (against a wide range of microorganisms) properties.

The anti-inflammatory effect of the substance is based on a decrease in capillary permeability, stabilization of cell membranes due to inhibition of biosynthesis and inactivation of cytokines, prostaglandins, bradykinin, histamine, complement factors and other non-specific damaging endogenous factors.

The action of benzydamine hydrochloride is aimed at suppressing the production of pro-inflammatory cytokines, in particular tumor necrosis factor-α (TNF-α) and, to a somewhat lesser extent, interleukin-lβ (IL-lβ).

Benzydamine can be classified as a cytokine-suppressing anti-inflammatory drug because its main feature is that it exhibits potent inhibition of pro-inflammatory cytokines, while being a weak inhibitor of prostaglandin biosynthesis.

The local anesthetic effect of the substance is based on the structural features of its molecule, similar to local anesthetics, the analgesic effect is based on an indirect decrease in the concentration of biogenic amines with algogenic properties, and an increase in the pain sensitivity threshold of the apparatus. Benzydamine also blocks the interaction of bradykinin and tissue receptors, increases the pain threshold and restores microcirculation in the inflammatory focus.

The antibacterial effect of benzydamine hydrochloride is due to its rapid penetration through the membranes of microorganisms, which leads to damage to cellular structures, disruption of metabolic processes and damage to cell lysosomes.

The substance has antifungal effect against twenty strains of Candida albicans and non-albicans strains. The mechanism of action is based on structural modifications of the cell wall of fungi and their metabolic chains, which, as a result, prevents their reproduction.

Pharmacokinetics

When applied topically, benzydamine hydrochloride is absorbed well through the mucous membranes, the substance quickly penetrates into inflamed tissues, and is found in blood plasma in an amount that is insufficient for the development of systemic effects.

Excretion is carried out mainly by the kidneys and through the intestines in the form of conjugation products or metabolites.

Indications for use

Benzydamine is prescribed for the symptomatic treatment of pain syndrome accompanying various etiologies of inflammation:

oral cavity: periodontal disease, glossitis, gingivitis, stomatitis (including conditions after radiation therapy);
ENT organs: laryngitis, pharyngitis, tonsillitis;
conditions after injuries and surgical interventions (jaw fractures, tonsillectomy), treatment / extraction of teeth;
calculous inflammation of the salivary glands;
candidiasis of the oral mucosa (in combination with other drugs).

For the treatment of diseases of infectious and inflammatory etiology, in which a systemic approach is required, Benzydamine is used as part of a combination therapy.

Contraindications

Absolute:

age up to 12 years;
pregnancy and lactation;
individual intolerance to the components of the drug.

Relative (Benzydamine is prescribed under medical supervision):

bronchial asthma (including a burdened history);
individual intolerance to acetylsalicylic acid or other NSAIDs.

Benzydamine, instructions for use: method and dosage

A solution of Benzydamine is applied topically as a gargle, after a meal.

For rinsing the mouth or throat, patients of all age groups (including the elderly) are shown to use 15 ml of solution 2-3 times a day. Rinsing is carried out for 20-30 seconds, after which the drug should be spat out.

In cases where the use of an undiluted solution leads to a burning sensation, the drug is diluted with water in a ratio of 1 ÷ 1.

The maximum duration of therapy is 7 days. If at the end of this period the condition does not improve or the development of new symptoms is noted, you should consult your doctor.

Side effects

During the period of use of Benzydamine, the following undesirable side effects may develop (> 10% - very often;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rarely):

local reactions: rarely - burning sensation in the oral cavity, xerostomia; with an unspecified frequency - a feeling of numbness in the oral cavity;
allergic reactions: infrequently - photosensitivity; rarely - skin rash, hypersensitivity reactions, pruritus; very rarely - laryngospasm, angioedema; with an unknown frequency - anaphylactic reactions;
others: with an unknown frequency - laryngospasm.

Overdose

There have been no reports of an overdose of Benzydamine. If you use the drug in accordance with the instructions, the development of an overdose is unlikely.

If Benzydamine is swallowed, the following symptoms may appear: respiratory depression, abdominal cramps, vomiting, convulsions, ataxia, tachycardia, fever, anxiety, hallucinations, fear.

Therapy: symptomatic. It is necessary to cleanse the stomach by induction of vomiting or rinse it using a gastric tube (the procedure should be carried out under the supervision of a doctor). The patient's condition must be monitored. Supportive therapy and ensuring the required level of hydration are indicated. No antidote known.

special instructions

If hypersensitivity reactions develop during therapy with Benzydamine, it is necessary to stop using the drug and seek medical advice.

In some patients, ulcers in the mouth and throat may indicate a more serious condition. If symptoms persist within 3 days of therapy, you should consult a doctor.

The composition of Benzydamine contains parahydroxybenzoates, which can lead to the development of allergic reactions.

Drivers of vehicles should take into account that 1 dose of Benzydamine contains 1200 mg of 95% alcohol.

Athletes should take into account that when using drugs containing ethanol, the results of anti-doping tests for the maximum permissible content of ethanol in the blood (according to the standards established by some sports federations) may turn out to be positive.

It is necessary to protect your eyes from contact with the solution. If this happens, the eyes should be flushed with plenty of water.

Application during pregnancy and lactation

It is not recommended to use benzydamine during pregnancy / lactation.

Pediatric use

The use of the drug in patients under 12 years of age is contraindicated.

Drug interactions

Studies to identify interactions between benzydamine hydrochloride and other drugs have not been conducted.

Analogs

Benzydamine analogues are Bronflex, Anidak, Benzidamine-Akrikhin, Zvezdochka ENT, Tantum Verde, Oralsept, VERTUM ENT, etc.

Terms and conditions of storage

Store at temperatures up to 25 ° C. Keep out of the reach of children.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Benzidamine

Probably, due to the lack of the drug in the pharmacy network, there are no reviews of Benzydamine, which would allow us to evaluate its therapeutic efficacy.

Price for Benzydamine in pharmacies

The price of Benzydamine is unknown as the drug is not available in pharmacies.

The approximate cost of analogs: Anhidak (metered spray, 1 bottle of 15 ml) - 201 rubles, Benzidamine-Akrikhin (spray, 1 bottle of 30 ml) - 198 rubles, ENT asterisk (spray, 1 bottle of 30 ml) - 216 rub.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!