Bagomet - Instructions For The Use Of Tablets, Analogues, Price, Reviews

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Bagomet

Bagomet: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. With impaired renal function
10. 10. Use in the elderly
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Bagomet

ATX code: A10BA02

Active ingredient: Metformin (Metformin)

Producer: QUIMICA MONTPELLIER, SA (Argentina)

Description and photo update: 2019-07-08

Bagomet is a drug with a hypoglycemic effect used to treat type 2 diabetes mellitus when therapy with sulfonylurea drugs is ineffective.

Release form and composition

The drug containing metformin hydrochloride as an active substance is produced in the following dosage forms:

• Film-coated tablets, 500 mg each (10 pcs. In blisters);
• Tablets of prolonged action, film-coated, 850 mg and 1000 mg each (10 pcs. In blisters).

Pharmacological properties

Pharmacodynamics

Bagomet lowers blood glucose levels in diabetic patients by suppressing gluconeogenesis in the liver, reducing the absorption of glucose from the gastrointestinal tract and increasing its rate of processing in tissues. The active component of the drug - metformin - does not stimulate the production of insulin and does not cause hypoglycemia and hypoglycemic reactions.

Bagomet helps to reduce body weight in overweight patients with diabetes mellitus by reducing hyperinsulinemia. Its active ingredient is also characterized by a lipolytic effect. The drug reduces the level of total cholesterol in blood plasma, triglycerides and low density lipoproteins.

Pharmacokinetics

After oral administration, metformin is completely and rapidly absorbed from the gastrointestinal tract. When taken on an empty stomach, the absolute bioavailability is 50-60%. The maximum concentration of metformin in plasma is 4 μg / ml and is reached within 1–3 hours after the drug enters the body. When the drug is taken with meals, the absorption of the active ingredient of Bagomet decreases and slows down.

The binding of metformin to plasma proteins is practically absent. Also, the substance is capable of accumulating in erythrocytes and quickly distributed in tissues. The volume of distribution is 63-276 liters. Metformin is metabolized very poorly and excreted through the kidneys, mainly unchanged. Its clearance in patients who do not have serious health problems is 400 ml / min. The half-life is approximately 6 hours. With renal dysfunction, accumulation of Bagomet is possible.

To remove metformin from the blood and treat lactic acidosis, hemodialysis is effective.

Indications for use

Bagomet is prescribed for the treatment of type 2 diabetes mellitus, especially in combination with obesity, including cases when therapy with drugs from the sulfonylurea group is ineffective.

The drug can be used in monotherapy or simultaneously with insulin or other oral hypoglycemic drugs.

Contraindications

• Hypersensitivity to the components included in the tablets;
• Diabetic ketoacidosis, diabetic precoma, coma;
• Renal failure or impaired renal function;
• Compliance with a low-calorie diet (less than 1000 kcal per day);
• Lactic acidosis (including history);
• Clinically pronounced manifestations of chronic and acute diseases that can lead to the development of tissue hypoxia (including acute myocardial infarction, heart or respiratory failure);
• Chronic alcoholism, acute alcohol poisoning;
• Liver failure, abnormal liver function.

The drug should not be taken in acute conditions occurring with the risk of developing renal dysfunction, such as:

• Dehydration (with vomiting, diarrhea), fever, severe infectious diseases;
• A state of hypoxia (sepsis, shock, bronchopulmonary diseases, renal infections).

The medicine is not prescribed for lactating and pregnant women. Also, Bagomet should not be taken during major surgical operations and in case of injuries, when insulin therapy is indicated.

Children under 10 years old are contraindicated to take 500 mg tablets, up to 18 years old - 850 mg and 1000 mg.

Caution requires the use of Bagomet in old age, as well as when performing heavy physical work.

Instructions for the use of Bagomet: method and dosage

The dose of Bagomet is determined by the concentration of glucose in the blood and is set individually by the doctor.

At the beginning of treatment, 2-3 tablets (500 mg each) are usually prescribed per day, which are recommended to be taken in 2-3 doses to reduce the severity of the manifestation of digestive disorders. In the absence of side effects, if necessary, the dosage can be gradually increased. Maximum - 6 tablets per day, divided into 3 doses.

For adolescents and children over 10 years of age, 1 tablet of Bagomet (500 mg) is usually prescribed per day. Depending on the reaction to the action of the drug, the dosage is adjusted after 10-14 days. The maximum daily dose is 4 tablets per day, divided into 3 doses.

As part of the combined treatment with insulin, the average daily dosage is 1500 mg. The insulin dose is selected by the doctor based on blood glucose levels.

When prescribing the drug in the form of tablets with prolonged action, the initial dosage is 850 mg or 1000 mg. The tablets should be taken with food with plenty of liquid. If Bagomet is well tolerated, a gradual increase in dosage is possible. Typically, the maintenance dose is 1700 mg, with a maximum of 2550 mg per day.

When taking the drug as part of a combination therapy, the daily dose is usually 1 tablet of 850 mg or 1000 mg.

Side effects

Most often, the development of lactic acidosis is observed, the early signs of which are digestive disorders (nausea, diarrhea, vomiting), dizziness, fever, pain in the abdomen and muscles.

If the medication is accidentally taken in an amount exceeding the recommended dosage, gastric lavage should be performed.

Overdose

Overdose can provoke the development of lactic acidosis with a possible fatal outcome. The cause of lactic acidosis can also be the accumulation of metformin due to malfunctioning of the kidneys. Early symptoms of this condition include a decrease in body temperature, muscle pain, abdominal pain, diarrhea, nausea, vomiting, and later on - dizziness, rapid breathing, loss of consciousness and coma.

When signs of lactic acidosis appear, Bagomet is immediately canceled, the patient is urgently sent to the hospital and the diagnosis is confirmed by determining the lactate content in the body. The most effective way to ensure the elimination of metformin and lactate from the body is hemodialysis. Also, if necessary, symptomatic treatment is prescribed.

special instructions

While taking Bagomet, regular monitoring of blood glucose concentration after meals and on an empty stomach is necessary.

Symptoms such as vomiting, muscle pain, general weakness, severe malaise may indicate the onset of lactic acidosis. If such signs appear, as well as the development of symptoms of an infectious disease of the urinary tract or bronchopulmonary infection, you should stop taking the medicine and consult a doctor.

The drug is canceled two days before the X-ray examination, operations under general, epidural or spinal anesthesia.

Alcohol should not be taken while using Bagomet, due to the increased risk of lactic acidosis.

There are no data on the negative effect of the drug on the ability to drive a car. However, during combination therapy with other hypoglycemic drugs, it is recommended to be careful when performing work that requires increased concentration of attention.

With impaired renal function

In severe renal dysfunction, the drug is contraindicated. In case of impaired renal function of mild and moderate severity, the work of this organ should be constantly monitored, since the accumulation of the drug cannot be ruled out.

Use in the elderly

According to the instructions, Bagomet is not recommended to be prescribed to patients over 60 years of age whose work is associated with intense physical activity, since taking the drug significantly increases the risk of lactic acidosis in them.

In elderly patients, the maximum daily dose should not exceed 1000 mg.

Drug interactions

When combining therapy with Bagomet with β-blockers, sulfonylurea derivatives, cyclophosphamide, acarbose, clofibrate derivatives, insulin, angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, oxytetracycline, monoamine oxidaseminexidase inhibitors, it is possible to increase the hypotransferase effect.

The hypoglycemic effect of Bagomet decreases when taken simultaneously with nicotinic acid derivatives, glucocorticosteroids, phenothiazine derivatives, oral contraceptives, loop and thiazide diuretics, epinephrine, thyroid hormone preparations, glucagon and sympathomimetics.

Cimetidine inhibits the excretion of Bagomet from the body, which increases the risk of lactic acidosis.

Metformin is able to weaken the effect of coumarin-derived anticoagulants. The combination of a drug with alcohol can provoke the development of lactic acidosis.

Analogs

Analogues of Bagomet are:

• By active substance: Langerin, Formetin, Glyformin, Metospanin, NovoFormin, Metadien, Glucophage, Sofamet;
• According to the mechanism of action: Glidiab, Glyumedex, Glibex, Diabefarm, Diabinax, Glyurenorm, Glibenclamide, Glucostabil, Gliclada, Glimepirid, Glemaz, Movogleken, Glimidstada, Maniglid, Diatica, Glidanil, Diabetalon, Meglidalon.

Terms and conditions of storage

The drug is dispensed by prescription (list B).

Store at temperatures up to 25 ° C.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Bagomet

Reviews of Bagomet among doctors are mostly positive. In their opinion, taking this inexpensive drug provides a stable concentration of metformin in blood plasma for 12 hours, which makes it possible to reduce the frequency of drug intake and improve monitoring of metabolic processes. This improves the absorption of metformin from the stomach and minimizes the risk of side effects from the gastrointestinal tract.

Price for Baghomet in pharmacies

In most pharmacies the price for Bagomet 850 mg is 180–230 rubles (60 pcs per pack). There are currently no other forms of the drug on sale.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!