Aktiferrin - Instructions For Use, Price, Reviews, Drops, Syrup, Capsules

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Aktiferrin

Aktiferrin: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Analogs
14. 14. Terms and conditions of storage
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Aktiferrin

ATX code: B03AE10

Active ingredient: iron sulfate + serine (ferrous sulfate + serin)

Manufacturer: GmbH Merkle, Germany

Description and photo update: 2019-13-08

Prices in pharmacies: from 231 rubles.

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Aktiferrin is a drug for replenishing iron deficiency.

Release form and composition

The drug is available in the form of capsules, syrup and drops.

The active ingredients in the capsules are ferrous sulfate monohydrate and serine. The auxiliary components are: yellow beeswax, lecithin, soybean oil, rapeseed oil.

The active substances of Aktiferrin in the form of a syrup are iron sulfate heptahydrate and serine, and the auxiliary ones are ascorbic acid, ethanol, invert sugar syrup, raspberry and cream flavors, purified water.

In addition to these auxiliary components, Aktiferrin drops also include potassium sorbate.

Pharmacological properties

Pharmacodynamics

Iron is a trace element that is a coenzyme of cytochrome oxidase, peroxidase, catalase and a component of hemoglobin, myoglobin, cytochromes and is involved in various metabolic processes in the body.

The daily requirement for iron for adults is 1–2 mg, for pregnant women - 2–5 mg, for children under the age of 7 years - 0.5–1.5 mg. The level of absorption of iron is on average 10%, therefore, when taken orally, to replenish the need for iron, it is necessary to prescribe doses that exceed the daily requirement by 10 times.

The total iron content in the body of adults is 3000–5000 mg, in newborns - 200–

300 mg. Approximately 60% of this amount is involved in the transport of oxygen in the composition of hemoglobin in erythrocytes. Approximately 1000 mg in the form of ferritin or hemosiderin (mobilizable form) is contained in the cells of macrophages of the spleen, liver, and bone marrow. Plasma transport of iron - about 4 mg. In the bone marrow, 25 mg of iron is transferred daily, which is formed as a result of hematopoiesis (mostly due to the destruction of red blood cells).

Pharmacokinetics

As a result of oral administration, 10-15% of ferrous iron is absorbed in the duodenum and jejunum. Also, iron absorption is possible through the mechanism of passive diffusion (this process is largely activated with increased erythropoiesis or with iron deficiency). With a low hemoglobin level and depletion of the iron depot, the degree of absorption can increase up to 60%. When these indicators are normalized, this value decreases to the normal level. The peak plasma concentration after taking iron supplements occurs after 2-4 hours.

When iron enters the bloodstream, it binds to plasma proteins by transferrins and is transported to specific depots and to the sites of hematopoiesis.

After binding with apoferritin, iron in the form of ferritin is deposited in the spleen, liver, and bone marrow. Iron passes through the placental barrier and is excreted in breast milk in minimal amounts.

Daily loss of iron through desquamation of mucosal and epithelial cells with urine and bile is approximately 1 mg. Iron loss during menstruation is about 1 mg.

A significant amount of iron released as a result of the destruction of hemoglobin is reutilized in the body (20–30 mg per day) and is used mainly for the synthesis of hemoglobin.

Indications for use

According to the instructions, Aktiferrin is prescribed for iron deficiency anemia and iron deficiency caused by:

• Great blood loss;
• The period of lactation and pregnancy;
• Chronic gastritis;
• Gastrointestinal ulcer;
• Tumor diseases;
• Gastric resection;
• Postponed infections.

The use of Aktiferrin for children is effective during active growth, during a period of reduced body resistance, as well as in infectious and tumor diseases.

Contraindications

According to the instructions, Aktiferrin is not prescribed in the following cases:

• Anemia of hemolytic, aplastic, sideroachrestic, caused by lead poisoning;
• Hemosiderosis;
• Hemochromatosis;
• Late porphyria of the skin;
• Chronic hemolysis;
• Hypersensitivity.

During lactation and pregnancy, the use of Aktiferrin is considered safe if an iron deficiency is diagnosed.

Instructions for the use of Aktiferrin: method and dosage

Adults and adolescents take the drug in capsules. Aktiferrin is prescribed to them 1 capsule 2-3 times a day. If there is poor tolerance, the dosage is gradually reduced, choosing the optimal one, but the duration of treatment is increased. Children under 6 years of age are prescribed 1 capsule of the drug 1 time per day.

Syrup Aktiferrin is prescribed for children over 2 years old. The permissible daily dosage is 5 ml per 12 kg of the child's weight. The drug in the form of a syrup for preschool children is prescribed 5 ml 1-2 times a day, for school-age children - 5 ml 2-3 times a day.

For newborns and children under 2 years of age, it is preferable to give the drug in drops. The daily dosage is 5 drops per 1 kg of the child's weight. Frequency rate of admission - 2-3 times a day. On average, infants are prescribed 10-15 drops, preschool - 25-35 drops, school - 50 drops 3 times a day.

You can take Aktiferrin during or after a meal with water. Do not chew the capsules.

Side effects

After using Aktiferrin, the following undesirable effects may occur:

• Decreased appetite;
• Bitter taste in the mouth;
• Flatulence;
• Diarrhea;
• Stomach ache;
• Constipation;
• Vomiting;
• Nausea;
• Allergic rash and itching;
• Dizziness;
• Irritability;
• Encephalopathy;
• Headache and toothache;
• Sore throat;
• A feeling of tightness in the chest;
• Anaphylactic shock (rare)

As a rule, side effects from the digestive tract disappear when the dosage is reduced.

In case of an overdose of Aktiferrin, you may experience:

• Weakness;
• Paresthesia;
• Pallor of the skin;
• Lowering blood pressure;
• Cardiopalmus;
• Abdominal pain;
• Bloody diarrhea.
• confusion
• Lethargy
• Convulsions
• Coma
• Hyperthermia
• Weak pulse

An overdose is treated by washing the stomach, taking milk, raw eggs, and prescribing Deferoxamine.

Overdose

Symptoms

In the case of the use of iron preparations by children, there is a high probability of intoxication, therefore, such medicines should be kept out of the reach. The occurrence of life-threatening conditions is possible with a dose of 1000 mg of ferrous sulfate. At the same time, the following symptoms were recorded: diarrhea, nausea, vomiting, severe abdominal pain, and in severe cases, the development of collapse, drowsiness, oliguria and shock.

Due to toxic hepatitis, there is a risk of developing jaundice, in some cases - disorders of the central nervous system (paralysis, convulsions, coma). Rarely there are blood clotting disorders.

Treatment

Before specific therapy, measures are shown to remove the iron preparation from the gastrointestinal tract (gastric lavage with phosphate and bicarbonate buffer solutions, induction of vomiting), followed by ingestion of milk and raw eggs.

Specific therapy

If the concentration of serum iron is exceeded (> 300-350 mcg / dl), an intravenous drip of 1000-2000 mg deferoxamine (Desferal) is required at the rate of 15 mg / kg of the patient's body weight per hour.

In the case of a course of treatment with iron preparations, the level of serum iron and other indicators of blood serum should be systematically monitored.

In case of an overdose of iron salts in patients with oligo- or anuria, hemodialysis is prescribed.

Special measures in case of severe intoxication - parenteral administration of Dimercaprol (diethylenetriaminepentaacetate calcium).

Due to the risk of neurotoxic complexes formation, diethylenetriaminepentaacetate calcium should be used with caution.

special instructions

In the presence of renal or hepatic insufficiency, the likelihood of accumulation of iron increases.

The use of Aktiferrin can provoke an exacerbation of inflammatory and ulcerative bowel diseases.

With regular use of the drug, darkening of the teeth may be observed.

The absorption of the product is reduced by:

• Etidronic acid;
• Antacids;
• Pancreatin;
• Egg yolks;
• Cereals;
• Vegetables;
• Milk;
• Coffee;
• Tea.

Reception Aktiferrin negatively affects the absorption of tetracyclines, fluoroquinolones, penicylamine.

When combined with ethanol, in some cases, the drug can cause toxic complications.

In high doses, the agent reduces the absorption of zinc by the kidneys.

Application during pregnancy and lactation

Preclinical studies of the effect of iron supplementation on reproductive function have not been conducted. Use during pregnancy, as well as during lactation, is allowed only after a doctor has assessed the ratio of potential benefits to the mother and possible risk to the fetus / child.

Pediatric use

Aktiferrin drops are used from the first days of life, syrup - from 2 years. The capsules are used in the treatment of children weighing 20 to 50 kg.

With impaired renal function

In the treatment of patients with impaired renal function, Aktiferrin is used with caution.

For violations of liver function

When treating patients with impaired liver function, Aktiferrin is used with caution.

Analogs

Among the analogues of Aktiferrin, the following drugs can be distinguished:

• Hemoferon;
• Globigen;
• Ranferon;
• Totem;
• Feron Forte;
• Sorbifer;
• Ferramine.

Terms and conditions of storage

The drug is dispensed from pharmacies by prescription. It must be stored in a dry place out of the reach of children, at a temperature not exceeding 25 ° C.

The shelf life of all dosage forms is 2 years. After opening, drops and syrup should be stored no longer than 1 month.

Reviews about Aktiferrin

Reviews of Aktiferrin are predominantly positive: users note the good tolerance of the drug, a low incidence of side effects, a relatively low cost and a variety of dosage forms.

Parents of infants note that Aktiferrin raises the hemoglobin level in children well. As disadvantages, cases of the development of side effects and difficulties with removing stains from the drug from clothing are indicated.

The price of Aktiferrin in pharmacies

The approximate price for Aktiferrin is: 50 capsules - 335 rubles, 20 capsules - 175 rubles, oral drops (30 ml) - 325 rubles, syrup (100 ml) - 240 rubles.

Aktiferrin: prices in online pharmacies

Drug name Price Pharmacy

Aktiferrin syrup 100 ml 1 pc. 231 RUB Buy

Aktiferrin syrup 100ml 237 r Buy

Aktiferrin drops for oral administration 30 ml 1 pc. 249 r Buy

Aktiferrin drops for internal approx. 30ml 376 r Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!