Otrivin
Otrivin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Use in the elderly
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Otrivin
ATX code: R01AA07
Active ingredient: xylometazoline (xylometazoline)
Manufacturer: Novartis Consumer Health S. A. (Novartis Consumer Health, SA) (Switzerland)
Description and photo update: 2019-20-08
Prices in pharmacies: from 109 rubles.
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Otrivin is a topical vasoconstrictor in otorhinolaryngology.
Release form and composition
Otrivin dosage forms:
- Nasal drops 0.05% (for children): a clear, colorless liquid, odorless (10 ml in polyethylene bottles with a dropper cap, providing control of the first opening, in a cardboard box 1 bottle);
- Nasal drops 0.1%: transparent liquid, colorless and odorless (10 ml in polyethylene bottles with a dropper cap, providing control of the first opening, in a cardboard box 1 bottle);
- Dosed nasal spray 0.05% (for children): transparent, colorless solution, almost odorless (10 ml in high density polyethylene bottles with a dosing device, in a cardboard box 1 bottle complete with a protective cap and tip);
- Dosed nasal spray 0.1%: colorless transparent solution, almost odorless (15 ml or 10 ml in polyethylene (high density) vials with a dosing device, in a cardboard box 1 vial with a protective cap and a polyethylene tip).
The active substance of Otrivin is xylometazoline hydrochloride:
- 1 ml drops of 0.05% - 0.5 mg;
- 1 ml of 0.1% drops - 1 mg;
- 1 ml of 0.05% solution - 0.5 mg;
- 1 ml of 0.1% solution - 1 mg.
Auxiliary components: hypromellose 4000, sodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate, sodium chloride, disodium edetate, sorbitol 70%, benzalkonium chloride (50% solution), water.
Pharmacological properties
Pharmacodynamics
Xylometazoline is a local vasoconstrictor (decongestant), has an α-adrenomimetic effect, contributing to the narrowing of blood vessels located in the nasal mucosa, eliminating edema and hyperemia of this membrane, and nasopharynx. This provides free nasal breathing for rhinitis.
Otrivin is well tolerated, which allows it to be used in patients with hypersensitivity of the nasal mucosa, and the mucus separation occurs without hindrance. The drug has a balanced pH, which practically coincides with that of the nasal cavity. It contains inactive components - hypromellose 4000 (methylhydroxypropyl cellulose) and sorbitol, which have a moisturizing effect. This reduces the severity of symptoms of irritation and dryness of the nasal mucosa, developing with prolonged use of xylometazoline.
When used in therapeutic concentrations, Otrivin does not lead to the development of hyperemia and does not irritate the mucous membrane. After administration, xylometazoline begins to act in a few minutes, and the duration of the effect is about 12 hours.
Pharmacokinetics
When applied topically, the absorption of xylometazoline is extremely low, and the content in the blood plasma is so insignificant that its determination using the methods of modern analytical chemistry is not possible.
Indications for use
- Rhinitis against the background of acute respiratory diseases;
- Acute rhinitis of allergic etiology;
- Sinusitis;
- Hay fever;
- Eustachite;
- Treatment of nasopharyngeal edema with otitis media;
- Preparing the patient for diagnostic examinations in the nasal passages.
Contraindications
- Atrophic rhinitis;
- Tachycardia;
- Arterial hypertension;
- Severe form of atherosclerosis;
- Hyperthyroidism;
- Glaucoma;
- A history of surgical operations on the meninges;
- Hypersensitivity to drug components.
According to the instructions, Otrivin is recommended to be used with caution in patients with cardiovascular pathologies, diabetes mellitus, hypersensitivity to adrenergic drugs that cause symptoms of dizziness, insomnia, arrhythmia, high blood pressure (BP), tremor.
In addition, 0.1% spray and 0.1% drops should not be used in children under 6 years of age. With caution, they should be prescribed for prostatic hyperplasia.
Instructions for use of Otrivin: method and dosage
Nasal drops 0.05% (for children)
Otrivin drops 0.05% are instilled into each nostril.
Dosing regimen:
- Children under 6 years old: 1-2 drops 1-2 times a day, the maximum frequency of use should not exceed 3 times a day;
- Children over 6 years old: 2-3 drops 3-4 times a day.
The duration of treatment is no more than 10 days.
Nasal drops 0.1%
Otrivin drops 0.1% are used intranasally, instilled into each nasal passage.
The recommended dosing regimen for patients over 6 years old: 2-3 drops 3-4 times a day, the course of treatment is 3-4 days. If necessary, longer therapy should be consulted by a doctor.
Dosed nasal spray 0.05% (for children)
Spray Otrivin 0.05% is used by injecting the drug into each nostril.
Dosing regimen:
- Children under 6 years of age: 1 injection 1-2 times a day, but no more than 3 times a day;
- Children over 6 years old: 2-3 injections 3-4 times a day.
The course of treatment is not more than 10 days.
Dosed nasal spray 0.1%
Spray Otrivin 0.1% is injected into each nostril.
The drug is prescribed to patients over 6 years of age, 1 injection 3-4 times a day for 10 days.
Side effects
Local reactions: with prolonged and / or frequent use - tingling, burning, dryness and / or irritation of the nasopharyngeal mucosa, hypersecretion, sneezing; rarely - swelling of the nasal mucosa.
Systemic reactions: with prolonged and / or frequent use - nausea; rarely - dizziness, vomiting, headache, palpitations, increased blood pressure, tachycardia, arrhythmia, blurred vision, insomnia, development of allergic reactions; with long-term therapy in high doses - depression.
Overdose
The main symptom of an overdose of Otrivin is an increase in side effects, including a rapid heart rate and increased blood pressure, in some cases - confusion. Symptomatic therapy is recommended.
Symptoms of xylometazoline overdose when applied topically in high doses or in case of accidental ingestion of the drug may be severe dizziness, hyperhidrosis, a sharp drop in body temperature, headache, bradycardia, increased blood pressure, respiratory depression, coma and convulsions. Following an increase in blood pressure, a sharp decrease can be observed.
It is recommended to carry out appropriate supportive measures in case of any suspicion of a possible overdose. In some cases, immediate symptomatic therapy is required under the supervision of a physician, including monitoring the patient for several hours. In severe poisoning with cardiac arrest, resuscitation should be carried out for at least 1 hour.
special instructions
You should not violate the recommended dosage regimen and the period of use of Otrivin, especially when treating children and elderly patients.
In children under 1 year of age, Otrivin should be used only as directed by a doctor.
Children under 6 years of age should be instilled or injected by an adult.
Do not use 0.1% drops for more than 10 days.
Influence on the ability to drive vehicles and complex mechanisms
Otrivin does not affect the patient's ability to drive vehicles and mechanisms.
Application during pregnancy and lactation
- nasal drops 0.05% and 0.1%: for pregnant and lactating women, Otrivin can be used strictly in recommended doses with a clinically significant excess of the benefits of therapy for the mother over the potential risk to the fetus / child;
- nasal spray 0.05% and 0.1%: it is forbidden to use during pregnancy. During breastfeeding, the spray is used strictly at the recommended doses with a clinically significant excess of the benefits of therapy for the mother over the potential risk to the child.
Pediatric use
Otrivin should be used to treat children in strict compliance with the prescribed dosage regimen. Therapy for children under 1 year old is carried out after consulting a doctor; in children under 6 years of age, instillation and application of the drug are carried out under the supervision of adults.
Age restrictions for children, depending on the form of release of Otrivin:
- 0.05% nasal drops: have no age restrictions;
- 0.1% nasal drops: for children over 6 years old;
- dosed nasal spray 0.05%: for children over 2 years old;
- dosed nasal spray 0.1%: for children over 12 years old.
Use in the elderly
Elderly patients are required to strictly adhere to the recommended dosing regimen.
Drug interactions
Otrivin is incompatible with tricyclic antidepressants and monoamine oxidase inhibitors.
Analogs
Otrivin's analogs are: Nazivin, Vicks Active, Tizin, Xilen, Nazol, Lazorin, Naphtizin, Sanorin, Afrin, Noxprey, Rint, Operil, Rinazolin, Rinorus, Rinostop, Nazo-Spray, Farmazolin, Dlinos, Galazolin, Grippostad Rinos Xylometazoline, Grippocitron Rinos, Xinos, Olint, Meralis, Rinoxil, Eucabal, Tizin Xylo, Sialor, Snoop.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 30 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Otrivin
When using a spray or drops strictly according to indications, in dosages recommended by a specialist, reviews about Otrivin leave mostly positive. Patients note its safety and effectiveness, as well as the speed and duration of relieving nasal congestion. In this case, side reactions are extremely rare.
There are numerous reports on the use of Otrivin in children. According to parents, drops well eliminate the symptoms of rhinitis in babies, starting from the 1st year of life, and when administered in therapeutic doses, do not lead to side effects. The spray is most often used for adolescents who are more suitable for this dosage form.
Otrivin price in pharmacies
The approximate price for Otrivin in the form of a 0.05% spray is 152‒188 rubles, in the form of a spray 0.1% - 167‒196 rubles (for a 10 ml bottle). Nasal drops 0.05% and 0.1% in the original 10 ml packaging are currently not available for sale.
Otrivin: prices in online pharmacies
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Drug name Price Pharmacy |
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Otrivin 0.05% nasal spray dosed [for children] 10 ml 1 pc. 109 RUB Buy |
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Otrivin Otrivin Children's nasal spray for children 0.05%, 10ml 143 r Buy |
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Otrivin 0.1% nasal spray dosed 10 ml 1 pc. 148 RUB Buy |
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Otrivin Otrivin Moisturizing formula, nasal spray dosed 0.1%, 10ml 152 RUB Buy |
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Otrivin Otrivin Menthol nasal spray dosed 0.1% 10ml 166 r Buy |
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Otrivin 0.1% nasal spray dosed with menthol and eucalyptus 10 ml 1 pc. 166 r Buy |
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Otrivin Express 0.05% dosed nasal spray with menthol aroma 10 ml 1 pc. 167 r Buy |
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Otrivin Baby spray for irrigation of the nasal cavity nasal spray for children 20 ml 1 pc. 167 r Buy |
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Otrivin 0.05% nasal drops for children 10 ml 1 pc. 178 r Buy |
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Otrivin Baby nozzles replaceable for nasal aspirator 10 pcs. RUB 181 Buy |
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Otrivin Baby Otrivin Baby disposable refills, 10 pcs. 183 r Buy |
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Otrivin Complex 0.6 mg / ml + 0.5 mg / ml nasal spray 10 ml 1 pc. 210 RUB Buy |
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Otrivin Baby drops for nasal cavity irrigation nasal drops 5 ml 18 pcs. 223 r Buy |
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Otrivin Otrivin Express nasal spray with menthol aroma, 0.05% 224 r Buy |
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Otrivin Baby Otrivin Baby drops for nasal cavity irrigation, 5ml, 18 pcs. 248 r Buy |
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Otrivin Otrivin Complex nasal spray dosed, 10ml 251 RUB Buy |
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Otrivin Baby Otrivin Baby nasal aspirator with replaceable nozzles, 3 pcs. RUB 298 Buy |
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Otrivin Baby Nasal Aspirator with 3 replaceable nozzles 1 pc. RUB 298 Buy |
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Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
