Tetracycline
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Prices in online pharmacies:
from 26 rubles.
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Tetracycline is a bacteriostatic antibiotic from the tetracyclines group. Possesses a wide spectrum of antibacterial action.
Release form and composition
Tetracycline is available in the following dosage forms:
- coated tablets: pink, round, biconvex (10 pcs. in blisters, one or two packs in a cardboard box; 40 pcs. in dark glass jars, one can in a cardboard box);
- ointment for external use 3%: yellow, homogeneous (10 g or 15 g each in aluminum tubes, one tube in a cardboard box);
- eye ointment 1%: yellowish or yellowish-brown in color, homogeneous (2, 3, 5 or 10 g in aluminum tubes, one tube in a cardboard box).
Composition for 1 coated tablet:
- active substance: tetracycline - 0.1 g;
- auxiliary components: basic magnesium carbonate, calcium stearate, corn starch, gelatin, sucrose, tropeolin O, talc, dextrin, acid red dye 2C.
Composition for 1 g of ointment for external use:
- active substance: tetracycline - 0.03 g;
- auxiliary components: ceresin, petroleum jelly, solid petroleum paraffin, sodium metabisulfite, anhydrous lanolin.
Composition for 1 g of eye ointment:
- active substance: tetracycline - 0.01 g;
- auxiliary components: petroleum jelly, anhydrous lanolin.
Indications for use
Tetracycline in the form of film-coated tablets is used for the following infectious diseases caused by microorganisms sensitive to the drug:
- bronchitis, tracheitis, pneumonia, pleural empyema;
- otitis media, stomatitis, tonsillitis, pharyngitis, gingivitis;
- endometritis, endocarditis, prostatitis;
- intestinal infections, pyelonephritis, cholecystitis;
- osteomyelitis;
- whooping cough, rickettsiosis, psittacosis, brucellosis, actinomycosis, gonorrhea, syphilis;
- blepharitis, conjunctivitis, trachoma;
- purulent infections of soft tissues;
- acne, furunculosis, folliculitis, infected eczema.
Tetracycline in the form of an ointment for external use is prescribed for purulent infections of soft tissues, acne, furunculosis, folliculitis and infected eczema.
Tetracycline in the form of an eye ointment is used for bacterial (including chlamydial) eye infections caused by antibiotic-sensitive microorganisms:
- trachoma;
- blepharitis;
- keratitis;
- meibomite (barley);
- blepharoconjunctivitis;
- keratoconjunctivitis.
Contraindications
Film-coated tablets
- leukopenia;
- children under 8 years old;
- second and third trimesters of pregnancy;
- period of breastfeeding;
- increased individual sensitivity to drug components.
Tetracycline in tablet form is used with caution in patients with renal failure.
Ointment for external use 3%
- fungal skin lesions;
- children up to age 11;
- increased individual sensitivity to drug components.
Eye ointment 1%
- impaired renal and / or liver function;
- children under 8 years old;
- period of pregnancy;
- period of breastfeeding;
- increased individual sensitivity to drug components.
Method of administration and dosage
Film-coated tablets
Tetracycline tablets are taken orally with plenty of water or other liquid.
The average recommended dose for adults is 0.25-0.5 g four times a day or 0.5-1 g twice a day (every 12 hours). The maximum dose is 4 g per day.
Children and adolescents aged 8-18 years are prescribed the drug at 6.25-12.5 mg / kg of body weight four times a day or 12.5-25 mg / kg of body weight twice a day.
Recommended doses of tetracycline for certain diseases:
- acne: 0.5–2 g per day in several doses. When the condition improves, which is observed after about 3 weeks, the dose of the drug is gradually reduced to a maintenance dose of 0.125–1 g per day. Adequate remission of the disease can be obtained with the use of tetracycline every other day or with intermittent treatment;
- uncomplicated endocervical, rectal and urethral infections caused by Chlamydia trachomatis: 0.5 g four times a day, the course of treatment is at least 7 days;
- brucellosis: 0.5 g four times a day (every 6 hours) for 3 weeks; during the first week, intramuscular injections of streptomycin are additionally performed (1 g twice a day), during the second week streptomycin is administered once a day;
- syphilis: 0.5 g four times a day, the course of treatment is 15 (for early syphilis) or 30 (for late syphilis) days;
- uncomplicated gonorrhea: the initial dose is 1.5 g per day, then the drug is administered at 0.5 g four times a day for 4 days.
Ointment for external use 3%
Tetracycline in the form of an ointment is applied to areas of the skin affected by the infection, or used as a gauze bandage, which is applied to the problem area. The frequency of application of the ointment is 1-2 times a day. The gauze bandage is changed every 12-24 hours. The therapeutic course varies from 2–3 days to 2–3 weeks.
Eye ointment 1%
Tetracycline in the form of an ophthalmic ointment is used topically. The drug is placed behind the eyelid. A single dose is a strip of ointment 0.5–1 cm long.
For trachoma, the ointment is applied every 2–4 hours or more often for 1–2 weeks. With a decrease in inflammation, the frequency of use of Tetracycline decreases to 2-3 times a day. The general course of treatment is 1–2 months.
With blepharoconjunctivitis and blepharitis, the ointment is used 3-4 times a day. The course of treatment is 5-7 days.
With keratoconjunctivitis and keratitis, the frequency of application of the drug is 2-3 times a day, and the course of treatment is 5-7 days. If there is no improvement on the 3rd-5th day of therapy, you should consult a doctor.
With barley, eye ointment is applied at night. The duration of the course is until the signs of inflammation disappear.
Side effects
When taking Tetracycline inside, side reactions from the following systems and organs are possible:
- digestive system: nausea, esophagitis, vomiting, gastritis, dysphagia, anorexia, glossitis, hypertrophy of the papillae of the tongue, ulceration of the duodenum and stomach, pancreatitis, diarrhea, intestinal dysbiosis, hepatotoxic effect, increased activity of liver enzymes;
- hematopoietic system: neutropenia, thrombocytopenia, hemolytic anemia;
- nervous system: instability or dizziness, increased intracranial pressure;
- immunopathological and allergic reactions: skin hyperemia, photosensitivity, Quincke's edema, medicinal lupus erythematosus, maculopapular rash, anaphylactoid reactions;
- urinary system: hypercreatininemia, azotemia;
- other reactions: discoloration of tooth enamel in children, candidiasis, hyperbilirubinemia, superinfection, deficiency of B vitamins.
When using the ointment for external use and eye ointment, allergic reactions (redness, slight burning and itching of the skin), edema and hyperemia of the eyelids, photosensitivity and transient blurred vision may occur.
special instructions
During the period of treatment with Tetracycline, it is necessary to limit insolation, since the development of photosensitivity is possible.
With prolonged use of the drug, the function of the liver, kidneys and hematopoietic organs should be periodically monitored.
Tetracycline can mask the symptoms of syphilis, therefore, if a mixed infection is likely, a serological test should be performed monthly (within 4 months).
In children, enamel hypoplasia and long-term staining of tooth enamel in a yellow-gray-brown color are possible during the development of teeth. This effect is due to the fact that tetracyclines interact with calcium and form stable complexes with it in any bone-forming tissue.
To prevent hypovitaminosis during treatment with Tetracycline, it is advisable to additionally take brewer's yeast, vitamin K and B vitamins.
Immediately after applying the eye ointment, it is not recommended to drive a car or work with other complex equipment, as the drug may cause temporary blurred vision.
Drug interactions
For external and local use of tetracycline, drug interactions have not been described.
When taking tetracycline orally, you should consider possible interactions:
- magnesium-, aluminum- and calcium-containing antacids, cholestyramine and iron preparations reduce the absorption of tetracycline;
- chymotrypsin increases the concentration of tetracycline and the duration of its circulation;
- retinol increases the likelihood of increased intracranial pressure.
With simultaneous use with indirect anticoagulants, the prothrombin index decreases; with penicillins and cephalosporins - the effectiveness of these drugs decreases; with estrogen-containing oral contraceptives - the contraceptive effect decreases and the risk of developing breakthrough bleeding increases.
Analogs
Tetracycline analogs are: Tetracycline-AKOS, Tetracycline-Lect.
Terms and conditions of storage
Store in a dry, dark place at a temperature not exceeding 15 ° C (eye ointment), 20 ° C (topical ointment) or 25 ° C (film-coated tablets). Keep out of the reach of children. The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Tetracycline: prices in online pharmacies
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Drug name Price Pharmacy |
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Tetracycline 100 mg film-coated tablets 20 pcs. RUB 26 Buy |
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Tetracycline 100 mg film-coated tablets 20 pcs. RUB 31 Buy |
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Tetracycline 100 mg film-coated tablets 20 pcs. 35 RUB Buy |
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Tetracycline (eye ointment) 1% eye ointment 3 g 1 pc. 42 RUB Buy |
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Reviews Tetracycline (eye ointment) 42 RUB Buy |
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Tetracycline eye ointment 1% 3g 52 RUB Buy |
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Tetracycline (eye ointment) 1% eye ointment 5 g 1 pc. RUB 59 Buy |
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Tetracycline with nystatin 100 mg + 22.2 mg film-coated tablets 10 pcs. RUB 60 Buy |
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Tetracycline tablets p.o. 100mg 20 pcs. RUB 61 Buy |
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Tetracycline eye ointment 1% 5g 73 rbl. Buy |
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Tetracycline (ointment) 3% ointment for external use 15 g 1 pc. 73 rbl. Buy |
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Tetracycline tab. p / o film. 0.1g No. 20 RUB 76 Buy |
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Tetracycline ointment 3% 15g Synthesis RUB 76 Buy |
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Tetracycline tablets p.o. 100mg 20 pcs. 77 RUB Buy |
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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
