Rankoff
Rankoff: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Rankof
ATX code: N02BE71
Active ingredient: paracetamol (Paracetamol) + caffeine (Coffeinum) + phenylephrine (Phenylephrine) + chlorphenamine (Chlorphenamine)
Manufacturer: NPO FarmVILAR (Russia); Sava Healthcare Ltd. (Sava Healthcare Ltd.) (India)
Description and photo update: 2019-04-12
Prices in pharmacies: from 99 rubles.
Buy
Rankof is a combined drug for eliminating symptoms of ARVI (acute respiratory viral infection), colds or flu, such as pain, high body temperature (fever) and runny nose.
Release form and composition
The drug is available in the form of tablets: pink interspersed with white, dark and light pink, capsule-shaped, biconvex, with beveled edges, with a dividing line on one side (10 pieces in blisters, in a cardboard box 1 blister and instructions for application of Rankoff).
1 tablet contains:
- active ingredients: paracetamol - 500 mg, caffeine - 30 mg, phenylephrine hydrochloride - 10 mg, chlorphenamine maleate - 2 mg;
- auxiliary components: corn starch, sodium carboxymethyl starch (type A), povidone K30, microcrystalline cellulose, magnesium stearate, methyl parahydroxybenzoate, crimson dye (Ponso 4R), talc.
Pharmacological properties
Pharmacodynamics
Rankof is a combined drug for eliminating the symptoms of colds, flu and SARS, which has antipyretic, analgesic, alpha-adrenostimulating, vasoconstrictor and antihistamine effects.
The effect of the drug is due to the properties of its active ingredients:
- paracetamol: is a non-narcotic analgesic. Acting on the centers of pain and thermoregulation, it blocks cyclooxygenase mainly in the central nervous system (CNS), has an analgesic and antipyretic effect;
- caffeine: a psychostimulant, activates the psychomotor centers of the brain, potentiates the effect of an analgesic, helps to eliminate drowsiness and fatigue, and to increase physical and mental performance;
- phenylephrine: an alpha-adrenergic agonist, has a moderate vasoconstrictor effect;
- chlorphenamine: the presence of chlorphenamine maleate in the preparation - a blocker of H 1 -histamine receptors - provides narrowing of the nasal vessels, eliminates swelling and hyperemia of the mucous membrane of the nasal cavity, nasopharynx and paranasal sinuses. Helps to reduce exudative manifestations and suppress the symptoms of allergic rhinitis.
Indications for use
The use of Rankof is indicated in the treatment of colds, influenza, ARVI, allergic and infectious rhinitis in order to relieve febrile syndrome, rhinorrhea and pain.
Contraindications
Absolute:
- increased blood pressure (BP);
- severe atherosclerosis of the coronary arteries;
- pheochromocytoma;
- diabetes;
- period of pregnancy;
- lactation;
- age up to 14 years;
- hypersensitivity to the components of the drug.
Rankof tablets should be taken with caution in patients with hepatic and / or renal failure, glucose-6-phosphate dehydrogenase deficiency, angle-closure glaucoma, congenital hyperbilirubinemia (Gilbert's syndrome, Dubin-Johnson syndrome or Rotor syndrome), prostatic hyperplasia, chronic obstructive diseases bronchitis, pulmonary emphysema), thyrotoxicosis, with concomitant therapy with tricyclic antidepressants, monoamine oxidase (MAO) inhibitors or beta-blockers.
Rankof, instructions for use: method and dosage
The tablets are taken orally.
The recommended dosage of Rankof for children over 14 years old and for adults: 1 pc. every 4-6 hours
The maximum daily dose is 4 pcs.
If after three days of using the drug, relief of symptoms is not observed, then you should consult your doctor.
Side effects
- from the immune system: allergic reactions (itching, skin rash, urticaria, angioedema);
- from the gastrointestinal tract: dry mouth, nausea, vomiting, epigastric pain;
- from the lymphatic system and blood: thrombocytopenia, anemia, agranulocytosis;
- on the part of the organ of vision: increased intraocular pressure, mydriasis, paresis of accommodation;
- from the nervous system: dizziness, increased excitability, sleep disturbance, increased blood pressure;
- others: urinary retention, with prolonged intake of high doses - hepatotoxicity, nephrotoxicity (renal colic, interstitial nephritis, glucosuria, papillary necrosis), methemoglobinemia, hemolytic or aplastic anemia, pancytopenia.
Overdose
Symptoms of an overdose of the drug are due to the presence of paracetamol in its composition (provided that the latter is taken at a dose of more than 10-15 g): pallor of the skin, decreased appetite, nausea, vomiting, toxic hepatitis (including the development of hepatonecrosis), an increase in the activity of hepatic transaminases and prothrombin time.
Treatment: immediate gastric lavage, the appointment of symptomatic therapy. In 8-9 hours after the overdose, the administration of methionine is indicated, and after 12 hours - N-acetylcysteine.
special instructions
During the treatment period, it is recommended to analyze the indicators of peripheral blood and the state of liver function.
You can not combine the reception of Rankof with anxiolytic (tranquilizers) and hypnotics, as well as with drugs that contain the active substances that make up its composition.
The simultaneous use of alcohol or ethanol-containing drugs is contraindicated.
Influence on the ability to drive vehicles and complex mechanisms
During the period of application of Rankof, one should not engage in the performance of potentially hazardous activities that require concentration of attention and a high speed of psychomotor reactions, including driving vehicles and complex mechanisms.
Application during pregnancy and lactation
The use of Rankof is contraindicated during pregnancy and lactation.
Pediatric use
The appointment of Rankof to children under the age of 14 is contraindicated.
With impaired renal function
It is recommended to take Rankof tablets with caution in case of renal failure.
For violations of liver function
Care should be taken when using Rankof to treat patients with hepatic impairment.
Drug interactions
- sedatives, MAO inhibitors, ethanol: enhance their effects;
- ethanol: helps to increase the sedative effect of the drug;
- antidepressants, antiparkinsonian drugs, antipsychotics, phenothiazine derivatives: concomitant therapy with the listed agents increases the risk of dry mouth, urinary retention and constipation;
- glucocorticosteroids: increase the risk of developing glaucoma;
- uricosuric drugs: reduce their effectiveness;
- MAO inhibitors, furazolidone: a combination with these drugs can cause agitation, hyperpyrexia, hypertensive crisis;
- tricyclic antidepressants: the adrenomimetic effect of phenylephrine is enhanced by interaction with tricyclic antidepressants;
- halothane: the appointment of halothane while taking Rankof may cause the development of ventricular arrhythmias;
- guanethidine: the hypotensive effect of guanethidine decreases, the activity of phenylephrine increases.
Analogs
The analogues of Rankoff are AdjiCOLD, Rinza, Rinikold, etc.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C, protected from moisture and light.
Shelf life is 4 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Rankof
Reviews about Rankof are mostly positive. Patients point to the high efficacy and rapid action of the drug when taken in order to eliminate the symptoms of colds, flu and SARS.
Price for Rankof in pharmacies
The price for Rankoff per package can be 85–127 rubles.
Rankoff: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Rankof Steril gel 60 ml 1 pc. RUB 99 Buy |
|
Rankof Rino 0.025% nasal spray 10 ml 1 pc. 106 RUB Buy |
|
Rankof Rino 0.05% nasal spray 10 ml 1 pc. 117 RUB Buy |
|
Rankof tablets 10 pcs. 126 RUB Buy |
|
Rankof Rino 0.025% nasal spray 20 ml 1 pc. 190 RUB Buy |
|
Rankof Rino 0.05% nasal spray 20 ml 1 pc. 199 RUB Buy |
|
Rankof Steril Gel 110 ml 1 pc. 199 RUB Buy |
|
Rankof Embro gel-balm 30 ml 1 pc. 249 r Buy |
|
Rankoff Tim syrup 100 ml 1 pc. RUB 319 Buy |
|
Rankof Timoshka syrup for children 100 ml 1 pc. RUB 319 Buy |
| See all offers from pharmacies |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
