Analgin Avexima
Analgin Avexima: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Analgin Avexima
ATX code: N02BB02
Active ingredient: metamizole sodium (Metamizole sodium)
Manufacturer: JSC "Avexima" (Russia)
Description and photo update: 2019-10-07
Prices in pharmacies: from 7 rubles.
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Analgin Avexima is a drug with analgesic, antipyretic and weak anti-inflammatory effect.
Release form and composition
Dosage form - tablets: white or white with a slightly yellowish tinge, flat-cylindrical shape, with a line and a chamfer (in a cardboard box 1 or 2 blister / non-cell packs of 10 tablets; in a group package - blister / non-cell packs together with an equal number of instructions on the use of Analgin Avexim).
Composition of 1 tablet:
- active substance: metamizole sodium - 500 mg;
- auxiliary components: sugar (sucrose), potato starch, talc, calcium stearate.
Pharmacological properties
Pharmacodynamics
Metamizole sodium - the active component of Analgin Avexim - has an analgesic, antipyretic and weak anti-inflammatory effect.
Being a pyrazolone derivative, the substance non-selectively blocks cyclooxygenase and helps to reduce the formation of prostaglandins from arachidonic acid. It also prevents the conduction of extra- and proprioceptive pain impulses. It has a weakly expressed anti-inflammatory property, which causes a slight effect on water-salt metabolism (water and sodium retention) and the mucous membrane of the gastrointestinal tract.
Metamizole sodium has an antispasmodic effect on the smooth muscles of the biliary and urinary tract.
The time required for the development of the effect of the drug after oral administration is from 20 to 40 minutes.
Pharmacokinetics
Metamizole sodium is absorbed from the gastrointestinal tract quickly and well, which leads to the development of a rapid clinical effect. The maximum plasma concentration is reached 1–1.5 hours after oral administration.
The substance passes into breast milk when used in therapeutic doses.
Metamizole sodium is hydrolyzed in the intestinal walls, with the formation of 4-methyl-amino-antipyrine - an active metabolite, which is further metabolized into 4-formyl-amino-antipyrine and other metabolites. Protein binding of the active metabolite occurs at a level of 50-60%. Excretion of metabolites is carried out by the kidneys. Also metabolites are excreted in breast milk.
Indications for use
- headache of different etiology;
- febrile syndrome associated with infectious and inflammatory diseases;
- weak and moderately severe pain syndrome, including neuralgia, myalgia, arthralgia, trauma, algodismenorrhea, myositis, sciatica, postoperative pain syndrome, biliary, renal and intestinal colic.
Contraindications
Absolute:
- renal and / or hepatic impairment;
- leukopenia;
- oppression of hematopoiesis (neutropenia, agranulocytosis);
- asthma developing while taking acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs;
- hereditary hemolytic anemia, which is associated with a deficiency of glucose-6-phosphate dehydrogenase, as well as other types of anemia;
- pregnancy (especially during the first trimester and in the last six weeks);
- lactation period;
- age up to 8 years;
- individual intolerance to the components of the drug.
Relative (the use of Analgin Avexima tablets should be carried out under medical supervision):
- severe renal and / or liver dysfunction;
- kidney disease (glomerulonephritis, pyelonephritis, including a burdened history);
- bronchial asthma;
- prolonged alcohol abuse;
- predisposition to arterial hypotension.
Analgin Avexima, instructions for use: method and dosage
Analgin Avexim tablets are taken orally, after meals.
Recommended single dose (with a frequency of administration 2-3 times a day):
- adolescents 14-18 years old and adults: 250-500 mg, maximum 1000 mg (3000 mg per day);
- children 8-14 years old: 250-300 mg.
You should not take the drug for more than five days without a doctor's advice.
Side effects
- urinary system: interstitial nephritis, impaired renal function, anuria, oliguria, proteinuria, urine staining red;
- hematopoietic organs: leukopenia, agranulocytosis, thrombocytopenia;
- allergic reactions: urticaria (including development on the conjunctiva and mucous membranes of the nasopharynx), angioedema; rarely - bronchospastic syndrome, Stevens-Johnson and Lyell syndromes, anaphylactic shock;
- others: lowering blood pressure.
Overdose
- main symptoms: vomiting, nausea, tachycardia, tinnitus, shortness of breath, paralysis of the respiratory muscles, gastralgia, hypothermia, oliguria, decreased blood pressure, drowsiness, convulsions, delirium, hemorrhagic syndrome, acute agranulocytosis, impaired consciousness, acute renal and / or hepatic failure;
- therapy: it is shown carrying out gastric lavage, taking saline laxatives, activated carbon. Forced diuresis, hemodialysis are effective, in case of convulsive syndrome, diazepam and fast-acting barbiturates are administered intravenously.
special instructions
If it is necessary to take Analgin Avexim in children under 8 years of age and patients receiving cytostatic drugs, therapy should be carried out only under medical supervision.
The risk of developing allergic reactions against the background of pollinosis and atopic bronchial asthma increases.
Since when using the drug there is a likelihood of agranulocytosis, in case of an unmotivated rise in body temperature, difficulty swallowing, chills, stomatitis, sore throat, and also in the event of proctitis or vaginitis, you should immediately stop taking Analgin Avexim.
In patients who require long-term use of the drug, it is necessary to monitor the picture of peripheral blood.
Until the cause of acute abdominal pain is clarified, it is impossible to take Analgin Avexima in order to relieve pain syndrome.
Application during pregnancy and lactation
Analgin Avexima during pregnancy (especially during the first trimester and in the last six weeks) and lactation is not prescribed.
Pediatric use
Analgin Avexima should not be used in patients under 8 years of age.
With impaired renal function
- renal failure: taking Analgin Avexim is contraindicated;
- severe renal impairment, kidney disease (glomerulonephritis, pyelonephritis, including a burdened history): the drug must be used with caution.
For violations of liver function
hepatic failure: taking Analgin Avexim is contraindicated;
severe liver disorders: the drug must be used with caution.
Drug interactions
- drugs with sedative and anxiolytic effects: the analgesic effect of metamizole sodium is enhanced;
- non-narcotic analgesics, tricyclic antidepressants, allopurinol, contraceptive hormonal drugs: against the background of combined use, increased toxicity is possible;
- chlorpromazine, phenothiazine: combination therapy can lead to severe hyperthermia;
- alcohol: when used simultaneously with metamizole sodium, its effect is enhanced;
- cyclosporine: its concentration in the blood decreases;
- colloidal blood substitutes, radiopaque drugs, penicillin: these drugs should not be used during the period of taking Analgin Avexim;
- barbiturates, phenylbutazone, other inducers of liver microsomal oxidation: reduce the effectiveness of sodium metamizole;
- indomethacin, indirect anticoagulants, oral hypoglycemic drugs, corticosteroids: with simultaneous administration, an increase in their activity is noted (which is associated with displacement from the connection with the protein).
Analogs
Analogs of Analgin Avexim are Analgin bufus, Analgin, Analgin-Rusfar, Analgin solution in ampoules, Baralgin M, Optalgin, Metamizole sodium, etc.
Terms and conditions of storage
Store in a place protected from light and moisture. Keep out of the reach of children.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Analgin Avexima
Reviews about Analgin Avexima are mostly positive. Many patients indicate that these pills are constantly in their medicine cabinet, as they help with any pain. At the same time, it is noted that the action of the drug is similar to other medicines containing metamizole sodium, but due to modern and more practical packaging, it costs a little more.
The price of Analgin Avexima in pharmacies
Approximate price for Analgin Avexima, 500 mg tablets: 10 pcs. in the package - 26 rubles; 20 pcs. in the package - 52 rubles.
Analgin Avexima: prices in online pharmacies
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Drug name Price Pharmacy |
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Analgin Avexima 500 mg tablets 10 pcs. RUB 7 Buy |
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Analgin Avexima 500mg tablets 10 pcs. 34 rbl. Buy |
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Analgin Avexima 500 mg tablets 20 pcs. RUB 47 Buy |
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Analgin Avexima 500mg tablets 20 pcs. RUB 51 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
