Analgin overdose
Analgin is one of the most famous representatives of the group of non-steroidal anti-inflammatory drugs, which has been used in medical practice for many years as an analgesic and antipyretic agent. Many people mistakenly believe that Analgin is completely safe, using it without a doctor's prescription and not observing the dosage too carefully.
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How much is needed for an overdose?
In an adult, symptoms of an overdose with Analgin occur with a single dose of more than 5 g. When ingested 15-20 g of Analgin is fatal.
Sometimes even the therapeutic dose of the drug or its slight excess can cause a clinical picture of an overdose. This can be observed in the following cases:
- the use of Analgin by patients suffering from liver or kidney diseases, which occur with impaired functions of these organs;
- taking Analgin simultaneously with other drugs (Luminal, Anaprilin, Codeine, Ketotifen), which enhance its effect.
The development of chronic overdose leads to the abuse of Analgin by patients suffering from chronic pain syndrome of any etiology.
This drug should not be used in chronic obstructive bronchitis and bronchial asthma, as it promotes bronchospasm and can provoke an attack of suffocation.
Signs of overdose
For an acute overdose of Analgin, a sharp decrease in the content of platelets and leukocytes in the blood is characteristic, which has the following manifestations:
- infectious and inflammatory processes in the oral cavity, organs of the respiratory system and urinary tract, caused by the activation of opportunistic microflora;
- increased blood clotting time, in severe cases - internal and / or external bleeding.
In case of chronic overdose with Analgin, the activity of inflammatory processes increases gradually. One of the first signs is the development of sluggish and resistant to therapy stomatitis, bronchitis, tracheitis, pharyngitis. There are frequent complaints of bouts of shortness of breath, shortness of breath, coughing.
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For chronic intoxication with Analgin, liver and kidney damage is also characteristic. In patients, diuresis decreases, and protein and bacteria are detected in the urine. Liver damage caused by chronic intoxication with Analgin has the following symptoms:
- itchy skin;
- icteric staining of mucous membranes and skin;
- an increase in the concentration of bilirubin in the blood serum.
First aid for overdose with Analgin
In case of an acute overdose, the victim should:
- Immediately flush the stomach: drink a few glasses of water and induce vomiting by pressing on the root of the tongue. It is advisable to repeat this several times to remove as much of the drug as possible.
- Then, to prevent the absorption of Analgin from the intestines into the bloodstream, the patient needs to drink an aqueous suspension of Activated carbon (crush tablets into fine powder at the rate of 1-2 tablets for every 10 kg of the patient's body weight and mix it with ½ glass of water).
- The next stage is the use of a saline laxative, for example, a hypertonic solution of Magnesium sulfate, or the setting of high cleansing enemas.
Chronic overdose does not require first aid measures. If you suspect it, you must immediately stop taking the drug and consult a doctor.
Antidote
There is no specific antidote to Analgin.
When is medical attention needed?
For any type of overdose with Analgin, it is imperative to seek medical help. This should be done even if the symptoms are mild, as the condition can worsen significantly at any time.
In the hospital, forced diuresis is used to accelerate the removal of Analgin from the victim's body. In cases where there are significant violations of the renal excretory function, instead of forced diuresis, extracorporeal hemodialysis is performed.
For the prevention and treatment of infectious and inflammatory complications, the use of broad-spectrum antibacterial drugs is shown.
For relief of convulsive seizures, patients are injected with Seduxen, Thiopental sodium, GHB.
Possible consequences
With a single ingestion of 5–8 g of Analgin, a lethal outcome may occur. It leads to acute renal and / or hepatic failure, severe internal bleeding or infectious complications that do not respond to antibiotic therapy and often occur with atypical symptoms.
The long-term consequences of an overdose of Analgin can be:
- chronic renal or hepatic impairment;
- neurological disorders associated with bleeding in the tissues of the brain;
- development of immunodeficiency.
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Elena Minkina Doctor anesthesiologist-resuscitator About the author
Education: graduated from the Tashkent State Medical Institute, specializing in general medicine in 1991. Repeatedly passed refresher courses.
Work experience: anesthesiologist-resuscitator of the city maternity complex, resuscitator of the hemodialysis department.
The information is generalized and provided for informational purposes only. At the first sign of illness, see your doctor. Self-medication is hazardous to health!
