Acyclovir Belupo - Instructions For Use, Tablets, Cream, Reviews

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Acyclovir Belupo

Acyclovir Belupo: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. Use in the elderly
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Aciclovir Belupo

ATX code: D06BB03; J05AB01

Active ingredient: acyclovir (Aciclovir)

Manufacturer: BELUPO d.d. (BELUPO dd) (Croatia)

Description and photo update: 2020-11-06

Prices in pharmacies: from 46 rubles.

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Acyclovir Belupo is an antiviral drug for systemic and local external use.

Release form and composition

Dosage forms of the drug:

• film-coated tablets: elliptical, with a line on one side, pale pink film shell (7 pcs. in blisters made of polyvinyl chloride / aluminum foil; in a cardboard box 1, 2, 3 or 5 blisters and instructions for use of the drug);
• cream for external use 5%: a homogeneous mass without mechanical impurities, white (2, 5 or 10 g in aluminum tubes; in a cardboard box 1 tube and instructions for use of Acyclovir Belupo).

Composition for 1 film-coated tablet:

• active substance: acyclovir - 400 mg;
• auxiliary components of the tablet core: sodium carboxymethyl starch, povidone, MCC (microcrystalline cellulose), magnesium stearate, colloidal silicon dioxide;
• film casing: Opadry Pink OY-24926 (hypromellose, macrogol, titanium dioxide, dye iron oxide red, dye iron oxide yellow).

Composition for 1 g of cream:

• active substance: acyclovir - 50 mg;
• auxiliary components: propylene glycol, a mixture of macrogol-100 stearate and glyceryl monostearate, cetostearyl alcohol (cetyl alcohol - 60% + stearyl alcohol - 40%), petroleum jelly, mineral oil, hydrochloric acid, sodium lauryl sulfate, water.

Pharmacological properties

Pharmacodynamics

Acyclovir Belupo is an antiviral drug, the active ingredient of which, acyclovir, is a synthetic analogue of an acyclic purine nucleoside and has a high selective activity against herpes viruses. Under the influence of viral thymidine kinase, a series of successive reactions of transformation of acyclovir into mono-, di- and acyclovir triphosphate inside the cells affected by the virus occurs, after which acyclovir triphosphate is incorporated into the polynucleotide chain with viral DNA, blocking its synthesis due to competitive inhibition of viral DNA polymerase.

In vitro Acyclovir Belupo is active against the viruses Herpes simplex (herpes simplex types I and II) and Varicella zoster (human herpesvirus type III). In higher concentrations, the drug is effective against the Epstein-Barr virus (human herpesvirus type IV).

In vivo, Acyclovir Belupo is effective therapeutically and prophylactically, mainly for infections caused by the Herpes simplex virus.

Pharmacokinetics

With oral administration of Acyclovir Belupo, the bioavailability of acyclovir is 15 to 30%. It passes well into all tissues and organs, including the brain and skin. It binds to plasma proteins at a level of 9–33%, regardless of plasma concentration. The concentration in cerebrospinal fluid is ~ 50% of the level determined in plasma.

Acyclovir crosses the placental barrier and accumulates in breast milk. C _max (maximum concentration) after oral administration of 200 mg 5 times / day is 0.7 μg / ml. T _Cmax (time to reach C _max) - from 1.5 to 2 hours.

Metabolism occurs in the liver, resulting in the formation of a pharmacologically inactive metabolite - 9-carboxymethoxymethylguanine.

In adult patients with normal renal function, T _1/2 (half-life) is 2-3 hours. In severe renal failure, T _1/2 increases to 20 hours, with hemodialysis, the indicator is 5.7 hours (the content of the substance in the plasma decreases up to 60% of the initial level). Acyclovir is excreted by the kidneys: unchanged - approximately 84%, in the form of a metabolite - 14%. Its renal clearance is 75–80% of the total plasma clearance. Less than 2% is excreted from the body through the intestines.

With external use of acyclovir: on intact skin - absorption is minimal, in blood and urine is not detected; on the affected skin - moderate absorption.

Indications for use

Acyclovir Belupo tablets:

• therapy of primary and secondary infectious lesions of the skin and mucous membranes (including genital herpes) caused by herpes simplex viruses of types I and II;
• therapy of primary and recurrent infections caused by human herpesvirus type III (chickenpox and shingles);
• complex therapy of patients with severe immunodeficiency [HIV-infected at the stages of early clinical manifestations and a detailed clinical picture of acquired immunodeficiency syndrome (AIDS)] and patients who underwent bone marrow transplantation;
• prevention in patients with normal immune status of exacerbations of recurrent infectious lesions caused by herpes simplex viruses type I and II;
• prevention in patients with immunodeficiency of primary and recurrent infections caused by herpes simplex viruses of types I and II.

Acyclovir Belupo cream is used to treat skin infections caused by herpes simplex virus types I and II (including genital herpes) and human herpesvirus type III (chickenpox and shingles).

Contraindications

Absolute:

• lactation period;
• children under 3 years of age (for tablets);
• established hypersensitivity to valacyclovir, ganciclovir, famciclovir, the active or auxiliary substances of Acyclovir Belupo.

The drug should be used with caution during pregnancy, renal failure, dehydration. Additionally, a relative contraindication for taking pills is neurological disorders, including in the anamnesis.

Acyclovir Belupo, instructions for use: method and dosage

Film-coated tablets

Acyclovir Belupo tablets are intended for oral administration. They should be taken with or immediately after meals and with plenty of water.

Therapy begins as soon as possible after the first symptoms of the disease appear.

The dosage regimen is set by the attending physician individually, taking into account the severity of the disease.

Recommended standard treatment regimens:

• therapy of primary and secondary infectious lesions of the skin and mucous membranes (including genital herpes) caused by herpes simplex viruses of types I and II: adults and children over 3 years old - 200 mg 5 times / day at 4-hour intervals during the day and at 8-hour intervals at night; the duration of the course is 5 days, according to the doctor's prescription for more severe lesions, treatment can be extended;
• therapy of chickenpox caused by human herpesvirus type III (Varicella zoster): adult patients - 800 mg 5 times / day at 4-hour intervals during the day and at 8-hour intervals at night, course duration - 7-10 days; children over 3 years of age - 20 mg / kg of body weight 4 times / day, course duration - 5 days. When treating children weighing more than 40 kg, Acyclovir Belupo is used in a dosage for adults;
• shingles (Herpes zoster) therapy caused by human herpesvirus type III: adult patients - 800 mg 4 times / day at 6-hour intervals, course duration - 5 days;
• complex therapy of patients with severe immunodeficiency [HIV-infected at the stages of early clinical manifestations and a detailed clinical picture of acquired immunodeficiency syndrome (AIDS)] and patients who have undergone bone marrow transplantation: 400 mg 5 times / day;
• prevention of exacerbations of recurrent infectious lesions caused by herpes simplex viruses of types I and II in patients with normal immune status: 200 mg 4 times / day at 6-hour intervals;
• prevention of primary and recurrent infectious lesions caused by herpes simplex viruses types I and II in patients with immunodeficiency: adults and children over 3 years old - 200 mg 4 times / day at 6-hour intervals; depending on the severity of the infection, the maximum dose may be prescribed - up to 400 mg 5 times / day.

Cream for external use 5%

Acyclovir Belupo cream is intended for topical use by applying a thin layer to damaged and adjacent skin areas.

It is recommended to carry out the procedure 5 times a day, observing 4-hour intervals between applications of the drug.

The cream should be applied with a cotton swab or with clean hands to avoid additional contamination of damaged skin areas. Treatment continues until a crust forms on the vesicles or until complete healing.

The duration of the course is at least 5, but not more than 10 days.

Side effects

Acyclovir Belupo is generally well tolerated.

Possible side reactions from systems and organs when taking Acyclovir Belupo inside (tablets):

• digestive tract: in isolated cases - abdominal pain, nausea, vomiting, diarrhea;
• laboratory data: a transient slight increase in the activity of liver enzymes; rarely - a slight increase in the concentration of urea and creatinine levels, leukopenia, hyperbilirubinemia, erythropenia;
• central nervous system: rarely - weakness, headache; in isolated cases, dizziness, tremors, increased fatigue, confusion, hallucinations, drowsiness, paresthesia, agitation;
• immune system: allergic skin reactions (pruritus, urticaria, Lyell's syndrome, erythema multiforme, including Stevens-Johnson syndrome), anaphylactic reactions, peripheral edema;
• others: rarely - fever, myalgia, alopecia, visual impairment, lymphadenopathy.

The use of Acyclovir Belupo cream can contribute to the development of hyperemia, dryness, peeling of the skin, as well as burning and inflammation when it gets on the mucous membranes. In rare cases, allergic dermatitis may appear.

Overdose

When taking acyclovir orally at a dose of 20 g, the development of specific symptoms was not observed. There is a possibility of manifestation of such adverse reactions from the central nervous system, such as tremors, convulsions, lethargy.

In case of intoxication as a result of taking Acyclovir Belupo inside, it is necessary to induce vomiting (preferably within 30 minutes after the drug enters the digestive tract) and take absorbents.

Patients with acute renal failure and anuria may require maintenance of vital functions and hemodialysis.

Cases of overdose of Acyclovir Belupo with external use have not been reported to date.

special instructions

With prolonged or repeated treatment with acyclovir in patients with reduced immunity, viral strains may appear that are resistant to its action.

In order to avoid complications for adults and children over 3 years old, Acyclovir Belupo tablets must be taken strictly as prescribed by a doctor. Patients should be provided with a sufficient volume of fluid into the body, as well as control of renal excretory function by monitoring the level of urea and the concentration of creatinine in the blood plasma.

Since acyclovir does not protect against sexual transmission of herpes, it is important to refrain from sexual intercourse during therapy, even if there are no clinical manifestations of the disease.

In order to achieve the maximum therapeutic effect of Acyclovir Belupo cream, the course should be started as early as possible, with the development of the first symptoms of infection: burning, itching, tingling, feeling of tension and redness.

It is not recommended to apply the cream to the mucous membranes of the mouth and eyes, as this can cause severe local inflammation.

Influence on the ability to drive vehicles and complex mechanisms

There is no data.

Application during pregnancy and lactation

Adequate and well-controlled clinical studies of the safety of acyclovir during pregnancy have not been conducted.

Since acyclovir crosses the placental barrier, prescribing Acyclovir Belupo to pregnant women is possible only if the intended benefit to the woman exceeds the potential risk to the fetus.

During lactation, the drug accumulates in breast milk. If it is necessary to use Acyclovir Belupo during breastfeeding, the issue of transferring the child to artificial feeding should be resolved.

Pediatric use

Acyclovir Belupo tablets are not used to treat children under 3 years of age.

With impaired renal function

The drug is prescribed with caution to patients with impaired renal function, since they may have an increase in T _{1/2 of} acyclovir.

Correction of the dosage regimen for oral administration of Acyclovir Belupo, depending on the CC (creatinine clearance):

• treatment and prevention of infections caused by Herpes simplex (CC <10 ml / min): the dose of acyclovir is reduced to 200 mg 2 times / day at 12-hour intervals;
• treatment of infections caused by Varicella zoster: CC <10 ml / min - the dose is reduced to 800 mg 2 times / day at 12-hour intervals; CC 10-25 ml / min - 800 mg 3 times / day at 8-hour intervals.

Use in the elderly

Since the T _{1/2 of} acyclovir increases in elderly patients, treatment should be carried out with sufficient water load and under the supervision of a specialist.

Drug interactions

• probenecid: promotes an increase in the average T _1/2 and a decrease in acyclovir clearance;
• nephrotoxic drugs: increased risk of impaired renal function;
• immunostimulants: Acyclovir Belupo is able to enhance their effectiveness.

Analogs

Analogs of Acyclovir Belupo are Agerp, Atsik, Acyclovir Avexima, Acyclovir Sandoz, Acyclostad, Vivorax, Virolex, Gervirax, Herperaks, Zovirax, Lipster, etc.

Terms and conditions of storage

Store at temperatures up to 25 ° C. Keep out of the reach of children.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Film-coated tablets are available with a prescription; cream - without a prescription.

Reviews about Acyclovir Belupo

According to reviews, Acyclovir Belupo is a very affordable, inexpensive and effective drug for the treatment of the herpes virus. Patients emphasize that the remedy works especially well under the condition of the simultaneous use of tablets and cream. Herpes in this case goes away much faster. They advise starting treatment at the very first onset of the disease, which will also speed up recovery.

Specialists who use Acyclovir Belupo in clinical practice, in turn, speak well of the drug, noting its low cost and low incidence of unwanted side reactions. It is effective in the treatment of shingles, demonstrates positive dynamics from the first day of administration, reduces the intensity of pain and stops the appearance of new rashes. In addition, it provides good results in the treatment of labial herpes. However, doctors do not recommend using Acyclovir Belupo without a prescription.

The price of Acyclovir Belupo in pharmacies

Estimated price of Acyclovir Belupo:

• film-coated tablets, 400 mg: 35 pcs. in the package - 316-390 rubles; 21 pcs. in the package - 199–237 rubles;
• cream for external use 5%: 5 g in a tube - 48–61 rubles; 10 g in a tube - 60–76 rubles.

Acyclovir Belupo: prices in online pharmacies

Drug name Price Pharmacy

Acyclovir Belupo 5% cream for external use 5 g 1 pc. RUB 46 Buy

Acyclovir Belupo cream 5% 5g RUB 48 Buy

Acyclovir Belupo 5% cream for external use 10 g 1 pc. RUB 60 Buy

Acyclovir Belupo cream 5% 10g RUB 65 Buy

Acyclovir Belupo 400 mg film-coated tablets 21 pcs. 207 r Buy

Acyclovir Belupo 400 mg film-coated tablets 35 pcs. 325 RUB Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!