Antigrippin-ANVI

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Antigrippin-ANVI: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. In case of impaired renal function
12. For violations of liver function
13. Drug interactions
14. Analogs
15. Terms and conditions of storage
16. Terms of dispensing from pharmacies
17. Reviews
18. Price in pharmacies

Latin name: Antigrippin-ANVI

ATX code: R05X

Active ingredient: Acetylsalicylic and ascorbic acid (Acidum acetylsalicylicum & ascorbinicum), Rutosidum (Rutosidum), Metamizol sodium (Metamizolum natrium), Calcium gluconate (Gluconas calcii), Diphenhydramine hydrochloride Hydramine Hydramine (Hydraminehydramine)

Manufacturer: AnviLab (Russia)

Description and photo update: 2018-23-10

Prices in pharmacies: from 117 rubles.

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Antigrippin-ANVI is a combined drug for the symptomatic treatment of colds.

Release form and composition

Capsule set:

capsules A: size No. 0, hard gelatinous, green; content - a mixture of granules and powder (lumps are possible), the color of the mixture is from light yellow to yellow with a greenish tint;
capsules B: size No. 0, hard gelatinous, white; content - a mixture of granules and powder (lumps may be present), the color of the mixture is white or white with a yellowish tinge.

Packing: 10 capsules A in a blister, 10 capsules B in a blister, 2 blisters (one A and B each) in a cardboard box.

Composition of capsule A:

active substances: ascorbic acid - 300 mg, acetylsalicylic acid - 250 mg, rutoside trihydrate - 20 mg (in terms of rutoside);
auxiliary components: potato starch, calcium stearate;
capsule shell: gelatin, titanium dioxide (E 171), diamond black dye (E 151), azorubin dye (E 122), quinoline yellow dye (E 104), diamond blue dye (E 133) or patented blue dye (E 131) …

Composition of capsule B:

active substances: metamizole sodium monohydrate - 250 mg, calcium gluconate monohydrate - 100 mg, diphenhydramine hydrochloride - 20 mg;
auxiliary components: potato starch, calcium stearate;
capsule shell: gelatin, titanium dioxide (E 171).

Pharmacological properties

Antigrippin-ANVI has an anti-cold, antipyretic, analgesic, anti-inflammatory, antihistamine and angioprotective effect.

Pharmacodynamics

The effect of the drug is due to the properties of its constituent components:

ascorbic acid helps to increase the body's resistance, plays an important role in tissue regeneration, blood clotting, regulation of carbohydrate metabolism and redox processes;
acetylsalicylic acid (ASA) inhibits platelet aggregation, has anti-inflammatory, analgesic and antipyretic effects;
rutoside (rutin) - an angioprotector that reduces capillary permeability, inflammation and swelling; inhibits the aggregation of erythrocytes and increases the degree of their deformation;
metamizole sodium (analgin) has antipyretic and analgesic effects; inhibits the synthesis of prostaglandins, due to which it also has a weak anti-inflammatory property;
calcium gluconate reduces vascular permeability, has an antiallergic effect, participates in the regulation of calcium and phosphorus metabolism;
diphenhydramine (diphenhydramine) has a decongestant, antiallergic and local anesthetic effect (reduces vascular permeability, eliminates sore throat, hyperemia and swelling of the nasal mucosa, as well as allergic reactions from the upper respiratory tract).

Indications for use

Antigrippin-ANVI is used for the symptomatic treatment of colds, acute respiratory viral infections and influenza in adults and adolescents from 15 years old.

Contraindications

diseases accompanied by bronchospasm;
aspirin and bronchial asthma;
increased tendency to bleeding;
gastrointestinal bleeding;
erosive and ulcerative lesions of the gastrointestinal tract (GIT) in the acute phase;
oppression of hematopoiesis (leukopenia, agranulocytosis, neutropenia);
hemorrhagic diathesis (von Willebrand disease, thrombocytopenia, hemophilia, hypoprothrombinemia, telangiectasia, thrombocytopenic purpura);
deficiency of glucose-6-phosphate dehydrogenase;
hereditary hemolytic anemia associated with a deficiency of glucose-6-phosphate dehydrogenase;
calcium nephrolithiasis, hypercalciuria;
hypercalcemia;
vitamin K deficiency;
sarcoidosis;
severe liver or kidney dysfunction;
portal hypertension;
dissecting aortic aneurysm;
intoxication with cardiac glycosides;
age up to 15 years;
pregnancy;
lactation;
hypersensitivity to drug components.

Antigrippin-ANVI should be used with caution in case of decompensated heart failure, gout, hyperuricemia, urate nephrolithiasis, gastric ulcer and / or duodenal ulcer in history.

Instructions for use Antigrippin-ANVI: method and dosage

Antigrippin-ANVI is taken orally: the capsules are swallowed whole with water after meals.

Adults and adolescents from 15 years old are prescribed 2 capsules at one time - 1 green (from blister A) and 1 white (from blister B).

The frequency of admission is 2-3 times a day.

Duration of treatment - until the symptoms of the disease disappear, but not more than 5 days. If you do not feel better, a doctor's consultation is required.

Side effects

allergic reactions: skin rashes, Quincke's edema, bronchospasm;
on the part of the cardiovascular system: increased blood pressure, tachycardia;
from the digestive system: gastrointestinal bleeding, erosive and ulcerative lesions of the gastrointestinal tract, nausea, gastralgia, anorexia, diarrhea, vomiting, liver failure;
others: renal failure.

With prolonged use of the drug (longer than 7 days), the following side effects may occur:

allergic reactions: toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, anaphylactic shock;
from the central nervous system: dizziness, headache;
on the part of the blood coagulation system: hypocoagulation, decreased platelet aggregation, hemorrhagic syndrome (including purpura, bleeding gums, nosebleeds);
from the hematopoietic system: agranulocytosis, thrombocytopenia, leukopenia;
from the urinary system: urine staining red, anuria, oliguria, interstitial nephritis, proteinuria, renal dysfunction, kidney damage with papillary necrosis;
from the senses: tinnitus, deafness, visual impairment;
others: in children - Reye's syndrome (liver dysfunction, vomiting, metabolic acidosis, hyperpyrexia, mental and nervous system disorders).

Overdose

The following symptoms may indicate an overdose of Antigrippin-ANVI: ringing in the ears, pallor of the skin, sweating, nausea, stomach pain, vomiting, tachycardia. In case of a significant overdose, the following are possible: anuria, drowsiness, shortness of breath, bronchospasm, collapse, bleeding, convulsions, respiratory acidosis, progressive respiratory paralysis.

When taking an overdose of the drug, it is necessary to artificially induce vomiting and rinse the stomach, take activated charcoal and saline laxative. In case of convulsive syndrome, intravenous administration of barbiturates and diazepam is indicated. If necessary, perform hemodialysis, forced diuresis.

special instructions

In low doses, ASA reduces the excretion of uric acid from the body, which is why there is a risk of a gout attack.

ASA has antiplatelet properties, therefore, with the upcoming surgical intervention, it is necessary to warn the attending physician about taking the drug.

With pollinosis and bronchial asthma, the likelihood of developing hypersensitivity reactions is increased.

Ascorbic acid can aggravate the course of rapidly proliferating and intensely metastatic tumors.

Antigrippin-ANVI contains sodium metamizole, therefore its simultaneous use with penicillin, colloidal blood substitutes and X-ray contrast agents is contraindicated.

The ascorbic acid contained in the preparation can distort the results of some laboratory tests, for example, to determine the activity of hepatic transaminases, the content of bilirubin, glucose and lactate dehydrogenase in the blood plasma.

Antigrippin-ANVI is not recommended to be taken during therapy with ticlopidine, anticoagulants, glucocorticosteroids, antihypertensive and uricosuric drugs.

During treatment, it is worth refraining from drinking alcoholic beverages, since ethanol increases the risk of gastrointestinal bleeding.

Ascorbic acid stimulates the synthesis of corticosteroid hormones, therefore, kidney function and blood pressure control is required.

With prolonged treatment, it is necessary to monitor laboratory parameters of the functional state of the liver and the picture of peripheral blood.

Influence on the ability to drive vehicles and complex mechanisms

Patients taking Antigrippin-ANVI should refrain from potentially dangerous activities that require speed of reactions and increased attention.

Application during pregnancy and lactation

Antigrippin-ANVI is not prescribed during pregnancy, since ASA has a teratogenic effect: when used in the first trimester, it can cause splitting of the upper palate, in the third trimester - premature closure of the ductus arteriosus in the fetus, as a result of which hyperplasia of the pulmonary vessels and hypertension in the vessels of the small the circle of blood circulation, as well as inhibition of labor. In the second trimester, the drug can only be used as directed by a doctor if the expected benefit outweighs the potential risks.

ASA penetrates into breast milk, which may lead to dysfunction of platelets and, as a result, bleeding in the child. For this reason, if it is necessary to carry out therapy during lactation, breastfeeding should be temporarily stopped.

Pediatric use

According to the instructions, Antigrippin-ANVI is contraindicated in patients under the age of 15 years. In the case of using ASA as an antipyretic agent in acute respiratory viral diseases in children under 15 years of age, there is a high risk of developing Reye's syndrome, manifested by encephalopathy and acute fatty liver disease with acute development of liver failure.

With impaired renal function

The use of the drug is contraindicated in patients with severe renal impairment.

For violations of liver function

The use of the drug is contraindicated in patients with severe liver dysfunction and portal hypertension.

Drug interactions

In case of simultaneous use of Antigrippin-ANVI:

enhances the action of steroid hormones, indirect anticoagulants, hypoglycemic agents, reserpine, heparin;
reduces the effect of uricosuric drugs, antihypertensive drugs, furosemide, spironolactone;
enhances the side effects of non-steroidal anti-inflammatory drugs, non-narcotic analgesics, sulfonylurea derivatives, glucocorticosteroids, methotrexate.

With the combined use of ethanol or ethanol-containing drugs, antiepileptic drugs, barbiturates, rifampicin, zidovudine, the risk of developing hepatotoxic effects increases, and therefore these combinations should be avoided.

Metamizole sodium enhances the effects of ethanol, reduces the level of cyclosporine in the blood. Its analgesic effect is increased by tranquilizers and sedatives. Allopurinol, oral contraceptives and tricyclic antidepressants disrupt its metabolism and increase the toxicity.

Melphalan and thiamazole in combination with metamizole sodium increase the risk of developing leukopenia.

Ascorbic acid improves the absorption of iron in the intestine.

Analogs

Antigrippin-ANVI analogs are Antigrippin, Antigrippin Apothecary, Antigrippin-Maximum, FluZiOZ-F.

Terms and conditions of storage

Store no more than 2 years out of the reach of children, in a dry, dark place at temperatures up to 25 ° C.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Antigrippin-ANVI

According to reviews, Antigrippin-ANVI is a popular drug. However, the opinions of users regarding the drug are rather contradictory. Some patients confirm the effectiveness of the drug, while others note the development of side effects and the short duration of the therapeutic effect or its complete absence.

Price for Antigrippin-ANVI in pharmacies

The price for Antigrippin-ANVI is 125-165 rubles per pack of 20 capsules.