Tizin Alerji - Instructions For Use, Price, Reviews, Spray Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Tizine Alerji

Tizin Alerji: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. Use in the elderly
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Tyzine Allergy

ATX code: R01AC02

Active ingredient: levocabastine (levocabastine)

Producer: Janssen Pharmaceutica (Belgium)

Description and photo update: 22.11.2018

Prices in pharmacies: from 240 rubles.

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Tizine Alerji is a local antiallergic drug used in ENT practice.

Release form and composition

Dosage form - dosed nasal spray: white homogeneous suspension (in a cardboard box 1 bottle 10 ml with a protective cap and a spray).

Composition of 1 ml spray:

• active substance: levocabastine - 0.5 mg (levocabastine hydrochloride - 0.54 mg);
• auxiliary components: benzalkonium chloride - 0.15 mg (in the form of a 50% solution - 0.03 ml); sodium hydrogen phosphate - 8.66 mg; propylene glycol - 0.048 26 ml; edetate disodium - 0.15 mg; sodium hydrogen phosphate monohydrate - 5.38 mg; polysorbate 80 - 1 mg; hypromellose - 2.5 mg; water for injection - up to 1 ml.

Pharmacological properties

Pharmacodynamics

Tizin Allergy is one of the anti-allergic drugs, long-acting selective histamine H ₁ receptor blockers. Helps to eliminate the symptoms of allergic rhinitis - nasal discharge, sneezing, itching in the nasal cavity.

The local effect develops within 5 minutes after the administration of the drug, its duration is 12 hours.

Pharmacokinetics

After each intranasal administration of one dose (0.05 mg), from 0.03 to 0.04 mg of levocabastine is absorbed. The time to reach C _max (maximum concentration of the substance) in blood plasma is approximately 3 hours.

The binding of levocabastine to blood plasma proteins is about 55%.

The main metabolite of levocabastine is acylglucuronide. It is formed in the liver by glucuronidation (the main pathway for the formation of metabolites).

T _1/2 (half-life) of levocabastine is from 35 to 40 hours. It is excreted mainly unchanged by the kidneys.

Indications for use

According to the instructions, Tizin Alerji is prescribed for the symptomatic treatment of seasonal and year-round allergic rhinitis.

Contraindications

Absolute:

• age up to 6 years;
• lactation period;
• individual intolerance to the components of the drug.

Relative (Tizin Alerji is prescribed under medical supervision):

• impaired renal function;
• elderly age;
• pregnancy.

Instructions for the use of Tizin Alerji: method and dosage

Spray Tizin Allergy is intended for intranasal injection.

Shake the bottle before each use.

The recommended regimen of the drug (regardless of age): 2 times a day, 0.1 mg (2 doses) in each nasal passage. If necessary, the frequency of application can be increased up to 3-4 times a day.

Therapy should be carried out until symptoms are eliminated.

The nasal cavity must be cleaned before using the spray. During the administration of the drug, you need to take an intense breath through the nose.

Before the first use, remove the protective cap and press the spray nozzle several times (until a cloud of fog appears).

Side effects

Possible adverse reactions (> 10% - very common;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rare):

• heart: infrequently - palpitations; rarely - tachycardia;
• nervous system: very often - headache; often - dizziness, drowsiness;
• digestive system: often - nausea;
• immune system: infrequently - hypersensitivity; with an indefinite frequency - anaphylactic reactions;
• respiratory system: often - nosebleeds, pain in the pharynx and larynx; infrequently - nasal congestion, shortness of breath; rarely - swelling of the nasal mucosa; with an indefinite frequency - cough, bronchospasm;
• parasitic / infectious diseases: often - sinusitis;
• organ of vision: with uncertain frequency - eyelid edema;
• general reactions: often - pain at the injection site, fatigue; infrequently - pain, irritation and dryness at the injection site, anxiety; rarely - discomfort and burning at the injection site.

Violations, the development of which was noted during post-registration observations:

• respiratory system: very rarely - shortness of breath, bronchospasm, swelling of the nasal mucosa;
• immune system: very rarely - hypersensitivity, anaphylactic reactions;
• organ of vision: very rarely - edema of the eyelids;
• heart: very rarely - tachycardia, palpitations;
• general reactions: infrequently - malaise.

Overdose

Overdose has not been reported.

If the drug is taken orally, the following symptoms may develop: lowering blood pressure, slight sedation, tachycardia.

In case of an overdose, you need to drink large amounts of liquid, which will accelerate the elimination of levocabastine from the body.

special instructions

If Tizine Alerji has become unusable or has expired, the drug should not be thrown out into the street or into wastewater. For proper disposal, the bottle must be put in a bag and thrown into the trash can.

Influence on the ability to drive vehicles and complex mechanisms

During therapy with Tizin Allergy, in cases of drowsiness, it is recommended to refrain from driving.

Application during pregnancy and lactation

• lactation period: therapy is contraindicated;
• pregnancy: Tizine Allergy can be used after evaluating the ratio of the expected benefit to the possible risk.

Childhood use

Therapy with Tizin Allergi is contraindicated in patients under 6 years of age.

With impaired renal function

Patients with impaired renal function should use Tizin Allergy under medical supervision.

Use in the elderly

Tizin Allergy for elderly patients is prescribed under medical supervision.

Drug interactions

With the combined use of Tizin Allergy with oxymetazoline, a transient decrease in the absorption of levocabastine may be observed.

Analogs

Analogs of Tizin Alerji are Reactin, Vizin Alerji, Allergodil, etc.

Terms and conditions of storage

Store at temperatures up to 25 ° C. Keep out of the reach of children.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Tizine Alerji

According to reviews, Tizin Alerji quickly relieves the symptoms of an allergic rhinitis, its availability in pharmacies, a convenient dosage form and packaging are also noted.

However, some patients find the spray insufficiently effective and unreasonably expensive. In addition, they indicate the development of adverse reactions in the form of skin reactions and headache.

The price of Tizin Alerji in pharmacies

The approximate price of Tizin Alerji nasal spray for 1 bottle of 10 ml is 301–367 rubles.

Tizin Allergy: prices in online pharmacies

Drug name Price Pharmacy

Tizin Alerji 50 mcg / dose nasal spray dosed 10 ml 1 pc. 240 RUB Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes and does not replace the official instructions. Self-medication is hazardous to health!