Neobutin - Instructions For The Use Of Tablets, Price, Reviews, Analogues

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Neobutin - Instructions For The Use Of Tablets, Price, Reviews, Analogues
Neobutin - Instructions For The Use Of Tablets, Price, Reviews, Analogues

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Neobutin: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  1. 9. Application during pregnancy and lactation
  2. 10. Use in childhood
  3. 11. Drug interactions
  4. 12. Analogs
  5. 13. Terms and conditions of storage
  6. 14. Terms of dispensing from pharmacies
  7. 15. Reviews
  8. 16. Price in pharmacies

Latin name: Neobutine

ATX code: A03AA05

Active ingredient: trimebutine (trimebutine)

Manufacturer: Samil Pharm. Co., Ltd. (Republic of Korea), "Pharmaceutical enterprise" Obolenskoe ", CJSC (Russia)," Evofarm ", LLC (Russia)

Description and photo update: 2018-23-10

Prices in pharmacies: from 111 rubles.


Neobutin tablets
Neobutin tablets

Neobutin is a drug that regulates the motility and tone of the gastrointestinal tract.

Release form and composition

Dosage form Neobutin - tablets: round, almost white or white; 100 mg each - flat-cylindrical, with a cross-shaped line and a chamfer; 200 mg - biconvex, with a risk (10, 15, 20 or 30 pcs. in blisters, in a cardboard box 1-3 packs).

Composition of 1 tablet:

  • active ingredient: trimebutin maleate - 100 or 200 mg;
  • additional components (100/200 mg): magnesium stearate - 2 / 3.2 mg; lactose monohydrate - 76 / 81.6 mg; corn starch - 20/32 mg; aerosil - 2 / 3.2 mg.

Pharmacological properties


The active substance of Neobutin - trimebutin - is a regulator of intestinal motility and affects its enkephalinergic system.

By exerting an effect on peripheral δ-, μ- and κ-receptors, including those located directly in smooth muscles along the entire length of the gastrointestinal tract (gastrointestinal tract), trimebutin regulates motility without affecting the central nervous system. This helps to restore the normal physiological activity of the intestinal musculature in various diseases of the gastrointestinal tract, which occur with impaired motility.

Due to the normalization of visceral sensitivity, trimebutin has an analgesic effect for abdominal pain.


After oral administration, trimebutin is rapidly absorbed from the gastrointestinal tract, C max (maximum concentration of the substance) in the blood plasma is observed after 1–2 hours. Bioavailability - 4 to 6%. V d (volume of distribution) is 88 liters.

The substance has a low degree of binding to plasma proteins - about 5%. It penetrates the placental barrier to an insignificant extent.

Metabolism of trimebutin occurs in the liver, excretion is provided by the kidneys, mainly in the form of metabolites (during the first 24 hours - about 70%). T 1/2 (half-life) - approximately 12 hours.

Indications for use

  • irritable bowel syndrome;
  • paralytic intestinal obstruction in the postoperative period.


  • lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
  • age up to 3 years;
  • pregnancy and lactation;
  • the presence of individual intolerance to the components of the drug.

Instructions for the use of Neobutin: method and dosage

Neobutin is taken orally, preferably before meals.

The recommended single dose (with a frequency of administration 3 times a day):

  • adults and children over 12 years old: 100-200 mg; after the course of treatment during the period of remission, in order to prevent relapse, it is recommended to continue therapy at 300 mg per day for a course of 12 weeks;
  • children 5–12 years old: 50 mg;
  • children 3-5 years: 25 mg.

Side effects

  • allergic reactions: skin rash;
  • nervous system: fatigue, drowsiness, dizziness, anxiety, headache, feeling cold / hot;
  • digestive system: nausea, unpleasant taste sensations, xerostomia, diarrhea, dyspeptic disorders, constipation;
  • others: urinary retention, painful enlargement of the mammary glands, menstrual irregularities.


Cases of trimebutine overdose have not been reported to date.

special instructions

The use of Neobutin for 4 weeks at 600 mg per day, and then for 12 weeks at 300 mg per day, avoids recurrence of irritable bowel syndrome.

Influence on the ability to drive vehicles and complex mechanisms

During the period of therapy, it is necessary to take into account the possible development of adverse reactions (dizziness and others), which may affect the ability to drive vehicles.

Application during pregnancy and lactation

According to the instructions, Neobutin should not be used during pregnancy and lactation, since the necessary data confirming its safety and effectiveness are not available.

Pediatric use

For patients under 3 years of age, the drug is not prescribed.

Drug interactions

There are no data on the interaction of Neobutin with other drugs.


Neobutin's analogues are: Neobutin Retard, Trimedat, Trimedat Valenta.

Terms and conditions of storage

Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.

Shelf life: 100 mg tablets - 2 years, 200 mg tablets - 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Neobutin

According to reviews, Neobutin is an effective drug. Quickly relieves abdominal cramps and pain, as well as flatulence. Of the shortcomings, they indicate the cost of the drug and the need for a long course.

Price for Neobutin in pharmacies

The approximate price for Neobutin 100 mg (10 pcs. In a package) is 150 rubles, 200 mg (30 pcs. In a package) - 333–356 rubles.

Neobutin: prices in online pharmacies

Drug name



Neobutin 100 mg tablets 10 pcs.

RUB 111


Neobutin tablets 100mg 10 pcs.

195 RUB


Neobutin Retard 300 mg film-coated tablets of prolonged action 20 pcs.

316 RUB


Reviews Neobutin Retard

316 RUB


Neobutin 200 mg tablets 30 pcs.

356 r


Neobutin tablets 200mg 30 pcs.

374 r


Neobutin retard tablets p.p. prolonged action 300mg 20 pcs.

410 RUB


Anna Kozlova
Anna Kozlova

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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