Nalorius - Instructions For Use, Reviews, Price, Analogs Of Tablets

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Nalorius - Instructions For Use, Reviews, Price, Analogs Of Tablets
Nalorius - Instructions For Use, Reviews, Price, Analogs Of Tablets

Video: Nalorius - Instructions For Use, Reviews, Price, Analogs Of Tablets

Video: Nalorius - Instructions For Use, Reviews, Price, Analogs Of Tablets
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Nalorius: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  1. 10. Use in childhood
  2. 11. In case of impaired renal function
  3. 12. Drug interactions
  4. 13. Analogs
  5. 14. Terms and conditions of storage
  6. 15. Terms of dispensing from pharmacies
  7. 16. Reviews
  8. 17. Prices in pharmacies

Latin name: Nalorius

ATX code: R06AX27

Active ingredient: desloratadine (desloratadine)

Producer: Biocom, CJSC (Russia)

Description and photo updated: 22.11.2018

Prices in pharmacies: from 319 rubles.


Film-coated tablets, Nalorius
Film-coated tablets, Nalorius

Nalorius is an anti-allergic drug.

Release form and composition

Dosage form of Nalorius - film-coated tablets: round, biconvex, slight surface roughness is allowed; the color of the shell of the tablets is blue, the cores are white with a yellowish tinge or white (in a cardboard box 1–3 or 5 blisters of 7 or 10 tablets).

Composition of 1 tablet:

  • active substance: desloratadine - 5 mg;
  • auxiliary components: croscarmellose sodium - 1.85 mg; microcrystalline cellulose - 14.8 mg; hypromellose - 3.7 mg; calcium hydrogen phosphate dihydrate - 145.4 mg; pregelatinized starch - 5.55 mg; colloidal silicon dioxide (aerosil) - 1.85 mg; magnesium stearate - 1.85 mg;
  • shell: simethicone emulsion - 0.033 mg; blue Opadry II (including brilliant blue - 0.38%; titanium dioxide - 23%; indigo carmine - 2.5%; lactose monohydrate - 36%; hypromellose - 28%; polyethylene glycol - 10%; yellow iron oxide - 0.12%) - 4.967 mg.

Pharmacological properties


Nalorius is a long-acting antihistamine with antipruritic and antiexudative efficacy.

Desloratadine is the primary active metabolite of loratadine. The substance inhibits the cascade of reactions of allergic inflammation. Thanks to its use, the following reactions are observed:

  • release of pro-inflammatory cytokines, including interleukin-4, -6, -8, -13, as well as pro-inflammatory chemokines;
  • production of superoxide anions by activated polymorphonuclear neutrophils;
  • adhesion and chemotaxis of eosinophils;
  • isolation of adhesion molecules, in particular P-selectin;
  • IgE-mediated release of histamine, leukotriene C4 and prostaglandin D2.

Thus, desloratadine prevents the occurrence of allergic reactions and facilitates their course, reduces capillary permeability, and prevents the occurrence of smooth muscle spasms and tissue edema.

Nalorius on the electrocardiogram does not cause prolongation of the QT interval, does not affect the central nervous system, practically does not lead to drowsiness (does not have a sedative effect) and does not affect the speed of psychomotor reactions.

The effect of the drug after taking a single dose develops within 30 minutes, its duration is 24 hours.


Being well absorbed in the gastrointestinal tract, desloratadine is determined in blood plasma after 30 minutes. The maximum concentration reaches an average of 3 hours.

Penetrates through the placental barrier and into breast milk; does not penetrate the blood-brain barrier.

The connection of desloratadine with plasma proteins is from 83 to 87%. When used in therapeutic doses for a course of 14 days, clinically significant cumulation of the drug does not occur.

Desloratadine is not an inhibitor of CYP3A4 and CYP2D6 isoenzymes and an inhibitor / substrate of P-glycoprotein. The simultaneous intake of Nalorius in a daily dose of 7.5 mg with food / grapefruit juice has no effect on the distribution of the substance.

Intensive metabolism occurs in the liver, by hydroxylation, followed by the formation of 3-OH-desloratadine combined with glucuronide.

Less than 2% of desloratadine taken is excreted by the kidneys, up to 7% (in the form of an unchanged substance) through the intestines. The average elimination half-life is 27 hours.

Indications for use

  • allergic rhinitis: Nalorius is prescribed to eliminate / relieve the main symptoms, including itchy palate, watery eyes, sneezing, nasal mucus, nasal congestion, itchy nose, redness / itching of the eyes;
  • urticaria: to reduce / eliminate the main symptoms, including skin itching, rash.


  • lactose intolerance, glucose-galactose malabsorption syndrome and lactase deficiency;
  • pregnancy and lactation;
  • age up to 12 years;
  • individual intolerance to the components of the drug, as well as loratadine.

According to the instructions, Nalorius in patients with severe renal insufficiency should be prescribed under medical supervision (a relative contraindication).

Instructions for use of Nalorius: method and dosage

Nalorius is taken orally with water, preferably regularly at the same time of the day, regardless of the meal time. Do not split / chew the tablet.

Scheme of taking Nalorius: 1 tablet once a day.

Patients with seasonal allergic rhinitis (with symptoms lasting up to 4 days a week or less than 4 weeks a year) should be evaluated for their disease. Reception of Nalorius after the disappearance of symptoms should be discontinued, resumption of therapy is possible when symptoms reappear.

With perennial allergic rhinitis (symptoms occur 4 days a week or longer than 4 weeks a year) Nalorius must be taken throughout the entire exposure period.

Side effects

Possible adverse reactions (> 10% - very common;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rare):

  • digestive system: infrequently - xerostomia; very rarely - diarrhea, vomiting, abdominal pain, dyspepsia, nausea, increased activity of hepatic transaminases, hepatitis, increased concentration of bilirubin;
  • cardiovascular system: very rarely - palpitations, tachycardia;
  • nervous system: infrequently - headache; very rarely - drowsiness, dizziness, psychomotor hyperactivity, insomnia, hallucinations, convulsions;
  • musculoskeletal system: very rarely - myalgia;
  • immune system: very rarely - rash, including urticaria, pruritus, shortness of breath, anaphylactic shock, angioedema;
  • other reactions: often - increased fatigue.


In clinical and pharmacological studies, when taking doses significantly higher than recommended, the development of serious adverse reactions was not observed.

Desloratadine is not excreted during hemodialysis, the effectiveness of peritoneal dialysis has not been established.

In cases of taking a large amount of Nalorius, you should immediately consult a doctor. Recommended measures: gastric lavage, intake of activated charcoal, symptomatic treatment.

special instructions

Influence on the ability to drive vehicles and complex mechanisms

The ability to drive vehicles during the period of Nalorius therapy is determined individually, based on the reaction to taking the drug, since it is possible to develop such disorders as dizziness, drowsiness, hallucinations.

Application during pregnancy and lactation

Nalorius is not prescribed during pregnancy / lactation.

Pediatric use

Nalorius therapy is contraindicated in patients under 12 years of age.

With impaired renal function

Nalorius therapy for severe renal failure should be performed under medical supervision.

Drug interactions

There were no changes in the concentration of desloratadine, which are of clinical importance, when used together with cimetidine, erythromycin, ketoconazole, fluoxetine and azithromycin.


Nalorius's analogs are Ezlor, Elisey, Lordestin, Blogir-3, Erius, Desloratadin, Alestamine, Desal, etc.

Terms and conditions of storage

Store in a place protected from light at temperatures up to 25 ° C. Keep out of the reach of children.

Shelf life is 4 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Nalorius

According to reviews, Nalorius effectively stops allergic reactions. The tablets are small, tasteless and odorless. Of the advantages, a convenient dosing regimen and a long shelf life of the drug are noted. In some cases, they indicate an insufficiently long therapeutic effect - 10-12 hours.

Price for Nalorius in pharmacies

The approximate price for Nalorius (10 tablets) is 238-499 rubles.

Nalorius: prices in online pharmacies

Drug name



Nalorius 5 mg film-coated tablets 10 pcs.

RUB 319


Anna Kozlova
Anna Kozlova

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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