Locoid - Instructions For Use, Ointment, Cream, Reviews, Analogues, Price

Table of contents:

Locoid - Instructions For Use, Ointment, Cream, Reviews, Analogues, Price
Locoid - Instructions For Use, Ointment, Cream, Reviews, Analogues, Price


Locoid: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  1. 9. Application during pregnancy and lactation
  2. 10. Use in childhood
  3. 11. Drug interactions
  4. 12. Analogs
  5. 13. Terms and conditions of storage
  6. 14. Terms of dispensing from pharmacies
  7. 15. Reviews
  8. 16. Price in pharmacies

Latin name: Locoid

ATX code: H02AB09

Active ingredient: hydrocortisone (hydrocortisone)

Manufacturer: Temmler Italia S.r. L. (Temmler Italia, SrL) (Italy), Astellas Pharma Europe B. V. (Astellas Pharma Europe, BV) (Netherlands)

Description and photo updated: 2018-23-11

Prices in pharmacies: from 153 rubles.


Ointment for external use 0.1% Locoid
Ointment for external use 0.1% Locoid

Locoid is a topical glucocorticosteroid.

Release form and composition

  • ointment for external use 0.1%: homogeneous, oily, soft, translucent, from light gray to almost white color (30 g of ointment in aluminum tubes, 1 tube in a cardboard box);
  • cream for external use 0.1%: homogeneous, white (30 g each in aluminum tubes, 1 tube in a cardboard box).

The active substance in the composition of 1 g of ointment and 1 g of cream: hydrocortisone 17-butyrate - 1 mg.

Auxiliary components:

  • ointment: polyethylene ointment base (95% - vaseline oil, 5% - polyethylene);
  • cream: white soft paraffin - 150 mg; cetostearyl alcohol - 72 mg; liquid paraffin - 60 mg; macrogol 25 cetostearyl ether - 18 mg; anhydrous citric acid - 4.2 mg; sodium citrate anhydrous - 2.8 mg; propyl parahydroxybenzoate - 1 mg; butyl parahydroxybenzoate - 0.5 mg; purified water - up to 1000 mg.

Pharmacological properties


Locoid is a synthetic non-halogenated glucocorticosteroid for external use. A feature of this drug is its production technology, which uses butyrate (butyric acid). Esterification of the hydrocortisone molecule with the remainder of this substance radically increased the activity of the drug in comparison with native hydrocortisone. Thus, Lokoid has a rapidly advancing anti-inflammatory, antipruritic and anti-edema effect.

Due to the use of the drug in therapeutic doses, there is no suppression of the hypothalamic-pituitary-adrenal system. However, when using large doses of Lokoid for a long time, especially under occlusive dressings, an increase in the content of cortisol in blood plasma is possible. This phenomenon usually does not lead to a decrease in the reactivity of the pituitary-adrenal system, and after withdrawal, the production of cortisol quickly normalizes.


When applied externally, Lokoid, the active substance accumulates in the epidermis, mainly in the granular layer. Systemic absorption of the drug is negligible, a small amount of unchanged hydrocortisone 17-butyrate is absorbed into the systemic circulation.

Most of the active substance of the drug is metabolized to hydrocortisone and other metabolites, first in the epidermis, then in the liver.

The drug and its metabolites are excreted by the kidneys and through the intestines.

Indications for use

According to the instructions, Lokoid is used to treat uninfected superficial skin diseases sensitive to local glucocorticosteroids, such as:

  • eczema;
  • dermatitis, including contact, atopic and seborrheic;
  • psoriasis.


  • violation of the integrity of the skin at the site of the intended application of the drug (wounds, ulcers);
  • perioral dermatitis, acne, rosacea;
  • neoplastic skin changes (benign and malignant tumors);
  • viral skin infections (eg, shingles, chickenpox, herpes simplex);
  • parasitic skin infections;
  • fungal infections of the skin;
  • bacterial skin infections (eg, gram-negative folliculitis, strepto- and staphyloderma);
  • tuberculous and syphilitic skin lesions;
  • post-vaccination period;
  • hypersensitivity to any component of Locoid ointment or cream.

The drug should be used with caution during pregnancy and lactation.

Instructions for use of Locoid: method and dosage

In the form of an ointment, Locoid is used for subacute and chronic processes, especially those accompanied by dryness, infiltration and lichenification. In the form of a cream, the drug is prescribed for subacute and acute skin processes that are not accompanied by oozing.

Cream or ointment should be applied in a thin layer to the affected areas with massaging movements (to improve drug penetration). Frequency rate of applications - 1-3 times a day. After improvement, the number of applications can be reduced to 2 or 3 times a week.

The weekly dose of the drug should not exceed 30-60 g.

In case of a resistant course of the disease, for example, in cases of localization of dense psoriatic plaques in the knees and elbows, it is recommended to use Locoid ointment. If necessary, it can be applied under an occlusive dressing.

Side effects

Locoid may irritate the skin. In rare cases, there are other local phenomena inherent in external steroid drugs.

With long-term treatment, application of the drug to large areas of the body and / or under occlusive dressings, side effects characteristic of systemic glucocorticosteroids may develop.


There is no information on overdose. With long-term use of Lokoid in high doses, the severity of the side effects described above may increase. If signs of hypercortisolism develop, therapy should be discontinued.

special instructions

Ointment / cream should not be applied to the periorbital area, as there is a risk of developing glaucoma. In case of systematic ingestion of the drug on the conjunctiva, there is a possibility of an increase in intraocular pressure.

For patients with exudative inflammation and people whose inflammatory process is localized on the scalp, it is recommended to use the emulsion for external use Lokoid Krelo.

It is undesirable to use the drug in the presence of atrophic skin changes.

If there is no effect within 2 weeks of continuous treatment, you should consult a doctor to clarify the diagnosis.

The use of Lokoid, like any other glucocorticosteroid, is recommended to be made in the minimum effective dose and for the shortest possible course.

The risk of developing side effects, including systemic ones, increases in childhood, when the drug is applied to large areas of the lesion, when using occlusive dressings, and long-term treatment.

Influence on the ability to drive vehicles and complex mechanisms

No information available.

Application during pregnancy and lactation

Hydrocortisone crosses the placenta. Its effect on the fetus can be especially pronounced when the drug is used on large areas of the body. How much hydrocortisone is excreted in breast milk is not exactly established. In this regard, during pregnancy and lactation, Locoid should be used with extreme caution and under medical supervision.

Pediatric use

Locoid can be used to treat children from the age of 6 months. It is important to take into account that the area of the body surface on which the drug is applied should not exceed 20% of the total.

In childhood, glucocorticosteroids can cause a more rapid suppression of the function of the adrenal cortex, as well as a decrease in the excretion of growth hormone. In this regard, long-term treatment requires monitoring the level of cortisol in plasma, the child's body weight and height. In the course of studies of children, for the treatment of whom 30-60 g of Lokoid was used per week for 4 weeks, not a single child was found to have dysfunctions of the adrenal cortex.

Drug interactions

No information available.


Lokoid's analogs are Cortef, Hydrocortisone, Latikort, Hydrocortisone-POS, Lokoid Krelo, Lokoid Lipokrem, Solu-Cortef, etc.

Terms and conditions of storage

Keep out of reach of children at temperatures up to 25 ° C. Do not freeze.

The shelf life of the cream is 3 years, the ointment is 5 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Locoid

Reviews about Locoid in the form of an ointment are contradictory. Some patients confirm the high effectiveness of the drug in this dosage form, the speed of its action and good tolerance. Others, on the contrary, write about the complete absence of the effect or about its very short action, as well as the development of negative skin phenomena. As for the Locoid cream, the reviews about it are mostly positive. The differences of opinion are probably due to improper use of the product. It is generally agreed that the drug can be successfully used strictly as directed by a physician after accurate confirmation of the diagnosis and selection of an appropriate dosage form.

The price of Locoid in pharmacies

Approximate prices for Lokoid: cream for external use 0.1% (tube 30 g) - 283-350 rubles, ointment for external use 0.1% (tube 30 g) - 245-315 rubles.

Locoid: prices in online pharmacies

Drug name



Lokoid Lipokrem 0.1% cream for external use 30 g 1 pc.

153 r


Locoid 0.1% ointment for external use 30 g 1 pc.

224 r


Locoid ointment 0.1% 30g

229 r


Locoid 0.1% cream for external use 30 g 1 pc.

244 RUB


Locoid Crelo 0.1% emulsion for external use 30 g 1 pc.

247 r


Lokoid Lipokrem cream 0.1% 30g

RUB 250


Lokoid Krelo emulsion for outside. approx. 0.1% 30g

308 RUB


Locoid cream 0.1% 30g

309 RUB


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Maria Kulkes
Maria Kulkes

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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