Dinolak - Instructions, Use For Children, Price, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Dinolak

Dinolac: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Dinolak

ATX code: AO6AD61

Active ingredient: Lactulose + Simethicone (Lactulosum + Simethiconum)

Manufacturer: AVVA-RUS, Russia

Description and photo update: 18.10.2018

Dinolac is a combined laxative drug.

Release form and composition

Dosage form - an emulsion for oral administration: a cloudy liquid with a homogeneous structure from yellow to almost colorless (100 ml, 200 ml, 500 ml or 1000 ml each in a polyethylene bottle complete with a measuring cup).

100 ml of emulsion contains:

• active ingredients: lactulose - 66 g, simethicone - 0.8 g;
• auxiliary components: citric acid, povidone (polyvinylpyrrolidone), aerosil (colloidal silicon dioxide).

Pharmacological properties

Pharmacodynamics

Synthetic disaccharide - lactulose, consisting of fructose and galactose, under the influence of disaccharidases of the microflora of the large intestine is broken down into monosaccharides and short-chain carboxylic acids. Short-chain carboxylic acids, by reducing the level of acidity in the large intestine, enhance peristalsis and suppress the growth of proteolytic microflora. Rapid absorption of short-chain fatty acids in the distal colon results in improved absorption of water and electrolytes.

Lactulose normalizes bowel function, has a laxative effect, stimulates the growth and reproduction of normal intestinal microflora.

After oral administration, the effect of lactulose occurs within 24–48 hours.

The defoaming properties of simethicone reduce the surface tension at the interface, counteracting the formation and facilitating the destruction of gas bubbles in the contents of the gastrointestinal tract (GIT). The gases released are absorbed by the intestinal walls or excreted from the body.

Reduces the feeling of discomfort in the abdominal area, which may accompany the action of lactulose.

Pharmacokinetics

Lactulose enters the large intestine practically unchanged. The drug is excreted from the body with intestinal contents, and only 3% is excreted through the kidneys.

Simethicone is not absorbed in the digestive tract, it is excreted from the body unchanged.

Indications for use

• constipation;
• prevention and treatment of hepatic encephalopathy, hepatic precoma and coma;
• hyperammonemia;
• regulation of stool for hemorrhoids, the need for surgery on the colon and perianal region;
• restoration of intestinal microflora after antibiotic therapy;
• prevention and treatment of dysbiosis of various etiologies.

Contraindications

• intestinal obstruction;
• galactosemia;
• intolerance to fructose or galactose, glucose-galactose malabsorption syndrome, lactase deficiency;
• hypersensitivity to the components of the drug.

Caution should be exercised in patients with diabetes mellitus.

Instructions for use of Dinolak: method and dosage

The emulsion is taken orally using a measuring cup.

Shake the contents of the bottle before use.

During the treatment period, it is necessary to take 1500-2000 ml of liquid per day.

Recommended dosage:

• constipation: daily dose for children under 1 year old - 5 ml, children aged 1–6 years - 5–10 ml, 7–14 years old - 15 ml, patients over 14 years old - the first 3 days, 15–45 ml each, then by 10-30 ml. For children, Dinolac should be taken once, during breakfast;
• hyperammonemia, hepatic coma, precoma, hepatic encephalopathy: the initial dose is 30-50 ml 3 times a day. The maximum daily dose is 190 ml. The maintenance dose is selected individually, it should provide soft stools no more than 2-3 times a day;
• intestinal dysbiosis: patients over 7 years old - 5 ml 1-2 times a day, the dose should be selected individually.

Side effects

Long-term treatment of hepatic encephalopathy with high doses of the drug can cause a violation of the water-electrolyte balance, which is manifested by weakness, nausea, increased fatigue, arrhythmia, headache, dizziness, myalgia.

Overdose

Symptoms: abdominal pain, diarrhea.

The patient needs a dose adjustment of the laxative.

special instructions

Patients who are on prolonged (more than 6 months) therapy with Dinolac are recommended to periodically conduct a study to determine the content of electrolytes in the blood plasma.

Since high doses of the drug are usually taken in the treatment of hepatic precoma or coma, patients with diabetes should take into account the possible content in the emulsion of a small amount of bound sugars, such as lactose, galactose or fructose.

Influence on the ability to drive vehicles and complex mechanisms

According to the instructions, Dinolac does not affect the patient's ability to control various mechanisms, including a car.

Application during pregnancy and lactation

During pregnancy and breastfeeding, the drug can be used according to clinical indications.

Pediatric use

Like other laxatives, Dinolac for children can only be used under medical supervision and in exceptional cases.

Drug interactions

The simultaneous use of clindamycin, neomycin, rifaximin and other antibiotics and antacids active against bifidobacteria and lactobacilli helps to reduce the effect of this drug.

Analogs

Dinolak's analogs are: drugs with a similar effect - Bisacodyl-Akrikhin, Guttalax, Dulcolax, Duphalac, Portalak.

Terms and conditions of storage

Keep out of the reach of children.

Store at temperatures up to 25 ° C in a dark place.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Dinolak

Reviews of Dinolac are mostly positive; users consider the benefits of the drug to be the rapid elimination of constipation in different age categories of patients, pleasant taste, and regulation of the intestines.

The price of Dinolac in pharmacies

The price of Dinolac, depending on the volume of the bottle: 1000 ml - from 814 rubles, 500 ml - from 497 rubles, 200 ml - from 357 rubles, 100 ml - from 248 rubles.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!