Polyvalent purified pyobacteriophage
Polyvalent purified pyobacteriophage: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Pyobacteriophagum polyvalentum purum
ATX code: V03A
Active ingredient: pyobacteriophage (Pyobacteriofag)
Manufacturer: Microgen NPO, JSC (Russia)
Description and photo update: 2019-09-07
Prices in pharmacies: from 736 rubles.
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Polyvalent purified pyobacteriophage - bacteriophage, a drug with immunostimulating action for oral, local and external use.
Release form and composition
Dosage form - solution for oral administration, external and local use: transparent yellow liquid of varying degrees of intensity, let’s say a greenish tint (in a cardboard box 4 or 10 bottles of 10 or 20 ml each and instructions for use of polyvalent purified Pyobacteriophage).
Composition of 1 ml solution:
- active substance: a mixture of sterile filtrates of phagolysates of streptococci, staphylococci, klebsiella (oxytoca and pneumonia), proteus, enterococci, colibacillus and Pseudomonas aeruginosa - 1 ml;
- auxiliary component (preservative): quinosole - 0.1 mg / ml (calculated content).
Pharmacological properties
Bacteriophage is a modern antimicrobial drug containing a complex of natural antibacterial agents that are capable of acting exclusively on pathogenic microflora.
Pharmacodynamics
The polyvalent purified pyobacteriophage has the ability to specifically lyse bacteria Klebsiella pneumoniae, Pseudomonas aeruginosa, Streptococcus, Staphylococcus, Escherichia coli, Proteus.
Indications for use
Polyvalent purified pyobacteriophage is prescribed for the treatment and prevention of various forms of enteral and purulent-inflammatory diseases caused by bacteria Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus, Proteus, Streptococcus, Escherichia coli, such as:
- diseases of the gastrointestinal tract, including intestinal dysbiosis, cholecystitis, gastroenterocolitis, pancreatitis;
- purulent inflammatory diseases of the ENT organs, oral cavity, sinuses of the nose, larynx, pharynx, pleura and lungs, including otitis media, tonsillitis, pharyngitis, periodontitis, stomatitis, frontal sinusitis, sinusitis, pneumonia, pleurisy;
- inflammatory diseases of newborns and young children, including intestinal dysbiosis, gastroenterocolitis, omphalitis, pyoderma, pemphigus, septicemia and septicopyemia of various localization;
- diseases of the organ of vision, including keratoconjunctivitis, post-traumatic conjunctivitis, iridocyclitis, purulent corneal ulcers;
- urogenital infections, including pyelonephritis, cystitis, vulvitis, endometritis, colpitis, bartholinitis, salpingo-oophoritis;
- surgical infections, including wound suppuration, burns, purulent skin lesions, peritonitis, mastitis, pleurisy, osteomyelitis;
- nosocomial infections caused by bacteria Streptococcus, Staphylococcus, Pseudomonas aeruginosa, Proteus, Escherichia coli, Klebsiella pneumoniae (prevention).
For effective treatment, it is important to first determine the phage sensitivity of the pathogen.
Contraindications
Contraindication to the use of polyvalent purified Pyobacteriophage is the presence of individual intolerance to its components.
Polyvalent purified pyobacteriophage, instructions for use: method and dosage
Methods of application of polyvalent purified pyobacteriophage: orally, in the form of irrigation, enemas, applications, introduction into the cavities of the sinuses of the nose, nose, vagina, uterus, wounds, as well as into the drained cavities (pleural, abdominal, abscess cavities, renal pelvis, bladder).
Inside, the solution should be taken on an empty stomach 30-60 minutes before meals.
Recommended dosing regimen, depending on age (oral / enema):
- up to 6 months: 5/10 ml;
- 6-12 months: 10/20 ml;
- 1-3 years: 15 / 20-30 ml;
- 3-8 years: 20 / 30-40 ml;
- from 8 years old: 20-30 / 40-50 ml.
When treating pyoinflammatory diseases with localized lesions, polyvalent purified pyobacteriophage should be applied simultaneously orally and topically.
If chemical antiseptics are used to treat the cavity of a purulent focus, before using the pyobacteriophage, it must be washed with a sterile 0.9% sodium chloride solution.
Method of application of polyvalent purified Pyobacteriophage for other indications:
- bronchitis, pneumonia: orally - 3 times a day, 10–20 ml; in the form of inhalations and aerosols (without the use of ultrasound and heating), duration of use - 15–20 days;
- angina, pharyngitis, laryngitis: rinsing the mouth and pharynx - 3 times a day, 10–20 ml, duration of use - 7–10 days;
- inflammation of the sinuses: rinsing the nasal cavity, sinuses of the nose and nasopharynx - 5–10 ml each, injection into the sinuses - 2-3 ml each. The procedure is carried out once a day every day for 7-10 days. Additionally, the introduction of the solution into the nasal cavity in the form of turunda moistened with bacteriophage is shown in turn in each nasal passage, the turunda is left for 30-60 minutes. The procedure is carried out 3 times a day, the duration of use is 7-15 days;
- otitis media: washing and injecting into the middle ear cavity - 1–3 times a day, 2–5 ml; duration of use - 7-15 days;
- conjunctivitis and keratoconjunctivitis: 4-5 times a day, 2-3 drops, duration of use - 5-7 days;
- stomatitis and chronic periodontitis: rinsing the mouth 3-4 times a day, 10-20 ml, injecting turunda soaked in bacteriophage into the periodontal pockets for 5-10 minutes for 7-10 days;
- purulent iridocyclitis: every 3 hours, 6–8 drops in combination with oral administration of pyobacteriophage in therapeutic doses for 7–10 days;
- purulent corneal ulcer: 4–5 drops a day for 7–10 days;
- peritonitis and pleurisy: the introduction of the solution through drainage tubes into the drained abdominal and pleural cavities is shown every day, once a day, 20–70 ml, duration of use - 10–15 days;
- abscess after opening and removal of purulent contents: the introduction of a solution with a volume less than the amount of removed pus is shown, once a day, the duration of use is 7-10 days;
- mastitis, suppuration of burns and wounds: irrigation, applications, dressings, introduction of 5–50 ml into the drainage (depending on the lesion focus) at least once a day, duration of use - 10–15 days;
- osteomyelitis: administration of the solution through drains and turundas into the wound cavity is shown, daily 1 time per day, 10-30 ml, duration of application - 15-20 days;
- cystitis, pyelonephritis, urethritis: orally at a therapeutic dose 3 times a day 60 minutes before meals, the duration of use is 10–20 days. If the cavity of the renal pelvis or bladder is drained, the solution can be injected through the nephrostomy or cystostomy 1-3 times a day, 5-7 or 20-50 ml into the renal pelvis or bladder, respectively, the duration of use is 7-15 days;
- purulent-inflammatory gynecological diseases (suppuration of wounds, endometritis, vulvitis, bartholinitis, colpitis, salpingo-oophoritis): irrigation, applications, introduction into the uterine cavity, vagina, wounds - 1 time per day, 5–20 ml, duration of use - 7–10 days;
- gastroenterocolitis, pancreatitis, cholecystitis, intestinal dysbiosis: orally 60 minutes before meals 3 times a day in age doses, duration of use - 7-15 days (according to clinical indications). In case of intestinal dysbiosis, piobacteriophage can be used simultaneously with normal flora preparations;
- indomitable vomiting: in the form of high enemas 2-3 times a day, 20-40 ml.
In order to prevent nosocomial surgical infections, polyvalent purified pyobacteriophage is used to treat freshly infected and postoperative wounds. The dose is determined by the lesion and ranges from 5 to 50 ml. The drug is used once a day every day for 5-7 days.
Use in children under 1 year of age (including premature babies):
- omphalitis, pyoderma, infected wounds: in the form of applications (a gauze napkin moistened with a bacteriophage is applied to the affected skin area or umbilical wound) 2-3 times a day, 5-10 ml, duration of application 7-15 days;
- gastroenterocolitis, pneumonia and sepsis of newborns: orally 30 minutes before feeding 2-3 times a day, 3-5 ml. In case of indomitable vomiting, the solution can be administered in the form of high enemas (through a catheter or gas tube) daily 1 time per day, 5-10 ml. The combined use of the drug by the oral and rectal route is possible. Duration of use - 7-15 days (determined by indications). In the case of a recurrent course of the disease, the pyobacteriophage can be used by a repeated course;
- prevention of the development of nosocomial infection in newborns: oral administration is shown 30 minutes before feeding according to epidemic indications 3 times a day, 3-5 ml during the entire period of the child's stay in the hospital.
Side effects
Not identified.
Overdose
There is no information.
special instructions
Before use, the bottle with the solution must be shaken and examined: the liquid in the bottle must be transparent, without visible sediment.
Before opening the package, you must thoroughly wash your hands, treat the cap of the bottle with an alcohol-containing solution, then remove it without opening the cap. Do not put the cork on the table or other objects with the inner surface, leave the bottle open. Once opened, the bottle can only be stored in the refrigerator.
If small doses of polyvalent purified pyobacteriophage are used (2–8 drops), the solution should be taken with a sterile syringe of 0.5–1 ml volume. A new, sterile syringe and needle must be used for each dose.
Subject to the above rules and storage conditions, the drug from an opened bottle can be used throughout the shelf life (in the absence of turbidity).
Application during pregnancy and lactation
The use of polyvalent purified pyobacteriophage during pregnancy and breastfeeding is allowed on the recommendation of a doctor, subject to the treatment of infections caused by phage-sensitive bacterial strains.
Pediatric use
In pediatric practice, the drug is used according to indications for the treatment of children, including premature babies, from the neonatal period.
Drug interactions
The use of polyvalent purified Pyobacteriophage does not exclude the use of other drugs (antibacterial, anti-inflammatory, etc.).
Analogs
The analogues of the polyvalent purified Pyobacteriophage are Sextaphage Polyvalent pyobacteriophage, Pyopolyphage, Complex pyobacteriophage.
Terms and conditions of storage
Store at 2-8 ° C. It is permissible to transport the drug at a temperature of 8–25 ° C for no longer than one month. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about polyvalent purified pyobacteriophage
Most of the reviews about the polyvalent purified pyobacteriophage are positive. Most often, its high safety and effectiveness are noted. They also indicate the absence of contraindications and side effects from the digestive system, the possibility of using the drug in newborns.
The cost is assessed by patients as high, especially when long-term use or large volumes are required.
Price for Pyobacteriophage polyvalent purified in pharmacies
The approximate price for polyvalent purified Pyobacteriophage (4 vials of 20 ml) is 630–867 rubles.
Polyvalent purified pyobacteriophage: prices in online pharmacies
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Drug name Price Pharmacy |
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Pyobacteriophage polyvalent purified solution for internal and external use 20 ml 4 pcs. 736 RUB Buy |
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Polyvalent purified pyobacteriophage (sextaphage) solution 20ml 4 pcs. 846 RUB Buy |
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Polyvalent purified pyobacteriophage 20ml 4 pcs. 861 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
