Bifosin - Instructions For Use From The Fungus, Reviews, Price, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Bifosin

Bifosin: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Bifosine

ATX code: D01AC10

Active ingredient: bifonazole (Bifonazole)

Producer: Sintez, JSC (Russia)

Description and photo updated: 2019-27-08

Bifosin is an antifungal drug intended for external use.

Release form and composition

Dosage forms:

• Solution for external use 1% (in dropper bottles made of dark glass, 15 g each, 1 bottle in a cardboard box);
• Cream for external use 1% (in aluminum tubes of 30 g, 1 tube in a cardboard box);
• Spray for external use 1% (in polymer bottles with a spray of 20 ml, 1 bottle in a cardboard box);
• Powder for external use 1% (in polyethylene cans of 30 g, 1 can in a cardboard box).

The cardboard box also contains instructions for the use of Bifosin.

The active ingredient is bifonazole - 10 mg per 1 g of the drug.

Auxiliary components:

• Solution: macrogol 400;
• Cream: macrogol 4000, macrogol 400, propylene glycol;
• Spray: isopropanol - 0.4 ml, propylene glycol - 0.3 ml, macrogol 400 - up to 1 ml;
• Powder: corn starch, zinc oxide - 150 mg per 1 g of the preparation, talc.

Pharmacological properties

Pharmacodynamics

Bifosin is one of the external broad-spectrum antifungal drugs.

The active ingredient of the drug, bifonazole, is an imidazole derivative. Shows a fungicidal effect against dermatophytes (Microsporum, Trichophyton, Epidermophyton), fungistatic - against yeast-like and mold fungi (Scopulariopsis brevicaulis, Aspergillus ferrus), Malassezia furfur.

Shows activity against bacteria: gram-positive bacillus Corynebacterium minutissimum (with a minimum inhibitory concentration in the range of 0.000 5-0.002 mg / ml) and against gram-positive cocci (with a minimum inhibitory concentration of 0.004-0.016 mg / ml), except for Enterococcus spp.

The main target of Bifosin is ergosterol, which is an essential component of the fungal membrane. The drug suppresses its synthesis at two stages of formation. Due to this, structural and functional damage to the cytoplasmic membrane of the fungi occurs.

The minimum effective concentration of bifonazole is 5 ng / ml with a duration of exposure of at least 6 hours. The concentration of 3 ng / ml allows to inhibit the growth of the rapidly proliferating mycelium of Trichophyton mentagrophytes.

It has a fungistatic effect on yeast-like fungi of the genus Candida, in concentrations from 20 ng / ml turning into fungicidal.

Pharmacokinetics

Bifonazole penetrates well into the affected skin layers. The absorption of the substance is 0.6–0.8%, the plasma concentration is not determined. The absorption of bifonazole when the cream is applied to the affected skin areas is 2–4%, the plasma concentration is 2 ng / ml.

6 hours after the application of the agent, the concentration of the substance in the skin reaches or many times exceeds the minimum effective for the main fungi that lead to the development of dermatomycosis: 1 mg / cm ² in the upper layer of the epidermis (Stratum corneum) and 5 mg / cm ² in the one located directly under the epidermis papillary layer (Stratum papillare).

The duration of the substance in the skin is from 36 to 48 hours (when applying the cream - from 48 to 72 hours).

T _1/2 (half-life) from the skin - 19–32 hours (the value of the indicator depends on the density of the skin).

Indications for use

The use of Bifosin is advisable in the treatment of skin lesions caused by dermatophytes, moldy, yeast-like fungi, Corynebacterium minutissimum and Malassezia furfur:

• Dermatomycosis of smooth skin;
• Superficial candidiasis of the skin;
• Mycoses of the hands and feet;
• Pityriasis versicolor;
• Erythrasma.
• Dermatomycosis of the scalp (for powder, spray and solution).

Contraindications

Contraindications to the use of Bifosin are:

• Hypersensitivity of the patient to the components of the drug;
• Lactation period.

The drug is prescribed with caution in the first trimester of pregnancy, as well as in infants.

Bifosin, instructions for use: method and dosage

The drug is recommended to be used once a day before bedtime.

Powder, cream and solution must be applied in a thin layer to the affected area of the skin and rubbed thoroughly.

The spray should be sprayed onto the affected and adjacent skin areas in a sufficient amount to moisturize them.

As a rule, a few drops of solution (about 3 ml) or strips of cream 0.5-1 cm long are enough for a palm-sized area.

Treatment should be continuous, the duration of therapy is determined by the disease that serves as an indication for prescribing the drug:

• Dermatomycosis of smooth skin - 2-3 weeks;
• Erythrasma, pityriasis versicolor - 2 weeks;
• Mycoses of the feet and interdigital spaces of the feet - 3-4 weeks;
• Superficial candidiasis of the skin - 2-4 weeks;
• Dermatomycosis of the scalp - 4 weeks.

In order to prevent relapse, Bifosin is recommended to be applied once a day for 2 weeks after the disappearance of the clinical manifestations of the disease.

Side effects

In some cases, the use of Bifosin can cause local reactions in the form of:

• Skin irritation;
• Allergic reactions;
• Itchy skin;
• Maceration;
• Hyperemia;
• Burning sensations;
• Eczema;
• Vesicular rash;
• Peeling;
• Allergic dermatitis (very rare).

Overdose

Overdose is almost impossible, since Bifosin has an extremely low systemic absorption.

special instructions

In the absence of a therapeutic effect or in case of insufficient effectiveness of Bifosin, it is recommended to conduct an additional examination of the patient (the state of the endocrine system, immunity, blood, microcirculation of the affected area) and, based on the results of the examination, adjust the treatment.

Avoid getting the drug in the eyes.

The use of Bifosin from a fungus in the treatment of children under 1 year old is possible only under the supervision of a doctor.

The drug has no effect on the implementation of potentially hazardous activities requiring the speed of psychomotor reactions and concentration of attention, including driving a car.

Influence on the ability to drive vehicles and complex mechanisms

The use of any form of Bifosin release does not affect the ability to engage in potentially hazardous activities that may require increased attention and quick reactions, including driving vehicles and complex mechanisms.

Application during pregnancy and lactation

• I trimester of pregnancy: Bifosin from the fungus should be used under medical supervision only under strict indications;
• Lactation period: therapy is contraindicated.

Pediatric use

In infants (up to one year old), the use of Bifosin is possible only under close medical supervision.

Drug interactions

No drug interaction reactions have been identified. Bifosin can be used in combination with other drugs / substances.

Analogs

The analogue of Bifosin is Mikospor.

Terms and conditions of storage

Shelf life is 2 years. Keep out of the reach of children and protected from light, solution, cream and powder at a temperature of 15-25 ° C, spray at a temperature not exceeding 25 ° C.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Bifosin

According to reviews, Bifosin is an inexpensive and effective remedy. Most often, users leave comments regarding the dosage form - the cream. It is noted that it relieves itching, pain and burning in the affected area. In some cases, it is used in the treatment of lichen. The main disadvantages are considered to be oily consistency, unpleasant odor and the need for a long course of treatment.

The price of Bifosin in pharmacies

Approximate price for Bifosin:

• Cream for external use (30 g in a tube) - 60–70 rubles;
• Powder for external use (dusting) 1% (30 g in a polyethylene can) - 33 rubles;
• Spray for external use 1% (20 ml in a polymer bottle with a spray) - 89 rubles.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!