Allergodil - Instructions For Use, Drops, Spray, Price, Reviews

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Allergodil - Instructions For Use, Drops, Spray, Price, Reviews
Allergodil - Instructions For Use, Drops, Spray, Price, Reviews

Video: Allergodil - Instructions For Use, Drops, Spray, Price, Reviews

Video: Allergodil - Instructions For Use, Drops, Spray, Price, Reviews
Video: How To Use Nasal Spray | How To Use Nasal Spray Properly | Nasal Spray Technique (2018) 2023, September


Allergodil: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  11. 11. Analogs
  12. 12. Terms and conditions of storage
  13. 13. Terms of dispensing from pharmacies
  14. 14. Reviews
  15. 15. Price in pharmacies

Latin name: Allergodil

ATX code: S01GX07

Active ingredient: azelastine (azelastine)

Manufacturer: Tubilyux Pharma S.p. A. (Tubilix Pharma SpA) (Italy), Meda Pharma GmbH & Co. KG (Germany)

Description and photo update: 2019-19-08

Prices in pharmacies: from 369 rubles.


Allergodil eye drops
Allergodil eye drops

Allergodil is a local antiallergic medication used in ophthalmology.

Release form and composition

  • eye drops 0.05%: colorless transparent solution (6 ml each in polyethylene bottles with a dropper);
  • nasal spray: colorless transparent solution (10 ml in dark glass vials with a spray dispenser).

1 ml of eye drops contains:

  • active substance: azelastine hydrochloride - 500 mcg;
  • excipients: hypromellose, disodium edetate, benzalkonium chloride, sorbitol 70%, sodium hydroxide, purified water.

1 dose of nasal spray contains:

  • active substance: azelastine hydrochloride - 140 μg (in 1 bottle - 10 mg);
  • excipients: hypromellose, disodium edetate dihydrate, anhydrous citric acid, sodium hydrogen phosphate dodecahydrate, sodium chloride, purified water.

Pharmacological properties


Azelastine is a histamine H 1 receptor blocker derived from phthalazinone. It has a long-term antiallergic and membrane stabilizing effect.

The main effects of azelastine:

  • decrease in capillary permeability and decrease in exudation;
  • stabilization of mast cell membranes and preventing the release of biologically active substances from them (including serotonin, histamine, leukotrienes, platelet activating factor), which cause bronchospasm and contribute to the early and late stages of allergic reactions and inflammation;
  • reduction of itching and nasal congestion, sneezing, rhinorrhea.

The systemic effect of azelastine when applied topically is insignificant.

Relief of symptoms of allergic rhinitis is usually noted 15 minutes after drug administration, its duration is 12 hours or more.

When carrying out long-term therapy with high doses of the drug, a clinically significant effect of azelastine on the QT interval is not observed.


The bioavailability of azelastine after intranasal administration of Allergodil is approximately 40%. The time to reach C max (maximum concentration of the substance) in the blood is from 2 to 3 hours. When using the spray at the recommended daily dose (1.1 mg), C ss (equilibrium concentration) in the blood is less than 1% of the dose. The serum concentration of the substance in the blood after intranasal administration is 8 times lower than after oral administration. In patients with allergic rhinitis, the concentration of azelastine in the blood is higher than in healthy people.

C max with repeated use of Allergodil eye drops (4 times a day, 1 drop in each eye) is very low and is detected at the limit / below the measurement limit.

Other pharmacokinetic parameters have been studied with oral azelastine.

The blood protein binding is 80–90%.

Azelastine metabolism occurs in the liver by oxidation with the participation of the cytochrome P450 system, followed by the formation of desmethylazelastine, an active metabolite.

It is excreted mainly in the form of inactive metabolites. The main route of elimination is through the kidneys. T 1/2 (half-life) of azelastine and desmethylazelastine is approximately 20 and 45 hours, respectively.

Indications for use

Eye drops

  • seasonal allergic conjunctivitis (therapy and prevention);
  • non-seasonal (year-round) allergic conjunctivitis (therapy).

Nasal spray

  • seasonal and perennial allergic rhinitis, including hay fever, and rhinoconjunctivitis (therapy);
  • vasomotor year-round non-allergic rhinitis, manifested by nasal congestion, rhinorrhea, sneezing, postnasal syndrome (symptomatic therapy).


According to the instructions, Allergodil is contraindicated in hypersensitivity, as well as in lactating and pregnant women.

Spray Allergodil should not be prescribed:

  • Children under 6 years of age in the treatment of allergic rhinitis and rhinoconjunctivitis;
  • Children under 12 years of age in the treatment of vasomotor rhinitis.

Allergodil in the form of eye drops is not used in children under 4 years of age.

Instructions for the use of Allergodil: method and dosage

In the treatment of seasonal allergic conjunctivitis, the medicine in the form of drops is prescribed for children over 4 years old and for adults 2 times a day (morning and evening), 1 drop in each eye. In severe cases, the frequency of application of Allergodil is increased up to 4 times a day. Against the background of non-seasonal (year-round) allergic conjunctivitis, the medication is used in the same way.

Allergodil drops can be used prophylactically.

Spray Allergodil is used intranasally. In the treatment of allergic rhinitis and rhinoconjunctivitis, children over 6 years of age and adults are prescribed 1 dose of the drug in each nasal passage 2 times a day. For children over 12 years old and adults, this dosage can be doubled if necessary.

Allergodil in the form of a spray can be used for a long time, but not more than two months.

Side effects

Estimation of the incidence of adverse reactions:> 10% - very often; > 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rare.

Allergodil eye drops:

  • organ of vision: increased tearing, foreign body sensation, increased sensitivity of the eye, discoloration of the conjunctival membrane, soreness, irritation, itching, swelling, redness; rarely - blepharitis, dry eyes;
  • systemic reactions: dysgeusia, dyspnea, dry skin.

Allergodil nasal spray:

  • allergic reactions: very rarely - itchy skin, rash, urticaria;
  • local reactions: rarely - a weak, transient irritation of the inflamed nasal mucosa (in the form of burning, itching, sneezing; very rarely - nosebleeds);
  • systemic reactions: very rarely - weakness, dizziness (may be associated with the disease itself);
  • others: often - a bitter taste in the mouth and, as a result, nausea (occurs with the wrong method of administration, when the head is thrown back).


There is no information.

special instructions

Allergodil, on the recommendation of a doctor, can be used in the treatment of infectious eye diseases as part of complex therapy. When used simultaneously with other eye drops, an interval of at least 15 minutes must be observed.

It is not recommended to wear contact lenses while using Allergodil.

Influence on the ability to drive vehicles and complex mechanisms

It must be borne in mind that during therapy with Allergodil, the development of blurred vision, fatigue and weakness is possible. In such cases, it is recommended to refrain from driving.

Application during pregnancy and lactation

The use of Allergodil is contraindicated in the I trimester of pregnancy (drops), I – III trimester of pregnancy (spray) and during lactation.

In the II and III trimesters of pregnancy, Allergodil in the form of drops can be prescribed by a doctor after assessing the balance of benefits with possible risks.

Pediatric use

Allergodil therapy is contraindicated:

  • up to 4 years (drops);
  • up to 6 years (spray for the treatment of allergic rhinitis and rhinoconjunctivitis);
  • up to 12 years (spray for the treatment of vasomotor rhinitis).


According to the mechanism of action, analogues of Allergodil are drugs: Alomid, Zaditen, Kromoglin, Reactin, Allergo-Komod, Lekrolin, Opatanol, Hi-krom, Histimet, KromoHexal, Ifiral, Krom-allerg.

Terms and conditions of storage

The shelf life of the drug in any dosage form is 3 years. After opening the bottle, eye drops can be used for 1 month, spray - for six months.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Allergodil

According to reviews, Allergodil is effective in any dosage form. It is noted that the drug has a quick and lasting effect.

The spray has a number of advantages over eye drops. Users note that it is more economical in consumption, it is evenly sprayed over the entire surface of the nasal mucosa, and is convenient for use in different conditions, including at work, while traveling.

The main disadvantage of Allergodil is considered its high cost. They also indicate the likelihood of developing a burning sensation after using a nasal spray and, in some cases, a short therapeutic effect.

The price of Allergodil in pharmacies

The approximate price for Allergodil is: spray (1 bottle of 10 ml) - 536-599 rubles, drops (1 bottle of 6 ml) - 437-482 rubles.

Allergodil: prices in online pharmacies

Drug name



Allergodil (eye drops) 0.05% eye drops 6 ml 1 pc.

369 r


Reviews Allergodil (eye drops)

369 r


Allergodil eye drops 0.05% 6ml

435 r


Allergodil 0.14 mg / dose nasal spray dosed 10 ml 1 pc.

437 r


Allergodil nasal spray. dosage. 140mcg / dose 10ml

502 RUB


Maria Kulkes
Maria Kulkes

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!