Enzix
Instructions for use:
- 1. Composition and form of release
- 2. Pharmacological action
- 3. Indications for use
- 4. Instructions for use
- 5. Contraindications to use
- 6. Side effects of the drug
- 7. Drug interactions
- 8. Storage conditions
Prices in online pharmacies:
from 225 rub.
Buy
Enzix is a combined
antihypertensive drug. Reviews about Enzix confirm its high therapeutic efficacy and speed.
Berlipril, Co-renitek, Enalozid, Enapril, Enap are Enzix analogs.
Composition and form of release of Enzix
Enzix is available in pill form. One pack of Enzix contains two medicines - Indapamide (diuretic) and Enalapril (ACE inhibitor).
The drug Enalapril contains maleatenalapril (active ingredient) and auxiliary components - magnesium stearate, magnesium carbonate, gelatin, crospovidone, lactose monohydrate.
The drug Indapamide contains indapamide, an active substance, and auxiliary ingredients - macrogol 6000, talc, titanium dioxide, hypromellose, magnesium thearate, sodium lauryl sulfate, lactose monohydrate, povidone K30, crospovidone.
The instructions for Enzix says that the simultaneous use of Enalapril and Indapamide enhances the mutual antihypertensive effect of Enzix.
Pharmacological action of Enzix
The action of Enalapril in Enzix helps to reduce the content of aldosterone by suppressing the conversion of group 1 angiotensin to group 2 angiotensin. Due to this, peripheral vascular resistance, diastolic and mean blood pressure, afterload and preload on the myocardium are reduced.
Enalapril enhances coronary and renal blood flow, increases the formation of prostaglandins, has a weak diuretic effect.
A decrease in blood pressure indicators within the therapeutic range does not affect cerebral circulation. The blood flow of the cerebral vessels against the background of reduced pressure indicators is maintained at a sufficient level.
Many reviews to Enziks confirm that long-term use of Enalapril helps to reduce hypertrophy of the left ventricular myocardium, as well as myocytes of the walls of resistant arteries by improving blood circulation, as a result of which the progression of heart failure is prevented and the process of left ventricular dilatation is suppressed.
The antihypertensive effect of Enalapril appears one hour after taking the drug inside, reaches a maximum after four to six hours and lasts about a day. The half-life of the drug is 11-12 hours.
Indapamide is an antihypertensive drug, a thiazide-like diuretic with a long duration and moderate effect, a derivative of benzamides. It reduces the tone of the smooth muscles of the arteries, reduces the total peripheral vascular resistance. It has moderate diuretic and saluretic effects, which are manifested in the blockade of reabsorption of chlorine, sodium, hydrogen ions, as well as potassium ions in the cortical section of the distal tubule and proximal tubules of the nephron. Indapamide reduces left ventricular hypertrophy. In therapeutic doses, it does not affect carbohydrate and lipid metabolism. The antihypertensive effect reaches its peak in a week with regular administration of the medication and is maintained throughout the day in the case of a single dose. The maximum plasma concentration of Indapamide is reached one to two hours after taking the drug. The half-life of Indapamide is 14-16 hours.
Indications for the use of Enzix
According to the instructions, Enzix is recommended to be taken with arterial hypertension.
Instructions for use
According to the instructions for Enzix, one tablet of Indapamide and one tablet of Enalapril should be taken simultaneously once a day.
Depending on the change in blood pressure indicators, the dose of Enalapril can be increased up to twice a day.
Contraindications to the use of Enzix
Contraindications of Enzix are considered on the basis of contraindications of the two drugs included in it - Enalapril and Indapamide.
Contraindications to the use of Indapamide:
- severe renal and / or hepatic impairment;
- hypokalemia;
- anuria;
- children and adolescents up to 18 years old;
- pregnancy;
- hypersensitivity to Indapamide;
- lactation period.
The drug is used with caution in diabetes mellitus and hyperruricemia.
Contraindications to the use of Enalapril:
- renal failure;
- a history of angioedema;
- hypersensitivity to Enalapril;
- children and adolescents up to 18 years old;
- lactation period;
- pregnancy.
With caution, Enzix is prescribed to elderly patients, as well as to patients with the following diseases:
- hepatic and / or renal failure;
- diabetes;
- cerebrovascular diseases;
- cardiac ischemia;
- systemic connective tissue diseases;
- mitral stenosis;
- aortic stenosis and idiopathic hypertrophic subaortic stenosis;
- hyperkalemia;
- primary hyperaldosteronism.
Side effects of the drug Enzix
Judging by the reviews to Enzix, this drug, with prolonged use, often causes nausea, dry mouth, tinnitus, impaired vision and hearing, gastralgia, diarrhea or constipation, allergic reactions, palpitations, decreased libido, insomnia, water-electrolyte disturbances, depression, dizziness, headache.
The instructions for Enziks say that very rarely, prolonged use of the drug leads to the development of myocardial infarction, cough, pharyngitis, sinusitis, muscle spasms, and also contributes to drowsiness, general weakness, malaise, and increased fatigue.
Drug interactions
The simultaneous use of Enalapril and NSAIDs, analgesics, antipyretics reduces the effectiveness of the drug.
The antihypertensive effect of Enalapril is enhanced by beta-blockers, diuretics, nitrates, prazosin and hydralazine.
The combined use of Enalapril with potassium-sparing diuretics (amiloride, spironolactone, triamterene), as well as with potassium-containing agents, increases the risk of hyperkalemia.
Enalapril weakens the effect of theophylline-containing drugs. Immunosuppressants increase the hematotoxicity of the drug.
The combined use of indapamide and saluretics, cardiac glycosides, gluco- and mineralocorticoids, tetracosactides, laxatives increases the risk of hypokalemia.
Indapamide increases the concentration of lithium in the blood plasma.
Baclofen enhances the hypotensive effect of Indapamide.
The simultaneous use of Indapamide and ACE inhibitors often leads to the development of arterial hypotension.
The combined use of Indapamide and iodine-containing drugs in high doses increases the risk of developing renal failure.
Antipsychotic drugs and tricyclic antidepressants enhance the hypotensive effect of Indapamide.
Storage conditions for Enzix
According to the instructions, Enzix should be stored in a dry place at a temperature of 20 ° to 25 ° C.
Shelf life is 3 years.
Enzix: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Enzix 2.5 mg + 10 mg tablets set of 30 pcs. 225 RUB Buy |
|
Enzix duo 10 mg + 2.5 mg tablets set 45 pcs. 228 r Buy |
|
Enzix DUO tablets 45 pcs. 285 r Buy |
|
Enzix duo forte tablets set 45 pcs. 287 r Buy |
|
Enzix DUO Forte tablets 45 pcs. 453 r Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
