Panavir
Panavir: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Panavir
ATX code: J05AX
Active ingredient: Polysaccharides of shoots of Solanum tuberosum
Producer: Zelenaya Dubrava CJSC (Russia)
Description and photo update: 2019-12-08
Prices in pharmacies: from 116 rubles.
Buy
Panavir is a drug that has antiviral and immunomodulatory effects.
Release form and composition
Panavir is available in the following dosage forms:
- Rectal suppositories: from white with a yellowish tinge to white, cylindrical or cone-shaped, odorless; the presence of yellowish-gray blotches is allowed (in blisters, 5 pcs., 1 or 2 packages in a cardboard box);
- Vaginal suppositories: translucent, grayish-white, cylindrical or cone-shaped (in blisters, 5 pcs., 1 package in a cardboard box);
- Gel for external and local use: white, homogeneous, has a weak specific odor (in aluminum tubes with an inner varnish coating of 3, 5, 10 or 30 g, 1 tube in a cardboard box);
- Solution for intravenous (iv) administration: slightly opalescent or transparent, with a light brown tint or colorless, odorless (in neutral glass ampoules or vials, sealed with rubber stoppers with rolling aluminum caps, 5 ml each, 2 or 5 each ampoules or vials in blisters, 1 or 2 packs in a cardboard box (for ampoules - complete with an ampoule knife or scarifier, or without it)).
The active substance is a purified extract of Solanum tuberosum shoots - a hexose glycoside consisting of uronic acids, rhamnose, glucose, galactose, arabinose, xylose, mannose (Panavir).
Composition of 1 rectal suppository:
- Active ingredient: Panavir - 0.2 mg;
- Additional components: paraffin - 90 mg, solid or confectionery fat - 1019.8 mg, emulsifier T-2 - 90 mg.
Composition of 1 vaginal suppository:
- Active ingredient: Panavir - 0.2 mg;
- Additional components: macrogol 1500 (polyethylene oxide 1500) - 1259.9 mg, macrogol 400 (polyethylene oxide 400) - 139.9 mg.
Composition of 10 mg gel for external and local use:
- Active ingredient: Panavir - 0.0002 mg;
- Additional components: 95% ethanol - 0.1 mg, sodium hydroxide - 0.04 mg, lanthanum nitrate hexahydrate - 0.22 mg, macrogol 4000 - 1.5 mg, macrogol 400 - 3.8 mg, glycerol - 3 mg, water - up to 10 mg.
Composition of 1 vial or ampoule of solution for intravenous administration:
- Active ingredient: Panavir - 0.2 mg;
- Additional components: sodium chloride - 45 mg, water for injection - up to 5 ml.
Pharmacological properties
Pharmacodynamics
Panavir is a purified extract of the shoots of the Solanum tuberosum plant. Its main active ingredient is hexose glycoside, which includes uronic acids, glucose, galactose, xylose, mannose, arabinose. This determines its antiviral and immunomodulatory properties.
The drug enhances the body's nonspecific resistance to pathogens of various infections and promotes the production of interferons alpha and gamma by blood leukocytes. In the recommended doses, the drug is usually well tolerated. Research proves the absence of embryotoxic, teratogenic, allergenic and carcinogenic effects. Preclinical studies in laboratory animals did not reveal a negative effect on reproductive function and prenatal development of the fetus. Studies of the model of experimental exudative edema confirmed the presence of anti-inflammatory properties of the drug.
Pharmacokinetics
When the solution is administered intravenously, polysaccharides are found in the blood approximately 5 minutes after drug administration. Later, they are captured by the cells of the reticuloendothelial system of the liver and spleen. These compounds are excreted mainly through the lungs and kidneys rather quickly. Polysaccharides are determined in urine and air exhaled by a person within 20-30 minutes after administration.
Indications for use
Rectal suppositories
- Cytomegalovirus infection, including recurrent miscarriage (Panavir can be used during preparation for pregnancy in women with interferon deficiency and chronic viral infection);
- Influenza and acute respiratory viral infections (in combination with other drugs);
- Infections caused by the herpes simplex virus of various localization, including herpes zoster, ophthalmic herpes, recurrent genital herpes;
- Anogenital warts (human papillomavirus infections) (in combination with other drugs);
- Secondary immunodeficiency states that developed against the background of infectious diseases;
- Tick-borne encephalitis (in combination with other drugs to reduce viral load and the severity of neurological symptoms, manifested as anisoreflexia, decreased reflexes, nystagmus, soreness of the exit points of the cranial nerves).
Vaginal suppositories
The indication for use is genital herpes in women (in combination with other drugs).
Gel
It is indicated for use in infectious and inflammatory diseases of the mucous membranes and / or skin caused by the herpes simplex virus types I and II, including genital herpes.
Solution for intravenous administration
- Secondary immunodeficiency states that have developed against the background of infectious diseases;
- Infections caused by the herpes simplex virus of various localization, including herpes zoster, ophthalmic herpes, recurrent genital herpes;
- Influenza and acute respiratory viral infections (in combination with other drugs);
- Anogenital warts (papillomavirus infection) (in combination with other drugs);
- Cytomegalovirus infections, including recurrent miscarriage (Panavir can be used during preparation for pregnancy in women with interferon deficiency and chronic viral infection);
- Peptic ulcer of the stomach and duodenum with long-term non-scarring ulcers and symptomatic ulcers of the gastroduodenal zone (in combination with other drugs);
- Rheumatoid arthritis, accompanied by herpesvirus infection in immunocompromised patients (in combination with other drugs to enhance the analgesic and anti-inflammatory effect of the main therapy);
- Chronic bacterial prostatitis (in combination with other drugs);
- Tick-borne encephalitis (in combination with other drugs to reduce viral load and severity of neurological symptoms, manifested by anisoreflexia, nystagmus, decreased reflexes, painful exit points of the cranial nerves).
Contraindications
- Severe diseases of the kidneys and spleen (for vaginal suppositories);
- Age up to 12 years (for solution for intravenous administration) or 18 years (for other dosage forms of the drug);
- Pregnancy (for vaginal and rectal suppositories; for a solution for intravenous administration - the appointment of Panavir is possible only after assessing the ratio of benefits to risks to the health of the woman and the fetus, with the exception of the use of the drug in the II-III trimester as part of complex treatment for exacerbation of chronic cytomegalovirus infection; for a gel - the appointment is possible only after assessing the ratio of benefits to risks to the health of the woman and the fetus);
- Lactation period;
- Hypersensitivity to drug components.
Instructions for the use of Panavir: method and dosage
Rectal suppositories
Method of application - rectally.
Application regimen (1 suppository - single dose):
- Influenza and acute respiratory viral infections: 5 doses every 24 hours;
- Cytomegalovirus and human papillomavirus infections: the first week - 3 doses with an interval of 48 hours, the second week - 2 doses with an interval of 72 hours;
- Herpesvirus infections and tick-borne encephalitis: 2 doses 24 or 48 hours apart. After 30 days, the course may be repeated.
Vaginal suppositories
Method of application - intravaginally, in the evening. Suppositories should be inserted as deeply as possible (in a supine position with slightly bent legs).
Panavir is administered daily in a course of 5 days, 1 suppository each. The doctor may prescribe a second treatment course.
Gel
Panavir gel should be applied in a thin layer to the affected areas of the skin and / or mucous membranes.
Recommended dosage regimen:
- Infectious and inflammatory diseases of the mucous membranes and / or skin caused by the herpes simplex virus types I and II (including genital herpes): 5 times a day for a course of 4-5 days (may be extended up to 10 days);
- Human papillomavirus infections: 2 times a day for a course of 15 days (5 days before and 10 days after laser removal of genital warts).
Solution for intravenous administration
Method of application - slowly intravenously.
Single adult dose - 0.2 mg of active ingredient (contents of 1 vial or ampoule).
Recommended regimen of Panavir for adults:
- Cytomegalovirus and human papillomavirus infections: the first week - 3 doses with an interval of 48 hours, the second week - 2 doses with an interval of 72 hours;
- Tick-borne encephalitis and herpesvirus infections: 2 doses 24 or 48 hours apart. After 1 month, the treatment course can be repeated;
- Rheumatoid arthritis occurring with herpesvirus infection in immunocompromised patients: 5 doses with an interval of 24-48 hours, the course may be repeated after 2 months;
- Peptic ulcer of the stomach and duodenum (exacerbation), symptomatic ulcers of the gastroduodenal zone: 5 doses with an interval of 48 hours;
- Bacterial chronic prostatitis: 5 doses 48 hours apart;
- Influenza and acute respiratory viral infections: 2 doses 18-24 hours apart.
For children over 12 years old, Panavir is prescribed 1 time per day, 0.1 mg.
Recommended dosage regimen:
- Cytomegalovirus and human papillomavirus infections: the first week - 3 doses with an interval of 48 hours, the second week - 2 doses with an interval of 72 hours;
- Tick-borne encephalitis and herpesvirus infections: 2 doses with an interval of 24 or 48 hours, it is possible to repeat the course after 1 month.
Side effects
Vaginal suppositories
The development of allergic reactions is possible.
In the event of any undesirable disorders, therapy should be interrupted and a specialist should be consulted.
Gel
At the site of application of Panavir, short-term redness and itching of the skin and / or mucous membranes may occur.
Rectal suppositories, solution for intravenous administration
Panavir is generally well tolerated by patients.
Possible violations may be associated with increased sensitivity to Panavir components.
Overdose
Overdose cases of Panavir have not been registered. The results of preclinical studies prove the low probability of toxic damage to the body as a result of the use of the drug.
special instructions
Vaginal suppositories
In order to prevent the development of urogenital reinfection, it is recommended to conduct simultaneous therapy of sexual partners. In the absence of effect or insufficient effectiveness of Panavir, the diagnosis should be confirmed.
Gel
It is recommended to start treatment in the early stages of the disease, when the first symptoms appear, such as itching, redness, tingling, feeling of tension. In this case, the occurrence of the vesicular stage of the disease can be prevented.
According to the instructions, Panavir is not used in ophthalmology.
When applying the gel to the face area, avoid contact with the eyes.
Solution for intravenous administration
In cytomegalovirus and herpesvirus infections, the use of Panavir during preparation for pregnancy helps to reduce the frequency of reproductive losses.
The introduction of a cloudy solution is prohibited.
Influence on the ability to drive vehicles and complex mechanisms
There are no reliable data indicating the negative impact of Panavir on the ability to drive a car and perform potentially hazardous types of work that require increased concentration and immediate psychomotor reactions.
Drug interactions
No significant interaction of Panavir with other drugs has been reported.
Analogs
Panavir's analogues are: Arbidol, Yodantipirin, Detoxopyrol, Ferrovil.
Terms and conditions of storage
Store in a dark, dry place out of reach of children.
Shelf life:
- Rectal suppositories - 3 years at a temperature of 2-8 ° C;
- Vaginal suppositories, gel - 3 years at a temperature of 2-25 ° C;
- Solution for intravenous administration - 5 years at a temperature of 2-25 ° C.
Terms of dispensing from pharmacies
Rectal and vaginal suppositories and solution are available with a prescription, gel - without a prescription.
Reviews about Panavir
According to reviews, Panavir in the form of rectal suppositories is well tolerated subject to the treatment regimen prescribed by the doctor, and there are practically no side effects. Doctors and patients say that intravenous administration of the drug gives excellent results after the first use for various diseases. However, Panavir solution must be used strictly in accordance with the recommendations of a specialist.
Patients also respond mostly positively about Panavir gel. According to them, in the treatment of herpes and papillomas, the drug acts much faster than analogues, in just a few days eliminating all the symptoms of herpetic activity. However, this dosage form can only cope with warts as part of complex therapy.
Vaginal suppositories can quickly get rid of discomfort in the intimate area and cure many infectious diseases.
Price for Panavir in pharmacies
The approximate price for Panavir in the form of a gel is 155-166 rubles (for a tube of 3 g) or 855-930 rubles (for a tube of 30 g). Rectal suppositories will cost 1,748–1800 rubles, and vaginal suppositories in most pharmacies can be bought for 1,739–1880 rubles (the package includes 5 pieces). The Panavir solution for intravenous administration costs 1,800–1944 rubles (the package consists of 2 ampoules).
Panavir: prices in online pharmacies
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Drug name Price Pharmacy |
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Panavir 0.002% gel for local and external use 3 g 1 pc. 116 RUB Buy |
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Panavir Dent with fluoride toothpaste 75 ml 1 pc. 116 RUB Buy |
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Panavir gel 0.002% 3g 120 RUB Buy |
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Panavir Toothpaste Dent 75 ml 134 r Buy |
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Panavir Inlight with eucalyptus gel spray for topical application with eucalyptus oil 40 ml 1 pc. 252 RUB Buy |
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Panavir Inlight spray gel 40ml 259 r Buy |
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Panavir inlay oral spray with orange fl. 40 ml 273 r Buy |
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Panavir Inlayt with orange gel spray for topical application with orange oil 40 ml 1 pc. 273 r Buy |
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Panavir Intimate spray gel-spray for topical application 40 ml 1 pc. 286 r Buy |
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Panavir Intim Spray Gel 40ml 293 r Buy |
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Panavir Inlight gel spray for local use 40 ml 1 pc. RUB 298 Buy |
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Panavir inlayt oral spray with strawberries fl. 40 ml 304 RUB Buy |
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Panavir Inlayt with strawberry gel spray for topical application 40 ml 1 pc. 304 RUB Buy |
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Panavir inlay mouth spray with mint fl. 40 ml 308 RUB Buy |
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Panavir Inlayt with mint gel spray for topical use with mint 40 ml 1 pc. 308 RUB Buy |
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Panavir inlayt oral spray with sage fl. 40 ml RUB 314 Buy |
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Panavir Inlayt with sage gel spray for topical application 40 ml 1 pc. RUB 314 Buy |
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Panavir Inlight oral spray 40 ml 317 r Buy |
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Panavir Intim Normaflor spray for intimate areas of the body 40ml 1 pc. RUB 318 Buy |
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Panavir 0.002% gel for local and external use 30 g 1 pc. 621 RUB Buy |
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Panavir supp. rekt. for children 100mkg 7 pcs. 648 r Buy |
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Panavir gel 0.002% 30g 715 RUB Buy |
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Panavir 200 mcg rectal suppositories 5 pcs. 1230 RUB Buy |
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Panavir 0.04 mg / ml solution for intravenous administration 5 ml 2 pcs. 1299 RUB Buy |
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Panavir 200 mcg vaginal suppositories 5 pcs. 1300 RUB Buy |
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Panavir solution for intravenous injection 0.004% amp. 5ml 2 pcs 1498 RUB Buy |
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Panavir vaginal suppositories. 200μg 5 pcs. RUB 1580 Buy |
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Panavir rectal suppositories. 200μg 5 pcs. 1645 RUB Buy |
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Panavir 0.04 mg / ml solution for intravenous administration 5 ml 5 pcs. 3285 RUB Buy |
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Panavir solution for intravenous injection 40μg / ml 5ml 5 pcs. 3383 RUB Buy |
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Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
