Ulkavis - Instructions For The Use Of Tablets, Price, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Ulcavis

Ulkavis: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Ulcavis

ATX code: A02BX05

Active ingredient: Bismuth tripotassium dicitrate (Bismuthate, tripotassium dicitrato)

Manufacturer: KRKA dd, Novo mesto (Slovenia)

Description and photo update: 19.10.2018

Prices in pharmacies: from 150 rubles.

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Ulcavis is a drug with antiulcer, gastroprotective and anti-Helicobacter properties.

Release form and composition

Dosage form of Ulkavis - film-coated tablets: round, slightly biconvex, with a beveled, white or almost white color; on the break, a white rough mass with a white or almost white shell is visible. Tablets are packed in blisters (10 pcs. / 14 or 15 pcs.) And packed in cardboard boxes (3, 4, 6, 10 or 24 blisters / 2, 4, 6 or 16 blisters).

Composition of 1 tablet:

• active ingredient: bismuth tripotassium dicitrate - 303.03 mg, which corresponds to 120 mg of bismuth oxide;
• auxiliary components: macrogol 6000 - 6 mg, corn starch - 72.17 mg, magnesium stearate - 2 mg, povidone K30 - 18 mg, potassium polacrilin - 23.8 mg;
• film shell: Opadry II transparent, consisting of macrogol 4000 (2.295 mg), talc (1.7 mg) and polyvinyl alcohol (4.505 mg) - 8.5 mg, titanium dioxide (E171) - 1.5 mg.

Pharmacological properties

Pharmacodynamics

Ulcavis is an anti-ulcer drug with bactericidal activity against the bacteria Helicobacter pylori, astringent and anti-inflammatory effect.

The mechanism of action of the drug is due to the ability of bismuth oxychloride and citrate to precipitate insoluble in the acidic environment of the stomach and form chelate compounds with a protein substrate in the form of a protective film on the surface of erosions and ulcers. Ulcavis increases the synthesis of prostaglandin E, the secretion of bicarbonate and the formation of mucus, stimulates the activity of cytoprotective mechanisms, reduces the activity of pepsin, increases the resistance of the mucous membrane of the gastrointestinal tract (GIT) to the effects of enzymes, hydrochloric acid, bile salts and pepsin. It leads to the accumulation of epidermal growth factor in the defect zone.

Pharmacokinetics

The active substance of the drug is practically not absorbed from the gastrointestinal tract. It is excreted mainly in the feces through the intestines. A small amount of bismuth that has entered the blood plasma is excreted by the kidneys.

Indications for use

• functional dyspepsia (only if it is not associated with organic diseases of the gastrointestinal tract);
• chronic gastritis and gastroduodenitis in the acute phase, including those associated with the bacterium Helicobacter pylori;
• peptic ulcer and 12 duodenal ulcer in the acute phase, including those associated with Helicobacter pylori;
• irritable bowel syndrome, accompanied mainly by diarrhea.

Contraindications

• severe renal failure (creatinine clearance less than 30 ml / min);
• children under 4 years of age;
• pregnancy;
• lactation;
• increased individual intolerance to the components of the drug.

Instructions for the use of Ulkavis: method and dosage

Ulcavis tablets are taken orally with a small amount of water half an hour before meals.

Recommended dosage of the drug:

• children from 12 years old and adults: 1 tablet 4 times a day (before meals and at night) or 2 tablets 2 times a day;
• children 8–12 years old: 1 tablet 2 times a day;
• children 4-8 years old: 1-2 tablets in 1-2 doses, but not more than 8 mg / kg / day.

The duration of treatment is 4 to 8 weeks.

For the eradication of the H. pylori bacteria, it is advisable to prescribe Ulcavis in combination with other antibacterial drugs, which are characterized by anti-Helicobacter activity.

Side effects

• digestive system: more frequent stools, constipation, nausea, vomiting (these phenomena are moderate and temporary);
• allergic reactions: skin rashes, itching;
• others: with prolonged use of the drug in high doses - encephalopathy.

Overdose

Symptoms: skin rash, dyspeptic disorders, characteristic darkening of the gums in the form of blue lines, inflammation of the oral mucosa; with long-term use of Ulkavis in high doses - impaired renal function. After discontinuation of the drug, these disorders are completely reversible.

As a therapeutic measure, gastric lavage, activated charcoal and a saline laxative should be taken. Further treatment is symptomatic. If renal dysfunction is diagnosed, which is accompanied by a high concentration of bismuth in the blood plasma, it is possible to use chelating agents (penicillamine or sodium dimercaptopropanesulfonate). If renal impairment is severe, hemodialysis is performed.

special instructions

The duration of treatment should not exceed 8 weeks. Do not increase the daily dose recommended by your doctor.

After the end of the course of therapy, in the case of using Ulkavis in recommended doses, the concentration of bismuth in the blood plasma does not exceed 58 μg / l. And although intoxication is possible at a concentration above 100 μg / l, during the period of therapy and within 8 weeks after its termination, the use of other drugs containing bismuth is contraindicated.

The drug may contribute to the staining of feces in a dark color. Some patients may experience slight darkening of the tongue.

Influence on the ability to drive vehicles and complex mechanisms

There was no negative effect of the drug on cognitive and psychomotor functions.

Application during pregnancy and lactation

The drug is contraindicated in women during pregnancy and lactation.

Pediatric use

According to the instructions, Ulkavis is contraindicated in children under the age of 4 years.

Drug interactions

Bismuth reduces the absorption of tetracycline.

Within half an hour before taking bismuth and half an hour after, it is not recommended to drink some liquids, take food or other drugs, in particular fruit juices, milk, fruits and antacids, since they can reduce the effect of bismuth.

Analogs

The analogues of Ulkavis are De-nol, Novobismol, Escape.

Terms and conditions of storage

Shelf life is 2 years.

Storage conditions - original packaging, place inaccessible to children, temperature up to 25 ° С.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Ulkavis

According to reviews, Ulcavis effectively eliminates heartburn and abdominal pain, improves the functioning of the gastrointestinal tract, and, subject to the dosage regimen and diet, helps to cure gastritis and stomach ulcers.

The price of Ulcavis in pharmacies

The price of Ulcavis, depending on the number of tablets in the package:

• 28 tablets - 178-233 rubles;
• 56 tablets - 325–422 rubles;
• 112 tablets - 526-648 rubles.

Ulkavis: prices in online pharmacies

Drug name Price Pharmacy

Ulcavis 120 mg film-coated tablets 28 pcs. RUB 150 Buy

Ulcavis 120 mg film-coated tablets 56 pcs. 182 r Buy

Ulcavis tablets p.p. 120mg 28 Pcs. 190 RUB Buy

Ulcavis 120 mg film-coated tablets 112 pcs. 307 r Buy

Ulcavis tablets p.p. 120mg 56 Pcs. 391 r Buy

Ulcavis tablets p.p. 120mg 112 Pcs. 589 r Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!