Tizalud
Tizalud: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Tisalud
ATX code: M03BX02
Active ingredient: tizanidine (tizanidine)
Manufacturer: OJSC "Veropharm" (Russia)
Description and photo updated: 2018-26-11
Prices in pharmacies: from 155 rubles.
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Tizalud is a centrally acting muscle relaxant.
Release form and composition
Tizalud is available in the form of tablets: white with a yellow tint or white, round, biconvex, with a dividing line (2 mg or 4 mg each: 10 pcs. In blisters, 3 packs in a cardboard box; 30 pcs. In polymeric cans, in a cardboard box 1 can).
1 tablet contains:
- active substance: tizanidine hydrochloride - 2.288 mg or 4.576 mg, which corresponds to the content of 2 mg or 4 mg of tizanidine;
- auxiliary components: anhydrous lactose (lactopress), sodium carboxymethyl starch (primogel), microcrystalline cellulose, magnesium stearate.
Pharmacological properties
Pharmacodynamics
Tizalud is a centrally acting muscle relaxant with the active substance tizanidine. The clinical efficacy of tizanidine is due to its ability to exert a stimulating effect on presynaptic alpha 2 -adrenergic receptors, suppressing the release of excitatory amino acids from intermediate neurons of the spinal cord. As a result, in the spinal cord, the polysynaptic transmission of excitation is inhibited, which causes a decrease in muscle tone. Along with muscle relaxant properties, the drug has a central moderately pronounced analgesic effect.
Due to a decrease in spasticity and clonic seizures, resistance to passive movements decreases, and the ability to increase the volume of active movements increases. Shown for use in painful muscle spasms, chronic spasms of spinal and cerebral genesis.
Pharmacokinetics
After oral administration, tizanidine is rapidly absorbed. The maximum concentration (C max) in plasma is reached after 1–2 hours. The bioavailability of the drug is 34%. Simultaneous food intake does not affect the pharmacokinetics of tizanidine.
The volume of distribution is 2.6 l / kg.
Plasma protein binding is 30% of the dose taken.
The linear nature of the pharmacokinetics of the drug remains in the dose range from 4 mg to 20 mg.
Metabolism occurs in the liver quickly, up to 95% of tizanidine is exposed to it with the formation of inactive metabolites.
The half-life (T 1/2) is 2-4 hours.
Through the kidneys, 70% of the dose is excreted in the form of metabolites, unchanged - 2.7%.
In renal failure with creatinine clearance (CC) up to 25 ml / min, plasma C max of tizanidine increases 2 times, and the total concentration (AUC) - 6 times. There is a deceleration of T 1/2 to 14 hours.
Indications for use
- muscle spasm caused by functional and static diseases of the cervical and lumbar spine, accompanied by pain syndrome;
- painful muscle spasm that arose after surgery, including for a herniated disc, osteoarthritis of the hip joint;
- spasticity of skeletal muscles in neurological diseases such as multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord, infantile cerebral palsy in patients over 18 years of age, the consequences of cerebrovascular accident.
Contraindications
- severe liver dysfunction;
- the simultaneous use of fluvoxamine, ciprofloxacin and other strong inhibitors of the CYP1A2 isoenzyme;
- hereditary lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome;
- age up to 18 years;
- breast-feeding;
- hypersensitivity to the components of the drug.
With caution, Tizalud tablets should be prescribed for arterial hypotension, bradycardia, renal failure, concomitant use of oral contraceptives, patients with congenital prolongation of the QT interval syndrome, patients over the age of 65 years.
Instructions for use Tizaluda: method and dosage
Tizalud tablets are taken orally.
Recommended dosage:
- painful muscle spasm: 2-4 mg 3 times a day. If necessary, to relieve severe muscle spasm, you can additionally take 2-4 mg of the drug before bedtime;
- treatment of muscle spasticity caused by neurological pathologies: the initial dose is 2 mg 3 times a day. With an interval of 3–7 days, the dose is gradually (by 2–4 mg) increased to an optimal daily dose of 12–24 mg, divided into 3–4 doses. The maximum daily dose is 36 mg.
The initial daily dose of Tizalud for patients with renal insufficiency with CC less than 25 ml / min should be 2 mg. Then, taking into account the effectiveness and tolerability of the drug, the dose can be gradually increased. To obtain a more pronounced effect, it is first recommended to use a single dose of an increased dose, and then proceed to increasing the frequency of administration.
Cancellation of Tizalud should be done by gradually reducing the dose of the drug, since a sharp cessation of its use can cause a withdrawal syndrome in the patient.
Side effects
- from the nervous system: sleep disturbances, insomnia, drowsiness, hallucinations, dizziness;
- from the musculoskeletal system: muscle weakness;
- on the part of the cardiovascular system: bradycardia, lowering of blood pressure (including pronounced, up to loss of consciousness and collapse);
- from the digestive system: dry mouth, dyspepsia, nausea, increased activity of liver enzymes, liver failure, hepatitis;
- others: increased fatigue, hypercreatininemia; against the background of abrupt withdrawal after long-term treatment and / or the use of high doses of the drug, as well as after therapy in combination with antihypertensive drugs - increased blood pressure (BP), tachycardia, in some cases, acute cerebrovascular accident is possible.
Overdose
Symptoms: drowsiness, a significant decrease in blood pressure, nausea, vomiting, dizziness, anxiety, respiratory failure, miosis, coma.
Treatment: immediate gastric lavage, intake of activated charcoal, appointment of forced diuresis, symptomatic therapy.
special instructions
The use of Tizaluda in a daily dose of 12 mg and above must be accompanied by regular monitoring of liver function (during the first 4 months of treatment - once a month). An examination of the functional state of the liver is also required for those patients who have such clinical signs of liver dysfunction as unexplained nausea, feeling of fatigue, anorexia. If the activity indices of ACT (aspartate aminotransferase) and ALT (alanine aminotransferase) consistently exceed 3 times or more the upper limit of the norm, the use of tizanidine should be canceled.
Tizalud should be used with caution in patients with congenital prolongation of the QT interval.
The use of alcohol and the ingestion of ethanol-containing drugs is contraindicated while taking tizanidine.
Influence on the ability to drive vehicles and complex mechanisms
According to the instructions, Tizalud can cause drowsiness, dizziness and have a negative effect on the speed of psychomotor reactions and the patient's ability to concentrate. In this regard, during the period of treatment, it is recommended to observe extreme caution when driving and working with complex mechanisms.
Application during pregnancy and lactation
It is not recommended to use Tizalud during gestation, unless, in the opinion of the doctor, the expected effect of treatment for the mother outweighs the possible risk to the fetus.
The appointment of tizanidine during lactation is contraindicated, since it is excreted in small quantities in breast milk. In case of clinical need for taking the drug, breastfeeding should be discontinued.
Pediatric use
Due to the limited experience with the use of tizanidine in children under 18 years of age, the use of Tizalud is not recommended for the treatment of patients of this age category.
With impaired renal function
With caution, Tizalud should be prescribed for renal failure.
For violations of liver function
The use of Tizalud is contraindicated in case of severe liver dysfunction.
Use in the elderly
It is recommended to take Tizalud with caution to patients over the age of 65 years.
Drug interactions
The concomitant use of Tizaluda with inhibitors of the CYP1A2 isoenzyme (including fluvoxamine, ciprofloxacin, amiodarone, mexiletine, propafenone, cimetidine, enoxacin, pefloxacin, norfloxacin, rofecoxib, ticlopidine, oral contraceptives) causes a significant increase in AUC. The consequence of this combination may be a condition that is accompanied by a clinically significant and prolonged decrease in blood pressure, drowsiness, delayed psychomotor reactions, and weakness. In some cases, there may be loss of consciousness, up to collapse.
When combined with antihypertensive drugs, the risk of a pronounced decrease in blood pressure and the development of bradycardia increases.
Sedative drugs, ethanol increase the sedative effect of tizanidine.
Analogs
Tizalud's analogues are: Liorezal, Tizanil, Baklosan, Midocalm, Tizanidin, Tolperizon, Tolperil, Sirdalud.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Tizaluda
Reviews about Tizaluda are mostly positive. Most patients indicate a high efficacy of the drug. They note the rapid onset of a decrease in muscle tone and analgesic action, and the absence of undesirable effects.
There are negative reviews of patients who immediately after taking the pill experienced weakness, dizziness, a sharp decrease in blood pressure and other side effects.
The price of Tizalud in pharmacies
The price of Tizalud for a package containing 30 tablets in a dose of 2 mg can range from 158 rubles, 4 mg - from 202 rubles.
Tizalud: prices in online pharmacies
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Drug name Price Pharmacy |
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Tizalud 2 mg tablets 30 pcs. 155 RUB Buy |
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Tizalud 4 mg tablets 30 pcs. 169 RUB Buy |
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Tizalud tablets 2mg 30 pcs. RUB 186 Buy |
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Tizalud tablets 4mg 30 pcs. 262 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
