Neuroubin
Neurorubin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Neurorubine
ATX code: A11DB
Active ingredient: thiamine hydrochloride (vitamin B1), pyridoxine hydrochloride (vitamin B6), cyanocobalamin (vitamin B12) [Thiamine hydrochloride (Vitamin B1), Pyridoxine hydrochloride (Vitamin B6), Cyanocobalamin (Vitamin B12)]
Producer: Merkle GmbH (Germany), Mefa LLS (Mepha LLC) (Switzerland)
Description and photo update: 2019-20-08
Neurorubin is a complex preparation of B vitamins.
Release form and composition
Neurorubin is produced in the form of a solution for injection (in dark glass ampoules, 3 ml, 5 ampoules in a cardboard box).
1 ampoule contains active substances:
- Vitamin B1 (as thiamine hydrochloride) - 100 mg
- Vitamin B6 (as pyridoxine hydrochloride) 100 mg
- Vitamin B12 (as cyanocobalamin) 1 mg
Auxiliary components: benzyl alcohol, potassium cyanide, water for injection.
Pharmacological properties
Pharmacodynamics
The combination of high doses of three B vitamins in the preparation Neurorubin: thiamine, pyridoxine and cyanocobalamin, provides its clinically significant effect on the activity of the nervous system. Each of them is necessary to optimize metabolic processes in nerve cells. In addition, the combination of high doses of these vitamins provides the analgesic effect of Neurorubin, relieving pain accompanying neurological diseases of various origins.
Vitamins B 1, B 6 and B 12 are not synthesized directly in the body, like all other vitamins. As essential nutrients, they require therapeutic administration to replenish insufficient dietary intake and provide the required amount of coenzymes. B vitamins are also included in the enzyme systems that regulate the metabolism of proteins, fats and carbohydrates, each of them performs a specific biological function, in a balanced amount, their presence is necessary for normal metabolism.
Vitamins B 1 and B 6 mutually potentiate the pharmacodynamic properties of each other, enhancing the positive effect on the nervous, cardiovascular and muscular systems.
Pharmacological action of the components of Neuroubin:
- thiamine (vitamin B 1): as a result of phosphorylation, it is transformed into cocarboxylase, an important coenzyme of many enzymatic reactions; plays a significant role in the processes of conduction in synapses of nervous excitement, is necessary for carbohydrate, protein and fat metabolism;
- pyridoxine (vitamin B 6): required for the normal functioning of the central and peripheral nervous system, participates in the metabolic process; the phosphorylated form of pyridoxine (pyridoxal-5-phosphate) acts as a coenzyme for a large number of enzymes that affect the non-oxidative metabolism of amino acids (for example, decarboxylation and transamination processes); pyridoxine takes part in the metabolism of methionine, cysteine, tryptophan, glutamic and other amino acids, is important in the metabolism of histamine, and also contributes to the normalization of fat metabolism;
- cyanocobalamin (vitamin B 12): has a high pharmacological activity; participates in the process of hematopoiesis, contributing to the maturation of erythrocytes; necessary for remethylation, hydrogen transport, formation of nucleic acids, methionine, choline, creatine; in erythrocytes contributes to the cumulation of compounds containing sulfhydryl groups; has a beneficial effect on the function of the nervous system and liver; stimulates hematopoiesis, relieves pain arising from damage to the peripheral nervous system, participates in the synthesis of the myelin sheath, stimulates the exchange of nucleic acids by activating folic acid; activates the hemocoagulation system, in high doses potentiates the growth of prothrombin and thromboplastin activity.
The use of thiamine, pyridoxine and cyanocobalamin in the complex therapy of various diseases of the nervous system is aimed at simultaneously compensating for the existing deficit (possibly due to an increased body demand due to the disease) and stimulating natural recovery mechanisms. Vitamins B 1, B 6 and B 12 have low toxicity, do not pose a potential risk to the patient. To date, there is no data on the mutagenic, carcinogenic or teratogenic effects of these vitamins.
Pharmacokinetics
Water-soluble vitamins are completely absorbed after entering the body, other pharmacokinetic properties:
- vitamin B 1: the proportion of assimilated thiamine is involved in the intestinal-hepatic circulation of bile acids. In unchanged form, thiamine is excreted in a small amount, mainly excreted in the form of metabolites: thiamincarboxylic acid and pyramine (2,5 dimethyl-4-aminopyrimidine);
- vitamin B 6: pyridoxine is aminated in the body to pyridoxamine or oxidized to pyridoxal; as a coenzyme, pyridoxine functions as pyridoxal-5-phosphate (PALP) resulting from phosphorylation at the CH 2 OH group in the fifth position; up to 80% of PALP binds to plasma proteins, accumulates pyridoxine in the form of PALP mainly in muscle tissue; excreted mainly in the form of 4-pyridoxinic acid;
- vitamin B 12: after absorption, cyanocobalamin in serum binds mainly to such proteins - specific B 12 -binding β-globulin (transcobalamin) and B 12 -binding α1-globulin; vitamin B 12 is accumulated mostly in the liver; half-life (T 1/2) from blood serum ~ 5 days, and from liver ~ 1 year.
Indications for use
- Neuritis;
- Neuropathy and polyneuropathy (alcoholic, diabetic and others);
- Sciatica, cervicobrachialgia, trigeminal neuralgia.
Contraindications
- Psoriasis;
- Age under 18;
- Pregnancy and lactation;
- Hypersensitivity to the components of Neurorubin.
Instructions for the use of Neurobin: method and dosage
Neurorubin is injected intramuscularly into the upper outer quadrant of the gluteus maximus.
In severe cases, at the beginning of treatment, 1 ampoule (3 ml) is prescribed daily or every other day. After reducing pain, Neurorubin is administered in the same dose 1-2 times a week.
In moderate cases, usually 1 ampoule is prescribed 1-2 times a week.
Side effects
- Cardiovascular system: in isolated cases - collapse, tachycardia, cyanosis;
- Central nervous system: anxiety, tremors, feeling of a lump in the throat, anxiety, dizziness;
- Digestive system: nausea, gastrointestinal bleeding, increased plasma aspartate aminotransferase activity;
- Endocrine system: inhibition of prolactin release;
- Respiratory system: pulmonary edema, shortness of breath;
- Skin: acne;
- Allergic reactions: itching, urticaria, Quincke's edema, anaphylactic shock;
- The body as a whole: a feeling of weakness, sudden sweating, facial flushing, increased body temperature.
Overdose
An overdose of Neurorubin increases symptoms of side effects such as arrhythmia, dizziness, convulsions.
Possible reactions in case of an overdose of the components of the B complex vitamins:
- vitamin B 1: due to the wide therapeutic range of thiamine, when taken in very high doses (more than 10,000 mg), the conduction of nerve impulses is suppressed, revealing a curariform effect;
- vitamin B 6: pyridoxine has ultra-low toxicity, but its use in high doses (more than 1000 mg per day) for several months can show neurotoxic effects; after administration in a daily dose of more than 2000 mg, reactions such as neuropathy with ataxia and sensory disturbances, cerebral convulsions with changes in the electroencephalogram have been described, in some episodes, seborrheic dermatitis and hypochromic anemia were observed;
- vitamin B 12: after parenteral administration of cyanocobalamin in doses higher than recommended, hypersensitivity reactions, a benign form of acne and eczematous skin rashes were observed in rare cases; long-term use of high doses can cause impaired activity of liver enzymes, hypercoagulability, pain in the heart.
If you suspect exceeding the recommended dosage, you should stop using Neuroubin and, if necessary, carry out symptomatic treatment.
special instructions
In some cases, repeated intramuscular injections of preparations containing vitamins can cause the development of anaphylactoid reactions in patients predisposed to them. If they occur, it is necessary to cancel Neurorubin and prescribe glucocorticosteroids and antihistamines.
The use of excessive doses of vitamin B6 (over 5 months at a dose of 500 mg or more) can lead to peripheral sensory neuropathy, which usually disappears after the end of therapy.
Due to the possible worsening of psoriasis symptoms, the use of vitamin B12 is contraindicated in patients with such a diagnosis.
Influence on the ability to drive vehicles and complex mechanisms
In rare cases, when using Neurorubin, dizziness, weakness, anxiety may develop, therefore, patients during therapy need to be careful when driving or performing potentially dangerous types of work.
Application during pregnancy and lactation
Neurorubin is contraindicated for pregnant women and women who are breastfeeding.
Pediatric use
According to the instructions, Neurorubin is contraindicated for the treatment of children and adolescents under 18 years of age.
With impaired renal function
Caution is required to prescribe Neurorubin to patients with severe renal impairment.
For violations of liver function
Caution is required to prescribe Neurorubin to patients with severe hepatic dysfunction.
Drug interactions
It is impossible to mix Neurorubin with other medicines.
Thiamine is incompatible with tannic acid, mercury chloride, oxidizing agents, carbonate, iodide, acetate, iron ammonium / citrate, as well as riboflavin, phenobarbital, benzylpenicillin, metabisulfite and dextrose.
With the simultaneous use of Neurorubin with some drugs, the following effects may occur:
- Levodopa: a decrease in its therapeutic effect (simultaneous use is not recommended);
- Isoniazid: increasing its toxicity;
- 5-fluorouracil, thiosemicarbazone: decrease in the effectiveness of vitamin B1;
- Altretamine: decrease in its effectiveness;
- Vitamin C: inactivation of vitamin B6.
Analogs
Neurobine analogs are: Vitaxon, Neurobion, Neurovitan, Neuromultivitis, Nerviplex, Neurobeks, Unigamma.
Terms and conditions of storage
Keep out of the reach of children at a temperature of 2-8 ° C (in the refrigerator).
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews of Neurorubin
Despite the fact that the drug is produced by a well-known pharmaceutical company, it has not passed state registration in the Russian Federation, so there are few reviews about Neurobin. Almost all patients are satisfied with the effect of the drug. The advantages of the vitamin complex include its effectiveness, a quick effect on nerve endings for back pain, and a beneficial effect on the nervous system.
The painfulness of the injections and the high cost of the solution are indicated as disadvantages.
Price for Neurorubin in pharmacies
The approximate price of Neuroubin, solution for injection, 3 ml in ampoules, per pack of 5 ampoules - 1350 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
