Motigect - Instructions For The Use Of Tablets, Price, Reviews, Analogues

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Motigect - Instructions For The Use Of Tablets, Price, Reviews, Analogues
Motigect - Instructions For The Use Of Tablets, Price, Reviews, Analogues

Video: Motigect - Instructions For The Use Of Tablets, Price, Reviews, Analogues

Video: Motigect - Instructions For The Use Of Tablets, Price, Reviews, Analogues
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Motigect: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  11. 11. In case of impaired renal function
  12. 12. For violations of liver function
  13. 13. Drug interactions
  14. 14. Analogs
  15. 15. Terms and conditions of storage
  16. 16. Terms of dispensing from pharmacies
  17. 17. Reviews
  18. 18. Price in pharmacies

Latin name: Motizhekt

ATX code: A03FA03

Active ingredient: Domperidone (Domperidone)


Description and photo update: 2018-24-10

Film-coated tablets, Motiject
Film-coated tablets, Motiject

Motiject is a centrally acting antiemetic drug, prokinetic.

Release form and composition

Dosage form Motijekt - film-coated tablets: round, biconvex, with a white or almost white shell, the core on a cross-section is white with a yellowish tinge or white (in a cell contour packaging of 10 or 15 pcs., In a cardboard box 3 packs of 10 pcs. Or 2 packs of 15 pcs.).

Composition of one Motiject tablet:

  • active substance: domperidone - 10 mg;
  • auxiliary components (core): lactose monohydrate (milk sugar), potato starch, microcrystalline cellulose, colloidal silicon dioxide (aerosil), magnesium stearate, medium molecular weight polyvinylpyrrolidone (povidone), sodium lauryl sulfate;
  • shell: opadry II [lactose monohydrate, hypromellose (hydroxypropyl methylcellulose), titanium dioxide, macrogol 4000].

Pharmacological properties


The pharmacological action of domperidone, the active substance of Motijekt, is due to the blockade of peripheral and central dopamine receptors, as a result of which the inhibitory effect of the neurotransmitter dopamine on the peristalsis and motor activity of the digestive system is suppressed. The drug stimulates the motor and evacuation activity of the stomach, thereby eliminating nausea, hiccups and has an antiemetic effect. Domperidone increases the concentration of lactogenic hormone in the blood serum.


The active substance is rapidly absorbed in the gastrointestinal tract when taken orally on an empty stomach. The food in the stomach, as well as the low acidity of the gastric juice, slow down and reduce absorption. The maximum content of domperidone in blood plasma occurs approximately 60 minutes after ingestion. Bioavailability after the effect of the first pass through the liver is about 15%. 90% of the substance binds to blood plasma proteins. Domperidone has the ability to penetrate into various tissues of the body, its passage through the blood-brain barrier is weak. Metabolism occurs through hydroxylation and N-dealkylation reactions in the liver and in the intestinal wall. The drug is excreted in the following proportions: 66% - through the intestines, 33% - by the kidneys, including in unchanged form - 10 and 1%, respectively. Half-life (T1/2) - from 7 to 9 hours (increases with severe renal dysfunction).

Indications for use

  • vomiting, nausea, hiccups of various origins: against the background of infections, organic and functional diseases; when conducting radiation therapy, toxemia, endoscopy, X-ray contrast studies of the gastrointestinal tract; with dietary disorders; while taking certain medications (levodopa, morphine, bromocriptine and apomorphine); in the postoperative period;
  • DVP (biliary dyskinesia);
  • atony and hypotension of the gastrointestinal tract (including postoperative);
  • reflux esophagitis;
  • flatulence, feeling of bloating;
  • cholecystitis, cholangitis;
  • various options for functional and organic dyspepsia;
  • nausea and vomiting caused by taking dopaminomimetics.



  • gastrointestinal bleeding;
  • perforation of the intestine or stomach;
  • intestinal obstruction of a mechanical nature;
  • prolactinoma;
  • hypolactasia (lactose intolerance), glucose-galactose malabsorption;
  • children under 5 years of age and body weight less than 20 kg;
  • individual hypersensitivity to domperidone or any auxiliary component.

Relative (diseases / conditions, the presence of which requires caution when prescribing Motijekt):

  • impaired renal function;
  • liver dysfunction;
  • pregnancy and lactation.

Instructions for the use of Motijekt: method and dosage

Motigect tablets are taken orally 15-30 minutes before meals.

Recommended dosage: adults and children over 5 years old - 1 tablet (10 mg) 3-4 times a day, if necessary, you can take an additional 1 tablet before bedtime. In cases of severe nausea, vomiting, severe indigestion - 2 tablets (20 mg) 3-4 times a day and before bedtime.

For patients with impaired renal function, the dose of domperidone should be adjusted by reducing the frequency of administration of the drug to 1-2 times a day.

Side effects

  • from the central nervous system: rarely - extrapyramidal syndromes (in patients with increased permeability of the blood-brain barrier and in children), increased excitability, headache;
  • from the digestive system: transient spasms of intestinal smooth muscles, thirst, dry mouth;
  • allergic reactions: urticaria, itching, skin rash;
  • others: an increase in the concentration of prolactin in the blood plasma (hyperprolactinemia), gynecomastia, galactorrhea.


In case of an overdose of the drug, the following symptoms may appear: disorientation, drowsiness, extrapyramidal syndromes (especially in children).

Treatment for intoxication is to take activated carbon. In cases of extrapyramidal disorders, anticholinergic, antiparkinsonian drugs or antihistamines with anticholinergic properties are used.

special instructions

The use of Motijekt in patients with impaired renal and liver function requires caution.

Application during pregnancy and lactation

It is necessary to use the drug in pregnant and breastfeeding women with caution and in the case when the expected benefit to the mother is higher than the potential risk to the fetus and child.

Pediatric use

According to the instructions, Motijekt is contraindicated in children under 5 years of age and children weighing less than 20 kg.

With impaired renal function

Patients with renal insufficiency should be careful to take Motiject, the frequency of administration is recommended to be reduced to 1-2 times a day.

For violations of liver function

The use of Motigect for violations of liver function requires caution.

Drug interactions

  • antacid and anticholinergic drugs: neutralizing the action of domperidone;
  • cimetidine, sodium bicarbonate: decreased bioavailability of domperidone;
  • antifungal agents of the azole series, HIV protease inhibitors, antibiotics of the macrolide group, nefazodone (antidepressant): increasing the concentration of domperidone in the blood plasma;
  • antipsychotic drugs (neuroleptics), dopamine receptor agonists (bromocriptine, levodopa): good compatibility when taken simultaneously with domperidone;
  • paracetamol, digoxin: no effect on their concentration in the blood.


Analogues of Motijekt are: Domperidon, Domridon, Motilak, Motilium, Motonium, Passage and others.

Terms and conditions of storage

Store in a dark, dry place at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Motijekt

In reviews about Motijekt, they note its effectiveness in cases of disorders of the digestive processes, as well as the low cost of the drug.

The medicine helps many with nausea, feeling of heaviness in the stomach, bloating, hiccups. In this case, the action occurs quickly enough. The drug practically does not cause side effects.

Price for Motiject in pharmacies

The average price for Motiject (for a pack of 30 tablets) is approximately 150 rubles.

Anna Kozlova
Anna Kozlova

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!