Momat Reno
Momat Rino: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Momat Rino
ATX code: R01AD09
Active ingredient: Mometasone (Mometasone)
Manufacturer: GLENMARK PHARMACEUTICALS, Ltd. (India)
Description and photo update: 2018-22-10
Prices in pharmacies: from 246 rubles.
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Momat Rino is a topical glucocorticosteroid (GCS).
Release form and composition
The dosage form of Momat Rino is a metered-dose nasal spray: a suspension of a thick consistency, translucent or opaque, almost white or white (60 and 120 doses each in polyethylene bottles with a dispensing device, 1 bottle in a cardboard box).
Spray composition:
- active substance: mometasone furoate (in the form of monohydrate), in 1 dose - 50 mcg;
- additional components: avicel RC-591 (microcrystalline cellulose, sodium carmellose), benzalkonium chloride, citric acid monohydrate, glycerol, polysorbate-80, sodium citrate dihydrate, water for injection.
Pharmacological properties
Pharmacodynamics
Mometasone furoate is a synthetic corticosteroids for local use with anti-inflammatory and antiallergic effects (when used in doses that do not cause systemic effects).
Mometasone increases the production of lipomodulin, an inhibitor of phospholipase A, as a result of which the release of arachidonic acid decreases, the synthesis of prostaglandins and cyclic endoperoxides (products of arachidonic acid metabolism) is inhibited. Prevents the marginal accumulation of neutrophil cells, thereby reducing inflammatory exudate and production of lymphokines, stopping the migration of macrophages, reducing the processes of infiltration and granulation.
The drug prevents the development of an immediate type of allergic reaction by inhibiting the production of metabolites of arachidonic acid and reducing the release of inflammatory mediators from mast cells. Reduces the severity of the inflammatory process by reducing the formation of the chemotaxis substance (affects the "late" allergy reactions).
Pharmacokinetics
The systemic bioavailability of mometasone with intranasal administration is less than 1% (with a sensitivity of the method of determination of 0.25 pg / ml). In the gastrointestinal tract, the suspension is practically not absorbed, and the small amount that can get there after nasal inhalation undergoes active primary metabolism even before excretion with bile and urine.
Indications for use
- nasal polyposis, accompanied by impaired sense of smell and nasal breathing, in adults;
- acute rhinosinusitis with mild to moderate symptoms in children over 12 years of age and adults (provided there are no signs of severe bacterial infection);
- acute sinusitis and exacerbation of chronic sinusitis in children from 12 years of age and adults (including the elderly) - as an aid in antibiotic therapy;
- seasonal and year-round allergic rhinitis in children from 2 years of age and adults;
- prevention of moderate and severe seasonal allergic rhinitis in children from 12 years of age and adults (2-4 weeks before the expected start of the dusting season).
Contraindications
- recent trauma with damage to the nasal mucosa or surgery (until the wound heals);
- hypersensitivity to any component of the drug.
Use in childhood: for allergic rhinitis, Momat Rino is contraindicated in children under 2 years of age, for sinusitis - up to 12 years, with polyposis - up to 18 years.
According to the instructions, Momat Reno should be used with caution (according to strict indications, only as directed by a doctor, after assessing the benefits / risks) in the following cases:
- untreated local infection in which the nasal mucosa is involved;
- active and latent tuberculosis infection of the respiratory tract;
- active systemic viral, bacterial, fungal infection or Herpes simplex infection with lesion.
Instructions for use of Momat Rino: method and dosage
Spray Momat Rino is used intranasally. Inhalation is carried out using the dispensing nozzle provided in the kit.
Before using the spray for the first time, you must calibrate it - press the dispensing nozzle 10 times until splashes appear. This indicates the readiness of the drug for use. If the product is not used for 14 or more days in a row, before use, you should make 2 test pressing in the air until splashes appear.
For inhalation, you need to tilt your head and inject a spray into each nasal passage as recommended by your doctor.
The dispensing tip must be cleaned regularly. This is essential for its correct operation. To do this, remove the protective cap, and then the spray tip and rinse them thoroughly in warm water, rinse under a tap and dry in a warm place, after which the tip must be attached to the bottle and closed with a protective cap.
Do not pierce the nasal applicator or try to open it with sharp objects (for example, needles), otherwise this will lead to damage and, possibly, inappropriate further dosing of the drug.
After cleaning, before the first use, it is necessary to calibrate - press the dispensing nozzle 2 times into the air.
Before each use of Momat Reno, shake the bottle vigorously.
Seasonal and perennial allergic rhinitis
For prevention and treatment, children over 12 and adults are prescribed 2 inhalations in each nostril once a day (total daily dose is 200 mcg). During therapy, after improvement of the condition, it is possible to reduce the dose to a maintenance one - 1 inhalation in each nasal passage once a day (total daily dose - 100 μg).
If it is not possible to reduce the symptoms of the disease when using Momat Rino in the recommended therapeutic dose, it is possible to increase the daily dose to 400 μg - 4 inhalations in each nostril 1 time per day. After reducing the severity of symptoms, the dose is reduced.
Children from 2 to 11 years old are prescribed 1 inhalation in each nasal passage once a day (the total daily dose is 100 mcg). Young children require adult help when using the drug.
Momat Rino nasal spray begins to act 12 hours after the first inhalation.
Acute sinusitis and exacerbation of chronic sinusitis (adjuvant therapy)
For prevention and treatment, children from 12 years old and adults are prescribed 2 inhalations in each nostril 2 times a day (total daily dose - 400 mcg).
If it is not possible to reduce the symptoms of the disease when using Momat Rino in the recommended therapeutic dose, it is possible to increase the daily dose to 800 mcg - 4 inhalations in each nostril 2 times a day. After a decrease in the severity of symptoms, the dose is reduced.
Acute rhinosinusitis without evidence of severe bacterial infection
Children from 12 years old and adults are prescribed 2 inhalations 2 times a day.
If symptoms worsen, a doctor should be consulted.
Polyposis of the nose
Adults are prescribed 2 inhalations in each nasal passage 2 times a day.
After reducing the symptoms of the disease, it is recommended to reduce the dose to 2 inhalations 1 time per day.
Side effects
Adults and adolescents
- on the part of the respiratory system, chest and mediastinal organs: very often (≥ 1/10) - nosebleeds (with nasal polyposis in the case of using the drug 2 times a day); often (from ≥ 1/100 to <1/10) - irritation of the nasal mucosa, burning sensation in the nose, ulceration of the nasal mucosa, nosebleeds (i.e., obvious bleeding, as well as the release of blood clots or blood-stained mucus); unspecified frequency (based on available data, it is not possible to determine the frequency of occurrence of adverse reactions) - perforation of the nasal septum;
- infectious and parasitic diseases: often - upper respiratory tract infections (this side effect rarely occurs with nasal polyposis if the drug is used 2 times a day), pharyngitis;
- from the nervous system: often - headache;
- from the gastrointestinal tract: often - irritation of the pharynx (with nasal polyposis in the case of using the drug 2 times a day); unspecified frequency - violation of taste and smell;
- on the part of the organ of vision: unknown frequency - glaucoma, increased intraocular pressure, cataract;
- from the immune system: unknown frequency - hypersensitivity reactions, including shortness of breath, bronchospasm, angioedema, anaphylactic reactions.
Children
The incidence of adverse events in children with Momat Rino was comparable to that with placebo.
During the period of drug therapy, the following side effects may be observed:
- from the nervous system: headache (3%);
- from the respiratory system, chest and mediastinal organs: nosebleeds (6%), irritation of the nasal mucosa (2%), sneezing (2%).
Intranasal GCS, especially when used in high doses and (or) for a long time, can cause the development of systemic side effects.
Overdose
With prolonged treatment with the drug in high doses, as well as in the case of the simultaneous use of other GCS, it is possible to suppress the function of the hypothalamic-pituitary-adrenal system.
Given the low systemic bioavailability of mometasone, it is unlikely that overdose (intentional or accidental) will require any therapeutic measures other than observation.
special instructions
When carrying out long-term therapy, patients need to undergo periodic examinations by a doctor in order to timely identify possible changes in the nasal mucosa and the development of systemic side effects.
In case of persistent irritation of the nasal or pharyngeal mucosa, it may be necessary to cancel the Reno Momat.
During the period of GCS therapy, patients have a potentially reduced immune reactivity, therefore, they need to be warned of the increased risk of infection in contact with patients with certain infectious diseases (for example, measles or chickenpox). If such contact has occurred, the patient should consult a doctor for advice.
If a local fungal infection of the nose / throat develops, Momat Reno is discontinued and appropriate therapy is prescribed.
Immediate medical advice is required if signs of severe bacterial infection appear: fever, swelling in the periorbital or orbital region, persistent and sharp toothache or pain on one side of the face.
Special observation is required for patients who are transferred to Momat Reno after prolonged use of systemic GCS. Systemic drugs, if discontinued, can lead to adrenal insufficiency, which may take several months to recover. For this reason, if signs of adrenal insufficiency appear, you should resume taking systemic corticosteroids and take other necessary measures.
In some patients, when switching to Momat Reno from systemic corticosteroids, despite a decrease in symptoms of damage to the nasal mucosa, initial symptoms of withdrawal syndrome occur [for example, fatigue, depression, muscle and / or joint pain], nevertheless, continued therapy is recommended nasal spray.
Also, when switching to local GCS, it is possible to develop allergic diseases (eczema, allergic conjunctivitis, etc.), which were already there, but were masked by drugs of systemic action.
The safety and efficacy of mometasone in the treatment of bleeding polyps, unilateral irregular polyps, polyps that completely cover the nasal cavity, and polyps associated with cystic fibrosis have not been studied.
When using GCS in higher doses than recommended, clinically significant suppression of adrenal function is possible. When prescribing Momat Rino in high doses during periods of stress and elective surgery, additional intake of systemic corticosteroids may be required.
With prolonged use of a nasal spray in high doses, systemic side effects may develop. This risk is significantly lower compared to taking systemic corticosteroids and may differ from patient to patient. Potential systemic reactions include a range of psychological and behavioral effects, including anxiety, sleep disturbance, psychomotor hyperactivity, depression and aggression (especially in children), as well as adrenal suppression, glaucoma, cataracts, Cushingoid features, Cushing's syndrome, growth retardation in children and adolescents.
Children who have been receiving mometasone for a long time should be monitored regularly for growth. If it slows down, it is necessary to revise the therapy regimen in order to reduce the dose of Momata Rino to the lowest effective dose that would allow controlling the symptoms of the disease. Consultation of a pediatrician is also required.
Influence on the ability to drive vehicles and complex mechanisms
No information available.
Application during pregnancy and lactation
For women during pregnancy and lactation, Momat Reno can only be prescribed if the expected benefits justify the potential risks, since well-controlled and specially designed studies on the use of mometasone during these periods have not been conducted.
Infants whose mothers received drug therapy during pregnancy should be carefully examined for possible adrenal hypofunction.
Pediatric use
With allergic rhinitis, Momat Rino is contraindicated in children under 2 years old, with sinusitis - up to 12 years old, with polyposis - up to 18 years old.
Drug interactions
Patients tolerate combination therapy with loratadine well. There was no negative effect of mometasone on the plasma concentration of loratadine or its metabolites.
Analogs
Analogues of Momat Rino are nasal sprays Galazolin Allegro, Dezrinit, Nasonex, Nosefrin.
Terms and conditions of storage
Store in a dark place, out of reach of children, at a temperature of 15-25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Momat Reno
On specialized medical forums, there are no reviews about Momat Rino, which would allow evaluating the effectiveness of the drug when used according to indications.
Price for Momat Reno in pharmacies
The price of Momat Reno is 310-450 rubles per bottle containing 120 doses. The cost of a bottle containing 60 doses is not known for sure, since it is difficult to find the drug in this package in the pharmacy network.
Momat Reno: prices in online pharmacies
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Drug name Price Pharmacy |
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Momat Rino 50 mcg / dose 60 doses nasal spray dosed 1 pc. 246 r Buy |
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Momat rino spray nasal dosage. 50mcg / dose vial 60 doses 253 r Buy |
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Momat Rino 50 mcg / dose 120 doses nasal spray dosed 1 pc. 304 RUB Buy |
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Momat Reno spray nasal. dosage. 50 mcg / dose vial 120 doses (with dosing device) 322 RUB Buy |
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Momat Rino Advance 140 mcg + 50 mcg / dose 150 doses nasal spray dosed 1 pc. 346 r Buy |
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Reviews Momat Rino Advance 346 r Buy |
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Momat Rino Advance 140 mcg + 50 mcg / dose 75 doses nasal spray dosed 1 pc. 359 r Buy |
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Momat Rino Advance ref. called dosage. 140 mcg + 50 mcg / dose vial 75 doses 441 r Buy |
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Momat Reno Advance nasal spray. dosage. 140mcg + 50mcg / dose 150 doses 480 RUB Buy |
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Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
