Myconorm
Miconorm: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Miconorm
ATX code: D01AE15
Active ingredient: terbinafine (Terbinafine)
Producer: Rusan Pharma, Ltd. (Rusan Pharma, Ltd) (India)
Description and photo update: 09.10.2019
Prices in pharmacies: from 389 rubles.
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Mikonorm is an antifungal agent for external use with a broad spectrum of antifungal activity.
Release form and composition
The dosage form is a cream for external use 1%: homogeneous, with a homogeneous structure, white or almost white (in an aluminum tube 15 g, in a cardboard box 1 tube together with instructions for use of Mikonorm).
In 1 g of cream, the content of the active ingredient - terbinafine hydrochloride - is 10 mg.
As auxiliary components in the composition of Mikonorm used: cetostearyl alcohol, benzyl alcohol, sodium hydrogen phosphate dihydrate, propylene glycol, soft white paraffin, liquid light paraffin, cetomacrogol 1000, Cremophor EL (macrogol glyceryl ricinoleate), trolamine, purified water.
Pharmacological properties
Pharmacodynamics
Mikonorm is a topical antimycotic agent with a broad spectrum of antifungal activity. It belongs to the group of allylamines (derivatives of N-methylnaphthalene). Used in low concentrations, it has a fungicidal effect against dermatophytes (Trichophyton rubrum, Trichophyton verrucosum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton violaceum, as well as Epidermophyton floccosum and Microsporum canis), certain dimorphic fungi (Pneumocystis) and plaque … In relation to yeast fungi, activity can be fungistatic or fungicidal (depending on their type). Active against the causative agent of varicoloured lichen (Malassezia furfur).
The active ingredient of the drug is terbinafine. It specifically affects the early stage of sterol biosynthesis that occurs in fungi. This causes intracellular accumulation of squalene and a deficiency of ergosterol, which ultimately leads to the death of the fungal cell. The action of terbinafine is due to the inhibition of the enzyme squalene epoxidase, which is located on the cell membrane of the fungus.
Terbinafine does not affect the cytochrome P 450 system in humans, and, therefore, the metabolism of hormones or other drugs.
Pharmacokinetics
Absorption with external application of Mikonorm is less than 5%. Terbinafine has a slight systemic effect.
Indications for use
Mikonorm cream is used to treat and prevent the following skin lesions:
- versicolor versicolor (Pityriasis versicolor), caused by Pityrosporum orbiculare (also known as Malassezia furfur);
- yeast infections of the skin, mainly caused by the genus Candida (for example, Candida albicans), in particular diaper rash;
- fungal infections of the skin, including mycoses of the feet (foot fungus), epidermophytosis inguinal (Tinea cruris), fungal infections of the smooth skin of the body (Tinea corporis) caused by dermatophytes such as Trichophyton (including Trichophyton rubrum, Trichophyton verphyrucosum, Trichophyton mentagrocosum Trichophyton tonsurans, Trichophyton violaceum), Microsporum canis and Epidermophyton floccosum.
Contraindications
The drug is contraindicated in persons with hypersensitivity to terbinafine or to any of the auxiliary components present in the composition of the drug.
The cream should be used with caution in liver and / or kidney failure, alcoholism, occlusive vascular diseases of the extremities, inhibition of bone marrow hematopoiesis, metabolic disease, tumors, in children under 12 years of age.
Because the absorption of terbinafine through the skin is minimal, it can be used in women who are breastfeeding and during pregnancy. However, due to the limited experience of use during the gestation period, the drug should be used only under strict indications and under the supervision of a physician.
Miconorm, instructions for use: method and dosage
Miconorm cream for fungus is used externally.
Before applying the product, the affected areas must be cleaned and dried. Apply the drug in a thin layer to the affected area and adjacent areas, rub in with light massage movements. For infections that are accompanied by diaper rash (in the interdigital spaces, under the mammary glands, in the groin, between the buttocks), the places where the cream is applied must be covered with gauze, especially at night.
Frequency rate and average duration of drug treatment:
- versicolor versicolor: 1-2 times a day; course - 14 days;
- candidiasis of the skin: 1-2 times a day; course - 7-14 days;
- dermatomycosis of the trunk, legs, feet: once a day; course - 7 days.
The severity of clinical manifestations usually decreases in the first days of using the cream. If treatment is irregular or is stopped before the full course of therapy is completed, the risk of re-infection increases. If there are no signs of improvement after 7-14 days of treatment, it is recommended to verify the diagnosis.
Side effects
Possible side effects when using Mikonorm:
- allergic reactions;
- local reactions (where the cream is applied): redness, itching / burning sensation.
Overdose
There are no reports of drug overdose cases. If the cream is accidentally swallowed, side effects similar to those arising from an overdose of oral forms of terbinafine may develop: nausea, dizziness, headache, pain in the epigastric region.
To eliminate the symptoms of terbinafine intoxication, activated carbon is used, in the future, it is possible to prescribe symptomatic maintenance therapy.
special instructions
When Mikonorm is used, a decrease in the severity of clinical manifestations of the disease is observed in the first days of treatment. If the treatment is carried out irregularly, or the course of application of the drug is not fully completed, the risk of recurrence of the infection increases significantly.
The drug is intended for external use only. May cause eye irritation. If the cream accidentally gets into your eyes, you should immediately rinse them with running water, and if persistent irritation develops, consult an ophthalmologist.
The occurrence of allergic reactions is the reason for discontinuation of the drug.
Influence on the ability to drive vehicles and complex mechanisms
Miconorm does not affect the ability to drive vehicles and complex mechanisms.
Application during pregnancy and lactation
In experimental studies of terbinafine, teratogenic properties were not revealed. There have been no reports of any fetal malformations when using Myconorm during pregnancy. However, due to the limited clinical experience of using terbinafine in pregnant women, the drug should be used only under strict indications.
Terbinafine is excreted in breast milk. When the cream is used by a nursing mother, only a small amount of the active substance is absorbed through the skin, and therefore the adverse effect of the drug on the infant is unlikely.
Pediatric use
Due to the lack of sufficient clinical experience, the use of Miconorm cream for fungus in children under 12 years of age is prohibited.
With impaired renal function
Caution should be exercised when using the drug for the treatment of patients with renal insufficiency.
For violations of liver function
When using Mikonorm for the treatment of patients with hepatic impairment, caution should be exercised.
Use in the elderly
There are no special recommendations on the dosage regimen for elderly patients.
Drug interactions
There is no information on drug interactions between Mikonorm and other drugs.
Analogs
The analogues of Mikonorm are Atifin, Binafin, Lamisil, Lamisil Dermgel, Lamisil Uno, Lamitel, Lamifungin, Tebikur, Terbized-Agio, Terbizil, Terbiks, Terbinafin, Terbinafin-MFF, Terbinox, Terbinafin-MFF, Terbinox, Terbifuni-gothin, Ekonzifin, Termizifin …
Terms and conditions of storage
Keep out of the reach of children. Store at a temperature of 5–25 ° C in a dark and dry place. Do not freeze.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Myconorm
Most patients leave positive reviews about Myconorm. It is noted that the drug helps with fungal infection of the toes, resulting from severe sweating, as well as in the treatment and prevention of diaper rash.
The price of Miconorm in pharmacies
The price of Miconorm is currently unknown as it is not available for sale. The estimated cost of analogues, the active ingredient of which is terbinafine, is:
- Thermicon, cream for external use 1%, tube 15 g - 283 rubles;
- Terbinafine, cream for external use 1%, tube 30 g - 219 rubles;
- Exifin, gel for external use 1%, tube 15 g - 316 rubles.
Miconorm: prices in online pharmacies
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Drug name Price Pharmacy |
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Miconorm 1% cream for external use 15 g 1 pc. 389 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
