Table of contents:
- Release form and composition
- Pharmacological properties
- Indications for use
- Mebeverin, instructions for use: method and dosage
- Side effects
- special instructions
- Application during pregnancy and lactation
- Pediatric use
- Drug interactions
- Terms and conditions of storage
- Terms of dispensing from pharmacies
- Reviews about Mebeverin
- The price of Mebeverin in pharmacies
- Mebeverin: prices in online pharmacies
Video: Mebeverin - Instructions For Use, Price, Reviews, Capsule Analogues
Mebeverin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Mebeverine
ATX code: A03AA04
Active ingredient: mebeverine (Mebeverine)
Manufacturer: Vertex, CJSC (Russia), Micro Labs Limited (India)
Description and photo update: 2019-08-07
Prices in pharmacies: from 399 rubles.
Mebeverin is a myotropic antispasmodic drug.
Release form and composition
The drug is available in the form of capsules of prolonged action: No. 0, gelatinous solid, white; inside capsules - almost white or white spherical pellets (in blisters: 10 pcs., in a cardboard box 1, 3, 6 or 9 packs, or 15 pcs., in a cardboard box 1, 2, 4 or 6 packs; 30 or 60 pcs. in polyethylene cans, in a cardboard box 1 can; each pack also contains instructions for the use of Mebeverin).
1 capsule weighing 250 mg contains:
- active substance: mebeverine hydrochloride - 200 mg;
- auxiliary components: sugar spheres, macrogol 6000, hypromellose, ethylcellulose, povidone K-30, magnesium stearate;
- capsule shell: gelatin, titanium dioxide.
Mebeverin is a myotropic antispasmodic drug. Its active ingredient is mebeverine hydrochloride, the direct action of which is directed to the smooth muscles of the gastrointestinal tract. The ability of the drug to block the passage of sodium ions into smooth muscle cells allows you to eliminate spasm without affecting normal intestinal motility. It does not cause reflex intestinal hypotension, does not have anticholinergic activity.
After oral administration, mebeverine is rapidly absorbed, the degree of absorption is high. The relative bioavailability is 97%. The prolonged form of the drug provides a clinical effect when using the dosage regimen 2 times a day.
Against the background of taking repeated doses, a significant cumulation of the drug does not occur.
Mebeverine is completely metabolized in the human body. Its metabolism mainly occurs with the help of esterases, which in the first stage break down the ether into mebeverine alcohol and veratric acid. The main metabolite of mebeverine circulating in blood plasma is demethylated carboxylic acid. When taking the drug 200 mg 2 times a day, the maximum concentration (C max) of demethylated carboxylic acid in the blood plasma is reached within about three hours and is 804 ng / ml. The half-life in the equilibrium state of the main metabolite is approximately 5.77 hours.
The drug is excreted from the body almost completely in the form of metabolites through the kidneys.
Elderly patients, as well as patients with impaired renal and / or liver function, do not require dose adjustment.
Indications for use
The use of Mebeverin is indicated as symptomatic therapy for the following conditions:
- pain, spasms, dysfunction and discomfort in the intestinal region due to irritable bowel syndrome;
- spasms of the gastrointestinal tract, including those caused by organic diseases.
- deficiency of sucrase or isomaltase, glucose-galactose malabsorption syndrome, fructose intolerance;
- age up to 18 years;
- period of pregnancy;
- hypersensitivity to the components of the drug.
Mebeverin, instructions for use: method and dosage
Mebeverin capsules are taken orally 20 minutes before a meal, swallowing whole (without chewing) and drinking a sufficient amount of water (at least 100 ml).
Recommended dosage: 200 mg 2 times a day (morning and evening). The doctor determines the duration of the course of treatment individually.
If the next dose is accidentally missed, treatment should be continued with the next dose at the appropriate time. Do not take the missed dose in addition to the usual dose.
During the period of post-marketing use of the drug, reports were received about the possible occurrence of allergic reactions in the form of urticaria, angioedema (including the face), exanthema, hypersensitivity reactions (anaphylactic reactions).
Symptoms: symptoms of overdose can be cardiovascular and neurological in nature, including in the form of increased excitability of the central nervous system. They are generally minor and quickly reversible.
Treatment: no later than one hour after taking a high dose of the drug, it is necessary to rinse the stomach, then symptomatic therapy is prescribed. Measures to reduce absorption are not required. The specific antidote has not been established.
Influence on the ability to drive vehicles and complex mechanisms
The adverse effect of the components of the drug on the patient's ability to drive vehicles and mechanisms has not been established.
Application during pregnancy and lactation
The use of Mebeverin capsules during gestation and breastfeeding is contraindicated.
The appointment of the drug for the treatment of patients under the age of 18 is contraindicated due to the lack of sufficient information about the efficacy and safety of mebeverine use in children and adolescents.
The research results indicate the absence of interaction when combining mebeverine with ethanol.
Mebeverin analogues are: Duspatalin, Dyutan, Veremed, Mebespalin retard, Talinda retard, Niaspam, Sparex, etc.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C in a dark place.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Mebeverin
The few reviews about Mebeverin are mostly positive. Patients report that taking the first dose of the drug ensures the elimination of pain and intestinal spasm within 0.5 hours. Patients consider the advantages of the drug to be the absence of adverse reactions.
The price of Mebeverin in pharmacies
The price of Mebeverin for a package containing 30 capsules can range from 308 rubles.
Mebeverin: prices in online pharmacies
Mebeverin 200 mg capsules of prolonged action 30 pcs.
Mebeverin caps. prolonged. action 200 mg 30 pcs.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!