Table of contents:
- Magnesium Diasporal 300
- Release form and composition
- Pharmacological properties
- Indications for use
- Magnesium Diasporal 300, instructions for use: method and dosage
- Side effects
- special instructions
- Application during pregnancy and lactation
- Childhood use
- With impaired renal function
- Drug interactions
- Terms and conditions of storage
- Terms of dispensing from pharmacies
- Reviews about Magnesium Diaspora 300
- Price for Magnesium Diasporal 300 in pharmacies
- Magnesium Diasporal 300: prices in online pharmacies
Video: Magnesium Diasporal 300 - Instructions For Use, Price, Reviews, Analogues
Magnesium Diasporal 300
Magnesium Diasporal 300: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Magnesium diasporal 300
ATX code: A12CC04
Active ingredient: magnesium citrate
Producer: Protina Pharmazeutische, GmbH (Germany)
Description and photo update: 2019-08-10
Prices in pharmacies: from 557 rubles.
Magnesium Diasporal 300 is a medicine that compensates for magnesium deficiency.
Release form and composition
The drug is produced in the form of granules for the preparation of a solution for oral administration: a mixture of powder and irregularly shaped yellow granules (5 g each in a sachet of a combined material; in a cardboard box 2 sachets connected by a heat-sealable seam, individually, 20 or 50 sachets and instructions for use Diasporal Magnesium 300).
Composition of 5 g of the drug (contents of 1 sachet):
- active substance: magnesium citrate - 1830 mg, which corresponds to magnesium in the amount of 295.7 mg;
- additional components: citric acid, sucrose, orange flavor, sodium bicarbonate, riboflavin (E101).
The active ingredient Magnesium Diasporala 300 - magnesium is one of the vital elements involved in the overwhelming majority of metabolic reactions. It initiates the activation of enzymes (including choline and cholinesterase), as a cofactor it participates in a variety of enzymatic processes. It controls the flow of energy supply to muscles, being a membrane protector, and helps to stabilize the phospholipids of the cell membrane. Acting as a physiological blocker of slow calcium channels, magnesium is able to displace calcium from the binding sites.
The drug ensures the course of metabolic processes, improves interneuronal transmission and regulates muscle excitability. By preventing the flow of calcium ions through the presynaptic membrane, in the central nervous system (CNS) and the peripheral nervous system, it reduces the amount of the neurotransmitter acetylcholine.
The absorption of magnesium is dose-dependent, mostly in the small intestine, its value depends on the serum level of the substance in the blood. In the presence of malabsorption syndrome and the use of fatty foods, the absorption of magnesium is impaired. The absorbed drug is eliminated by the kidneys, and only a small part through the sweat glands and with bile. The unabsorbed portion of the drug is excreted through the intestines and may have a laxative effect. The rate of elimination by the kidneys is proportional to the plasma level of the agent and the value of glomerular filtration.
The blood serum contains approximately 1% of absorbed magnesium (0.8-1 mmol / l). Of this amount, on average, 45% of the substance binds to albumin. Ionized magnesium is characterized by physiological activity. About half of the total volume of the biogenic element is localized inside the cells, the rest is in the bone tissue. Serum magnesium levels are subject to daily fluctuations. Magnesium ions pass through the blood-brain barrier (BBB) and the placenta.
Since an equilibrium is maintained between the serum concentration of a substance in the blood and the level of its content in bone tissue, it is impossible to judge about its lack from the concentration of magnesium in the serum. The deficiency of magnesium in the body may be evidenced by the existing violation of neuromuscular excitability.
Indications for use
Magnesium Diasporal 300 is recommended for use in the presence of a diagnosed magnesium deficiency, isolated or caused by other deficiency conditions, and manifested by the following symptoms: fatigue, minor sleep disturbances, increased irritability, gastrointestinal cramps, tingling sensations, spasms and muscle pain.
If a month after the start of taking the drug, there is no decrease in these disorders, it is inappropriate to continue therapy.
- atrioventricular block (AVB);
- severe renal failure with creatinine clearance (CC) below 30 ml / min;
- myasthenia gravis;
- deficiency of sucrase-isomaltase, syndrome of impaired absorption of glucose or galactose, fructose intolerance (because the drug contains sucrose);
- hypersensitivity to any component of the drug.
With extreme caution, it is required to use the drug in the presence of a moderate impairment of the functional state of the kidneys.
Magnesium Diasporal 300, instructions for use: method and dosage
Magnesium Diasporal 300 granules are taken orally.
The recommended daily intake for adults is 295.7 mg of magnesium, i.e. the contents of 1 sachet. Before use, the granules from 1 sachet should be diluted with ½ cup of water, tea or fruit juice.
On average, a continuous course of therapy is 30 days. Reception of Magnesium Diasporal 300 must be stopped after reaching the normal level of magnesium in the blood.
On the part of the nervous system, weakness is extremely rare, which develops against the background of prolonged use of the drug. If such a reaction occurs, drug treatment should be discontinued and resumed after improvement in a lower dosage.
Taking Magnesium Diasporal 300 with an unknown frequency on the part of the immune system can provoke the development of allergic reactions (including skin reactions).
Side effects from the digestive tract: infrequently (at the beginning of the course) - loose stools (up to diarrhea), as a rule, this effect disappears with continued therapy without appropriate treatment; with an unknown frequency - flatulence, abdominal pain, nausea.
If during the period of taking the drug there is the appearance of other undesirable phenomena or the aggravation of the above, you need to consult a doctor.
In individuals with normal renal function, toxic reactions from an overdose of magnesium taken orally, as a rule, do not develop. However, overdose symptoms may appear in patients with severe renal dysfunction. Such disorders, the severity of which depends on the plasma level of magnesium, may include: vomiting, nausea, a decrease in blood pressure (BP), changes in the electrocardiogram (ECG), depression of the central nervous system, slowing reflexes, anuria syndrome, respiratory depression, coma, respiratory paralysis, arrest hearts.
Therapy: intravenous (i / v) calcium injections and intramuscular (i / m) or subcutaneous (s / c) administration of neostigmine methyl sulfate in 1-2 ampoules (0.5-1 mg / ml); IV infusion or oral administration of sodium chloride 0.9%. Patients with renal insufficiency are prescribed hemodialysis or peritoneal dialysis.
Patients on a salt-free diet or on a low-salt diet should take into account that one sachet pellet contains 1.75 mmol (40 mg) sodium.
If a simultaneous deficiency in the body of calcium and magnesium is detected, the deficiency of the latter should be replenished before using calcium preparations or dietary supplements with calcium.
Influence on the ability to drive vehicles and complex mechanisms
Magnesium Diasporal 300 does not adversely affect the ability to drive cars and other complex mechanisms.
Application during pregnancy and lactation
It is possible to take Magnesium Diasporal 300 granules during pregnancy only if necessary, on the recommendation of a doctor, when the expected benefit of treatment for the mother outweighs the potential danger to the fetus.
Due to the fact that magnesium is found in breast milk, the appointment of the drug during lactation requires the termination of breastfeeding.
In pediatric practice, Magnesium Diasporal 300 is not used, since there is no data on the safety of its intake in children and adolescents.
With impaired renal function
In the presence of severe renal impairment (CC less than 30 ml / min), the drug is contraindicated.
Patients with moderate impairment of renal function are advised to use Magnesium Diasporal 300 with caution due to the aggravation of the threat of hypermagnesemia.
- diuretics (furosemide, thiazides), aminoglycoside antibiotics; drugs that inhibit the production of gastric juice (pantoprazole, omeprazole); cyclosporin A, cisplatin, erlotinib, cetuximab, foscarnet, amphotericin, rapamycin, pentamidine: the elimination of magnesium is accelerated, which can lead to its deficiency in the body;
- ions of magnesium, iron, fluorides and tetracycline (for oral administration): against the background of the simultaneous use of these substances with magnesium, their mutual influence on the absorption of each other is noted, as a result of this, it is recommended to observe an interval of at least between taking preparations containing these substances and Magnesium Diasporal 300 2-3 hours;
- iron supplements: iron absorption decreases;
- indirect anticoagulants: the effect of these drugs is weakened;
- products containing calcium salts or phosphates: a significant decrease in the absorption of magnesium in the digestive tract is possible.
The analogues of Magnesium Diasporal 300 are Magne B6 Forte, Magnelis B6, Magwit, Magnelis B6 Forte, etc.
Terms and conditions of storage
Store at a temperature of 15-25 ° C, out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Magnesium Diaspora 300
According to reviews about Magnesium Diasporal 300, found on specialized sites, the drug has a quick positive effect in sleep disorders, excessive irritability, heart palpitations, and increased fatigue. Almost all patients note that the drug has improved the state of their nervous system, helped to increase the efficiency and endurance of the body, and in a short time eliminated or significantly reduced the intensity of cramps in the calf muscles, feet and toes. The reviews also indicate the pleasant taste of the prepared solution and the convenient dosing regimen.
The disadvantages of Magnesium Diasporal 300 include the appearance in some cases of side effects in the form of allergic reactions and the onset of severe weakness, especially after waking up. Sometimes the absence of the drug in many pharmacies is noted.
Price for Magnesium Diasporal 300 in pharmacies
The price of Magnesium Diasporal 300, granules for preparation of oral solution (295.7 mg sachets), can be 740-800 rubles. per package containing 20 sachets.
Magnesium Diasporal 300: prices in online pharmacies
Magnesium Diasporal 300 mg granules for preparation of oral solution 5 g 20 pcs.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes and does not replace the official instructions. Self-medication is hazardous to health!