Diabetone
Diabeton: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Diabeton
ATX code: A10BB09
Active ingredient: gliclazide (gliclazide)
Manufacturer: Servier Laboratories (Les Laboratoires Servier Industrie) (France)
Description and photo update: 2019-20-08
Prices in pharmacies: from 228 rubles.
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Diabeton is a drug with hypoglycemic action.
Release form and composition
Diabeton is produced in the form of tablets (30 pcs. In blisters, 2 blisters in a cardboard box).
The active ingredient is a part of 1 tablet: gliclazide - 80 mg.
Pharmacological properties
Pharmacodynamics
The active ingredient of Diabeton is gliclazide - a derivative of II generation sulfonylurea, hypoglycemic action. It is effective in metabolic, latent diabetes mellitus, including in patients with exogenous constitutional obesity.
Gliclazide improves glucose utilization and increases the secretion of insulin by the beta cells of the pancreas. Stimulates the activity of muscle glycogen synthetase.
The drug normalizes the glycemic profile within a few days of treatment. It shortens the time from meal intake to onset of insulin secretion, restoring the early peak in insulin secretion. Reduces food-induced hyperglycemia. Improves rheological properties of blood, hematological parameters, microcirculation and hemostasis. Prevents the development of microvasculitis, including lesions of the retina of the eye. Provides continuous blood flow in the capillaries, improves vascularization of the conjunctiva, eliminates the signs of microconstriction. Shows antioxidant properties. Significantly increases the index of relative disaggregation, inhibits platelet aggregation, increases fibrinolytic and heparin activity, and increases heparin tolerance.
It has been reliably established that gliclazide slows down the development of diabetic retinopathy. In the case of long-term use in this disease, the drug does not affect renal function, while reducing proteinuria, improves control of blood glucose and blood pressure. Does not contribute to an increase in body weight, on the contrary, in obese patients it reduces it (subject to an appropriate diet). Does not cause hyperinsulinemia.
According to the results of experiments on animals (rabbits and rats), during which chronic and specific types of toxicity of gliclazide were studied, no signs of carcinogenicity, teratogenicity and mutagenicity, as well as a negative effect on fertility, were revealed.
Pharmacokinetics
After taking Diabeton inside, gliclazide is rapidly and completely absorbed from the gastrointestinal tract. The maximum concentration reaches within 2-6 hours. Equilibrium plasma concentration is observed after 2 days. It binds to plasma proteins by 85–99%. The volume of distribution is 13-24 liters.
With a single dose, the duration of action is maintained for 24 hours.
It is metabolized in the liver by oxidation, hydroxylation and glucuronidation to form 8 inactive metabolites, one of which has a pronounced effect on microcirculation.
The half-life is 8-12 hours. The drug is excreted mainly in the form of metabolites (unchanged less than 1%): by the kidneys with urine - 65%; through the intestines - 12%.
Indications for use
According to the instructions, Diabeton is prescribed for the treatment of non-insulin dependent diabetes mellitus.
Contraindications
- Juvenile diabetes;
- Comatose and precomatose states;
- Ketoacidosis;
- Severe renal and hepatic impairment;
- Pregnancy and lactation (breastfeeding);
- Hypersensitivity to the components of the drug, as well as to other sulfamides.
Instructions for the use of Diabeton: method and dosage
The tablets should be taken orally with meals.
The doctor determines the dosage regimen individually, depending on the severity of the disease. The dose can range from 1 to 4 tablets per day.
Usually, the drug is prescribed 2 tablets per day (1 tablet in the morning and evening).
Side effects
During therapy, the following side effects may develop:
- Reversible hematological disorders;
- Hypoglycemia;
- Dyspeptic symptoms (very rare);
- Allergic reactions including erythema, pruritus, and hives (rare, usually mild).
Overdose
In case of an overdose, hypoglycemic conditions of varying severity develop. Symptoms of moderate hypoglycemia are malaise, pallor, excessive sweating, and tachycardia. Adjustment of the Diabeton dose is indicated. In severe cases, disturbances of consciousness, coma, and cerebral edema are also possible. Intravenous administration of a glucose solution is shown, with cerebral edema - an osmotic diuretic mannitol. Monitoring of glucose, urea nitrogen and serum electrolytes is required.
special instructions
Do not take Diabeton and miconazole at the same time.
During therapy, you need to regularly monitor the blood glucose level after meals, on an empty stomach and the "daily curve".
To prevent the development of dyspeptic symptoms, it is recommended to take Diabeton with meals.
Therapy does not eliminate the need for a low-calorie, low-carbohydrate diet.
Influence on the ability to drive vehicles and complex mechanisms
Patients receiving Diabeton should be careful while driving vehicles and performing potentially hazardous types of work that require increased attention and speed of reactions.
Application during pregnancy and lactation
Diabeton is contraindicated in pregnant women and breastfeeding women. If it is necessary to take the drug during lactation, breastfeeding should be discontinued.
Pediatric use
Due to the lack of data on the efficacy and safety of gliclazide in pediatrics, Diabeton is not used to treat children and adolescents under the age of 18 years.
With impaired renal function
Diabetone is prohibited for patients with severe renal failure.
For violations of liver function
Diabetone is prohibited for patients with hepatic impairment.
Drug interactions
With the simultaneous use of Diabeton with some drugs, a change in its effectiveness may be observed:
- Barbiturates and diuretics: decreased effectiveness;
- Sulfonamides, non-steroidal anti-inflammatory drugs, beta-blockers: increased effectiveness.
Analogs
Analogs of Diabeton are: Diabeton MV, Diabeton MV, Glidiab, Gliclazid MV, Gliklada, Glykinorm, Glidia, Glioral, Diazid, Diaglizid, Maninil, Panmicron, Reklid.
Terms and conditions of storage
Keep out of reach of children at temperatures up to 30 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Diabeton
According to reviews, Diabeton is an effective remedy for lowering blood sugar levels. Patients note its good tolerance, however, only a doctor should prescribe the drug, since it is not suitable for everyone.
You can also find reviews about Diabetone from athletes. The active ingredient gliclazide increases the production of insulin and stimulates the activity of muscle glycogen synthetase, thereby accelerating the growth of muscle mass. However, doctors are categorically against the use of the drug for other purposes, since this can cause hypoglycemia, which is dangerous to health.
Price for Diabeton in pharmacies
The price of Diabeton is unknown as it is currently not available for sale. The cost of its safer analogue of Diabeton MV (in the form of 60 mg modified-release tablets) averages 300 rubles per pack containing 30 tablets.
Diabetone: prices in online pharmacies
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Drug name Price Pharmacy |
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Diabeton MB 60 mg modified release tablets 30 pcs. 228 r Buy |
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Reviews Diabeton MB 228 r Buy |
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Diabeton mb modified release tab 60mg n30 241 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
