Dexon
Dexon: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Dexona
ATX code: S03CA01
Active ingredient: Neomycin (Neomycin), Dexamethasone (Dexamethasone)
Manufacturer: CADILA HEALTHCARE Ltd. (India)
Description and photo update: 2019-07-08
Dexon is a combined agent for topical use in otolaryngology and ophthalmology, anti-inflammatory and antibacterial action.
Release form and composition
Dosage form: solution-eye and ear drops (5 ml each in dark glass bottles, complete with a dropper, 1 set in a cardboard box).
Content of active ingredients in 1 ml:
- Neomycin sulfate - 5 mg;
- Dexamethasone sodium phosphate - 1 mg.
Excipients: hydrogen phosphate disodium, benzalkonium chloride (preservative), ethylenediaminetetraacetic acid disodium salt, creatinine, sodium chloride, propylene glycol, sodium metabisulfite, water for injection.
Pharmacological properties
Pharmacodynamics
Neomycin is an aminoglycoside antibiotic. Produced by Streptococcus fradiae. Acts bactericidal, disrupting protein synthesis in microbial cells. Active against gram-negative and gram-positive microorganisms, including Streptococcus pneumoniae, Staphylococcus aureus, Shigella, E. coli and Proteus. Has low efficacy against streptococci and P. aeruginosa. Neomycin has no effect on anaerobic microorganisms, viruses and pathogenic fungi. Antibiotic resistance develops slowly and to a small extent.
Dexamethasone is a glucocorticosteroid. It has a desensitizing, anti-allergic and anti-inflammatory effect. Actively suppresses the process of inflammation, inhibiting the migration of mast cells, the release of inflammatory mediators by eosinophils and reducing capillary permeability. In combination with neomycin, the risk of an infectious process is reduced.
Pharmacokinetics
After instillation of the drug, neomycin is almost not absorbed into the bloodstream. It is found in the vitreous body, corneal stroma and moisture of the anterior chamber within 6 hours.
Aminoglycoside antibiotics are not metabolized and are excreted by the kidneys unchanged, so their concentration in the urine is quite high. The rate of excretion depends on renal function, patient age and comorbidities. The half-life of aminoglycosides is 2–4 hours in adult patients with normal renal function, 5–8 hours in neonates, and 2.5–4 hours in older children. With impaired renal function, the half-life of aminoglycosides can increase to 70 hours or more.
After instillation of the drug into the conjunctival sac, dexamethasone penetrates into the epithelium of the conjunctiva and cornea. The highest therapeutic concentrations are found in the anterior chamber of the eye, vitreous body and cornea within 1.5–2 hours after the instillation of Dexon drops and persist for 4–8 hours. The absorption of dexamethasone into the systemic circulation in the local treatment of ear and eye diseases is insignificant.
Indications for use
- Chronic and acute form of bacterial blepharitis, conjunctivitis, iridocyclitis, keratitis (in the absence of damage to the epithelium);
- Prevention of inflammation of the anterior part of the eye after surgery;
- Acute and chronic otitis externa;
- Allergic and infectious pathologies of the outer ear.
Contraindications
- Chicken pox;
- Keratitis caused by Herpes simplex or Varicella zoster virus (treelike keratitis);
- Mycobacterial eye infections;
- Diseases of the conjunctiva and cornea of viral etiology;
- Fungal eye pathologies;
- Application after removal of a foreign object from the cornea without complications;
- Breastfeeding period;
- Childhood;
- Hypersensitivity to drug components.
Instructions for use of Dexona: method and dosage
Dosing of the drug for the treatment of moderate or mild infectious eye disease - 1-2 drops in the conjunctival sac, instill every 4-6 hours. In the case of a severe form of the infectious process, instillation is recommended to be carried out every hour, the interval between instillations is increased as the inflammatory phenomenon decreases.
Dosing in the treatment of ear diseases - 3-4 drops are instilled 2-4 times a day.
Side effects
The drug can cause side effects due to an antibiotic or glucocorticosteroid (GCS), as well as their combination.
Development of allergic reactions: often in the form of swelling of the eyelids, itching, redness of the conjunctiva (due to the action of neomycin).
From the side of the organ of vision: it is possible - a slowdown in the wound healing process, an increase in intraocular pressure with a possible risk of developing glaucoma, against the background of which there is a characteristic lesion of the optic nerve and visual field, the formation of posterior subcapsular cataract (due to the action of dexamethasone).
The use of drops in the treatment of pathologies that contribute to the thinning of the sclera or cornea can cause perforation of the fibrous membrane of the eye.
The combined agent (antibiotic with GCS) can cause the development of a secondary infection, as a consequence of the antibiotic suppression of the protective function of the patient's body. In the treatment of acute purulent infections of the eye, the presence of GCS in the composition can hide or intensify the inflammatory process.
Prolonged use of drops containing corticosteroids can cause damage to the cornea by a fungus. The appearance of non-healing ulcers indicates the development of fungal invasion.
Overdose
In case of drug overdose, local adverse reactions are possible.
There is no specific antidote. It is necessary to cancel the drug and prescribe symptomatic treatment.
special instructions
Dexon's solution is not for injection.
Use during pregnancy is allowed only if the expected benefit to the mother outweighs the potential risk to the fetus.
The simultaneous use of the drug with the systemic administration of aminoglycoside antibiotics must be carried out under the control of the level of the drug in the blood serum.
If it is necessary to use the drug for more than 10 days in a row, intraocular pressure should be measured regularly.
You can not use contact lenses during the treatment of eye pathologies.
To avoid bacterial contamination of the contents of the vial, it is necessary to avoid contact of the pipette with any surface.
The carcinogenic and mutagenic activity of the drug has not been studied.
Application during pregnancy and lactation
During pregnancy, Dexon drops are used only in cases where the expected benefit from treatment outweighs the possible risk to the fetus.
The drug is contraindicated for use during breastfeeding.
Pediatric use
According to the instructions, it is not recommended to prescribe Dexon to children and adolescents under 18 years of age, since the safety and efficacy of using drops in patients of this age group of patients have not been established at present.
Drug interactions
The drug interaction has not been established.
Analogs
Dexons are analogs: Betagenot, Garazon, Maxitrol, Sofradex, Tobradex, Tobrazon, DexaTobropt.
Terms and conditions of storage
Keep out of reach of children, protected from light at temperatures up to 25 ° C, do not freeze.
The shelf life is 3 years.
Shelf life after opening the bottle is 1 month.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Dexon
On the Internet, reviews of Dexon are rare. Perhaps this is due to the fact that the drug is not sold in all pharmacies, and it can be problematic to buy it. However, a few messages on the forums speak of the effectiveness of the drug for seasonal allergies and a cold, as well as during colds with beginning otitis media. Unpleasant symptoms (itching and redness of the eyes, allergic rhinitis, watery eyes) disappear within 5 days, and sometimes even earlier.
Patients also note that when the drug is instilled into the eyes, a slight burning sensation may occur, which quickly passes.
Price for Dexon in pharmacies
The drops are available with a prescription. In the absence of a drug in a particular pharmacy, you must use one of the analogues.
The price of a 5 ml Dexona bottle is approximately 130-155 rubles and varies slightly in different pharmacies.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
