Glycodine
Glycodin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. With impaired renal function
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Glycodin
ATX code: R05FB02
Active ingredient: terpinhydrate (terpinhydras), levomenthol (levomenthol), dextromethorphan (dextromethorphan)
Manufacturer: Alembic (India)
Description and photo update: 2019-14-08
Glycodin is a combined drug with antitussive and mucolytic effects.
Release form and composition
Glycodin is produced in the form of a syrup: thick, viscous, from dark yellow with a brownish tint to yellow, opalescent, with a characteristic odor (50 or 100 ml in dark glass bottles, complete with a measuring cap or spoon, 1 set in a cardboard pack).
The composition of 5 ml of syrup contains active substances:
- Dextromethorphan hydrobromide - 10 mg;
- Levomenthol - 3.75 mg;
- Terpin hydrate - 10 mg.
Auxiliary components in Glycodin: Alem (BBA) - 0.0165 ml; sucrose - 3250 mg; sodium methyl parahydroxybenzoate - 5.5 mg; caramel - 65 mg; sodium propyl parahydroxybenzoate - 2.75 mg; sodium saccharinate - 10 mg; glycerol - 600 mg; citric acid monohydrate - 0.85 mg; propylene glycol - 400 mg; purified silicon and distilled water - in sufficient quantity to achieve the required volume.
Pharmacological properties
Pharmacodynamics
Dextromethorphan is an antitussive agent similar in potency to codeine. It increases the threshold of sensitivity of the cough center located in the medulla oblongata, helps suppress coughs of any etiology, eliminates dry, unproductive cough and is well tolerated by patients of any age. Dextromethorphan has some sedative effect, but is not characterized by hypnotic, narcotic and analgesic effects. It does not reduce the activity of the ciliated epithelium and does not depress the respiratory center. The substance begins to act 10-30 minutes after oral administration, and the duration of exposure is 5-6 hours in adults and 6-9 hours in children.
Terpinghydrate has an expectorant effect, improves the secretory function of the epithelial glands of the respiratory tract, increases the volume of secretion and reduces the viscosity of the secreted secretion, protects the inflamed surface of the epithelium of the respiratory tract from direct contact with the external environment, which makes it possible to accelerate the regeneration processes in the epithelium.
Levomenthol is characterized by a moderate antispasmodic effect and relieves the condition with symptoms of bronchitis, laryngitis, pharyngitis and acute rhinitis.
Pharmacokinetics
After oral administration, dextromethorphan is completely absorbed in the gastrointestinal tract and participates in metabolic processes in the liver. The maximum concentration of the substance in the blood plasma is reached 2 hours after ingestion. Up to 45% of dextromethorphan is excreted in the urine.
Terpinghydrate is rapidly absorbed from the gastrointestinal tract after oral administration. Part of the active substance circulates in the blood unchanged and is excreted with the exhaled air, as well as with sweat and urine, giving them a special specific smell. The rest of the terpine hydrate is involved in oxidation processes in the body and is excreted in the urine in the form of phenols.
Levomenthol is excreted in the bile and urine as glucuronide.
Indications for use
According to the instructions, Glycodin is prescribed for the treatment of acute and chronic respiratory diseases, which are accompanied by an irritating dry cough.
Contraindications
- Sucrase / isomaltase deficiency;
- Bronchial asthma;
- Glucose-galactose malabsorption (due to the presence of sucrose in the syrup);
- Fructose intolerance;
- Pregnancy and lactation;
- Age up to 4 years;
- Hypersensitivity to drug components.
Glycodin should be taken with caution in patients with liver dysfunction.
Instructions for the use of Glycodin: method and dosage
Glycodine syrup is taken orally.
Adults are usually prescribed 5 ml (1 teaspoon) of syrup. A single dose for children is determined by age:
- Children 4-6 years - 1 / 4 teaspoon;
- Children 7-12 years - 1 /2 tsp.
The frequency of taking the drug is 3-4 times a day. The duration of the therapeutic course is determined by the doctor individually.
Side effects
During treatment, side effects such as dizziness, drowsiness, itching, nausea, and urticaria may develop.
Overdose
Symptoms of an overdose of Glycodin syrup are dyspeptic disorders, dizziness, agitation, tachycardia, decreased blood pressure, depression of the respiratory center. In this case, artificial ventilation of the lungs and the appointment of symptomatic therapy are recommended. A specific antidote is naloxone, which is used for drug overdose 100 or more times.
special instructions
Patients with diabetes mellitus, when taking Glycodin, should take into account that the syrup contains 3250 mg of sucrose, which is less than 1 bread unit (XE).
During therapy, the development of addiction does not occur.
Terpinhydrate, which is part of Glycodin, can give sweat and urine a specific odor, which has no clinical significance.
During the period of taking the drug, patients need to be careful when driving vehicles and when performing potentially hazardous types of work that require a high concentration of attention and quick psychomotor reactions.
With impaired renal function
Experience with the use of Glycodin in patients with chronic renal failure is limited.
Drug interactions
Glycodin enhances the effect of antitussive drugs and other drugs that depress the central nervous system.
Interaction with monoamine oxidase inhibitors is possible (a combination of drugs is not recommended).
Analogs
The analogues of Glycodin are: Zedex, Codelac, Codterpin, Coldakt Broncho, Neo Codion, Libeksin, Sinekod.
Terms and conditions of storage
Store in a dark place, out of reach of children, at temperatures up to 25 ° C. Do not freeze.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Glycodin
According to reviews, Glycodin has worked well in the treatment of dry cough. In most patients, there is a significant improvement in their condition even after a single dose of the drug. At the same time, it remains affordable and begins to act quite quickly, however, some patients mention side effects, among which drowsiness and allergic reactions are considered the most common.
Sometimes there are opinions that Glycodin supposedly has a narcotic effect. However, they are wrong: the remedy does not cause a state of euphoria and addiction. When taking too large a dose of the drug, only pronounced side reactions such as itching may occur.
The price of Glycodin in pharmacies
The approximate price for Glycodin is 100-118 rubles (for a bottle of 100 ml).
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
