Hepabene
Gepabene: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. For violations of liver function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Hepabene
ATX code: A05AX
Active ingredient: herb of medicinal smoke + fruits of milk thistle (Fumariae herba + Fructus Silybi mariani)
Producer: Merkle, GmbH (Merckle, GmbH) (Germany)
Description and photo update: 2019-20-08
Prices in pharmacies: from 300 rubles.
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Gepabene is a combined herbal preparation with hepatoprotective and choleretic action.
Release form and composition
Dosage form: capsules No. 0 gelatinous solid light brown, containing powder from orange-brown to light brown interspersed with a lighter shade (10 pieces in blisters, in a cardboard box of 3 or 10 blisters).
Content of active ingredients in 1 capsule:
- Herb smoky medicinal in the form of dry extract - 275.1 mg, including protopin - 4.13 mg;
- Milk thistle fruits in the form of a dry extract - 83.1 mg, including silymarin - 50 mg, with a silybinin content of at least 22 mg.
Excipients: corn starch, microcrystalline cellulose, magnesium stearate, copolyvidone, macrogol 6000, silicon dioxide, talc.
The composition of the capsule shell: iron oxide (black, yellow and red), gelatin, titanium dioxide, purified water.
Pharmacological properties
Pharmacodynamics
Medicinal smoke extract contains the alkaloid fumarin, which eliminates spasm of the gallbladder and bile ducts and normalizes the amount of bile produced, which facilitates its transportation to the intestines.
The milk thistle extract contains silymarin, which provides a hepatoprotective effect when taken in case of acute and chronic intoxication of the body, is characterized by membrane stabilizing and antioxidant activity, binds toxins and free radicals in liver tissues, enhances protein synthesis, and promotes the regeneration of hepatic parenchyma cells.
The drug improves liver function in various pathological conditions occurring in a chronic form.
Pharmacokinetics
After oral administration, the flavonoids that are part of silymarin are excreted mainly in the bile and are involved in the processes of intestinal-hepatic recirculation.
Indications for use
According to the instructions, Gepabene is used as part of the complex therapy of the following diseases:
- Chronic toxic liver damage;
- Dyskinesia of the biliary tract, including after resection of the gallbladder;
- Chronic hepatitis.
Contraindications
- The period of exacerbation of inflammatory diseases of the biliary tract and liver;
- Age under 18;
- Hypersensitivity to drug components.
During pregnancy and lactation (breastfeeding), the use of Hepabene is allowed only as directed by a specialist.
Instructions for use of Hepabene: method and dosage
Capsules should be taken orally with meals, without chewing, with a small amount of water.
The period of treatment is prescribed by the doctor based on clinical indications, the dosage is usually 1 capsule 3 times a day.
Patients suffering from pain syndrome at night are advised to take an additional 1 capsule at bedtime.
The maximum daily dose is no more than 6 capsules, the frequency of administration is 3-4 times a day.
Side effects
The use of Hepabene can cause the development of allergic reactions.
Sometimes the drug is the cause of the undesirable effect in the form of increased urine output, laxative action.
Overdose
At the moment, cases of overdose of Gepabene have not been described.
If an overdose is suspected, the patient should urgently consult a doctor.
special instructions
During the period of treatment, patients should strictly follow all the doctor's prescriptions, do not take other medications without agreement with him, follow a diet and categorically exclude the use of alcohol.
Influence on the ability to drive vehicles and complex mechanisms
Reception of Gepabene does not affect the ability to perform potentially hazardous types of work that require increased concentration and immediate psychomotor reactions, such as the work of an operator or dispatcher, traffic control, work with moving mechanisms, etc.
Application during pregnancy and lactation
Pregnant and lactating women can use Gepabene only as directed by a doctor.
Pediatric use
Hepabene is not used to treat children and adolescents under 18 years of age.
For violations of liver function
Acute inflammatory diseases of the liver and biliary tract are a contraindication for the use of the drug.
Drug interactions
There is no information on drug interactions.
Analogs
Analogs of Hepabene are: Allochol, Artichoke extract, Choleretic collection No. 3, Konvaflavin, Kavehol, Leptandra Compositum, Liobil, Odeston, Olimetin, Tansy flowers, Flamin, Phytohepatol, Hofitol, Holagol, Tsikvalon.
Terms and conditions of storage
Keep out of reach of children at temperatures up to 25 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Gepabene
Basically, doctors leave positive reviews about Gepabene, since the drug has long been used with good results to treat liver and gallbladder diseases. Although some experts theoretically doubt the effectiveness of hepatoprotectors, in practice this drug has proven itself well.
Patients also speak well of Gepabene. Occasionally, there are references to certain adverse reactions (diarrhea, weakness, pain and / or heaviness in the right hypochondrium). At the same time, advice is given to use the drug only as directed by a doctor who will be convinced of the appropriateness of its appointment and the absence of contraindications.
Price for Gepabene in pharmacies
The price of Gepabene in pharmacy chains averages from 398 to 670 rubles. per package containing 30 capsules.
Gepabene: prices in online pharmacies
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Drug name Price Pharmacy |
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Hepabene capsules 30 pcs. RUB 300 Buy |
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Hepabene capsules 30 pcs. 394 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
