Hexetidine
Hexetidine: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Hexetidine
ATX code: A.01. AB12
Active ingredient: Hexetidine (Hexetidine)
Manufacturer: OOO YuzhFarm (Russia)
Description and photo update: 2019-11-07
Prices in pharmacies: from 154 rubles.
Buy
Hexetidine is a topical antiseptic drug.
Release form and composition
The drug is produced in the form of a spray for local use, which is a transparent, slightly colored or colorless liquid with a characteristic odor (40 ml each in aluminum cylinders or polymer vials equipped with a dosing device, a spray bottle and a protective cap, in a cardboard package 1 cylinder or 1 bottle and instructions for use of Hexetidine).
Composition for 100 ml spray:
- active ingredient: hexetidine - 200 mg;
- auxiliary components: citric acid monohydrate, glycerol, macrogol lauryl ether, peppermint leaf oil, sodium saccharinate dihydrate, sodium hydroxide, ethanol, levomenthol, eucalyptol, purified water.
Pharmacological properties
Pharmacodynamics
Hexetidine is a thiamine antagonist. Its antimicrobial effect is due to the suppression of the oxidative reactions of the metabolism of bacterial cells.
The drug is active against a wide range of bacteria and fungi, including gram-positive bacteria and fungi of the genus Candida. In addition, it fights effectively against infections caused by Proteus spp. and Pseudomonas aeruginosa. The concentration of hexetidine 100 mg / ml is sufficient to suppress most bacterial cell strains. No emergence of resistance was noted.
The drug has a weak anesthetic effect on the mucous membrane of the oral cavity and pharynx. In addition, it has antiviral properties and is active against viruses that infect the respiratory tract: PC virus (respiratory syncytial virus), influenza A virus and HSV-1 (herpes simplex virus type 1).
Pharmacokinetics
Hexetidine is almost not absorbed into the systemic circulation, as it attaches to the mucous membranes. After a single use of the drug, traces of the active substance are found on the mucous membrane of the gums for another 65 hours. Within 10-14 hours after spraying, active concentrations of hexetidine are retained in dental plaque.
Indications for use
- symptomatic therapy of infectious and inflammatory diseases of the oral cavity and larynx, namely acute and chronic tonsillitis (including ulcerative membranous tonsillitis and angina of the lateral ridges), stomatitis, gingivitis, pharyngitis, periodontal disease and glossitis;
- symptomatic therapy of fungal diseases of the oral cavity and pharynx;
- prevention of complications of an infectious nature before and after operations on the larynx and oral cavity, as well as in case of various injuries (including prevention of infection of the alveoli after tooth extraction);
- oral hygiene (including eliminating bad breath).
Contraindications
- erosive and ulcerative lesions of the mucous membranes of the oral cavity;
- children under 3 years old;
- hypersensitivity to the main or auxiliary components of the drug.
Hexetidine, instructions for use: method and dosage
Spray Hexetidine is applied topically by spraying into the pharynx or mouth. The drug should be sprayed after meals or between meals.
In children aged 3–6 years, the spray can only be used after consulting a specialist.
In children over 6 years of age and adults, Hexetidine is used 2 times a day for 5-7 days.
Before using for the first time, press the sprayer several times to ensure an even spray.
When injecting the drug, the bottle must be held in an upright position. With each use, press the sprayer 3–4 times all the way. The patient should hold his breath while the spray is being administered.
Side effects
- gastrointestinal tract: very rarely (<1 / 10,000) - nausea, dry mouth, vomiting, difficulty swallowing, enlargement of the salivary glands;
- respiratory system: very rarely - shortness of breath (as a result of increased sensitivity), cough;
- nervous system: very rarely - a violation of taste, a decrease or loss of taste;
- immune system: very rarely - Quincke's edema, urticaria and other hypersensitivity reactions;
- other disorders: very rarely - discoloration of the teeth and tongue, irritation of the mucous membrane of the pharynx and oral cavity and a burning sensation, ulceration, blistering and inflammation of the mucous membrane, impaired sensitivity of the tongue and oral mucosa.
In case of aggravation of the listed side effects or the appearance of new adverse reactions not specified in the instructions, you should consult a doctor.
Overdose
The likelihood of a toxic effect of the drug in the case of its application strictly according to indications and in the recommended doses is very low.
If a large amount of the spray is accidentally swallowed, symptoms / signs of alcohol poisoning may appear (since Hexetidine contains ethanol). It is necessary to consult a doctor. The measures taken for drug intoxication are similar to those for alcohol poisoning. Within two hours after taking an excess dose of the spray, the stomach should be flushed.
special instructions
There are no special regulations.
In children, the drug can be used from the age of 3 years, when the child does not resist the spray nozzle in the oral cavity and is able to hold his breath at the moment the spray is injected, and there is also no risk of uncontrolled swallowing of the drug.
Do not inhale the spray. Avoid contact with eyes.
It should be borne in mind that the daily dose of the drug contains from 24 to 48 mg of ethanol.
Influence on the ability to drive vehicles and complex mechanisms
Hexetidine does not affect the patient's ability to drive vehicles, operate other dangerous machinery and engage in other potentially hazardous activities.
Application during pregnancy and lactation
There is no information on the negative effects of hexetidine during pregnancy and lactation.
When prescribing the drug to pregnant women or mothers who are breastfeeding, the expected benefit for the woman and the potential risk to the fetus or baby should be assessed, since there is no reliable data on the penetration of hexetidine through the placental barrier and into breast milk.
Pediatric use
Topical spray is contraindicated in children under 3 years of age.
In children aged 3-6 years, Hexetidine spray can be used only after consultation with a specialist.
Drug interactions
There are no data on drug interactions with other drugs and substances.
Analogs
Analogues of Hexetidine are: Hexoral, Hexoral Tabs, Maxicold Lor, Maxisprey, Stopangin, Stopangin-Teva, Stomatidin, etc.
Terms and conditions of storage
Store in a dark place, out of reach of children, at a temperature not exceeding 25 ° C.
The shelf life of the spray is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Hexetidine
The drug is not as popular as other similar drugs, so there are relatively few reviews about Hexetidine. Users note the high effectiveness of the spray: it helps with stomatitis and oral ulcers, and also eliminates bleeding gums. Adverse reactions are rare. The only drawback of the drug, according to patients, is the unpleasant taste of the solution.
Price for Hexetidine in pharmacies
The current price for Hexetidine is unknown, since the drug is not available in pharmacies. The cost of similar medicines, the active ingredient of which is hexetidine, averages from 195 rubles. (spray for topical application Stopangin-Teva 0.2%, 30 ml) up to 260 rubles. (aerosol Hexoral 0.2%, 40 ml).
Hexetidine: prices in online pharmacies
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Drug name Price Pharmacy |
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Hexetidine spray 40 ml 1 pc. 154 RUB Buy |
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Hexetidine spray for topical application 0.2% bottle 40ml 253 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
