Gastrosidine
Gastrosidin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Gastrosidin
ATX code: A02BA03
Active ingredient: famotidine (famotidine)
Manufacturer: ZENTIVA (Turkey)
Description and photo update: 2019-26-08
Gastrosidine is an H 2 -histamine receptor blocker, antiulcer drug.
Release form and composition
Gastrosidine is available in the form of coated tablets: light beige, biconvex round, the core of the tablet is white (10 pcs. In a blister, in a cardboard box 1 or 3 blisters).
1 tablet contains:
- active substance: famotidine - 0.02 or 0.04 g;
- auxiliary components: corn starch, magnesium stearate, lactose, colloidal silicon dioxide;
- shell composition: propylene glycol 6000, hypromellose, hydroxypropyl cellulose, titanium dioxide, yellow iron oxide, red iron oxide, talc.
Pharmacological properties
Pharmacodynamics
The active substance of Gastrosidin is famotidine, a blocker of H 2 -histamine receptors of the third generation.
The drug suppresses the production of hydrochloric acid, both basal and stimulated by histamine, acetylcholine and gastrin. Reduces the activity of pepsin. Strengthens the protective mechanisms of the gastric mucosa. Increases the formation of gastric mucus and the content of glycoproteins in it, stimulates the secretion of bicarbonate by the gastric mucosa, increases the endogenous synthesis of prostaglandins and the rate of regeneration in it, due to which Gastrosidin helps to heal lesions of the gastric mucosa associated with the effect of hydrochloric acid (including helping to stop gastrointestinal intestinal bleeding and scarring of stress ulcers).
Famotidine has no significant effect on plasma gastrin concentration. The oxidase system of cytochrome P 450 in the liver weakly inhibits.
The action of Gastrosidin begins 1 hour after oral administration, reaches a maximum within 3 hours, lasts for 12-24 hours (depending on the dose) after a single dose.
Pharmacokinetics
After taking famotidine enters the gastrointestinal tract, from where it is rapidly absorbed. The maximum concentration in blood plasma reaches within 1–3.5 hours. The bioavailability of the drug is 40-45%, increases when taking tablets with food, decreases in the case of simultaneous use of antacids.
The connection with plasma proteins is low - 15–20%. Famotidine crosses the placental barrier and into breast milk.
About 30–35% of the received dose of famotidine is metabolized in the liver to form S-oxide. It is excreted mainly through the kidneys in the urine unchanged (27-40%). The half-life (T ½) is 2.5-4 hours, in patients with creatinine clearance (CC) 10-30 ml / min increases to 10-12 hours, with CC <10 ml / min - up to 20 hours.
Indications for use
- treatment and prevention of recurrence of gastric ulcer and duodenal ulcer;
- treatment and prevention of symptomatic gastric and duodenal ulcers arising from stress, taking non-steroidal anti-inflammatory drugs (NSAIDs), undergoing surgery;
- functional dyspepsia associated with increased gastric secretory function;
- erosive gastroduodenitis;
- reflux esophagitis;
- Zollinger-Ellison syndrome;
- prevention of recurrence of bleeding from the upper gastrointestinal tract (GIT);
- Mendelssohn's syndrome - prevention of gastric juice entering the respiratory tract during general anesthesia.
Contraindications
- liver failure;
- the period of pregnancy and breastfeeding;
- childhood;
- individual intolerance to the components of the drug.
According to the instructions, Gastrosidine should be prescribed with caution in case of impaired liver function, liver cirrhosis with a history of portosystemic encephalopathy, renal failure.
Instructions for the use of Gastrosidin: method and dosage
Gastrosidin tablets are taken orally, swallowed whole and washed down with plenty of water.
Recommended dosage:
- exacerbation of stomach and duodenal ulcers, symptomatic ulcers, erosive gastroduodenitis: 20 mg 2 times a day or 40 mg 1 time a day (before bedtime). In the absence of a sufficient therapeutic effect, the daily dose can be increased to 80–160 mg. The duration of the course of treatment is 28–56 days;
- dyspepsia caused by increased gastric secretory function: 20 mg 1-2 times a day;
- prevention of recurrence of gastric ulcer and duodenal ulcer: 20 mg 1 time per day before bedtime;
- reflux esophagitis: 20-40 mg 2 times a day, the course of treatment is 42-84 days;
- Zollinger-Ellison syndrome: the initial dose is 20 mg every 6 hours, if necessary, it can be increased to 160 mg every 6 hours. The dose and duration of therapy are set individually;
- prevention of aspiration under general anesthesia: 40 mg in the evening (the day before the operation) or in the morning (just before the operation).
In renal failure with creatinine clearance less than 30 ml / min, the daily dose of Gastrosidine should not exceed 20 mg.
Side effects
- on the part of the cardiovascular system: lowering blood pressure, bradycardia, atrioventricular block;
- from the digestive system: loss of appetite, dry mouth, abdominal pain, nausea, vomiting, increased activity of liver enzymes, acute pancreatitis, hepatitis;
- on the part of the hematopoietic organs: rarely - thrombocytopenia, leukopenia; very rarely - agranulocytosis, hypoplasia, pancytopenia, bone marrow aplasia;
- from the nervous system: hallucinations, dizziness, headache, confusion;
- on the part of the reproductive system: against the background of long-term use of high doses of Gastrosidin - decreased libido, hyperprolactinemia, amenorrhea, gynecomastia, impotence;
- from the senses: ringing in the ears, accommodation paresis, blurred vision;
- allergic reactions: dry skin, pruritus, rash, urticaria, angioedema, bronchospasm, anaphylactic shock;
- others: rarely - arthralgia, myalgia, fever.
Overdose
Possible symptoms of an overdose of Gastrosidin: vomiting, tremors, motor agitation, tachycardia, decreased blood pressure, collapse.
Treatment is symptomatic.
special instructions
The use of Gastrosidin should be started only after excluding a malignant neoplasm in the esophagus, stomach or duodenum.
Cancellation of the drug is desirable to produce a gradual decrease in the daily dose, since abrupt cessation of therapy can cause a rebound syndrome.
Long-term treatment of debilitated patients can contribute to bacterial damage to the stomach and the spread of infection.
During the period of treatment, the patient is advised to follow a diet that excludes the use of food and drinks that cause irritation of the gastric mucosa. You should also exclude the intake of drugs that have an irritating effect on the digestive system.
Gastrosidine may interfere with the effects of histamine and pentagastrin on gastric acid-related function, so it is recommended that you stop taking it 24 hours before the test.
In addition, blockers of H 2 -histaminoreceptors can suppress an immediate-type skin reaction to histamine, in order to obtain reliable results of diagnostic tests to identify an allergic skin reaction, it is necessary to temporarily stop using Gastrosidin.
Influence on the ability to drive vehicles and complex mechanisms
Potentially hazardous activities should be carried out with caution, including driving vehicles and other mechanisms.
Application during pregnancy and lactation
Gastrosidine is contraindicated during pregnancy and breastfeeding.
Pediatric use
The drug is not used in pediatric practice.
With impaired renal function
Gastrosidin tablets should be used with caution in renal failure.
For violations of liver function
Gastrosidine should be used with extreme caution in liver dysfunction and liver cirrhosis with a history of portosystemic encephalopathy.
With severe hepatic impairment, taking the drug is contraindicated.
Drug interactions
With the simultaneous use of Gastrosidine:
- ketoconazole, itraconazole reduce their absorption;
- sucralfate, antacids help to reduce the intensity of absorption of the drug, if this combination is necessary, the interval between taking these drugs and famotidine should be 1–2 hours;
- amoxicillin, clavulanic acid increase their absorption;
- drugs that have a depressant effect on the bone marrow increase the risk of developing neutropenia.
Analogs
Analogs of Gastrosidin are: Kvamatel, Ulfamid, Famosan, Famotidine.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 30 ° C.
Shelf life is 4 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Gastrosidin
Reviews of Gastrosidin are predominantly positive: the drug effectively lowers excessive acidity of the stomach and eliminates unpleasant symptoms associated with it (such as stomach discomfort, heartburn, etc.), and is also well tolerated and does not cause side effects, therefore it is often used as a prophylactic agent.
Price for Gastrosidin in pharmacies
The price of Gastrosidine is currently unknown because the drug is not available on the market. The approximate cost of popular analogs: Kvamatel, 20 mg film-coated tablets - 136-145 rubles. per pack of 28 pieces, 40 mg each - 111-126 rubles. per pack of 14 pcs.; Famotidine, film-coated tablets of 20 mg - 30 rubles. per pack of 20 and 50 rubles. for a package of 30 pcs., 40 mg each - 25-40 rubles. per pack of 20
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
