Gainomax
Gainomax: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Gaynomax
ATX code: G01AF20
Active ingredient: tinidazole (tinidazole) + tioconazole (tioconazole)
Manufacturer: Embil Pharmaceutical, Co. Ltd. (Turkey)
Description and photo update: 2019-19-08
Prices in pharmacies: from 685 rubles.
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Gainomax is a combined agent for topical use in gynecology, which has antifungal, antibacterial and antiprotozoal effect.
Release form and composition
Dosage form - vaginal suppositories: flat form with a rounded end in the form of a truncated ellipse, yellowish (7 pcs. In contoured cell-free packages, in a cardboard box 1 package complete with 7 disposable fingertips).
Active substances in each suppository:
- tinidazole - 150 mg;
- thioconazole - 100 mg.
Additional substance: witepsol.
Pharmacological properties
Pharmacodynamics
The action of Gainomax is determined by the properties of its active substances.
Thioconazole is a synthetic antifungal agent with high activity against yeast-like and other fungi (dermatophytes), as well as against bacterial pathogens - Bacteroides spp., Gardnerella vaginalis, some gram-positive bacteria (including Staphylococcus and Streptococcus spp.).
The mechanism of action of thioconazole causes an increase in the permeability of the cell membrane of the fungus by inhibiting the synthesis of ergosterol (which is its main component). With an increase in the permeability of the cell membrane, the intracellular ionic balance is disturbed, which causes cell death. According to clinical studies, the efficacy of thioconazole in terms of clinical and microbiological indicators is higher than miconazole.
The second active component of Gaynomax, tinidazole, is active against most anaerobic bacteria and protozoal pathogens (Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica, Bacteroides fragilis, Gardnerella vaginalis, Bacteroides spp., Bacterium spp., Bacterella spp., Bacterella spp. spp., Peptostreptococcus spp.).
The mechanism of action of tinidazole is not fully understood. The reduction of the nitro group is mediated by the low redox potential and the ferredoxin system.
Despite the fact that the 5-nitroimidazole group is characterized by cross-resistance, 65–70% of Trichomonas vaginalis strains highly resistant to metronidazole have an increased sensitivity to tinidazole.
According to the results of clinical studies, with intravaginal administration, the effectiveness of the combined use of thioconazole and tinidazole is approximately 90-100% (recovery in terms of microbiological indicators - 85%).
Pharmacokinetics
Absorption of the active components of Gainomax with intravaginal use is negligible.
Indications for use
According to the instructions, Gainomax is a drug for the treatment of vaginitis caused by pathogens of the genera Gardnerella, Candida or Trichomonas (gardnerella vaginitis, Trichomonas vulvovaginitis, vaginal candidiasis, nonspecific vaginitis).
Also, the tool is used for mixed infections.
Contraindications
- leukemia, hematopoietic disorders;
- organic diseases of the nervous system, including in the anamnesis;
- virginity;
- age up to 18 years;
- I trimester of pregnancy;
- lactation;
- hypersensitivity to the components of the drug, derivatives of tinidazole or thioconazole.
Instructions for use of Gaynomax: method and dosage
Gainomax suppositories are intended for intravaginal use. Suppositories should be inserted deep into the vagina using the supplied disposable fingertips.
Adult women are prescribed 1 suppository 1 time per day at night.
The course of treatment is 7 days.
It is also possible to carry out an alternative treatment regimen: 1 suppository 2 times a day (morning and evening) for 3 days.
Side effects
Side effects identified in clinical trials (the results of both treatment regimens were evaluated - 3 and 7 days; 348 women participated in the studies):
- 3.3–4.5% - allergic reactions;
- 1.9% - local itching;
- 1.7% - burning sensation.
In most cases, adverse reactions were moderate. In only 0.75% of cases, treatment had to be interrupted due to allergic reactions.
Side effects identified during postmarketing observations:
- local reactions: rarely - irritation and swelling of the vaginal mucosa;
- central and peripheral nervous system: rarely - increased fatigue, headache;
- urinary system: rarely - darkening of urine;
- allergic reactions: rarely - skin rashes; in individual cases - Quincke's edema.
Although no cases of transient leukopenia were noted with intravaginal use of a combination of tinidazole and thioconazole, it should be borne in mind that there are cases of development of this symptom associated with gastrointestinal or neurological symptoms due to the use of tinidazole.
Overdose
In case of accidental oral intake of a large amount of Gainomax, gastric lavage is performed. There is no specific antidote, symptomatic therapy is indicated.
special instructions
During treatment and for 2 days after discontinuation of the drug, it is recommended to refrain from drinking alcohol.
During the period of Gainomax therapy, you should not use mechanical contraceptives - condoms, contraceptive diaphragms or caps, which is due to the risk of interaction of Witepsol with the latex base of these funds.
The drug does not have any effect on the speed of reactions and the ability to concentrate.
Application during pregnancy and lactation
- I trimester of pregnancy, lactation period: therapy is contraindicated;
- II and III trimesters of pregnancy: Gainomax suppositories can be used after a doctor evaluates the balance of benefits with a possible risk.
Pediatric use
Gainomax therapy is not prescribed for patients under 18 years of age, as well as for virgins.
Drug interactions
Tinidazole in a dosage form for systemic action, used simultaneously with ethanol, can cause skin redness, nausea, intestinal colic, and vomiting. When using vaginal suppositories, tinidazole practically does not enter the systemic circulation, but the likelihood of interaction with ethanol should be taken into account.
Analogs
Gainomax analogs are: Mycosan, Ginesol, Clotrimazole, Ginalgin, Gino-Pevaril, Ginofort, Trichopol, Livarol, Trichocept, Flagil and others.
Terms and conditions of storage
Store at temperatures up to 25 ° C out of reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Gaynomax
Reviews about Gaynomax are mostly positive. They note its effectiveness in the treatment of vaginitis. There are practically no reports of the development of side effects.
The price of Gainomax in pharmacies
The approximate price for Gainomax (7 suppositories) is 1115–1139 rubles.
Gainomax: prices in online pharmacies
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Drug name Price Pharmacy |
|
Gainomax 150 mg + 100 mg vaginal suppositories 7 pcs. RUB 685 Buy |
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Gainomax vaginal suppositories. 150mg + 100mg 7 pcs. 956 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
