Vitridinol
Vitridinol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Vitridinol
ATX code: A02BX05
Active ingredient: bismuth tripotassium dicitrate (Bismuthate tripotassium dicitrate)
Manufacturer: Velpharm LLC (Russia); FBU "GILS and NP" ("State Institute of Medicines and Good Practices") (Russia)
Description and photo update: 2019-11-07
Prices in pharmacies: from 323 rubles.
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Vitridinol is an antiulcer drug with bactericidal activity against Helicobacter pylori.
Release form and composition
Dosage form - film-coated tablets: light yellow, round biconvex, the number "120" is embossed on one side (10 tablets in blisters, 2-6 packs in a cardboard box; 56 or 112 tablets in cans of polyethylene terephthalate, in a cardboard box 1 can and instructions for the use of Vitridinol).
Composition of 1 tablet:
- active substance: bismuth oxide (Bi 2 O 3) - 120 mg (in the form of bismuth tripotassium dicitrate - 304.6 mg);
- auxiliary components: potassium polyacrylate - 23.6 mg; povidone K30 - 17.7 mg; corn starch - 70.6 mg; macrogol 6000 - 6 mg; magnesium stearate - 2 mg;
- shell: Opadry II 85F38077 (polyethylene glycol / macrogol 3350, polyvinyl alcohol, talc, quinoline yellow, indigo carmine, titanium dioxide) - 4.3 mg.
Pharmacological properties
Pharmacodynamics
Bismuth tripotassium dicitrate is the active substance of Vitridinol, an antiulcer agent with bactericidal activity against Helicobacter pylori. It also has anti-inflammatory and astringent effects. When bismuth oxide enters the acidic environment of the stomach, insoluble citrate and bismuth oxychloride are precipitated, chelated compounds with a protein substrate are formed in the form of a protective film on the surface of erosions and ulcers.
By increasing the biosynthesis of prostaglandin E, the formation of mucus and the secretion of bicarbonate, bismuth oxide stimulates the activity of cytoprotective mechanisms, helps to increase the resistance of the mucous membrane of the gastrointestinal tract to the effects of salts and enzymes of bile acids, hydrochloric acid, pepsin. Also, the substance reduces the activity of pepsinogen and pepsin, leading to the accumulation of epidermal growth factor in the area of the defect.
Pharmacokinetics
Bismuth tripotassium dicitrate is practically not absorbed from the gastrointestinal tract. Excretion is carried out mainly with feces. Bismuth, which entered the plasma in a small amount, is excreted from the body by the kidneys.
Indications for use
- gastroduodenitis, chronic gastritis, gastric ulcer and duodenal ulcer in the acute phase, including those associated with Helicobacter pylori;
- functional dyspepsia, which is not associated with organic diseases of the gastrointestinal tract;
- irritable bowel syndrome, accompanied mainly by signs of diarrhea.
Contraindications
- impaired renal function;
- pregnancy and lactation;
- age up to 4 years;
- individual intolerance to the components of the drug.
Vitridinol, instructions for use: method and dosage
Vitridinol tablets are taken orally 30 minutes before meals or 2 hours after the last meal and washed down with a little water.
Recommended dosage regimen:
- children 4–8 years old: daily dose - 8 mg / kg in 1–2 doses;
- children 8-12 years old: 2 times a day, 1 tablet (120 mg);
- children from 12 years old and adults: 4 times a day, 1 tablet (120 mg) or 2 times a day, 2 tablets (240 mg).
The duration of the course is from 28 to 56 days. At the end of treatment, preparations containing bismuth should not be taken for the next 8 weeks.
For the eradication of Helicobacter pylori, it is advisable to use Vitridinol in combination with other antibiotics that have anti-Helicobacter activity.
Side effects
- digestive system: nausea, vomiting, more frequent stools, constipation (these undesirable phenomena are temporary and not dangerous for health);
- allergic reactions: itching and rash;
- others: with a long course using high doses - encephalopathy (due to the accumulation of bismuth in the central nervous system).
Overdose
The main symptom of an overdose associated with prolonged use of Vitridinol in doses exceeding recommended is renal dysfunction (completely reversible after discontinuation of therapy).
Therapy: gastric lavage, intake of saline laxatives and activated charcoal. In the future, symptomatic treatment is carried out. In case of impaired renal function, which is accompanied by a high plasma level of bismuth in the blood, complexing agents can be administered - dimercaptosuccinic and dimercaptopropanesulfonic acids. Patients with severe renal impairment are prescribed hemodialysis.
special instructions
Vitridinol should not be taken for longer than 8 weeks.
During the period of therapy, it is impossible to use other drugs containing bismuth, since an increase in the concentration of bismuth in the blood can lead to the development of systemic adverse reactions.
During treatment, feces may become dark in color, which is associated with the formation of bismuth sulfide. Some patients experience a slight darkening of the tongue.
Application during pregnancy and lactation
Vitridinol is not prescribed during pregnancy / lactation.
Pediatric use
It is contraindicated to carry out therapy in patients under 4 years of age.
With impaired renal function
Vitridinol tablets for violations of renal function are contraindicated.
Drug interactions
You should not drink alcohol during treatment with Vitridinol.
There should be a break of at least 30 minutes between using the drug and taking other medicines (orally), liquid and food (antacids, fruits, fruit juices, milk). With simultaneous use, it is possible to reduce the effectiveness of Vitridinol.
Combination therapy with tetracyclines leads to a decrease in their absorption.
Analogs
Vitridinol analogs are Bismuth tripotassium dicitrate, Ventrisol, Bismopepsin, Vikanol Life, De-Nol, Ulkavis, Escape, Novobismol.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Vitridinol
In a few reviews of Vitridinol, patients talk about its more affordable cost in comparison with some analogues. Indicate the effectiveness of the drug, but at the same time note the development of side effects.
Price for Vitridinol in pharmacies
Approximate price for Vitridinol, 120 mg film-coated tablets, 56 pcs. in the package is 322 rubles; 60 pcs. - 348 rubles.
Vitridinol: prices in online pharmacies
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Drug name Price Pharmacy |
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Vitridinol 120 mg film-coated tablets 60 pcs. 323 r Buy |
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Vitridinol 120 mg film-coated tablets 56 pcs. 333 r Buy |
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Vitridinol tablets p.p. 120 mg 56 pcs 349 r Buy |
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Vitridinol tablet p / o captive 120 mg No. 112 666 RUB Buy |
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Vitridinol 120 mg film-coated tablets 112 pcs. 666 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
