Wilprafen Solutab
Vilprafen Solutab: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Wilprafen solutab
ATX code: J01FA07
Active ingredient: Josamycin (Josamycin)
Producer: ASTELLAS PHARMA EUROPE BV (Netherlands)
Description and photo update: 2018-22-10
Prices in pharmacies: from 550 rubles.
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Vilprafen Solutab is a macrolide antibiotic.
Release form and composition
Dosage form of Vilprafen Solutab - dispersible tablets: oblong, white or white with a yellowish tinge, with the inscription "1000" on one side, with a line and the inscription "IOSA" on the other, with a strawberry smell and a sweet taste (5 pcs. in blisters, 2 blisters in a cardboard box).
Composition of 1 tablet:
- active substance: josamycin (in the form of propionate) - 1000 mg;
- additional components: microcrystalline cellulose (564.53 mg), hyprolose (199.82 mg), strawberry flavor (50.05 mg), magnesium stearate (34.92 mg), aspartame (10.09 mg), sodium docusate (10, 02 mg), colloidal silicon dioxide (2.91 mg).
Pharmacological properties
Pharmacodynamics
The active substance of Wilprafen Solutab - josamycin - is an antibacterial agent from the macrolide group. The mechanism of its action is due to the ability to disrupt protein synthesis in a microbial cell due to reversible binding to the 508-subunit of the ribosome. When used in therapeutic doses, the drug, as a rule, has a bacteriostatic effect, slowing down the reproduction and growth of bacteria. In cases of creation of high concentrations in the focus of inflammation, it can have a bactericidal effect.
Vilprafen Solutab is active against the following microorganisms: gram-positive bacteria (Staphylococcus spp., Including methicillin-susceptible strains of Staphylococcus aureus, Propionibacterium acnes, Corynebacterium diphtheriae, Bacillus pythonescus anthracis, Listeria monocytogenes, S. bacteria (Moraxella catarrhalis, Helicobacter pylori, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Haemophilus ducreyi, Brucella spp., Campylobacter jejuni, Legionella spp., Bordetella spp., Bordetella spp.), intracellular organisms spp., including C. trachomatis, Chlamydophila spp., including C. pneumoniae, Mycoplasma spp., including M. hominis, M. pneumoniae and M. Genitalium), some anaerobes (Peptococcus spp.,Clostridium spp., Bacteroides fragilis, Peptostreptococcus spp.).
Vilprafen Solutab, as a rule, is not effective against enterobacteria, therefore it has some effect on the microflora of the gastrointestinal tract.
In some cases, josamycin remains active with resistance to erythromycin and other 14- and 15-membered macrolides (staphylococci, streptococci). Josamycin resistance is less common than 14- and 15-membered macrolides.
Pharmacokinetics
After oral administration, the active substance of Vilprafen Solutab is rapidly absorbed from the gastrointestinal tract. Its bioactivity is independent of food intake. The peak plasma concentration, which at a dose of 1000 mg is 2-3 μg / ml, the drug reaches after 60 minutes.
About 15% of josamycin binds to plasma proteins. The substance is well distributed in tissues and organs (with the exception of the brain), especially in the lungs, tonsils, saliva, lacrimal fluid and sweat, creates concentrations higher than plasma concentrations in them (for comparison, the concentration of the drug in sputum is 8-9 times higher than plasma), which remain at a therapeutic level for a long time.
Josamycin crosses the placental barrier, excreted in breast milk.
The drug is metabolized in the liver with the formation of less active metabolites. It is excreted mainly with bile, in a small amount (no more than 10%) is excreted by the kidneys. The period T 1/2 (half-life) is 1-2 hours, with impaired hepatic function it may increase.
Indications for use
According to the instructions, Vilprafen Solutab is prescribed for infectious and inflammatory diseases of the following systems and organs caused by microorganisms sensitive to josamycin:
- skin and soft tissues: acne, panaritium, furunculosis, boil, phlegmon, anthrax, abscess, folliculitis, erysipelas, lymphadenitis, lymphangitis, burns and wounds (including postoperative) infections;
- genitourinary system: epididymitis, cervicitis, prostatitis, urethritis caused by chlamydia and / or mycoplasma, lymphogranuloma venereum, gonorrhea, syphilis (in patients with hypersensitivity to penicillin);
- oral cavity (dentistry): alveolitis, pericoronitis, periodontitis, gingivitis, alveolar abscess;
- LOP organs and upper respiratory tract: laryngitis, sinusitis, tonsillitis, paratonsillitis, otitis media, pharyngitis, scarlet fever (in patients with hypersensitivity to penicillin), diphtheria (in addition to therapy with diphtheria toxoid);
- lower respiratory tract: psittacosis, whooping cough, acute bronchitis and exacerbation of chronic, community-acquired pneumonia (including caused by atypical pathogens);
- gastrointestinal tract (infections associated with Helicobacter pylori): chronic gastritis, gastric ulcer, duodenal ulcer;
- organ of vision (ophthalmology): blepharitis, dacryocystitis.
Contraindications
- severe functional disorders of the liver;
- body weight in children less than 10 kg;
- hypersensitivity to any auxiliary component of the drug, josamycin or other macrolides.
Instructions for the use of Vilprafen Solutab: method and dosage
Dispersible tablets Vilprafen Solutab can be taken whole with a liquid, or just before taking it by dissolving in water (at least 20 ml) and thoroughly stirring the resulting suspension. The latter option is most acceptable for children, especially small ones.
For adults and adolescents from 14 years of age, the drug is prescribed in a daily dosage of 1000-2000 mg in 2-3 doses. In severe cases of the course of the infectious process, it is possible to increase the dose to 3000 mg per day.
The daily dose for children weighing at least 10 kg (usually from 1 year) is calculated on the basis of weight: 40-50 mg / kg in 2-3 doses.
Thus, children, depending on body weight, are prescribed:
- from 10 to 20 kg - 250-500 mg of josamycin (¼ – ½ tablets) 2 times a day;
- from 20 to 40 kg - 500–1000 mg (½ – 1 tablet) 2 times a day;
- more than 40 kg - 1000 mg (1 tablet) 2 times a day.
The duration of therapy is determined by the doctor, depending on the indications and the course of the disease, it can be 5–21 days. The complete cure of streptococcal tonsillitis, according to the recommendations of the World Health Organization (WHO), requires at least 10 days.
For common and nodular acne, Vilprafen Solutab at the beginning of treatment (the first 2–4 weeks) is indicated in a dosage of 500 mg 2 times a day, during the next 8 weeks, maintenance therapy is carried out - 500 mg 1 time a day.
For diseases of the gastrointestinal tract associated with the bacterium Helicobacter pylori, Vilprafen Solutab is prescribed at a dose of 1000 mg 2 times / day for 7-14 days in addition to one of the standard anti-Helicobacter therapy regimens:
- 40 mg / day famotidine or 150 mg 2 times / day ranitidine + 500 mg 2 times / day metronidazole;
- 40 mg / day famotidine + 100 mg 2 times / day furazolidone + 240 mg 2 times / day bismuth tripotassium dicitrate;
- 20 mg of omeprazole (or 20 mg of rabeprazole, or 20 mg of esomeprazole, or 30 mg of lansoprazole, or 40 mg of pantoprazole) 2 times / day + 240 mg 2 times / day of bismuth tripotassium dicitrate + 1000 mg 2 times / day of amoxicillin;
- 20 mg of omeprazole (or 20 mg of rabeprazole, or 20 mg of esomeprazole, or 30 ml of lansoprazole, or 40 mg of pantoprazole) 2 times / day + 1000 mg 2 times / day of amoxicillin.
If the patient has atrophy of the gastric mucosa, accompanied by achlorhydria, confirmed by pH-metry, Vilprafen Solutab is prescribed at a dose of 1000 mg 2 times / day in addition to the following therapy: 1000 mg 2 times / day amoxicillin + 240 mg 2 times / day bismuth tripotassium dicitrate …
Side effects
- from the gastrointestinal tract: often (from> 1/100 to 1/1000 to 1/10 000 to <1/1000) - stomatitis, loss of appetite, constipation; very rarely (<1/10 000) - pseudomembranous colitis;
- from the liver and biliary tract: very rarely - jaundice, hepatic dysfunction;
- hypersensitivity reactions: rarely - urticaria, anaphylactoid reaction, Quincke's edema; very rarely - bullous dermatitis, erythema multiforme exudative;
- from the senses: very rarely - dose-dependent transient hearing impairment;
- others: very rarely - purpura.
Overdose
To date, there have been no reports of specific symptoms in case of overdose. Presumably, if the dose is exceeded, side effects characteristic of josamycin may develop, especially on the part of the digestive system.
special instructions
If severe diarrhea occurs during drug therapy, the likelihood of developing life-threatening pseudomembranous colitis associated with antibiotic therapy must be taken into account.
Patients with renal insufficiency during treatment need careful monitoring of the kidney condition (determination of endogenous creatinine clearance) and, if necessary, adjust the dose of josamycin.
When prescribing Vilprafen Solutab, the presence of resistance to other macrolide antibiotics should be taken into account, since microorganisms resistant to antibacterial agents related in chemical structure may also be resistant to josamycin.
Influence on the ability to drive vehicles and complex mechanisms
During the period of treatment with this drug, the development of any reactions that could adversely affect the ability to work with complex mechanisms, drive a car or perform other potentially dangerous actions requiring increased attention and an increased reaction rate were not noted.
Application during pregnancy and lactation
For pregnant and lactating women, Vilprafen Solutab 1000 mg is prescribed if the expected benefits outweigh the possible risks. The WHO European Office recommends josamycin as the primary drug for the treatment of chlamydial infection in pregnant women.
Pediatric use
Prescription of the drug is possible for children weighing at least 10 kg.
With impaired renal function
If there are indications for the use of Vilprafen Solutab in patients with renal insufficiency, the drug should be used under the control of renal function and the general condition of the patient.
For violations of liver function
According to the instructions, Vilprafen Solutab is contraindicated in patients with severe hepatic impairment.
Drug interactions
You should not use josamycin in combination with lincosamides, since there may be a mutual decrease in their action.
It is not recommended to simultaneously prescribe bacteriostatic antibiotics, since in vitro a decrease in the antimicrobial effect has been noted.
Josamycin slows down the elimination of xanthines (eg theophylline). And although this effect is less than some other representatives of the macrolide group, the possible risk of intoxication should be taken into account.
Concomitant use of astemizole or terfenadine increases the likelihood of life-threatening arrhythmias.
Josamycin may increase plasma levels of cyclosporine and the risk of developing nephrotoxicity. When using this combination, it is necessary to control the concentration of cyclosporine.
Josamycin may increase plasma levels of digoxin.
There are some reports that after the combined use of macrolide antibiotics and ergot alkaloids, vasoconstriction increased.
Analogs
An analogue of Vilprafen Solutab (1000 mg) is the drug Vilprafen (500 mg).
Terms and conditions of storage
Store in a place protected from light and high humidity, out of the reach of children, with a temperature up to 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Wilprafen Solutab
Reviews about Wilprafen Solutab are mostly positive. Patients characterize the antibiotic as a highly effective remedy that allows you to quickly get rid of symptoms and cure infectious diseases caused by microorganisms that are sensitive to it.
Opinions about the dosage form - dispersible tablets are ambiguous: some assess it as a disadvantage, indicating that the suspension has an unpleasant aftertaste, while others, on the contrary, consider it an advantage, since it is more convenient for them to take the drug and give it to children in this form.
Among the side effects that occur, complaints of gastrointestinal tract disorders and skin allergic manifestations are most often received. Nevertheless, some patients consider these undesirable reactions of Wilprafen Solutab not such a serious drawback when compared with the benefits of the drug, namely, quick recovery, and are ready to take it "as an emergency option if there is no time to get sick."
Price for Wilprafen Solutab in pharmacies
In the pharmacy chain, the price for Vilprafen Solutab ranges from 605–710 rubles per pack of 10 dispersible tablets.
Vilprafen Solutab: prices in online pharmacies
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Drug name Price Pharmacy |
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Vilprafen Solutab 1000 mg dispersible tablets 10 pcs. RUB 550 Buy |
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Vilprafen Solutab tablets dispersion 1000mg 10 pcs. 707 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
