Venoruton

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Venoruton: instructions for use and reviews

1. Release form and composition
2. Pharmacodynamics and pharmacokinetics
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Drug interactions
11. Analogs
12. Terms and conditions of storage
13. Terms of dispensing from pharmacies
14. Reviews
15. Price in pharmacies

Latin name: Venoruton

ATX code: C05CA51

Active ingredient: Rutoside (Rutoside)

Manufacturer: Novartis Consumer Health (Switzerland), SwissCo Services (Switzerland), Novartis Farmaceutica (Spain)

Description and photo updated: 2019-30-07

Prices in pharmacies: from 788 rubles.

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Venoruton is a drug with angioprotective and venotonic effects.

Release form and composition

Capsules: gelatinous, yellow-beige, matte, with the inscription "Venoruton 300", odorless; content - odorless powder, yellow or yellowish-brown color (10 pcs. in blisters, in a cardboard box 2 or 5 blisters);
Gel for external use 2%: homogeneous, transparent, golden yellow color, sometimes slightly opalescent, practically odorless (40 and 100 g each in aluminum tubes, 1 tube in a cardboard box).

Active ingredient: hydroxyethylrutosides, in 1 capsule - 300 mg, in 1 g of gel - 20 mg.

Additional components of capsules:

Excipients: macrogol 6000, titanium dioxide, iron dye yellow dioxide, gelatin;
Ink composition: propylene glycol, shellac, water, n-butanol, isopropanol, iron dye black dioxide.

Excipients of the gel: disodium EDTA, sodium hydroxide 30%, benzalkonium chloride, carbomer, purified water.

Pharmacodynamics and pharmacokinetics

The drug is a rutin derivative. It affects the capillaries and veins, strengthening their walls and increasing tone, and generally improves blood circulation.

Acting on the fibrous matrix located between the endothelial cells, Venoruton narrows the intercellular pores.

By inhibiting the aggregation of erythrocytes and increasing the degree of their deformability, the drug causes an anti-inflammatory effect.

Venoruton reduces the severity of pain, edema, trophic disorders, seizures and varicose ulcers in chronic venous insufficiency; relieves the symptoms of hemorrhoids (itching, pain, bleeding).

The beneficial effect of the drug on the resistance and permeability of the capillary walls slows down the development of diabetic retinopathy, and due to the effect on the rheological properties of the blood, retinal microthrombosis is prevented.

The maximum plasma concentration of the drug is reached within 2-9 hours. The concentration remains measurable for 40 hours. 27-29% of the drug binds to plasma proteins. The active substances and their metabolites are excreted mainly in the bile, about 3–6% are excreted by the kidneys within 48 hours. The half-life is 13.5-25.7 hours, but this value is constant in each patient.

When applied topically, the active ingredients quickly penetrate the epidermal barrier: after 30 minutes they appear in the dermis, and after 2-5 hours - in the layer of subcutaneous adipose tissue. When using Venoruton gel, the concentration of active ingredients in the blood plasma is low and is not determined by the currently available methods for measuring the plasma concentration of substances.

Indications for use

For capsules:

Trophic disorders in varicose veins;
Postphlebitic syndrome;
Chronic venous insufficiency;
Trophic ulcers;
Hemorrhoids (exudation, itching, pain and bleeding);
Lymphostasis after removal of varicose veins and sclerotherapy (as an auxiliary drug);
Retinopathy in patients with diabetes mellitus, arterial hypertension and atherosclerosis (as adjunctive therapy);
Hemorrhoids and venous insufficiency in pregnant women (starting from the second trimester).

For the gel:

Pain and heaviness in the legs, swelling of the ankles;
Swelling and pain associated with chronic venous insufficiency;
Edema and pain of traumatic origin (including with bruises and sprains of muscles, damage to ligaments);
Pain after sclerotherapy.

Contraindications

I trimester of pregnancy;
Hypersensitivity to drug components.

Instructions for the use of Venoruton: method and dosage

The capsules should be taken orally with meals with plenty of water. The initial dose is 300 mg 3 times a day. After 2 weeks of treatment, the drug is canceled or the dose is reduced to the minimum maintenance dose - 600 mg per day, if necessary, the dose is left unchanged.

With diabetic retinopathy, the daily dose is 900-1800 mg, with lymphostasis - 3000 mg.

According to the instructions, Venoruton gel is applied to the affected area, rubbing gently until completely absorbed, 2 times a day - in the morning and in the evening. If necessary, the drug can be applied under elastic stockings or bandages.

Side effects

When using Venoruton in capsule form, the following side effects are possible (usually disappear after the drug is discontinued):

Digestive system: heartburn, nausea, and diarrhea;
Allergic reactions: skin rash;
Others: flushing of the face, headache.

When using Venoruton in the form of a gel, local skin reactions are possible due to increased sensitivity to the components of the drug.

Overdose

No cases of overdose accompanied by clinical symptoms were recorded.

special instructions

If the severity of the symptoms of the disease does not decrease during treatment, you should consult a doctor to clarify the diagnosis.

Application during pregnancy and lactation

In pregnant women, the use of the drug was studied in clinical trials only in the II and III trimesters. In the first trimester, the use of the drug is contraindicated.

Studies carried out on laboratory animals have not revealed teratogenic and other harmful effects on the fetus.

Venoruton in the form of capsules can be used no earlier than the second trimester of pregnancy and only in cases where the benefit to the mother outweighs the potential risk to the fetus.

Drug interactions

The action of Venoruton, taken orally, is enhanced by ascorbic acid.

There is no information on the interaction of the drug with other drugs when used externally.

Analogs

Venoruton analogs are: Rutozid, Rutin, Vasoket.

Terms and conditions of storage

Store in a dry place, out of reach of children, at temperatures up to 30 ° C.

Shelf life for capsules is 3 years, for gel - 5 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Venoruton

Positive reviews about Venoruton are met quite regularly, while the effectiveness of the drugs both in capsules and in the form of a gel is confirmed. During treatment with the drug, the patient's well-being noticeably improves with various types of lymphovenous insufficiency.

Experts quite often prescribe a drug for violations of venous outflow, especially with hemorrhoids. This is due to the fact that the drug is one of the most effective venotonics. However, one should not forget that only a comprehensive approach to the disease helps to achieve a full cure: changing the lifestyle and diet, wearing special compression underwear, drug therapy and other procedures that have a beneficial effect on the functioning of veins and lymphatic vessels.

Price for Venoruton in pharmacies

The cost of Venoruton in capsule form varies from 670-850 rubles (price per package containing 5 blisters of 10 capsules).

Gel for external use can be purchased in pharmacies at a price of 370-380 rubles for a 40 g tube.

Venoruton: prices in online pharmacies

Drug name

Price

Pharmacy

Venoruton 300 mg capsule 50 pcs.

RUB 788

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Venoruton Venoruton for venous insufficiency, capsules 300 mg, 50 pieces

1215 RUB

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Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!