Betacor
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Betacor - a selective beta-adrenergic receptor blocker; a drug with antihypertensive, antianginal and antiarrhythmic action.
Release form and composition
Dosage form - film-coated tablets: round, biconvex, almost white or white, with a risk (10 pcs. In a blister, 3 blisters in a cardboard box).
Active ingredient: betaxolol hydrochloride, 1 tablet - 20 mg.
Auxiliary components: microcrystalline cellulose, sodium starch glycolate, aerosil, lactose monohydrate, magnesium stearate, Opadry II White film coating mixture.
Indications for use
- treatment of arterial hypertension;
- prevention of angina attacks.
Contraindications
- sick sinus syndrome;
- cardiogenic shock;
- arterial hypotension (systolic blood pressure below 100 mm Hg);
- AV block II – III degree;
- sinus bradycardia (heart rate less than 50 bpm);
- decompensated heart failure;
- Raynaud's syndrome;
- obstructive respiratory failure;
- congenital galactosemia;
- childhood;
- pregnancy and lactation;
- increased individual sensitivity to drug components.
Carefully:
- AV block I degree;
- peripheral circulatory disorders;
- hyperthyroidism;
- hypoglycemia;
- impaired liver and kidney function;
- tendency to bradycardia;
- unstable angina;
- muscle weakness;
- diabetes mellitus in the stage of decompensation;
- chronic obstructive pulmonary disease;
- suspicion of vasospastic angina (variant or Prinzmetal);
- elderly age.
Method of administration and dosage
Betacor should be taken orally in the morning, swallowing the tablets whole and drinking a small amount of liquid. Meal time does not matter.
The doctor selects the dose individually, depending on the patient's pulse rate and the effectiveness of the drug.
At the beginning of treatment, usually 10 mg (½ tablet) is prescribed once a day. If the severity of the effect is not enough, which is assessed after 7-14 days, the dose is increased to 20 mg (1 tablet). If, in this case, the effect of the drug is not expressed as necessary, after 7-14 days the dose is increased to 40 mg (2 tablets).
The highest permissible dose is 40 mg per day.
For the elderly and patients with impaired renal function on hemodialysis, the recommended daily dose is 10 mg.
Side effects
- from the cardiovascular system: exacerbation of intermittent claudication, hypotension, anemia, AV blockade, leukocytosis, palpitations, thrombocytopenia, bradycardia, purpura, vasospastic angina pectoris, thrombosis, heart failure, myocardial infarction;
- from the respiratory system: chest pain, cough, sinusitis, rhinitis, shortness of breath, pharyngitis, bronchospasm, dyspnea, respiratory failure;
- from the gastrointestinal tract: dry mouth, dysphagia, nausea, dyspepsia, constipation / diarrhea, abdominal discomfort, vomiting, anorexia, hepatitis;
- from the nervous system and sensory organs: drowsiness, dizziness, stupor, paresthesia, sensitivity disorders, headache, emotional lability, impaired concentration, anxiety, hallucinations, depression, amnesia, insomnia, syncope, asthenia, pain and tinnitus, partial hearing loss, vestibular disorders, neuropathy, tremor, neuralgia;
- on the part of the musculoskeletal system: tendinitis, arthralgia, myalgia;
- from the genitourinary system: pain and fibrocystic changes in the mammary glands, menstrual irregularities, decreased libido, impotence, prostatitis, Peyronie's disease, edema, proteinuria, oliguria, cystitis, dysuria, renal colic;
- on the part of the skin: exacerbation of psoriasis, alopecia, hypertrichosis;
- others: withdrawal syndrome, hyperlipidemia, hyperglycemia, hyperuricemia, hypothermia, hypercholesterolemia, changes in body weight, acidosis, hypokalemia, increased concentration of lactate dehydrogenase and hepatic transaminases;
- allergic reactions: in case of hypersensitivity to the components of the drug - skin rash, eczema, erythema.
special instructions
Betacor treatment should be carried out under the close supervision of a physician.
In patients with diabetes mellitus, it is necessary to control blood glucose levels, since betaxolol can mask the symptoms of hypoglycemia and enhance the effect of antidiabetic agents.
With hyperfunction of the thyroid gland, the drug can mask the tachycardia caused by thyrotoxicosis.
There is no need to adjust the dose in patients with hepatic insufficiency, but clinical observation is indicated during the first 4 days of treatment.
With pheochromocytoma, Betacor can be prescribed only after the implementation of an adequate alpha-blockade.
The drug reduces the severity of compensatory cardiovascular reactions in response to the use of general anesthetics and iodine-containing contrast agents.
If it is necessary to carry out a planned operation, the patient should warn the anesthesiologist about taking betaxolol.
Elderly patients are at risk of developing side effects from the cardiovascular system, as well as mental disorders and hypothermia. Their excretion of the drug slows down, so it is recommended to reduce the therapeutic dose.
Against the background of a burdened allergic history, the severity of the hypersensitivity reaction may increase, there may be no therapeutic effect from the use of conventional doses of adrenaline.
Betacor should be withdrawn gradually, over about 2 weeks.
Betaxolol can alter the results of some laboratory tests, for example, doping tests and an increase in antinuclear antibody titer.
During treatment, one should refrain from drinking alcohol, be careful when driving a car and performing potentially dangerous types of work.
Drug interactions
- other antihypertensive drugs: their effect is enhanced (abrupt withdrawal of centrally acting antihypertensive drugs should not be allowed, since a significant increase in blood pressure is possible);
- non-depolarizing muscle relaxants: their action is potentiated;
- alpha-methyldopa, verapamil, cardiac glycosides, quinidine, diltiazem, amiodarone, reserpine: the risk of violations of automatism, contractility and conduction of the heart increases;
- dihydropyridine calcium antagonists: the likelihood of hypotension and cardiac decompensation increases, especially in patients with latent heart failure (the combination is not recommended);
- lidocaine: its metabolism in the liver is inhibited;
- tricyclic antidepressants: the hypotensive effect of betaxolol increases, the risk of developing orthostatic hypotension;
- enveloping and antacids, glucocorticoids, non-steroidal anti-inflammatory drugs, estrogens: the hypotensive effect of betaxolol decreases;
- cimetidine, phenothiazines: the concentration of betaxolol in plasma increases;
- monoamine oxidase inhibitors: the hypotensive effect is significantly enhanced (this combination is not recommended);
- allergens and their extracts used for skin tests: the risk of anaphylaxis or severe systemic reactions increases.
In the case of arterial hypotension and anaphylactic reactions caused by the use of iodine-containing contrast agents, the severity of compensatory reactions of the cardiovascular system can reduce β-adrenergic receptor blockers.
Analogs
There is no information on analogues.
Terms and conditions of storage
Store in its original packaging out of the reach of children at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
