Walvir
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Prices in online pharmacies:
from 529 rub.
Buy
Valvir is a drug with antiviral action.
Release form and composition
Dosage form Valvira - film-coated tablets: color - almost white or white, biconvex, oval, on one side the marking "VC2" (500 mg) or "VC3" (1000 mg) (500 mg - 10 pcs. in blisters, in a cardboard box 1 blister; 14 pcs. in blisters, in a cardboard box 3 blisters; 1000 mg - 7 pcs. in blisters, in a cardboard box 1 or 4 blisters).
Composition of 1 tablet:
- active substance: valacyclovir - 500 or 1000 mg (valaciclovir hydrochloride hydrate - 611.7 or 1223.4 mg);
- additional components: povidone K30 - 24.5 / 49 mg, microcrystalline cellulose - 59.6 / 119.2 mg, magnesium stearate - 4.2 / 8.4 mg;
- film shell: Opadry white Y-5-7068 (hypromellose 3cP - 7.35 / 14.7 mg, hyprolose - 6.3 / 12.6 mg, titanium dioxide - 4.2 / 8.4 mg, macrogol / PEG 400 - 2.1 / 4.2 mg, hypromellose 50cP - 1.05 / 2.1 mg) - 21/42 mg.
Indications for use
- infections of the skin and mucous membranes caused by the herpes simplex virus, including newly diagnosed and recurrent genital herpes (therapy and prevention of relapse);
- herpes zoster (therapy);
- genital herpes (reduction of infection in a healthy partner if Valvir is taken as suppressive therapy in combination with safe sex);
- labial herpes (therapy);
- cytomegalovirus infection (CMV), which develops during organ transplantation (prevention to reduce the severity of the reaction of acute graft rejection in patients with kidney transplants, the likelihood of developing opportunistic infections and other viral infections caused by Varicella zoster and Herpes simplex viruses) in children from 12 years of age and adults.
Contraindications
Absolute:
- kidney and bone marrow transplant;
- HIV infection in clinically expressed forms with a CD4 + lymphocyte content of less than 100 / μl;
- age up to 12 years (with CMV therapy), up to 18 years (prescription for other indications);
- individual intolerance to the components of the drug, as well as acyclovir.
Relative (the appointment of Valvir requires caution in the presence of the following diseases / conditions):
- renal failure;
- HIV infection in clinically expressed forms;
- combined use with nephrotoxic drugs;
- pregnancy and lactation (the use of Valvir is possible only after assessing the ratio of the expected benefit with the possible risk).
Method of administration and dosage
Valvir is taken orally.
Recommended dosage regimen:
- herpes zoster (treatment): 3 times a day, 1000 mg for 7 days;
- herpes simplex (treatment): 2 times a day, 500 mg for a course of 3 or 5 days (for relapses) or up to 10 days (for the first episode with a severe course); in case of relapses, Valvir is recommended to be prescribed in the prodromal period or when the first symptoms of the disease appear in the form of tingling, itching, burning;
- labial herpes (treatment): 2 times 2000 mg for one day (the second dose should be taken about 12 hours, but not earlier than 6 hours after the first dose; longer treatment is ineffective);
- herpes simplex (prevention): with preserved immunity - 500 mg once a day; with very frequent relapses (from 10 times a year) - 2 times a day, 250 mg; adult patients with immunodeficiency - 2 times a day, 500 mg. The duration of the course is from 4 to 12 months;
- genital herpes (prevention of infection of a healthy partner): infected heterosexual adults with preserved immunity with relapses up to 9 times a year - once a day, 500 mg for a course of 1 year or more; with regular sexual activity, Valvir is taken daily, with irregular sexual intercourse, therapy begins 3 days before the expected sexual intercourse;
- CMV (prevention): adults and adolescents from 12 years old - 4 times a day, 2000 mg (as early as possible after transplantation) for a course of 90 days, patients at high risk may be prescribed a longer treatment.
With a significant decrease in renal function, lower doses are indicated (depending on creatinine clearance).
Shingles:
- 15-30 ml / min - 2 times a day, 1000 mg;
- <15 ml / min - 1000 mg once a day.
Herpes simplex: <15 ml / min - 500 mg once a day.
Labial herpes:
- 31–49 ml / min - 2 times within 1 day, 1000 mg each;
- 15-30 ml / min - 2 times within 1 day, 500 mg;
- <15 ml / min - 500 mg once a day.
Herpes simplex (patients with preserved / reduced immunity): <15 ml / min - once a day, 250/500 mg.
Genital herpes (to reduce infection): <15 ml / min - once a day, 250 mg.
CMV:
- ≥ 75 ml / min - 4 times a day, 2000 mg;
- 50-74 ml / min - 4 times a day, 1500 mg;
- 25–49 ml / min - 1500 mg 3 times a day;
- 10-24 ml / min - 2 times a day, 1500 mg;
- <10 ml / min or hemodialysis - 1500 mg once a day.
Patients on hemodialysis are recommended to use Valvir immediately after the end of the session in the same dose as in patients with creatinine clearance <15 ml / min.
Patients on dialysis should take the drug after the end of the hemodialysis session.
The creatinine clearance rate should be measured frequently, especially during periods when renal function is changing rapidly, for example, immediately after engraftment or transplantation. The Valvir dose should be adjusted in accordance with the creatinine clearance rates.
Side effects
Adverse reactions that occur most often while taking Valvir: nausea, headache. More serious disorders include hemolytic uremic syndrome / thrombotic thrombocytopenic purpura, neurological disorders, and acute renal failure.
Possible violations (> 10% - very often;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rarely; with an unknown frequency - if it is impossible to assess the frequency of development violations):
- immune system: very rarely - anaphylaxis;
- digestive system: often - nausea; rarely - abdominal discomfort, including abdominal pain, vomiting, diarrhea; very rarely - reversible violations of functional liver tests (in some cases, are regarded as manifestations of hepatitis);
- lymphatic system and blood: very rarely - leukopenia (in most cases in patients with reduced immunity), thrombocytopenia;
- respiratory system: infrequently - dyspnea;
- nervous system and psyche: often - headache; infrequently - agitation, including aggressive behavior; rarely - a decrease in mental abilities, dizziness, hallucinations, confusion; very rarely - ataxia, agitation, dysarthria, tremor, psychotic symptoms, including mania, encephalopathy, depression, convulsions, coma (the disorders are reversible, usually observed in patients with impaired renal function or against the background of other diseases);
- skin and subcutaneous tissue: infrequently - rashes, including manifestations of photosensitivity; rarely - itching;
- urinary system: infrequently - hematuria (often associated with other renal disorders); rarely - functional disorders of the kidneys; very rarely - renal failure in the acute course, renal colic (may be associated with functional impairment of the kidneys); due to the likelihood of deposition of crystals of the active substance in the lumen of the renal tubules during the period of therapy, it is recommended to observe an adequate drinking regimen;
- hematopoietic organs: with an unknown frequency - aplastic anemia, neutropenia, thrombotic thrombocytopenic purpura, leucoclastic vasculitis;
- organs of vision: with an unknown frequency - visual impairment;
- skin: with an unknown frequency - erythema multiforme;
- allergic reactions: very rarely - angioedema, urticaria;
- laboratory parameters: with an unknown frequency - hypercreatininemia, decreased hemoglobin;
- others: in severe immunity disorders, especially in patients with acquired immune deficiency in a far advanced stage and long-term high doses of valacyclovir (8000 mg per day), cases of microangiopathic hemolytic anemia, renal failure, thrombocytopenia, in some cases in combination (such complications were observed in patients with the same diseases, but not receiving valacyclovir); with an unknown frequency - fatigue, nasopharyngitis, dysmenorrhea, tachycardia, arthralgia, facial edema, respiratory tract infections, increased blood pressure; additionally in children - dehydration, fever, rhinorrhea.
special instructions
Long-term use of high doses of Valvir in conditions that are accompanied by severe immunodeficiency (bone marrow / kidney transplantation, clinically pronounced forms of HIV infection) can lead to hemolytic uremic syndrome and thrombocytopenic purpura, up to death. Therapy is canceled in cases of adverse reactions from the central nervous system, including agitation, hallucinations, confusion, delirium, convulsions, and encephalopathy.
In the presence of the likelihood of dehydration, especially in elderly patients, it is necessary to ensure adequate hydration of the body. An increased risk of developing neurological complications is noted in patients with renal insufficiency.
In case of impaired hepatic function in patients with mild / moderate liver cirrhosis (while maintaining the synthetic liver function), the Valvir dose adjustment is not required. The condition of patients with severe cirrhosis of the liver (with impaired liver synthetic function and the presence of shunts between the common vascular bed and the portal system) requires monitoring, due to the lack of sufficient data.
In cases of side effects that affect the speed of psychomotor reactions, care must be taken when driving.
Drug interactions
With the combined use of Valvir with certain drugs / substances, the following effects may develop:
- nephrotoxic drugs, including aminoglycosides, organic platinum compounds, iodinated contrast agents, methotrexate, pentamidine, foscarnet, cyclosporine and tacrolimus: the combination requires caution, especially in functional renal impairment, and regular monitoring of renal function is also necessary;
- drugs that compete with acyclovir for the elimination pathway (at high doses of valacyclovir - 4000 mg per day): there is a possibility of an increase in the plasma concentration of drugs (one or both) or their metabolites;
- mycophenolate mofetil: increases the AUC (area under the concentration-time curve) of acyclovir and the inactive metabolite of mycophenolate mofetil.
Analogs
Valvir's analogs are: Valtrovir, Valtsik, Valtrex, Valmax, Gerpeval.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Valvir: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Valvir 500 mg film-coated tablets 10 pcs. 529 r Buy |
|
Valvir 1000 mg film-coated tablets 7 pcs. 572 r Buy |
|
Valvir tablets p.p. 500mg 10 pcs. 837 RUB Buy |
|
Valvir tablets p.p. 1000mg 7 pcs. 1032 RUB Buy |
|
Valvir 500 mg film-coated tablets 42 pcs. RUB 1,500 Buy |
|
Valvir tablets p.p. 500mg 42 pcs. 2051 RUB Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
